SIMILAR PATTERNS OF AMINO ACIDS FOR 5WBV_B_SAMB402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae)
PF00450
(Peptidase_S10)
3 HIS A 448
GLU A  88
ASN A  74
None
0.92A 5wbvB-1ac5A:
0.0
5wbvB-1ac5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens)
PF00191
(Annexin)
3 HIS A 295
GLU A 257
ASN A 246
None
0.84A 5wbvB-1axnA:
0.0
5wbvB-1axnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gco GLUCOSE
DEHYDROGENASE


(Bacillus
megaterium)
PF13561
(adh_short_C2)
3 HIS A 147
GLU A  96
ASN A 196
None
None
NAD  A 601 (-3.9A)
0.99A 5wbvB-1gcoA:
0.0
5wbvB-1gcoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B


(Sorghum
bicolor;
Sorghum bicolor)
PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10)
3 HIS B 414
GLU A  76
ASN A  61
DKA  A 701 (-4.0A)
None
DKA  A 701 (-3.8A)
0.96A 5wbvB-1gxsB:
0.0
5wbvB-1gxsB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqo HYPOTHETICAL PROTEIN
MTH1880


(Methanothermobacter)
PF05370
(DUF749)
3 HIS A  87
GLU A  39
ASN A  60
None
0.98A 5wbvB-1iqoA:
undetectable
5wbvB-1iqoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k77 HYPOTHETICAL PROTEIN
YGBM


(Escherichia
coli)
PF01261
(AP_endonuc_2)
3 HIS A 202
GLU A 143
ASN A  60
None
MG  A 300 ( 2.7A)
None
0.79A 5wbvB-1k77A:
undetectable
5wbvB-1k77A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus)
PF14592
(Chondroitinas_B)
3 HIS A 272
GLU A 245
ASN A 213
None
ASG  A 608 (-3.7A)
None
0.94A 5wbvB-1ofmA:
0.0
5wbvB-1ofmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus)
PF01403
(Sema)
3 HIS A 515
GLU A 478
ASN A  44
None
0.92A 5wbvB-1q47A:
0.0
5wbvB-1q47A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE


(Pyrococcus
furiosus)
PF03070
(TENA_THI-4)
3 HIS A  20
GLU A  25
ASN A  35
None
1.02A 5wbvB-1rtwA:
0.0
5wbvB-1rtwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila)
PF00871
(Acetate_kinase)
3 HIS A 180
GLU A 384
ASN A   7
SO4  A 400 (-3.9A)
None
None
0.90A 5wbvB-1tuuA:
undetectable
5wbvB-1tuuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE


(Thermus
thermophilus)
PF01761
(DHQ_synthase)
3 HIS A 243
GLU A  62
ASN A 141
None
0.86A 5wbvB-1ujnA:
undetectable
5wbvB-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE


(Thermus
thermophilus)
PF01761
(DHQ_synthase)
3 HIS A 247
GLU A  62
ASN A 141
None
0.75A 5wbvB-1ujnA:
undetectable
5wbvB-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE


(Oxalobacter
formigenes)
PF02515
(CoA_transf_3)
3 HIS A 404
GLU A 411
ASN A  32
None
0.95A 5wbvB-1vgqA:
undetectable
5wbvB-1vgqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2


(Trypanosoma
brucei)
PF00913
(Trypan_glycop)
3 HIS A  71
GLU A 313
ASN A 306
None
NAG  A 366 (-3.5A)
None
0.92A 5wbvB-1vsgA:
undetectable
5wbvB-1vsgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus;
Thermus
thermophilus)
PF02347
(GDC-P)
PF02347
(GDC-P)
3 HIS B 166
GLU B 136
ASN A 318
None
0.78A 5wbvB-1wytB:
undetectable
5wbvB-1wytB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)


(Mycobacterium
tuberculosis)
PF00484
(Pro_CA)
3 HIS A 104
GLU A 153
ASN A 111
ZN  A 401 ( 3.3A)
None
None
0.96A 5wbvB-2a5vA:
undetectable
5wbvB-2a5vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 249
GLU A 192
ASN A 244
MN  A1002 ( 3.5A)
MN  A1003 ( 3.0A)
P3S  A5001 ( 4.7A)
1.01A 5wbvB-2d3aA:
undetectable
5wbvB-2d3aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eql HORSE MILK LYSOZYME

(Equus caballus)
PF00062
(Lys)
3 HIS A 114
GLU A  33
ASN A  37
None
1.00A 5wbvB-2eqlA:
undetectable
5wbvB-2eqlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE


