SIMILAR PATTERNS OF AMINO ACIDS FOR 5W4Z_A_RBFA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 ASN A 257
ASP A 283
SER A 255
ARG A 208
 None
ZN  A1424 (-2.2A)
ZN  A1424 ( 4.2A)
ZN  A1424 (-2.2A)
 1.40A 5w4zA-1gw1A:
10.6		 5w4zA-1gw1A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i71 APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASN A  52
GLN A   7
ASP A  54
ARG A  35
 None
None
None
SO4  A 300 (-3.6A)
 1.11A 5w4zA-1i71A:
undetectable		 5w4zA-1i71A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 179
GLN A 182
ASP A 181
ARG A  72
 None
 1.30A 5w4zA-1kfiA:
undetectable		 5w4zA-1kfiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ASN A 923
GLN A 926
ASP A 925
ARG A 690
 None
 1.22A 5w4zA-1kspA:
undetectable		 5w4zA-1kspA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 ASN Q 250
GLN Q 257
ASP Q 191
ARG Q 190
 None
 1.40A 5w4zA-1oh2Q:
undetectable		 5w4zA-1oh2Q:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 GLN A 367
ASP A 368
SER A 431
ARG A 371
 None
 1.31A 5w4zA-1tr1A:
7.7		 5w4zA-1tr1A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		4 GLN X 827
ASP X 828
SER X1075
ARG X 803
 None
 1.29A 5w4zA-1uyoX:
undetectable		 5w4zA-1uyoX:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 ASN A 328
GLN A 331
ASP A 330
ARG A 379
 None
 1.49A 5w4zA-1wzaA:
11.1		 5w4zA-1wzaA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byg CHANNEL ASSOCIATED
PROTEIN OF
SYNAPSE-110

(Homo sapiens) 		PF00595
(PDZ) 		4 GLN A 214
ASP A 219
SER A 221
ARG A 244
 None
 1.39A 5w4zA-2bygA:
undetectable		 5w4zA-2bygA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 309
ASP A 327
SER A 329
ARG A  29
 None
 1.31A 5w4zA-2c4kA:
undetectable		 5w4zA-2c4kA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if7 SLAM FAMILY MEMBER 6

(Homo sapiens) 		PF07686
(V-set) 		4 ASN A  65
GLN A  73
SER A  75
ARG A  63
 None
 1.46A 5w4zA-2if7A:
undetectable		 5w4zA-2if7A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 322
ASP A 340
SER A 342
ARG A  41
 None
 1.31A 5w4zA-2ji4A:
undetectable		 5w4zA-2ji4A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 ASN B 243
ASP B 241
SER B 240
ARG A  13
 None
 1.34A 5w4zA-2pbiB:
undetectable		 5w4zA-2pbiB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ASN A 235
ASP A 328
SER A 714
ARG A 347
 None
 1.27A 5w4zA-2vdcA:
7.0		 5w4zA-2vdcA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 GLN A  94
ASP A  96
SER A  81
ARG A  86
 None
 1.44A 5w4zA-2wc7A:
9.3		 5w4zA-2wc7A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		4 ASN A 181
GLN A 184
ASP A 183
ARG A 186
 None
 1.37A 5w4zA-3asaA:
undetectable		 5w4zA-3asaA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF09183
(DUF1947) 		4 ASN A  76
ASP A  79
SER A  78
ARG A 133
 None
 1.50A 5w4zA-3d79A:
undetectable		 5w4zA-3d79A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		4 GLN A   3
ASP A   4
SER A   5
ARG A   6
 None
 1.28A 5w4zA-3dmpA:
undetectable		 5w4zA-3dmpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 ASN A 199
ASP A 202
SER A 197
ARG A 206
 None
 1.30A 5w4zA-3do6A:
undetectable		 5w4zA-3do6A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		4 ASN A1316
GLN A1321
ASP A1320
SER A1319
 None
 1.39A 5w4zA-3eujA:
undetectable		 5w4zA-3eujA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ASN B1052
GLN A 468
ASP A 319
ARG B1004
 None
 1.33A 5w4zA-3hkzB:
undetectable		 5w4zA-3hkzB:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 GLN A 397
ASP A 395
SER A 405
ARG A 407
 None
None
None
PO4  A   1 (-3.1A)
 1.35A 5w4zA-3icfA:
undetectable		 5w4zA-3icfA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1z UBIQUITIN
CONJUGATION FACTOR
E4 B

(Homo sapiens) 		PF04564
(U-box) 		4 ASN B1271
GLN B1273
ASP B1268
SER B1249
 None
 1.37A 5w4zA-3l1zB:
undetectable		 5w4zA-3l1zB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mep UNCHARACTERIZED
PROTEIN ECA2234

