SIMILAR PATTERNS OF AMINO ACIDS FOR 5W7P_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
154l GOOSE LYSOZYME

(Anser anser) 		PF01464
(SLT) 		5 ALA A  67
GLY A  68
SER A  71
LEU A  93
ASP A  46
 None
 1.10A 5w7pA-154lA:
0.0		 5w7pA-154lA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A  97
GLY A  96
LEU A 154
VAL A 150
LEU A 129
 None
 1.12A 5w7pA-1fheA:
0.0		 5w7pA-1fheA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 ALA A 119
SER A 115
LEU A  98
PHE A  96
LEU A 191
 None
 1.13A 5w7pA-1gz0A:
1.5		 5w7pA-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ALA A 154
GLY A 155
LEU A 398
VAL A 402
TRP A 142
 None
 1.14A 5w7pA-1loxA:
0.0		 5w7pA-1loxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 GLU B  48
ALA B 230
GLY B 227
LEU B 234
PHE B 261
 None
 1.12A 5w7pA-1mabB:
undetectable		 5w7pA-1mabB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		6 ALA A  51
GLY A  55
LEU A  49
VAL A  12
LEU A  64
TRP A  59
 None
None
XE  A1118 ( 4.5A)
XE  A1118 ( 3.9A)
HEM  A1117 (-4.3A)
None
 1.45A 5w7pA-1uvyA:
undetectable		 5w7pA-1uvyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb0 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF00653
(BIR) 		5 GLY A 288
LEU A 307
VAL A 298
ARG A 286
ASP A 315
 None
 1.08A 5w7pA-1xb0A:
undetectable		 5w7pA-1xb0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm7 PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF13599
(Pentapeptide_4) 		5 ALA A 132
LEU A 153
VAL A 152
LEU A 124
ASP A 128
 None
 1.14A 5w7pA-2bm7A:
undetectable		 5w7pA-2bm7A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 ALA A  84
GLY A  83
SER A  81
PHE A  90
ASP A  65
 None
None
NAD  A 242 (-2.9A)
None
None
 1.19A 5w7pA-2dc1A:
undetectable		 5w7pA-2dc1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 ALA A 242
GLY A 243
SER A  60
LEU A 156
ASP A 112
 None
 1.09A 5w7pA-2drwA:
undetectable		 5w7pA-2drwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		6 PHE A 149
GLU A 254
ALA A 214
GLY A 213
LEU A 179
ARG A 278
 None
 1.02A 5w7pA-2ef0A:
4.7		 5w7pA-2ef0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 433
GLY A 437
SER A 438
LEU A 475
TRP A 446
 None
 1.02A 5w7pA-2hckA:
undetectable		 5w7pA-2hckA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 411
GLY A 415
SER A 416
LEU A 453
TRP A 424
 None
 1.21A 5w7pA-2hk5A:
undetectable		 5w7pA-2hk5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 ALA A 177
GLY A 178
SER A 179
ARG A 270
ASP A 266
 None
 1.20A 5w7pA-2obmA:
3.2		 5w7pA-2obmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		5 GLU A 115
GLY A  41
SER A  40
LEU A   3
ASP A 110
 None
 1.12A 5w7pA-2oz8A:
undetectable		 5w7pA-2oz8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 ALA A 273
GLY A 274
LEU A  17
LEU A 302
ARG A 159
 None
FAD  A 500 (-3.3A)
None
None
None
 1.14A 5w7pA-2qa2A:
undetectable		 5w7pA-2qa2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		5 ALA A 140
GLY A 119
LEU A 157
PHE A 142
LEU A 147
 None
 1.17A 5w7pA-2xt4A:
undetectable		 5w7pA-2xt4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ALA A 341
SER A 339
LEU A 142
VAL A 135
ASP A 262
 None
None
A5A  A 801 (-4.2A)
None
None
 1.14A 5w7pA-2ztgA:
undetectable		 5w7pA-2ztgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PHE A 240
GLY A 236
SER A 237
ARG A  62
ASP A  76
 None
 1.09A 5w7pA-2zxhA:
undetectable		 5w7pA-2zxhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN

(Streptomyces
coelicolor) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 ALA A  33
GLY A  32
SER A  31
LEU A  53
PHE A 131
 None
 1.08A 5w7pA-3akaA:
undetectable		 5w7pA-3akaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ALA A 293
GLY A 294
SER A 273
LEU A 336
ARG A 277
 None
None
FNR  A 669 ( 4.5A)
None
FNR  A 669 (-2.8A)
 1.16A 5w7pA-3b05A:
undetectable		 5w7pA-3b05A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ

(Salmonella
enterica) 		PF02518
(HATPase_c) 		5 GLU A 415
ALA A 471
GLY A 470
SER A 466
LEU A 447
 None
RDC  A 700 (-3.3A)
None
None
RDC  A 700 (-3.9A)
 1.11A 5w7pA-3cgyA:
undetectable		 5w7pA-3cgyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 ALA X 170
SER X 148
LEU X 195
PHE X 172
LEU X 185
 None
 1.19A 5w7pA-3du1X:
undetectable		 5w7pA-3du1X:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF04045
(P34-Arc)
PF05856
(ARPC4) 		5 PHE D 291
GLU F 137
LEU D 295
PHE F 116
LEU F 104
 None
 1.08A 5w7pA-3dwlD:
undetectable		 5w7pA-3dwlD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		5 ALA A 106
GLY A 105
LEU A  94
PHE A  60
LEU A 252
 None
 1.19A 5w7pA-3e59A:
undetectable		 5w7pA-3e59A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed0 (3R)-HYDROXYMYRISTOY
L-ACYL CARRIER
PROTEIN DEHYDRATASE

(Helicobacter
pylori) 		PF07977
(FabA) 		5 ALA A  75
GLY A  78
SER A  77
VAL A  30
PHE A 101
 None
 1.14A 5w7pA-3ed0A:
undetectable		 5w7pA-3ed0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		5 ALA A 161
GLY A 216
LEU A 223
VAL A 222
LEU A  50
 None
 1.21A 5w7pA-3ek5A:
3.2		 5w7pA-3ek5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 254
LEU A 287
VAL A 284
LEU A 262
ASP A 250
 None
None
None
None
MG  A 382 (-3.2A)
 1.13A 5w7pA-3fcpA:
undetectable		 5w7pA-3fcpA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 GLY A 191
VAL A 217
PHE A 241
ASP A 260
TRP A 261
 SAH  A 350 (-3.6A)
SAH  A 350 ( 4.7A)
SAH  A 350 (-3.6A)
MQA  A 351 (-2.8A)
None
 0.36A 5w7pA-3gxoA:
31.5		 5w7pA-3gxoA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 178
LEU A 201
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.46A 5w7pA-3i58A:
28.4		 5w7pA-3i58A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 179
LEU A 201
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.91A 5w7pA-3i58A:
28.4		 5w7pA-3i58A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxt DISKS LARGE HOMOLOG
3

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLU A 443
ALA A 438
SER A 441
PHE A 416
ASP A 448
 None
 1.21A 5w7pA-3jxtA:
undetectable		 5w7pA-3jxtA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 GLY A 190
VAL A 216
PHE A 238
LEU A 239
TRP A 257
 SAH  A 346 (-3.6A)
None
SAH  A 346 (-3.4A)
SAH  A 346 ( 4.4A)
None
 0.47A 5w7pA-3lstA:
22.9		 5w7pA-3lstA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ALA A  13
GLY A  18
LEU A   9
VAL A  87
LEU A  59
 None
 1.20A 5w7pA-3lylA:
undetectable		 5w7pA-3lylA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A 278
SER A 276
LEU A 271
LEU A 287
ARG A 155
 None
 1.20A 5w7pA-3mn3A:
undetectable		 5w7pA-3mn3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ALA A 371
GLY A 333
SER A 367
PHE A 382
ARG A 413
 None
 1.13A 5w7pA-3n05A:
3.2		 5w7pA-3n05A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		6 ALA A 121
GLY A 100
SER A  99
LEU A 138
PHE A 123
LEU A 128
 None
 1.15A 5w7pA-3n90A:
undetectable		 5w7pA-3n90A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 ALA A 250
GLY A 249
SER A 246
VAL A 218
LEU A  59
 None
 1.01A 5w7pA-3o82A:
undetectable		 5w7pA-3o82A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9c CAFFEIC ACID
O-METHYLTRANSFERASE