(Haemophilus
influenzae)
PF11463
(R-HINP1I)
3 HIS A 118
GLU A 145
ASN A 111
None
0.92A 5wbvB-2fl3A:
undetectable
5wbvB-2fl3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kld POLYCYSTIN-2

(Homo sapiens)
no annotation 3 HIS A 775
GLU A 774
ASN A 737
None
1.00A 5wbvB-2kldA:
undetectable
5wbvB-2kldA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Novosphingobium
aromaticivorans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 HIS A 343
GLU A 169
ASN A  37
None
0.98A 5wbvB-2qjjA:
undetectable
5wbvB-2qjjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II


(Streptococcus
pneumoniae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 HIS A 337
GLU A 346
ASN A 168
None
0.98A 5wbvB-2rjtA:
undetectable
5wbvB-2rjtA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 253
GLU A 196
ASN A 248
None
MG  A 401 (-3.2A)
None
0.93A 5wbvB-2uu7A:
undetectable
5wbvB-2uu7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR


(Klebsiella
pneumoniae)
PF04198
(Sugar-bind)
PF13936
(HTH_38)
3 HIS A  98
GLU A  66
ASN A  60
None
0.73A 5wbvB-2w48A:
undetectable
5wbvB-2w48A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Thermus
thermophilus)
PF09488
(Osmo_MPGsynth)
3 HIS A 115
GLU A  96
ASN A  63
None
1.00A 5wbvB-2wvlA:
undetectable
5wbvB-2wvlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
3 HIS A 682
GLU A 623
ASN A 763
None
0.96A 5wbvB-2x05A:
undetectable
5wbvB-2x05A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00155
(Aminotran_1_2)
3 HIS A  95
GLU A 229
ASN A 199
None
0.93A 5wbvB-2xh1A:
undetectable
5wbvB-2xh1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Candida
albicans)
PF01704
(UDPGP)
3 HIS A 363
GLU A 391
ASN A 227
None
None
GN1  A1001 (-3.1A)
0.94A 5wbvB-2yqhA:
undetectable
5wbvB-2yqhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus)
PF01979
(Amidohydro_1)
3 HIS A 310
GLU A  63
ASN A  89
None
1.02A 5wbvB-2z00A:
undetectable
5wbvB-2z00A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Pyrococcus
horikoshii)
PF09488
(Osmo_MPGsynth)
3 HIS A 116
GLU A  97
ASN A  61
None
0.96A 5wbvB-2zu8A:
undetectable
5wbvB-2zu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE


(Methanocaldococcus
jannaschii)
PF13476
(AAA_23)
3 HIS A 979
GLU A 947
ASN A  34
None
None
ADP  A1006 ( 4.8A)
1.02A 5wbvB-3auxA:
undetectable
5wbvB-3auxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
3 HIS A 434
GLU A 530
ASN A 195
None
0.94A 5wbvB-3c49A:
undetectable
5wbvB-3c49A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE


(Helicobacter
pylori)
PF01761
(DHQ_synthase)
3 HIS A 248
GLU A  63
ASN A 142
ZN  A 344 (-2.9A)
NAD  A 400 (-2.7A)
NAD  A 400 (-3.0A)
0.75A 5wbvB-3clhA:
undetectable
5wbvB-3clhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cne PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron)
PF01965
(DJ-1_PfpI)
3 HIS A 131
GLU A 160
ASN A  46
None
1.01A 5wbvB-3cneA:
undetectable
5wbvB-3cneA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE


(Bacteroides
fragilis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 HIS A 324
GLU A 503
ASN A 418
None
0.95A 5wbvB-3fn9A:
undetectable
5wbvB-3fn9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5


(Homo sapiens)
PF11648
(RIG-I_C-RD)
3 HIS A1021
GLU A1017
ASN A1012
None
1.02A 5wbvB-3ga3A:
undetectable
5wbvB-3ga3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Yersinia
pseudotuberculosis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
3 HIS A 153
GLU A 152
ASN A 227
None
MG  A 501 (-2.4A)
MG  A 501 ( 4.1A)
0.88A 5wbvB-3iieA:
2.4
5wbvB-3iieA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE


(Staphylococcus
aureus)
PF00724
(Oxidored_FMN)
3 HIS A 191
GLU A 206
ASN A 146
None
0.64A 5wbvB-3l5aA:
undetectable
5wbvB-3l5aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE


(Streptomyces
coelicolor)
no annotation 3 HIS A 264
GLU A 189
ASN A 178
None
0.92A 5wbvB-3lg5A:
0.6
5wbvB-3lg5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mti RRNA METHYLASE

