SIMILAR PATTERNS OF AMINO ACIDS FOR 5W3J_B_TA1B502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 VAL A 203
HIS A 393
GLY A 368
LEU A 369
 None
 0.93A 5w3jB-13pkA:
3.1		 5w3jB-13pkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)

(Cricket
paralysis virus) 		no annotation 5 VAL B 237
ASP B 238
GLN B 240
GLY B 121
LEU B 198
 None
 1.29A 5w3jB-1b35B:
undetectable		 5w3jB-1b35B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 VAL A  99
ASP A 120
HIS A 127
GLY A 117
 None
 0.93A 5w3jB-1do5A:
undetectable		 5w3jB-1do5A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 VAL A   4
ASP A   5
GLY A  10
LEU A  13
 None
 0.87A 5w3jB-1drtA:
undetectable		 5w3jB-1drtA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 VAL A 263
ASP A 246
GLY A 223
LEU A 224
 None
 0.92A 5w3jB-1e25A:
undetectable		 5w3jB-1e25A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		4 VAL A  46
ASP A  47
HIS A  34
GLY A  50
 None
 0.77A 5w3jB-1eyeA:
2.1		 5w3jB-1eyeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga7 HYPOTHETICAL 23.7
KDA PROTEIN IN
ICC-TOLC INTERGENIC
REGION

(Escherichia
coli) 		PF00293
(NUDIX) 		4 GLU A 116
HIS A 169
GLY A 118
LEU A 119
 None
 0.65A 5w3jB-1ga7A:
undetectable		 5w3jB-1ga7A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		4 VAL A  71
ASP A  72
GLU A  73
GLY A  77
 None
 0.75A 5w3jB-1gqrA:
2.2		 5w3jB-1gqrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 PRO A  90
GLN A  91
GLY A  92
LEU A  93
 None
 0.70A 5w3jB-1gtkA:
undetectable		 5w3jB-1gtkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 VAL A 508
GLN A 522
GLY A 718
LEU A 715
 None
 0.79A 5w3jB-1jj7A:
undetectable		 5w3jB-1jj7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 VAL A  93
ASP A  94
GLN A  96
GLY A 100
 None
 0.68A 5w3jB-1jm1A:
undetectable		 5w3jB-1jm1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 GLU A 397
PRO A 398
GLN A 396
LEU A 323
 None
 0.85A 5w3jB-1li7A:
undetectable		 5w3jB-1li7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 270
ASP A 271
GLU A 272
LEU A 279
 None
 0.85A 5w3jB-1mx3A:
undetectable		 5w3jB-1mx3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		4 VAL A  77
ASP A  78
HIS A 237
GLY A 268
 None
 0.86A 5w3jB-1n31A:
undetectable		 5w3jB-1n31A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 ASP A 790
HIS A 627
PRO A 785
LEU A 808
 None
 0.90A 5w3jB-1nstA:
3.0		 5w3jB-1nstA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 VAL A 121
ASP A 122
GLU A 123
GLY A 168
 None
 0.94A 5w3jB-1nylA:
undetectable		 5w3jB-1nylA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 155
PRO A  36
GLY A  34
LEU A  33
 None
 0.91A 5w3jB-1o5zA:
undetectable		 5w3jB-1o5zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 4 VAL A 135
ASP A 134
PRO A 129
GLY A  98
 None
 0.90A 5w3jB-1onsA:
undetectable		 5w3jB-1onsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 VAL A 234
ASP A 236
HIS A 201
GLN A 243
 None
None
AC1  A 992 ( 3.8A)
None
 0.84A 5w3jB-1oseA:
undetectable		 5w3jB-1oseA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 VAL A 124
GLU A 128
GLY A 231
LEU A 137
 None
None
CA  A 601 (-4.2A)
None
 0.85A 5w3jB-1ot5A:
3.6		 5w3jB-1ot5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 451
HIS A 454
GLY A 446
LEU A 445
 None
 0.90A 5w3jB-1ovmA:
undetectable		 5w3jB-1ovmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 VAL A  97
ASP A  96
GLY A  93
LEU A  38
 None
 0.92A 5w3jB-1p1vA:
undetectable		 5w3jB-1p1vA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		4 VAL A  15
ASP A   9
GLY A  42
LEU A  46
 None
 0.87A 5w3jB-1r44A:
undetectable		 5w3jB-1r44A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 VAL A 359
HIS A 370
GLY A 224
LEU A 139
 None
None
CA  A   1 ( 4.4A)
None
 0.80A 5w3jB-1r6vA:
3.2		 5w3jB-1r6vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 386
GLN A 401
GLY A 171
LEU A 170
 None
 0.91A 5w3jB-1rblA:
undetectable		 5w3jB-1rblA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 379
GLN A 394
GLY A 164
LEU A 163
 None
 0.92A 5w3jB-1svdA:
undetectable		 5w3jB-1svdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 VAL A 129
ASP A 128
HIS A 105
GLY A 122
 None
 0.58A 5w3jB-1uioA:
2.1		 5w3jB-1uioA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		4 VAL A 143
ASP A 144
PRO A 123
LEU A  62
 None
 0.94A 5w3jB-1un1A:
undetectable		 5w3jB-1un1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A 374
HIS A 355
GLN A 301
GLY A 332
 None
 0.85A 5w3jB-1uwyA:
3.8		 5w3jB-1uwyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		5 VAL A  57
ASP A  51
GLN A  52
GLY A 124
LEU A 125
 None
SAM  A3142 (-2.8A)
SAM  A3142 (-3.9A)
None
None
 0.97A 5w3jB-1wg8A:
3.6		 5w3jB-1wg8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgo VPS10
DOMAIN-CONTAINING
RECEPTOR SORCS2