(Lolium perenne) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 206
LEU A 229
VAL A 232
ASP A 267
TRP A 268
 SAH  A 401 ( 4.0A)
SAH  A 401 (-4.3A)
None
None
None
 0.76A 5w7pA-3p9cA:
24.1		 5w7pA-3p9cA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 GLY A 953
SER A 952
LEU A 948
PHE A 962
LEU A 966
 None
 1.17A 5w7pA-3psiA:
undetectable		 5w7pA-3psiA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		5 ALA A 274
GLY A 276
SER A 278
VAL A 252
LEU A 261
 None
 1.21A 5w7pA-3q1yA:
4.3		 5w7pA-3q1yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 PHE A  91
GLU A  66
ALA A  31
GLY A  30
LEU A  94
 None
 0.81A 5w7pA-3qljA:
5.5		 5w7pA-3qljA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		5 GLU A  14
ALA A 293
SER A 317
VAL A 330
LEU A   5
 None
 1.05A 5w7pA-3rplA:
undetectable		 5w7pA-3rplA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvt DISKS LARGE 1 TUMOR
SUPPRESSOR PROTEIN

(Drosophila
melanogaster) 		PF00018
(SH3_1)
PF00625
(Guanylate_kin) 		5 GLU A 851
GLY A 883
SER A 882
LEU A 879
LEU A 894
 None
 1.19A 5w7pA-3tvtA:
undetectable		 5w7pA-3tvtA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 439
LEU A 361
PHE A 435
LEU A 380
ASP A 640
 None
07U  A   1 ( 4.8A)
None
None
None
 1.16A 5w7pA-3txoA:
undetectable		 5w7pA-3txoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 999
GLY A 998
SER A 997
LEU A 989
PHE A 396
 None
 1.20A 5w7pA-3w9hA:
undetectable		 5w7pA-3w9hA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 ALA A  61
GLY A  60
PHE A  94
LEU A 133
ARG A 120
 None
 1.16A 5w7pA-3wkhA:
undetectable		 5w7pA-3wkhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 ALA A  67
GLY A  68
SER A  71
LEU A  93
ASP A  46
 None
 1.08A 5w7pA-3wyhA:
undetectable		 5w7pA-3wyhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 ALA A 142
GLY A 141
SER A 140
PHE A 119
LEU A 104
 None
 0.84A 5w7pA-3zyiA:
undetectable		 5w7pA-3zyiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		7 PHE A 143
GLY A 188
VAL A 214
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.57A 5w7pA-4a6eA:
29.1		 5w7pA-4a6eA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		6 PHE A 143
GLY A 189
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 1.13A 5w7pA-4a6eA:
29.1		 5w7pA-4a6eA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 GLY A  79
LEU A 143
LEU A  37
ARG A  81
ASP A  72
 None
 1.09A 5w7pA-4abyA:
undetectable		 5w7pA-4abyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 GLU D  49
ALA D 230
GLY D 227
LEU D 234
PHE D 261
 None
 1.15A 5w7pA-4b2qD:
2.1		 5w7pA-4b2qD:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei) 		PF00669
(Flagellin_N)
PF12613
(FliC_SP) 		5 ALA A  77
GLY A  80
SER A  79
LEU A  74
LEU A 144
 None
 1.15A 5w7pA-4cfiA:
undetectable		 5w7pA-4cfiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czz REST COREPRESSOR 3

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		5 ALA B 356
GLY B 359
LEU B 395
VAL B 398
PHE B 385
 None
 1.16A 5w7pA-4czzB:
undetectable		 5w7pA-4czzB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1g FIBER PROTEIN

