SIMILAR PATTERNS OF AMINO ACIDS FOR 5W7B_B_PA1B204_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE


(Arthrobacter
sp. 1C)
PF02317
(Octopine_DH)
PF02558
(ApbA)
3 GLY A  13
ASN A  14
ARG A 292
None
0.67A 5w7bD-1bg6A:
3.3
5w7bD-1bg6A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens)
PF01341
(Glyco_hydro_6)
3 GLY A 185
ASN A 183
ARG A 276
None
0.47A 5w7bD-1dysA:
3.6
5w7bD-1dysA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max)
PF00190
(Cupin_1)
3 GLY A 199
ASN A 168
ARG A  62
None
0.79A 5w7bD-1fxzA:
undetectable
5w7bD-1fxzA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
PROTEIN (INVARIANT
CHAIN)


(Homo sapiens)
PF00086
(Thyroglobulin_1)
PF00112
(Peptidase_C1)
3 GLY A  20
ASN A  18
ARG I 250
None
0.70A 5w7bD-1icfA:
undetectable
5w7bD-1icfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
3 GLY A 337
ASN A 340
ARG A 125
None
0.78A 5w7bD-1kczA:
undetectable
5w7bD-1kczA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
3 GLY A 289
ASN A  12
ARG A 203
None
0.74A 5w7bD-1kk0A:
4.2
5w7bD-1kk0A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Pseudomonas
putida)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
3 GLY A 531
ASN A 535
ARG A 609
None
0.65A 5w7bD-1kv9A:
undetectable
5w7bD-1kv9A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Pseudomonas
putida)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
3 GLY A 602
ASN A 535
ARG A 609
None
0.72A 5w7bD-1kv9A:
undetectable
5w7bD-1kv9A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpl HYPOTHETICAL 25.4
KDA PROTEIN F53F4.3
IN CHROMOSOME V


(Caenorhabditis
elegans)
PF01302
(CAP_GLY)
3 GLY A 208
ASN A 191
ARG A 199
None
0.78A 5w7bD-1lplA:
undetectable
5w7bD-1lplA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE


(Salvia
officinalis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 GLY A 391
ASN A 394
ARG A 303
None
0.70A 5w7bD-1n21A:
undetectable
5w7bD-1n21A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
3 GLY A 633
ASN A 575
ARG A 627
None
0.76A 5w7bD-1n7rA:
undetectable
5w7bD-1n7rA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE


(Deinagkistrodon
acutus)
PF00089
(Trypsin)
3 GLY A  19
ASN A  20
ARG A 137
None
0.75A 5w7bD-1op2A:
undetectable
5w7bD-1op2A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 GLY A 144
ASN A 138
ARG A  68
CA  A 905 ( 4.7A)
None
None
0.16A 5w7bD-1q5aA:
undetectable
5w7bD-1q5aA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1


(Pinus taeda)
PF05368
(NmrA)
3 GLY A 274
ASN A 278
ARG A 216
None
0.78A 5w7bD-1qycA:
4.5
5w7bD-1qycA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ


(Bordetella
pertussis)
PF05860
(Haemagg_act)
3 GLY A  90
ASN A  43
ARG A  87
None
0.65A 5w7bD-1rwrA:
undetectable
5w7bD-1rwrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE


(Acetobacter
pasteurianus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
3 GLY A 377
ASN A 376
ARG A 394
None
0.75A 5w7bD-1ryyA:
2.6
5w7bD-1ryyA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT


(Methanocaldococcus
jannaschii)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
3 GLY A 316
ASN A  39
ARG A 230
None
0.59A 5w7bD-1s0uA:
3.4
5w7bD-1s0uA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
3 GLY A 258
ASN A 289
ARG A 177
None
0.62A 5w7bD-1sqgA:
2.7
5w7bD-1sqgA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria))
PF01270
(Glyco_hydro_8)
3 GLY A 218
ASN A 160
ARG A 153
None
0.75A 5w7bD-1v5cA:
undetectable
5w7bD-1v5cA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
3 GLY A  89
ASN A 111
ARG A  38
None
UNX  A 276 (-3.8A)
None
0.66A 5w7bD-2a4kA:
5.7
5w7bD-2a4kA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3i RESTIN