(Streptococcus
thermophilus)
PF06962
(rRNA_methylase)
3 HIS A 109
GLU A 113
ASN A  78
None
0.95A 5wbvB-3mtiA:
undetectable
5wbvB-3mtiA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC


(Bos taurus)
PF00074
(RnaseA)
3 HIS A 176
GLU A 177
ASN A 231
None
1.01A 5wbvB-3mx8A:
undetectable
5wbvB-3mx8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 272
GLU A 215
ASN A 267
MN  A 477 (-3.2A)
MN  A 475 (-3.1A)
None
0.93A 5wbvB-3ng0A:
undetectable
5wbvB-3ng0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2


(Brucella
abortus)
PF01261
(AP_endonuc_2)
3 HIS A 201
GLU A 142
ASN A  60
None
MN  A 262 (-2.6A)
None
0.91A 5wbvB-3ngfA:
undetectable
5wbvB-3ngfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE


(Nostoc
punctiforme)
PF02633
(Creatininase)
3 HIS A   4
GLU A  45
ASN A  64
None
0.89A 5wbvB-3no4A:
undetectable
5wbvB-3no4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
3 HIS A 734
GLU A 597
ASN A 628
None
0.99A 5wbvB-3o8lA:
undetectable
5wbvB-3o8lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE


(Vibrio cholerae)
PF01761
(DHQ_synthase)
3 HIS A 268
GLU A  77
ASN A 156
None
NAD  A 367 (-3.0A)
NAD  A 367 ( 3.5A)
0.52A 5wbvB-3okfA:
undetectable
5wbvB-3okfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis)
PF12741
(SusD-like)
3 HIS A 383
GLU A 380
ASN A 250
None
0.99A 5wbvB-3p1uA:
undetectable
5wbvB-3p1uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00342
(PGI)
3 HIS A 122
GLU A 103
ASN A 320
None
0.91A 5wbvB-3qkiA:
3.0
5wbvB-3qkiA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00342
(PGI)
3 HIS A 122
GLU A 119
ASN A 106
None
0.74A 5wbvB-3qkiA:
3.0
5wbvB-3qkiA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN


(Sphingomonas
sp. SKA58)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 HIS A 344
GLU A 170
ASN A  38
None
None
GOL  A 406 (-3.7A)
0.99A 5wbvB-3thuA:
undetectable
5wbvB-3thuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE


(Brucella
abortus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 HIS A 333
GLU A 342
ASN A 165
None
NA  A 410 (-3.1A)
None
0.94A 5wbvB-3u0fA:
undetectable
5wbvB-3u0fA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
3 HIS L 351
GLU L 549
ASN L  45
None
1.01A 5wbvB-3uscL:
undetectable
5wbvB-3uscL:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE


(Caulobacter
vibrioides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 HIS A 344
GLU A 170
ASN A  38
None
None
GOL  A 502 (-3.8A)
0.95A 5wbvB-3vcnA:
undetectable
5wbvB-3vcnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum;
Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
3 HIS A 250
GLU A 545
ASN B  77
None
0.93A 5wbvB-3vrbA:
undetectable
5wbvB-3vrbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w57 C2 DOMAIN PROTEIN

(Scophthalmus
maximus)
PF00168
(C2)
3 HIS A  87
GLU A  55
ASN A  52
None
0.99A 5wbvB-3w57A:
undetectable
5wbvB-3w57A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
3 HIS A 255
GLU A 245
ASN A 487
None
0.99A 5wbvB-3wfaA:
undetectable
5wbvB-3wfaA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2


(Mus musculus)
PF00856
(SET)
3 HIS A  32
GLU A 117
ASN A 182
SAH  A1247 (-3.6A)
SAH  A1247 (-2.8A)
SAH  A1247 (-3.1A)
0.35A 5wbvB-4au7A:
32.3
5wbvB-4au7A:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN


(Homo sapiens;
Homo sapiens)
PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10)
3 HIS B 429
GLU A  69
ASN A  55
S35  A1259 ( 3.9A)
None
S35  A1259 ( 3.7A)
0.97A 5wbvB-4az3B:
undetectable
5wbvB-4az3B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 237
GLU A 180
ASN A 232
None
0.87A 5wbvB-4baxA:
undetectable
5wbvB-4baxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7


(Zobellia
galactanivorans)
PF08787
(Alginate_lyase2)
3 HIS A 149
GLU A 179
ASN A 186
SRT  A 400 (-3.4A)
None
None
1.02A 5wbvB-4be3A:
undetectable
5wbvB-4be3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52