(Homo sapiens) 		PF00801
(PKD) 		4 VAL A  98
ASP A  67
HIS A  88
LEU A  79
 None
 0.84A 5w3jB-1wgoA:
undetectable		 5w3jB-1wgoA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 VAL A 159
ASP A 162
PRO A 243
LEU A 203
 None
 0.83A 5w3jB-1z26A:
undetectable		 5w3jB-1z26A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		4 VAL A1927
HIS A1954
PRO A1893
GLY A1914
 None
 0.84A 5w3jB-2adoA:
undetectable		 5w3jB-2adoA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 VAL A 168
ASP A 169
HIS A 193
LEU A 177
 None
 0.85A 5w3jB-2ay9A:
undetectable		 5w3jB-2ay9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A 544
GLU A 543
HIS A  47
GLN A 541
GLY A 540
 None
 1.44A 5w3jB-2b39A:
undetectable		 5w3jB-2b39A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 218
ASP A 217
HIS A 282
GLY A 135
 None
 0.88A 5w3jB-2bujA:
undetectable		 5w3jB-2bujA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt9 ASPARTOKINASE

(Thermus
thermophilus) 		PF01842
(ACT)
PF13840
(ACT_7) 		4 VAL A  45
GLN A  18
GLY A  20
LEU A  21
 None
 0.81A 5w3jB-2dt9A:
undetectable		 5w3jB-2dt9A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt9 ASPARTOKINASE

(Thermus
thermophilus) 		PF01842
(ACT)
PF13840
(ACT_7) 		4 VAL A  66
GLN A  18
GLY A  20
LEU A  21
 None
 0.87A 5w3jB-2dt9A:
undetectable		 5w3jB-2dt9A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		4 VAL A 132
GLU A 136
HIS A 205
LEU A 183
 None
 0.83A 5w3jB-2g5cA:
4.4		 5w3jB-2g5cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		4 HIS A  55
GLN A  85
GLY A  11
LEU A  12
 None
 0.79A 5w3jB-2iueA:
undetectable		 5w3jB-2iueA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  99
HIS A 153
GLN A 146
GLY A 145
 None
 0.86A 5w3jB-2iwiA:
undetectable		 5w3jB-2iwiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 214
HIS A 260
GLY A 232
LEU A 235
 None
 0.87A 5w3jB-2jgdA:
undetectable		 5w3jB-2jgdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jp0 T-CELL SURFACE
GLYCOPROTEIN CD5