(Snake
atadenovirus A) 		no annotation 5 ALA A 275
GLY A 337
VAL A 334
PHE A 258
LEU A 248
 None
 1.14A 5w7pA-4d1gA:
undetectable		 5w7pA-4d1gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		6 PHE A 168
GLU A 164
SER A 160
LEU A 167
LEU A 131
ASP A  66
 MN  A 402 ( 4.8A)
MN  A 401 (-1.7A)
None
None
None
MN  A 402 (-2.3A)
 1.44A 5w7pA-4dr0A:
undetectable		 5w7pA-4dr0A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 209
LEU A 232
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.39A 5w7pA-4eviA:
26.5		 5w7pA-4eviA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLU A 333
GLY A 326
LEU A 319
PHE A 306
ASP A 303
 None
 1.20A 5w7pA-4frxA:
undetectable		 5w7pA-4frxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 PHE A 141
ALA A 360
GLY A 359
LEU A 137
ARG A 110
 None
 0.98A 5w7pA-4mm0A:
undetectable		 5w7pA-4mm0A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nim VERSICOLORIN
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 GLY A  20
SER A  15
LEU A  35
PHE A  27
LEU A   5
 None
 1.17A 5w7pA-4nimA:
6.1		 5w7pA-4nimA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF02962
(CHMI) 		6 ALA E   8
LEU E  88
VAL E 102
PHE E  44
LEU E  22
ARG E  13
 None
 1.43A 5w7pA-4nwpE:
undetectable		 5w7pA-4nwpE:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 SER A 381
LEU A 378
LEU A 355
ARG A 342
ASP A 339
 None
 1.19A 5w7pA-4ow2A:
undetectable		 5w7pA-4ow2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 207
LEU A 230
VAL A 233
ASP A 268
TRP A 269
 SAM  A 401 ( 3.9A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
None
None
 0.64A 5w7pA-4pghA:
24.7		 5w7pA-4pghA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ALA L 248
GLY L 249
VAL L 280
LEU L 270
ARG L 348
 None
 1.00A 5w7pA-4tkxL:
undetectable		 5w7pA-4tkxL:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umi FIBER PROTEIN

(Snake
atadenovirus A) 		no annotation 5 ALA A 275
GLY A 337
VAL A 334
PHE A 258
LEU A 248
 None
 1.16A 5w7pA-4umiA:
undetectable		 5w7pA-4umiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 ALA A 273
GLY A 274
LEU A  17
LEU A 302
ARG A 159
 None
FAD  A 503 (-3.3A)
None
None
None
 1.17A 5w7pA-4x4jA:
undetectable		 5w7pA-4x4jA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh7 MULTIPLE PDZ DOMAIN
PROTEIN