(Pectobacterium
atrosepticum) 		PF07081
(DUF1349) 		4 GLN A  79
ASP A  78
SER A 172
ARG A 175
 None
 1.29A 5w4zA-3mepA:
undetectable		 5w4zA-3mepA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLN A 212
ASP A 175
SER A 177
ARG A 189
 None
 1.34A 5w4zA-3p5pA:
undetectable		 5w4zA-3p5pA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 GLN A  17
ASP A   5
SER A   3
ARG A  73
 None
 1.39A 5w4zA-3zdnA:
undetectable		 5w4zA-3zdnA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 GLN A 385
ASP A 386
SER A 449
ARG A 389
 None
 1.33A 5w4zA-4b3kA:
8.1		 5w4zA-4b3kA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ASN A   6
GLN A 101
ASP A 102
ARG A   7
 None
 1.35A 5w4zA-4b7xA:
undetectable		 5w4zA-4b7xA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		4 ASN A 183
ASP A 219
SER A 218
ARG A 174
 None
 1.15A 5w4zA-4blqA:
undetectable		 5w4zA-4blqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvw APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASN A  52
GLN A   7
ASP A  54
ARG A  35
 None
None
HKY  A1080 (-3.0A)
CL  A1081 (-3.8A)
 1.18A 5w4zA-4bvwA:
undetectable		 5w4zA-4bvwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		4 ASN B 455
GLN B 458
ASP B 459
ARG B 436
 None
 1.50A 5w4zA-4bwcB:
undetectable		 5w4zA-4bwcB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwy P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		4 ASN A 183
ASP A 219
SER A 218
ARG A 174
 None
 1.11A 5w4zA-4bwyA:
3.0		 5w4zA-4bwyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 GLN A 109
ASP A 110
SER A  87
ARG A  73
 None
 1.41A 5w4zA-4czxA:
undetectable		 5w4zA-4czxA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 GLN A 109
ASP A 110
SER A  87
ARG A 112
 None
 1.27A 5w4zA-4czxA:
undetectable		 5w4zA-4czxA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ASN A 409
GLN A 364
ASP A 413
ARG A  68
 None
 1.46A 5w4zA-4duuA:
undetectable		 5w4zA-4duuA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 GLN A 892
ASP A 893
SER A 869
ARG A 895
 None
 1.49A 5w4zA-4ecoA:
undetectable		 5w4zA-4ecoA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0j NON-STRUCTURAL
PROTEIN 2

(Rotavirus A) 		PF02509
(Rota_NS35) 		4 ASN A 120
GLN A 122
ASP A 123
ARG A 117
 None
 1.14A 5w4zA-4g0jA:
undetectable		 5w4zA-4g0jA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 ASN A 578
ASP A 576
SER A 575
ARG A 571
 None
 1.43A 5w4zA-4hhrA:
undetectable		 5w4zA-4hhrA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ASN A  92
ASP A  96
SER A  94
ARG A 351
 None
 1.40A 5w4zA-4je5A:
undetectable		 5w4zA-4je5A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 ASN A  97
GLN A 100
ASP A  99
ARG A 119
 None
 1.10A 5w4zA-4kw5A:
undetectable		 5w4zA-4kw5A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLN A 768
ASP A 767
SER A 769
ARG A 754
 None
 1.39A 5w4zA-4lglA:
undetectable		 5w4zA-4lglA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 330
GLN A 333
ASP A 332
ARG A 422
 None
None
GOL  A 602 (-2.8A)
None
 1.50A 5w4zA-4m8uA:
8.5		 5w4zA-4m8uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 GLN A 281
ASP A 363
SER A 320
ARG A 367
 None
 1.00A 5w4zA-4ogcA:
undetectable		 5w4zA-4ogcA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		4 GLN A   9
ASP A  26
SER A  11
ARG A  24
 None
 1.48A 5w4zA-4uxaA:
undetectable		 5w4zA-4uxaA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 GLN A 200
ASP A 199
SER A 198
ARG A 236
 None
 1.50A 5w4zA-4v1yA:
4.8		 5w4zA-4v1yA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN B  37
ASP B  41
SER B  40
ARG B  44
 None
 1.47A 5w4zA-5a8rB:
undetectable		 5w4zA-5a8rB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 ASN A 143
ASP A 161
SER A 159
ARG A 156
 None
 1.36A 5w4zA-5b5uA:
undetectable		 5w4zA-5b5uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 GLN A 367
ASP A 366
SER A 429
ARG A 369
 None
 1.50A 5w4zA-5dt5A:
8.6		 5w4zA-5dt5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		4 ASN A  19
ASP A  22
SER A 146
ARG A 144
 None
 1.48A 5w4zA-5hr6A:
5.2		 5w4zA-5hr6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 ASN A 225
ASP A  68
SER A  95
ARG A 162
 None
 1.42A 5w4zA-5hyhA:
undetectable		 5w4zA-5hyhA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		4 GLN C 240
ASP C 241
SER C 239
ARG C 245
 None
 1.45A 5w4zA-5k1cC:
undetectable		 5w4zA-5k1cC:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 4 ASN A  23
ASP A  26
SER A  12
ARG A  15
 None
 1.35A 5w4zA-5mszA:
undetectable		 5w4zA-5mszA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 GLN A 384
ASP A 385
SER A 448
ARG A 388
 None
 1.43A 5w4zA-5naqA:
4.6		 5w4zA-5naqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 4 GLN A  60
ASP A  59
SER A  38
ARG A  64
 None
 1.29A 5w4zA-5nfqA:
undetectable		 5w4zA-5nfqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odd MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 26

(Homo sapiens) 		no annotation 4 ASN A  24
GLN A  22
ASP A  20
ARG A  26
 None
 1.49A 5w4zA-5oddA:
undetectable		 5w4zA-5oddA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 474
GLN A1051
ASP A1050
SER A1052
 None
BTN  A1202 ( 4.7A)
None
None
 1.28A 5w4zA-5vywA:
8.5		 5w4zA-5vywA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cty DIHYDROOROTASE

(Yersinia pestis) 		no annotation 4 ASN A 299
ASP A 244
SER A 243
ARG A 245
 None
 1.40A 5w4zA-6ctyA:
5.5		 5w4zA-6ctyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 4 GLN A  78
ASP A  77
SER A  76
ARG A 113
 None
 1.43A 5w4zA-6dxpA:
undetectable		 5w4zA-6dxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 GLN A 278
ASP A 355
SER A 351
ARG A 363
 None
 1.39A 5w4zA-6ei1A:
undetectable		 5w4zA-6ei1A:
17.65