SIMILAR PATTERNS OF AMINO ACIDS FOR 5WAU_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 TYR A 351
ARG A 350
THR A 191
LEU A 192
 None
AEP  A 683 (-2.8A)
None
None
 1.48A 5wauj-1lfwA:
0.0		 5wauj-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR A1179
ARG A1205
THR A1207
LEU A1210
 None
 1.17A 5wauj-2b39A:
0.0		 5wauj-2b39A:
3.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
ARG J  33
THR J  37
LEU J  40
 None
 0.53A 5wauj-2y69J:
7.8		 5wauj-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apf CULLIN 3

(Homo sapiens) 		PF00888
(Cullin) 		4 TYR B  58
ARG B  59
THR B  63
LEU B  66
 None
 1.18A 5wauj-4apfB:
0.0		 5wauj-4apfB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		4 TYR A  17
ARG A  13
THR A  65
LEU A  64
 None
 1.42A 5wauj-4f62A:
0.0		 5wauj-4f62A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		4 TYR A 208
ARG A 209
THR A 213
LEU A 217
 None
 1.19A 5wauj-4kmrA:
0.0		 5wauj-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb9 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Bos taurus) 		PF00083
(Sugar_tr) 		4 TYR D 149
ARG D  98
THR D 101
LEU D 103
 None
 0.97A 5wauj-4yb9D:
0.0		 5wauj-4yb9D:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 4 TYR A1302
ARG A1240
THR A1148
LEU A1152
 None
 1.33A 5wauj-5j1iA:
1.8		 5wauj-5j1iA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oed GTGE
RAS-RELATED PROTEIN
RAB-32

(Salmonella
enterica;
Homo sapiens) 		no annotation
no annotation 		4 TYR B  54
ARG B  55
THR B  57
LEU A 150
 None
 1.44A 5wauj-5oedB:
undetectable		 5wauj-5oedB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus) 		PF08904
(DUF1849) 		4 TYR A 235
ARG A 236
THR A 251
LEU A 250
 None
 1.06A 5wauj-5uc2A:
undetectable		 5wauj-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhv ALKYLPURINE DNA
GLYCOSYLASE ALKC

(Pseudomonas
fluorescens) 		no annotation 4 TYR A  69
ARG A 106
THR A  74
LEU A  76
 None
 1.38A 5wauj-5vhvA:
undetectable		 5wauj-5vhvA:
9.70