(Mus musculus) 		PF00595
(PDZ) 		5 GLY A 581
SER A 583
VAL A 549
LEU A 562
ASP A 590
 None
 1.17A 5w7pA-4xh7A:
undetectable		 5w7pA-4xh7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 GLY A 239
SER A 240
LEU A  52
VAL A  55
LEU A 168
 None
 1.10A 5w7pA-4y1kA:
undetectable		 5w7pA-4y1kA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 ALA A 115
GLY A 114
SER A 113
LEU A 102
ARG A  73
 None
 0.95A 5w7pA-4yeiA:
undetectable		 5w7pA-4yeiA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 ALA A  72
VAL A 374
PHE A 104
LEU A 405
ARG A  85
 None
 1.19A 5w7pA-4yn5A:
undetectable		 5w7pA-4yn5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 5 PHE A 177
LEU A 158
VAL A 207
LEU A 226
ARG A 172
 None
 1.16A 5w7pA-5a7tA:
undetectable		 5w7pA-5a7tA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv8 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA)
PF16164
(VWA_N2) 		5 PHE A1438
GLU A1452
LEU A1440
PHE A1299
LEU A1384
 None
 1.13A 5w7pA-5bv8A:
undetectable		 5w7pA-5bv8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 GLY A 161
LEU A 103
VAL A 137
LEU A  87
ASP A 120
 GOL  A 303 ( 3.8A)
None
None
None
None
 1.15A 5w7pA-5c5yA:
undetectable		 5w7pA-5c5yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 212
LEU A 235
VAL A 238
ASP A 273
TRP A 274
 SAH  A 401 ( 4.2A)
SAH  A 401 (-4.3A)
None
N7I  A 402 ( 2.7A)
None
 0.39A 5w7pA-5cvvA:
28.3		 5w7pA-5cvvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 ALA A 119
GLY A 120
SER A 121
LEU A  17
ASP A  20
 None
 1.02A 5w7pA-5dmnA:
undetectable		 5w7pA-5dmnA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 193
GLY A 192
LEU A  40
PHE A 203
LEU A 206
 None
 1.13A 5w7pA-5eytA:
undetectable		 5w7pA-5eytA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 ALA A 201
GLY A 202
VAL A 228
ASP A 271
TRP A 272
 EDO  A 504 ( 3.8A)
None
None
AGI  A 501 (-2.4A)
None
 0.76A 5w7pA-5i2hA:
5.8		 5w7pA-5i2hA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 GLU A 405
ALA A 339
GLY A 342
LEU A 275
ASP A 507
 None
ANP  A 700 (-3.1A)
None
None
ANP  A 700 (-2.8A)
 1.18A 5w7pA-5i35A:
undetectable		 5w7pA-5i35A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 5 PHE B 596
ALA B 561
GLY B 560
LEU B 549
ASP B 594
 None
 0.95A 5w7pA-5kdjB:
undetectable		 5w7pA-5kdjB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		5 PHE A 596
ALA A 561
GLY A 560
LEU A 549
ASP A 594
 None
 0.96A 5w7pA-5kdsA:
undetectable		 5w7pA-5kdsA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLY A 602
SER A 616
LEU A 620
LEU A 625
ASP A 329
 None
None
None
None
ACP  A 904 ( 4.7A)
 1.21A 5w7pA-5ksdA:
undetectable		 5w7pA-5ksdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 ALA L 137
GLY L 138
SER L 142
LEU L 174
ASP L 150
 None
 1.18A 5w7pA-5lf7L:
undetectable		 5w7pA-5lf7L:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6m E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		5 GLY A 288
LEU A 307
VAL A 298
ARG A 286
ASP A 315
 None
7H8  A 403 (-3.4A)
7H8  A 403 (-4.8A)
None
None
 1.15A 5w7pA-5m6mA:
undetectable		 5w7pA-5m6mA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei) 		PF00117
(GATase) 		5 ALA A 425
VAL A 389
PHE A 543
LEU A 540
ARG A 431
 None
 1.17A 5w7pA-5n29A:
undetectable		 5w7pA-5n29A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh0 REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
NL63) 		no annotation 5 PHE A 185
GLU A 194
GLY A 170
SER A 169
ARG A 130
 None
None
None
None
DMS  A 303 (-3.5A)
 1.15A 5w7pA-5nh0A:
undetectable		 5w7pA-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no4 30S RIBOSOMAL
PROTEIN S7

(Escherichia
coli) 		PF00177
(Ribosomal_S7) 		5 LEU G  66
VAL G  69
PHE G  26
LEU G  23
ARG G 111
 None
 1.12A 5w7pA-5no4G:
undetectable		 5w7pA-5no4G:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 ALA A 471
GLY A 470
VAL A 501
PHE A 430
ARG A 438
 None
 1.17A 5w7pA-5tr1A:
undetectable		 5w7pA-5tr1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 GLY A 164
SER A 165
LEU A 193
VAL A 190
LEU A  34
 None
 1.08A 5w7pA-5ujsA:
undetectable		 5w7pA-5ujsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ALA A 165
GLY A 162
LEU A 355
LEU A 348
ASP A 261
 None
 1.20A 5w7pA-5v4lA:
undetectable		 5w7pA-5v4lA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 7 ALA A 243
SER A 245
LEU A 270
VAL A 273
PHE A 293
LEU A 294
ARG A 309
 SAM  A 501 (-3.1A)
SAM  A 501 (-3.5A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 4.1A)
SAM  A 501 (-4.2A)
 1.08A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 12 PHE A 194
GLU A 211
ALA A 243
GLY A 244
SER A 245
LEU A 270
VAL A 273
PHE A 293
LEU A 294
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.5A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 4.1A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 0.04A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 ALA A 273
GLY A 274
LEU A  17
LEU A 302
ARG A 157
 None
FAD  A 501 (-3.5A)
None
None
None
 1.19A 5w7pA-5xgvA:
undetectable		 5w7pA-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoh BERGAPTOL
O-METHYLTRANSFERASE

(Peucedanum
praeruptorum) 		no annotation 5 PHE A 158
GLY A 204
LEU A 227
VAL A 230
TRP A 266
 SAH  A 401 ( 3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-4.1A)
None
None
 0.50A 5w7pA-5xohA:
27.2		 5w7pA-5xohA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yal ESTERASE

