SIMILAR PATTERNS OF AMINO ACIDS FOR 5W4Z_B_RBFB502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		4 ASN A 226
GLN A 228
ASP A 229
THR A 175
 None
 1.18A 5w4zB-1s6rA:
0.0		 5w4zB-1s6rA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 ASN A 384
GLN A 368
ASP A 367
THR A 457
 None
 1.21A 5w4zB-1xfuA:
0.0		 5w4zB-1xfuA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkw CARBOXYLESTERASE

(Alcaligenes sp.) 		no annotation 4 ASN A 296
GLN A 159
ASP A 303
THR A  77
 None
 1.36A 5w4zB-2wkwA:
0.7		 5w4zB-2wkwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		4 ASN A 226
GLN A 228
ASP A 229
THR A 175
 None
 1.20A 5w4zB-2zc7A:
0.0		 5w4zB-2zc7A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ASN A3669
GLN A3266
ASP A3262
THR A3256
 None
 1.45A 5w4zB-3vkgA:
undetectable		 5w4zB-3vkgA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 4 ASN A 283
GLN A 328
ASP A 327
THR A 177
 None
None
RNS  A1001 ( 2.8A)
None
 1.36A 5w4zB-4gjiA:
7.0		 5w4zB-4gjiA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12697
(Abhydrolase_6) 		4 ASN A 314
GLN A 147
ASP A 321
THR A  79
 None
 1.36A 5w4zB-4q34A:
undetectable		 5w4zB-4q34A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12697
(Abhydrolase_6) 		4 ASN A 323
GLN A 147
ASP A 321
THR A  79
 None
 1.47A 5w4zB-4q34A:
undetectable		 5w4zB-4q34A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 ASN I  83
GLN I  85
ASP I  80
THR I 133
 None
 1.46A 5w4zB-5a5uI:
undetectable		 5w4zB-5a5uI:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		4 ASN A 230
GLN A 226
ASP A 227
THR A 259
 None
 1.41A 5w4zB-5bo6A:
undetectable		 5w4zB-5bo6A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ASN B 181
GLN B 177
ASP B 178
THR B 105
 None
 1.47A 5w4zB-5do8B:
3.3		 5w4zB-5do8B:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k82 APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE
3G,APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE 3G

(Macaca mulatta) 		PF08210
(APOBEC_N) 		4 ASN A 162
GLN A 158
ASP A 159
THR A  89
 None
 1.41A 5w4zB-5k82A:
undetectable		 5w4zB-5k82A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 4 ASN A 758
GLN A 688
ASP A 690
THR A 714
 None
 1.44A 5w4zB-5n8dA:
undetectable		 5w4zB-5n8dA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ASN A 276
GLN A 272
ASP A 273
THR A 461
 None
 1.29A 5w4zB-5uohA:
undetectable		 5w4zB-5uohA:
11.02