(Arabidopsis
thaliana)
no annotation 3 HIS A 146
GLU A   9
ASN A  91
None
0.91A 5wbvB-4c6sA:
undetectable
5wbvB-4c6sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL22
MRPL39


(Sus scrofa;
Sus scrofa)
PF00237
(Ribosomal_L22)
no annotation
3 HIS c  91
GLU W 133
ASN W 131
None
0.92A 5wbvB-4ce4c:
undetectable
5wbvB-4ce4c:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2


(Homo sapiens)
PF02854
(MIF4G)
3 HIS A 314
GLU A 271
ASN A 220
None
0.98A 5wbvB-4cemA:
undetectable
5wbvB-4cemA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Caulobacter sp.
K31)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 HIS A 344
GLU A 170
ASN A  38
None
None
GOL  A 502 (-3.8A)
0.97A 5wbvB-4fi4A:
undetectable
5wbvB-4fi4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE


(Pseudomonas
fluorescens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 HIS A 320
GLU A 246
ASN A 223
None
MG  A 501 (-2.8A)
TLA  A 502 (-3.7A)
0.97A 5wbvB-4it1A:
undetectable
5wbvB-4it1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 HIS A 296
GLU A 504
ASN A 412
None
0.99A 5wbvB-4jhzA:
undetectable
5wbvB-4jhzA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 HIS A 295
GLU A 501
ASN A 407
None
0.99A 5wbvB-4jklA:
undetectable
5wbvB-4jklA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 245
GLU A 189
ASN A 240
PO4  A 504 ( 3.1A)
GLN  A 503 ( 2.7A)
GLN  A 503 (-4.6A)
0.98A 5wbvB-4lnfA:
undetectable
5wbvB-4lnfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
vulgatus)
PF13204
(DUF4038)
PF16586
(DUF5060)
3 HIS A 303
GLU A 228
ASN A 223
None
0.80A 5wbvB-4n0rA:
undetectable
5wbvB-4n0rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E


(Butyrivibrio
proteoclasticus)
PF04616
(Glyco_hydro_43)
3 HIS A 258
GLU A 227
ASN A 158
CA  A 401 (-3.7A)
None
None
0.83A 5wbvB-4novA:
undetectable
5wbvB-4novA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus)
PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec)
3 HIS A 255
GLU A 397
ASN A 473
None
0.90A 5wbvB-4uwaA:
undetectable
5wbvB-4uwaA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli)
PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C)
3 HIS A 181
GLU A 186
ASN A 214
None
1.01A 5wbvB-4xjxA:
undetectable
5wbvB-4xjxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF02348
(CTP_transf_3)
3 HIS A 134
GLU A 131
ASN A 234
None
1.00A 5wbvB-4xwiA:
undetectable
5wbvB-4xwiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
3 HIS E 144
GLU E 145
ASN E 186
PGE  E 305 (-4.3A)
None
None
0.96A 5wbvB-5brrE:
undetectable
5wbvB-5brrE:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1


(Homo sapiens)
PF00856
(SET)
3 HIS B  98
GLU B 206
ASN B 272
SAM  B 402 (-3.7A)
SAM  B 402 (-2.9A)
SAM  B 402 (-3.1A)
0.22A 5wbvB-5cprB:
35.5
5wbvB-5cprB:
97.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11


(Methanocaldococcus
jannaschii)
PF00149
(Metallophos)
3 HIS A   0
GLU A 118
ASN A 232
None
0.73A 5wbvB-5dnyA:
undetectable
5wbvB-5dnyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica)
PF13354
(Beta-lactamase2)
3 HIS A  71
GLU A  98
ASN A  89
None
1.02A 5wbvB-5e2eA:
undetectable
5wbvB-5e2eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE


(Acinetobacter
baumannii)
PF01761
(DHQ_synthase)
3 HIS A 263
GLU A  72
ASN A 151
MG  A 401 (-3.3A)
NAD  A 400 (-3.0A)
NAD  A 400 (-3.4A)
0.56A 5wbvB-5eksA:
undetectable
5wbvB-5eksA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5


(Populus
trichocarpa)
PF00043
(GST_C)
PF02798
(GST_N)
3 HIS A  46
GLU A  40
ASN A  33
None
1.00A 5wbvB-5f05A:
undetectable
5wbvB-5f05A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fma NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1


(Homo sapiens)
PF00008
(EGF)
PF07645
(EGF_CA)
3 HIS A 171
GLU A 181
ASN A 197
None
CA  A1295 (-2.9A)
CA  A1295 (-3.0A)
1.01A 5wbvB-5fmaA:
undetectable
5wbvB-5fmaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2