(Streptomyces
cinnamoneus) 		no annotation 5 ALA A 188
GLY A 189
SER A  98
PHE A 316
LEU A 320
 None
 1.21A 5w7pA-5yalA:
undetectable		 5w7pA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 5 PHE A 138
GLY A 184
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.85A 5w7pA-6c5bA:
31.3		 5w7pA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 5 PHE A 138
VAL A 209
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.42A 5w7pA-6c5bA:
31.3		 5w7pA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Enterococcus
faecium) 		no annotation 5 ALA A 106
GLY A 107
PHE A 102
LEU A 150
ASP A  79
 None
None
None
MPD  A 401 (-4.4A)
None
 1.15A 5w7pA-6cfdA:
undetectable		 5w7pA-6cfdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 5 ALA A 578
GLY A 579
SER A 576
PHE A 560
LEU A 564
 None
 1.21A 5w7pA-6ekvA:
undetectable		 5w7pA-6ekvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 GLY D 448
SER D 447
VAL D 375
PHE D 418
ASP D 441
 None
 1.05A 5w7pA-6f5dD:
3.5		 5w7pA-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A  90
HIS A  31
ASP A  55
ASP A  62
 None
 1.32A 5w7pA-1bxtA:
undetectable		 5w7pA-1bxtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 151
HIS A 343
ASP A 169
ASP A 172
 None
 1.37A 5w7pA-2qq6A:
0.5		 5w7pA-2qq6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 247
HIS A 189
ASP A 136
ASP A 282
 None
 1.20A 5w7pA-3gdoA:
3.2		 5w7pA-3gdoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 TYR A 242
ASP A 558
ASP A 552
ARG A 148
 None
 0.94A 5w7pA-3i04A:
2.0		 5w7pA-3i04A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 238
HIS A 180
ASP A 127
ASP A 273
 None
 1.27A 5w7pA-3kuxA:
4.6		 5w7pA-3kuxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 TYR C 424
HIS C 562
ASP C 606
ASP C 651
 None
 1.43A 5w7pA-3v64C:
undetectable		 5w7pA-3v64C:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 TYR A 582
HIS A 574
ASP A 578
ARG A 783
 None
 1.31A 5w7pA-4a5wA:
0.0		 5w7pA-4a5wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 HIS A 146
ASP A  80
ASP A  85
ARG A 107
 CTT  A 401 (-3.7A)
None
None
None
 1.32A 5w7pA-4hu0A:
0.4		 5w7pA-4hu0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 TYR A 123
HIS A 146
ASP A  80
ASP A  85
 None
CTT  A 401 (-3.7A)
None
None
 1.33A 5w7pA-4hu0A:
0.4		 5w7pA-4hu0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 HIS A 608
ASP A 602
ASP A 128
ARG A 811
 None
ZN  A1101 ( 3.6A)
None
None
 1.47A 5w7pA-4k0eA:
0.2		 5w7pA-4k0eA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 TYR A  52
ASP A 578
ASP A   4
ARG A 650
 None
CA  A1114 (-2.9A)
None
None
 1.27A 5w7pA-4nenA:
undetectable		 5w7pA-4nenA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		4 HIS A 174
ASP A 117
ASP A  88
ARG A 167
 None
 1.48A 5w7pA-4qrjA:
undetectable		 5w7pA-4qrjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 TYR A 136
HIS A 182
ASP A 142
ARG A 101
 None
 1.49A 5w7pA-5dtrA:
10.3		 5w7pA-5dtrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 TYR A  79
HIS A 485
ASP A 481
ASP A  76
 9UB  A 803 (-4.4A)
None
None
MN  A 802 (-3.3A)
 1.15A 5w7pA-5oglA:
undetectable		 5w7pA-5oglA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 4 HIS A 246
ASP A 269
ASP A 292
ARG A 310
 SAM  A 501 (-3.8A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.1A)
 0.89A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 5 TYR A 198
HIS A 246
ASP A 269
ASP A 292
ARG A 309
 SAM  A 501 (-4.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.2A)
 0.01A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 HIS A 624
ASP A 621
ASP A 584
ARG A 667
 None
CA  A1001 (-2.1A)
None
None
 1.46A 5w7pA-5xqoA:
undetectable		 5w7pA-5xqoA:
undetectable