(Homo sapiens) 		PF00530
(SRCR) 		4 VAL A  59
GLN A  47
GLY A  46
LEU A  37
 None
 0.92A 5w3jB-2jp0A:
undetectable		 5w3jB-2jp0A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		4 VAL A 324
GLU A 322
GLY A 259
LEU A 300
 None
 0.90A 5w3jB-2l26A:
undetectable		 5w3jB-2l26A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3o POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 VAL A  60
HIS A 133
PRO A  57
GLY A  49
 None
U  B  12 ( 2.8A)
None
None
 0.83A 5w3jB-2n3oA:
undetectable		 5w3jB-2n3oA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohf GTP-BINDING PROTEIN
9

(Homo sapiens) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 VAL A  91
ASP A  92
HIS A 113
GLY A  29
 None
 0.92A 5w3jB-2ohfA:
undetectable		 5w3jB-2ohfA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 GLU A 106
GLN A  84
GLY A 328
LEU A  88
 None
 0.91A 5w3jB-2oodA:
undetectable		 5w3jB-2oodA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN
H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 VAL A  72
HIS B  10
GLY B 154
LEU B 138
 None
 0.93A 5w3jB-2p24A:
undetectable		 5w3jB-2p24A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 509
ASP A 510
GLY A 517
LEU A 518
 None
 0.93A 5w3jB-2panA:
2.4		 5w3jB-2panA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzd SERINE PROTEASE
HTRA2

(Homo sapiens) 		PF13180
(PDZ_2) 		4 VAL A 427
ASP A 426
GLN A 422
LEU A 369
 None
 0.93A 5w3jB-2pzdA:
undetectable		 5w3jB-2pzdA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 ASP A 252
HIS A 112
GLY A 245
LEU A 244
 None
ZN  A 700 (-3.3A)
None
None
 0.91A 5w3jB-2q42A:
undetectable		 5w3jB-2q42A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpv UNCHARACTERIZED
PROTEIN ATU1531

(Agrobacterium
fabrum) 		no annotation 4 VAL A  60
PRO A  78
GLY A  56
LEU A  55
 None
 0.86A 5w3jB-2qpvA:
undetectable		 5w3jB-2qpvA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 VAL A   3
HIS A 230
GLN A 209
GLY A  43
 None
 0.76A 5w3jB-2vdcA:
undetectable		 5w3jB-2vdcA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 188
PRO A  62
GLY A  60
LEU A  59
 None
 0.81A 5w3jB-2vosA:
undetectable		 5w3jB-2vosA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 VAL A 389
PRO A 489
GLY A  94
LEU A  93
 None
 0.82A 5w3jB-2wpgA:
undetectable		 5w3jB-2wpgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		4 VAL A 209
GLN A  99
GLY A  37
LEU A  38
 None
 0.85A 5w3jB-2xszA:
undetectable		 5w3jB-2xszA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xty QNRB1

(Klebsiella
pneumoniae) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		4 VAL A 189
ASP A 190
GLN A 192
GLY A 193
 None
 0.84A 5w3jB-2xtyA:
undetectable		 5w3jB-2xtyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A 157
HIS A 225
PRO A 160
GLY A  85
 None
 0.93A 5w3jB-2yu1A:
undetectable		 5w3jB-2yu1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		5 VAL A 304
ASP A 303
GLU A 302
GLY A 314
LEU A 299
 None
 1.40A 5w3jB-2z36A:
undetectable		 5w3jB-2z36A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 ASP A 609
PRO A 576
GLY A 578
LEU A 579
 None
 0.93A 5w3jB-3a0fA:
undetectable		 5w3jB-3a0fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 ASP A 788
GLU A 787
GLN A 792
LEU A 828
 None
 0.90A 5w3jB-3av6A:
undetectable		 5w3jB-3av6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 VAL B 107
ASP B 112
GLN B 110
GLY B 183
 None
 0.93A 5w3jB-3cdkB:
undetectable		 5w3jB-3cdkB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdn PHEROMONE-BINDING
PROTEIN ASP1