(Homo sapiens)
no annotation 3 HIS I 593
GLU I 570
ASN I 599
None
0.95A 5wbvB-5furI:
0.9
5wbvB-5furI:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus)
PF00067
(p450)
3 HIS A 412
GLU A 350
ASN A 346
None
0.99A 5wbvB-5fygA:
undetectable
5wbvB-5fygA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN


(Danio rerio)
PF07393
(Sec10)
3 HIS A 425
GLU A 422
ASN A 418
None
None
BR  A 809 ( 4.7A)
1.00A 5wbvB-5h11A:
undetectable
5wbvB-5h11A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7a IMMUNOGLOBULIN
G-BINDING PROTEIN A


(Staphylococcus
aureus)
no annotation 3 HIS C 138
GLU C 135
ASN C  96
None
0.62A 5wbvB-5h7aC:
undetectable
5wbvB-5h7aC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE


(Mus musculus)
PF00149
(Metallophos)
3 HIS A 317
GLU A 318
ASN A 381
PO4  A 710 (-3.7A)
None
None
0.90A 5wbvB-5hqnA:
undetectable
5wbvB-5hqnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE


(Francisella
tularensis)
PF01761
(DHQ_synthase)
3 HIS A 264
GLU A  72
ASN A 152
NAD  A 401 ( 4.6A)
NAD  A 401 (-2.6A)
NAD  A 401 (-3.5A)
0.68A 5wbvB-5hvnA:
undetectable
5wbvB-5hvnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE


(Homo sapiens)
PF00149
(Metallophos)
3 HIS A 319
GLU A 320
ASN A 383
PC  A 727 (-3.7A)
None
None
0.94A 5wbvB-5i85A:
2.2
5wbvB-5i85A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 HIS A  25
GLU A  23
ASN A 102
None
0.89A 5wbvB-5ijzA:
0.1
5wbvB-5ijzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens)
PF00028
(Cadherin)
3 HIS A 142
GLU A  69
ASN A  12
None
CA  A 614 ( 2.9A)
CA  A 605 ( 3.9A)
0.89A 5wbvB-5iryA:
undetectable
5wbvB-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens)
PF00028
(Cadherin)
3 HIS A 253
GLU A 179
ASN A 120
None
CA  A 616 ( 2.6A)
CA  A 615 (-2.2A)
0.94A 5wbvB-5iryA:
undetectable
5wbvB-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans)
PF03055
(RPE65)
3 HIS A 284
GLU A 418
ASN A 122
FE  A 501 ( 3.3A)
None
None
1.02A 5wbvB-5j55A:
undetectable
5wbvB-5j55A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE


(Synechocystis
sp. PCC 6803)
PF03055
(RPE65)
3 HIS A 304
GLU A 426
ASN A 137
FE2  A 502 (-3.8A)
None
None
0.90A 5wbvB-5kjaA:
undetectable
5wbvB-5kjaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
3 HIS A 269
GLU A 212
ASN A 264
None
0.98A 5wbvB-5ldfA:
undetectable
5wbvB-5ldfA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982)
3 HIS A 329
GLU A 526
ASN A 425
None
GOL  A 901 (-2.2A)
GOL  A 901 (-3.2A)
1.00A 5wbvB-5uj6A:
undetectable
5wbvB-5uj6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7


(Homo sapiens)
PF00400
(WD40)
PF12937
(F-box-like)
3 HIS B2359
GLU B2328
ASN B2635
None
0.95A 5wbvB-5v4bB:
undetectable
5wbvB-5v4bB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptococcus
agalactiae)
no annotation 3 HIS A 212
GLU A 102
ASN A 167
None
0.94A 5wbvB-6az6A:
undetectable
5wbvB-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-)
no annotation 3 HIS A 309
GLU A 516
ASN A 424
None
E0V  A 701 (-2.6A)
E0V  A 701 (-3.3A)
1.02A 5wbvB-6bo6A:
undetectable
5wbvB-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE


(Candida
albicans)
no annotation 3 HIS A 280
GLU A  80
ASN A 159
None
NAD  A 401 (-2.7A)
NAD  A 401 (-3.2A)
0.78A 5wbvB-6c5cA:
undetectable
5wbvB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY


(Thermobifida
fusca)
no annotation 3 HIS G  74
GLU G  69
ASN G  50
None
0.98A 5wbvB-6c66G:
undetectable
5wbvB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum)
no annotation 3 HIS A  87
GLU A  86
ASN A 375
None
1.02A 5wbvB-6ercA:
1.4
5wbvB-6ercA:
undetectable