(Homo sapiens)
PF01302
(CAP_GLY)
3 GLY A 116
ASN A  99
ARG A 107
None
0.74A 5w7bD-2e3iA:
undetectable
5w7bD-2e3iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 GLY A 703
ASN A 393
ARG A 709
None
0.66A 5w7bD-2hnhA:
undetectable
5w7bD-2hnhA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 GLY A 760
ASN A 455
ARG A 766
None
0.67A 5w7bD-2hpiA:
undetectable
5w7bD-2hpiA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis)
PF00544
(Pec_lyase_C)
3 GLY A 142
ASN A  65
ARG A 206
None
0.68A 5w7bD-2o04A:
undetectable
5w7bD-2o04A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes)
PF13614
(AAA_31)
3 GLY A  99
ASN A 102
ARG A  93
None
0.68A 5w7bD-2ozeA:
4.0
5w7bD-2ozeA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE


(Infectious
bursal disease
virus)
PF04197
(Birna_RdRp)
3 GLY A 730
ASN A 727
ARG A 439
None
0.74A 5w7bD-2pggA:
undetectable
5w7bD-2pggA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1


(Arabidopsis
thaliana)
PF00724
(Oxidored_FMN)
3 GLY A 206
ASN A 199
ARG A 152
None
0.78A 5w7bD-2q3rA:
undetectable
5w7bD-2q3rA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkb RIBONUCLEASE H1

(Homo sapiens)
PF00075
(RNase_H)
3 GLY A 167
ASN A 171
ARG A 275
None
0.71A 5w7bD-2qkbA:
undetectable
5w7bD-2qkbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE


(Streptococcus
sp.)
PF01266
(DAO)
PF16901
(DAO_C)
3 GLY A 468
ASN A 507
ARG A 175
None
0.69A 5w7bD-2rghA:
undetectable
5w7bD-2rghA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa)
PF00063
(Myosin_head)
3 GLY A 459
ASN A 477
ARG A 667
VO4  A1791 (-3.3A)
EDO  A1793 ( 4.6A)
None
0.58A 5w7bD-2v26A:
undetectable
5w7bD-2v26A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE


(Kluyveromyces
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 GLY A 120
ASN A 119
ARG A 127
None
0.73A 5w7bD-2vk4A:
undetectable
5w7bD-2vk4A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
3 GLY A 240
ASN A 291
ARG A 170
None
0.71A 5w7bD-2vsaA:
undetectable
5w7bD-2vsaA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9)
3 GLY A 297
ASN A 292
ARG A 308
None
0.70A 5w7bD-2w5fA:
3.9
5w7bD-2w5fA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlv GAG POLYPROTEIN

(Human
immunodeficiency
virus 2)
PF00607
(Gag_p24)
3 GLY B 104
ASN B  52
ARG B  69
None
0.66A 5w7bD-2wlvB:
undetectable
5w7bD-2wlvB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI


(Streptococcus
mutans)
PF02324
(Glyco_hydro_70)
3 GLY A1009
ASN A 451
ARG A 921
None
0.75A 5w7bD-3aibA:
undetectable
5w7bD-3aibA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR


(Bordetella
pertussis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 GLY A 118
ASN A 116
ARG A 310
None
0.71A 5w7bD-3efmA:
undetectable
5w7bD-3efmA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 GLY A 481
ASN A 479
ARG A 781
None
0.71A 5w7bD-3fawA:
undetectable
5w7bD-3fawA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feh CENTAURIN-ALPHA-1

(Homo sapiens)
PF00169
(PH)
PF01412
(ArfGap)
3 GLY A  77
ASN A  18
ARG A  82
None
0.78A 5w7bD-3fehA:
undetectable
5w7bD-3fehA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis)
PF06028
(DUF915)
3 GLY A 178
ASN A 183
ARG A 199
None
0.75A 5w7bD-3fleA:
undetectable
5w7bD-3fleA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL


(Plasmodium
falciparum)
PF01180
(DHO_dh)
3 GLY A 231
ASN A 289
ARG A 296
None
0.75A 5w7bD-3i6rA:
undetectable
5w7bD-3i6rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idv PROTEIN
DISULFIDE-ISOMERASE
A4