(Apis mellifera) 		PF01395
(PBP_GOBP) 		4 VAL A  65
ASP A  66
GLY A  72
LEU A  74
 CL  A 120 ( 4.4A)
None
None
None
 0.86A 5w3jB-3cdnA:
undetectable		 5w3jB-3cdnA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjd TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Jannaschia sp.
CCS1) 		PF00440
(TetR_N)
PF13305
(WHG) 		4 VAL A 164
HIS A  95
GLY A 171
LEU A 172
 None
 0.80A 5w3jB-3cjdA:
undetectable		 5w3jB-3cjdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 VAL A 185
GLN A 162
GLY A 158
LEU A 157
 None
 0.93A 5w3jB-3cmnA:
undetectable		 5w3jB-3cmnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 VAL A 388
PRO A 488
GLY A  93
LEU A  92
 None
 0.82A 5w3jB-3czeA:
undetectable		 5w3jB-3czeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 VAL A 213
GLN A 300
GLY A 324
LEU A 325
 None
 0.87A 5w3jB-3d0qA:
4.0		 5w3jB-3d0qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		4 VAL A 157
ASP A 158
GLN A 160
GLY A 165
 None
 0.61A 5w3jB-3dxpA:
undetectable		 5w3jB-3dxpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP1
PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 VAL 1  47
GLU 1  48
GLY 2 123
LEU 2 233
 None
 0.94A 5w3jB-3epf1:
undetectable		 5w3jB-3epf1:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE

(Lactobacillus
plantarum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 HIS A 162
GLN A 150
GLY A 149
LEU A 152
 None
 0.77A 5w3jB-3evtA:
undetectable		 5w3jB-3evtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1t UNCHARACTERIZED
PROTEIN Q9I3C8_PSEAE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 VAL A  54
GLN A  43
GLY A  24
LEU A  25
 None
 0.93A 5w3jB-3f1tA:
undetectable		 5w3jB-3f1tA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20

(Saccharomyces
cerevisiae) 		PF04437
(RINT1_TIP1) 		5 ASP A 620
HIS A 643
GLN A 616
GLY A 613
LEU A 614
 None
 1.45A 5w3jB-3fhnA:
undetectable		 5w3jB-3fhnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 GLU A 557
HIS A 282
GLN A 561
LEU A 559
 None
 0.93A 5w3jB-3fjoA:
undetectable		 5w3jB-3fjoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 ASP A 168
HIS A  81
GLY A 129
LEU A 315
 None
 0.69A 5w3jB-3gayA:
undetectable		 5w3jB-3gayA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 111
ASP A 112
GLY A 282
LEU A 285
 None
 0.82A 5w3jB-3gazA:
3.1		 5w3jB-3gazA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE

(Bacillus
thuringiensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 259
HIS A 236
GLY A 224
LEU A 227
 None
 0.90A 5w3jB-3gmsA:
2.4		 5w3jB-3gmsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 VAL A 181
PRO A 144
GLN A 174
GLY A 146
 None
 0.93A 5w3jB-3h0lA:
undetectable		 5w3jB-3h0lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 GLU A 228
HIS A 272
GLY A 192
LEU A 195
 None
 0.75A 5w3jB-3hfwA:
undetectable		 5w3jB-3hfwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 639
ASP A 638
GLN A 619
GLY A 616
 None
 0.90A 5w3jB-3hm8A:
undetectable		 5w3jB-3hm8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 197
ASP A 198
GLY A 202
LEU A 203
 None
MG  A 386 (-2.5A)
None
None
 0.87A 5w3jB-3i6eA:
3.7		 5w3jB-3i6eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A  78
GLN A  95
GLY A  96
LEU A  97
 None
 0.85A 5w3jB-3il3A:
undetectable		 5w3jB-3il3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 VAL A 244
HIS A  61
GLY A  83
LEU A  82
 None
 0.88A 5w3jB-3kd8A:
undetectable		 5w3jB-3kd8A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lev RNA POLYMERASE SIGMA
FACTOR

(Thermus
aquaticus) 		PF04542
(Sigma70_r2) 		4 VAL A 210
GLN A 229
GLY A 161
LEU A 162
 None
 0.92A 5w3jB-3levA:
undetectable		 5w3jB-3levA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdp CYCLIC
NUCLEOTIDE-BINDING
DOMAIN (CNMP-BD)
PROTEIN

(Geobacter
metallireducens) 		PF00027
(cNMP_binding) 		4 VAL A 107
ASP A 108
GLY A 111
LEU A 114
 None
EDO  A 143 (-3.3A)
None
None
 0.84A 5w3jB-3mdpA:
undetectable		 5w3jB-3mdpA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE

(Nostoc
punctiforme) 		PF02633
(Creatininase) 		4 VAL A 193
PRO A 170
GLY A 219
LEU A 220
 None
 0.93A 5w3jB-3no4A:
4.2		 5w3jB-3no4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 HIS A 329
PRO A 451
GLN A 448
GLY A 524
LEU A 523
 None
 1.28A 5w3jB-3nzpA:
undetectable		 5w3jB-3nzpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		4 VAL A 221
GLN A 286
GLY A 299
LEU A 300
 None
 0.91A 5w3jB-3o47A:
4.7		 5w3jB-3o47A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 VAL A 212
ASP A 213
GLY A 255
LEU A 254
 None
None
CA  A 411 (-4.0A)
None
 0.82A 5w3jB-3p4gA:
undetectable		 5w3jB-3p4gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdh FIMBRIAL STRUCTURAL
SUBUNIT

(Actinomyces
naeslundii) 		PF16569
(GramPos_pilinBB) 		4 GLU A 450
PRO A 454
GLN A 380
GLY A 378
 None
 0.79A 5w3jB-3qdhA:
undetectable		 5w3jB-3qdhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qni PROTEIN KINASE C AND
CASEIN KINASE
SUBSTRATE IN NEURONS
PROTEIN 1

(Homo sapiens) 		PF00611
(FCH) 		4 GLU A  96
GLN A  99
GLY A  57
LEU A  60
 None
 0.86A 5w3jB-3qniA:
undetectable		 5w3jB-3qniA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL X 353
GLU X 478
GLN X 349
GLY X 347
 None
 0.88A 5w3jB-3rwkX:
undetectable		 5w3jB-3rwkX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Bacillus
anthracis) 		PF04321
(RmlD_sub_bind) 		4 VAL A 138
HIS A  59
GLN A  92
GLY A  95
 None
 0.93A 5w3jB-3sc6A:
5.8		 5w3jB-3sc6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii) 		PF07475
(Hpr_kinase_C) 		4 GLU A  65
HIS A 104
GLN A  64
LEU A  62
 None
 0.92A 5w3jB-3tqfA:
undetectable		 5w3jB-3tqfA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 201
ASP A 202
GLY A 206
LEU A 207
 None
MG  A 500 (-3.1A)
None
None
 0.84A 5w3jB-3ugvA:
2.5		 5w3jB-3ugvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		4 VAL A 156
HIS A  47
GLY A 227
LEU A 231
 None
 0.83A 5w3jB-3unvA:
undetectable		 5w3jB-3unvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 PRO A 266
GLN A 267
GLY A 268
LEU A 269
 None
 0.60A 5w3jB-3up8A:
undetectable		 5w3jB-3up8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 GLU A 452
PRO A 456
GLN A 379
GLY A 377
 None
 0.91A 5w3jB-3uxfA:
undetectable		 5w3jB-3uxfA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 VAL A  99
ASP A 100
PRO A 129
GLY A 131
LEU A 103
 None
 1.47A 5w3jB-3ve9A:
undetectable		 5w3jB-3ve9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 ASP A 147
HIS A 141
GLY A 263
LEU A 266
 None
 0.93A 5w3jB-3wecA:
undetectable		 5w3jB-3wecA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 189
PRO A 218
GLY A 196
LEU A 197
 None
 0.89A 5w3jB-3wpeA:
undetectable		 5w3jB-3wpeA:
20.72