(Homo sapiens)
PF00085
(Thioredoxin)
3 GLY A 261
ASN A 192
ARG A 246
None
0.76A 5w7bD-3idvA:
undetectable
5w7bD-3idvA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus)
PF00291
(PALP)
3 GLY A 186
ASN A 154
ARG A 135
PLP  A 350 (-3.6A)
PLP  A 350 (-4.3A)
MLI  A 341 (-3.2A)
0.77A 5w7bD-3l6cA:
undetectable
5w7bD-3l6cA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens)
PF00291
(PALP)
3 GLY A 186
ASN A 154
ARG A 135
LLP  A  56 ( 3.7A)
LLP  A  56 ( 4.7A)
MLI  A 347 (-3.0A)
0.79A 5w7bD-3l6rA:
undetectable
5w7bD-3l6rA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE


(Saccharomyces
cerevisiae)
PF03074
(GCS)
3 GLY A 209
ASN A 339
ARG A 329
None
0.75A 5w7bD-3lvvA:
undetectable
5w7bD-3lvvA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE


(Saccharomyces
cerevisiae)
PF03074
(GCS)
3 GLY A 344
ASN A 339
ARG A 329
None
0.69A 5w7bD-3lvvA:
undetectable
5w7bD-3lvvA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
3 GLY A 658
ASN A 609
ARG B 812
None
0.68A 5w7bD-3o8oA:
undetectable
5w7bD-3o8oA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
3 GLY B  88
ASN B  87
ARG B 157
None
CA  B 538 (-2.8A)
None
0.69A 5w7bD-3ojyB:
undetectable
5w7bD-3ojyB:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA


(Sulfolobus
solfataricus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
3 GLY A 293
ASN A  11
ARG A 207
None
0.57A 5w7bD-3penA:
3.5
5w7bD-3penA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
smegmatis)
PF03641
(Lysine_decarbox)
3 GLY A  62
ASN A  57
ARG A  69
None
0.76A 5w7bD-3quaA:
undetectable
5w7bD-3quaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 3 GLY M 242
ASN L 566
ARG M 313
None
0.67A 5w7bD-3rkoM:
undetectable
5w7bD-3rkoM:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE


(Paenibacillus
sp. JDR-2)
PF00331
(Glyco_hydro_10)
3 GLY A 230
ASN A 192
ARG A 301
None
0.77A 5w7bD-3ro8A:
undetectable
5w7bD-3ro8A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Streptomyces
avermitilis)
PF00215
(OMPdecase)
3 GLY A 194
ASN A 187
ARG A 144
None
0.46A 5w7bD-3v75A:
undetectable
5w7bD-3v75A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhh NUCLEOPROTEIN

(California
encephalitis
orthobunyavirus)
PF00952
(Bunya_nucleocap)
3 GLY B  16
ASN B  15
ARG B  94
U  R  14 ( 4.1A)
U  R  15 ( 2.8A)
U  R  16 ( 4.0A)
0.77A 5w7bD-4bhhB:
undetectable
5w7bD-4bhhB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cua BETA-GALACTOSIDASE

(Streptococcus
pneumoniae)
no annotation 3 GLY A1578
ASN A1585
ARG A1621
EDO  A2646 (-4.1A)
EDO  A2646 (-3.5A)
EDO  A2646 (-3.8A)
0.72A 5w7bD-4cuaA:
undetectable
5w7bD-4cuaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzz NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
3 GLY A 465
ASN A 463
ARG A 428
None
0.77A 5w7bD-4hzzA:
undetectable
5w7bD-4hzzA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Agrobacterium
fabrum)
PF13561
(adh_short_C2)
3 GLY A  18
ASN A  94
ARG A 196
NAP  A 300 (-3.2A)
NAP  A 300 (-3.2A)
NAP  A 300 (-3.6A)
0.79A 5w7bD-4imrA:
6.6
5w7bD-4imrA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
3 GLY A 386
ASN A 412
ARG A 611
None
0.77A 5w7bD-4j0mA:
undetectable
5w7bD-4j0mA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN


(Pseudomonas
aeruginosa)
PF03372
(Exo_endo_phos)
3 GLY A 219
ASN A 217
ARG A 245
None
0.75A 5w7bD-4jg3A:
undetectable
5w7bD-4jg3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


([Haemophilus]
ducreyi)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
3 GLY A 448
ASN A 445
ARG A 364
None
0.68A 5w7bD-4k3cA:
undetectable
5w7bD-4k3cA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN


(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
3 GLY B 198
ASN B 199
ARG B 217
None
0.72A 5w7bD-4k3jB:
undetectable
5w7bD-4k3jB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
3 GLY A 369
ASN A 367
ARG A 327
None
0.74A 5w7bD-4k3yA:
undetectable
5w7bD-4k3yA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome)
PF00331
(Glyco_hydro_10)
3 GLY A 238
ASN A 207
ARG A 333
None
0.74A 5w7bD-4k68A:
undetectable
5w7bD-4k68A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli)
PF16168
(AIDA)
3 GLY A 341
ASN A 321
ARG A 393
None
0.54A 5w7bD-4kh3A:
undetectable
5w7bD-4kh3A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism)
PF04616
(Glyco_hydro_43)
3 GLY A  43
ASN A  42
ARG A  81
None
0.67A 5w7bD-4mlgA:
undetectable
5w7bD-4mlgA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III


(Scadoxus
multiflorus)
PF00704
(Glyco_hydro_18)
3 GLY A  25
ASN A  26
ARG A  16
None
0.74A 5w7bD-4n42A:
undetectable
5w7bD-4n42A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE


(Novosphingobium
aromaticivorans)
PF00378
(ECH_1)
3 GLY A 161
ASN A 162
ARG A 104
None
0.72A 5w7bD-4og1A:
undetectable
5w7bD-4og1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q63 UNCHARACTERIZED
PROTEIN LPG0364


(Legionella
pneumophila)
PF07238
(PilZ)
3 GLY A  14
ASN A  12
ARG A  97
None
0.78A 5w7bD-4q63A:
undetectable
5w7bD-4q63A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Rhodoferax
ferrireducens)
PF00903
(Glyoxalase)
3 GLY A  63
ASN A  62
ARG A 111
None
0.77A 5w7bD-4qb5A:
undetectable
5w7bD-4qb5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 GLY A  67
ASN A  48
ARG A 232
None
0.44A 5w7bD-4rvwA:
undetectable
5w7bD-4rvwA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 GLY A 297
ASN A 207
ARG A 200
None
0.62A 5w7bD-4w1tA:
undetectable
5w7bD-4w1tA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
3 GLY A 460
ASN A 457
ARG A 516
None
0.69A 5w7bD-4wd9A:
undetectable
5w7bD-4wd9A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2)
3 GLY A 367
ASN A 362
ARG A 198
None
0.77A 5w7bD-4xqkA:
undetectable
5w7bD-4xqkA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
3 GLY A 183
ASN A 254
ARG A 261
None
0.76A 5w7bD-4xwtA:
undetectable
5w7bD-4xwtA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF03734
(YkuD)
3 GLY A 161
ASN A 181
ARG A 168
None
0.74A 5w7bD-4y4vA:
undetectable
5w7bD-4y4vA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zro 3C-LIKE PROTEINASE

(Alphacoronavirus
1)
PF05409
(Peptidase_C30)
3 GLY A 169
ASN A 168
ARG A 130
None
0.75A 5w7bD-4zroA:
undetectable
5w7bD-4zroA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa)
PF00022
(Actin)
3 GLY A  17
ASN A  37
ARG A 188
ADP  A 800 ( 3.1A)
None
None
0.65A 5w7bD-5afuA:
undetectable
5w7bD-5afuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans)
no annotation 3 GLY A 221
ASN A 223
ARG A 236
None
0.72A 5w7bD-5ah0A:
2.2
5w7bD-5ah0A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC


(Homo sapiens)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 GLY O 214
ASN O 212
ARG O 406
None
0.78A 5w7bD-5c7oO:
undetectable
5w7bD-5c7oO:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0
VP1


(Enterovirus A)
PF00073
(Rhv)
PF02226
(Pico_P1A)
3 GLY B 202
ASN A 278
ARG A 267
None
0.79A 5w7bD-5c8cB:
undetectable
5w7bD-5c8cB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1


(Arabidopsis
thaliana)
PF00520
(Ion_trans)
3 GLY A 487
ASN A 490
ARG A 428
None
0.74A 5w7bD-5dqqA:
undetectable
5w7bD-5dqqA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI


(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
3 GLY A 367
ASN A 362
ARG A 198
None
0.63A 5w7bD-5ffjA:
undetectable
5w7bD-5ffjA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 GLY A 703
ASN A 393
ARG A 709
None
0.64A 5w7bD-5fkuA:
undetectable
5w7bD-5fkuA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkk PUTATIVE HOMING
ENDONUCLEASE


(Thermotoga
neapolitana)
PF00961
(LAGLIDADG_1)
3 GLY A  21
ASN A 135
ARG A  39
None
0.71A 5w7bD-5gkkA:
undetectable
5w7bD-5gkkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzs GGDEF FAMILY PROTEIN

(Vibrio cholerae)
PF00497
(SBP_bac_3)
3 GLY A 468
ASN A 465
ARG A 269
None
0.79A 5w7bD-5gzsA:
undetectable
5w7bD-5gzsA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlt MIDDLE TRANSCRIPTION
REGULATORY PROTEIN
MOTA


(Escherichia
virus T4)
PF09158
(MotCF)
3 GLY A 188
ASN A 187
ARG A 150
None
0.79A 5w7bD-5jltA:
undetectable
5w7bD-5jltA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE


(Saccharomyces
cerevisiae)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
3 GLY A 414
ASN A 378
ARG A 867
None
0.60A 5w7bD-5jm0A:
undetectable
5w7bD-5jm0A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC


(Mycobacterium
tuberculosis)
PF01547
(SBP_bac_1)
3 GLY A 230
ASN A 242
ARG A 234
None
0.61A 5w7bD-5k2yA:
undetectable
5w7bD-5k2yA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa)
PF13402
(Peptidase_M60)
3 GLY A 368
ASN A 109
ARG A 237
PO4  A1004 (-3.3A)
None
None
0.72A 5w7bD-5kdxA:
undetectable
5w7bD-5kdxA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus)
PF15892
(BNR_4)
3 GLY A 304
ASN A 280
ARG A 230
None
0.79A 5w7bD-5mvhA:
undetectable
5w7bD-5mvhA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4


(Homo sapiens)
no annotation 3 GLY A 335
ASN A 378
ARG A 209
EDO  A 628 (-3.5A)
None
None
0.80A 5w7bD-5nqaA:
undetectable
5w7bD-5nqaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY


(Caulobacter
vibrioides)
no annotation 3 GLY A 127
ASN A 211
ARG A 234
None
0.65A 5w7bD-5oynA:
undetectable
5w7bD-5oynA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24


(Escherichia
virus T4)
PF07068
(Gp23)
3 GLY a 191
ASN a 190
ARG a  21
None
0.68A 5w7bD-5vf3a:
undetectable
5w7bD-5vf3a:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE


(Drosophila
melanogaster)
no annotation 3 GLY A 463
ASN A 481
ARG A 672
None
0.79A 5w7bD-5w1aA:
undetectable
5w7bD-5w1aA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT


(Oryctolagus
cuniculus)
no annotation 3 GLY B 340
ASN B 372
ARG B 378
FTT  B 609 ( 3.3A)
FTT  B 609 (-3.1A)
PO4  B 607 (-3.3A)
0.17A 5w7bD-5w7aB:
65.6
5w7bD-5w7aB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE


(Mycolicibacterium
hassiacum)
PF00561
(Abhydrolase_1)
3 GLY A 105
ASN A 101
ARG A 162
None
0.55A 5w7bD-5w8oA:
2.8
5w7bD-5w8oA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE


(Mycobacteroides
abscessus)
PF00561
(Abhydrolase_1)
3 GLY A 108
ASN A 104
ARG A 165
GOL  A 407 (-4.7A)
GOL  A 407 ( 4.8A)
None
0.61A 5w7bD-5w8pA:
3.4
5w7bD-5w8pA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1


(Mus musculus)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec)
3 GLY A 158
ASN A 156
ARG A 137
None
0.68A 5w7bD-5xa1A:
undetectable
5w7bD-5xa1A:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium)
PF01341
(Glyco_hydro_6)
3 GLY A 349
ASN A 436
ARG A 371
None
0.80A 5w7bD-5xcyA:
3.3
5w7bD-5xcyA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG


(Klebsiella
pneumoniae)
no annotation 3 GLY A  96
ASN A  97
ARG A  63
None
0.77A 5w7bD-5xktA:
2.3
5w7bD-5xktA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z4i UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 20


(Homo sapiens)
no annotation 3 GLY A  54
ASN A  39
ARG A  80
None
0.69A 5w7bD-5z4iA:
undetectable
5w7bD-5z4iA:
19.10