SIMILAR PATTERNS OF AMINO ACIDS FOR 5VYH_A_FOLA409_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aoh | CELLULOSOMAL-SCAFFOLDING PROTEIN A (Ruminiclostridiumthermocellum) |
PF00963(Cohesin) | 5 | PRO A 65PRO A 56ALA A 85GLY A 89THR A 90 | None | 1.36A | 5vyhA-1aohA:0.0 | 5vyhA-1aohA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyn | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEB (Homo sapiens) |
PF00160(Pro_isomerase) | 5 | PRO A 92ALA A 109GLY A 80THR A 81ALA A 111 | None | 1.33A | 5vyhA-1cynA:undetectable | 5vyhA-1cynA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezr | NUCLEOSIDE HYDROLASE (Leishmaniamajor) |
PF01156(IU_nuc_hydro) | 5 | PRO A 70ALA A 176GLY A 272THR A 271ILE A 263 | None | 1.02A | 5vyhA-1ezrA:0.0 | 5vyhA-1ezrA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f1x | HOMOPROTOCATECHUATE2,3-DIOXYGENASE (Brevibacteriumfuscum) |
PF00903(Glyoxalase) | 5 | ARG A 117PRO A 125GLY A 111THR A 132ALA A 115 | None | 1.17A | 5vyhA-1f1xA:0.0 | 5vyhA-1f1xA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz4 | NAD-DEPENDENT MALICENZYME (Homo sapiens) |
PF00390(malic)PF03949(Malic_M) | 5 | ALA A 494GLY A 282THR A 283ILE A 470ALA A 289 | None | 1.16A | 5vyhA-1gz4A:0.0 | 5vyhA-1gz4A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5z | FOLYLPOLYGLUTAMATESYNTHASE/DIHYDROFOLATE SYNTHASE (Thermotogamaritima) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | PRO A 75HIS A 76ALA A 55GLY A 46ILE A 45 | None CL A 602 (-4.7A)NoneNoneNone | 1.22A | 5vyhA-1o5zA:0.0 | 5vyhA-1o5zA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojl | TRANSCRIPTIONALREGULATORY PROTEINZRAR (Salmonellaenterica) |
PF00158(Sigma54_activat)PF02954(HTH_8) | 5 | PRO A 310ALA A 179THR A 164ILE A 278ALA A 280 | None | 1.37A | 5vyhA-1ojlA:0.0 | 5vyhA-1ojlA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r75 | HYPOTHETICAL PROTEIN (Leishmaniamajor) |
PF09149(DUF1935) | 5 | PRO A 70ALA A 46GLY A 23THR A 24ILE A 37 | None | 1.10A | 5vyhA-1r75A:undetectable | 5vyhA-1r75A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s58 | B19 PARVOVIRUSCAPSID (Primateerythroparvovirus1) |
PF00740(Parvo_coat) | 5 | PRO A 462HIS A 52ALA A 482GLY A 223ILE A 126 | None | 1.30A | 5vyhA-1s58A:0.0 | 5vyhA-1s58A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 5 | PRO A 162ALA A 186GLY A 139THR A 140ALA A 188 | None | 1.34A | 5vyhA-1sqjA:undetectable | 5vyhA-1sqjA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tt7 | YHFP (Bacillussubtilis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PRO A 115ALA A 70GLY A 129THR A 130ALA A 89 | None | 1.29A | 5vyhA-1tt7A:undetectable | 5vyhA-1tt7A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uxt | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE(NADP+) (Thermoproteustenax) |
PF00171(Aldedh) | 5 | PRO A 170PRO A 199ALA A 118GLY A 456ILE A 457 | None | 1.25A | 5vyhA-1uxtA:undetectable | 5vyhA-1uxtA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb5 | TRANSLATIONINITIATION FACTOREIF-2B (Pyrococcushorikoshii) |
PF01008(IF-2B) | 5 | HIS A 208ALA A 178THR A 141ILE A 139ALA A 181 | None | 1.19A | 5vyhA-1vb5A:undetectable | 5vyhA-1vb5A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdk | FUMARATE HYDRATASECLASS II (Thermusthermophilus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | PRO A 130HIS A 129GLY A 228ILE A 227ALA A 56 | None | 1.25A | 5vyhA-1vdkA:undetectable | 5vyhA-1vdkA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxd | SHIKIMATE5-DEHYDROGENASE (Thermusthermophilus) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | PRO A 250PRO A 248GLY A 228THR A 227ALA A 257 | None | 1.28A | 5vyhA-1wxdA:undetectable | 5vyhA-1wxdA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybt | HYDROLASE,ALPHA/BETA HYDROLASEFOLD FAMILY (Mycobacteriumtuberculosis) |
PF00211(Guanylate_cyc) | 5 | HIS A 331ALA A 358GLY A 379ILE A 380ALA A 350 | None | 1.32A | 5vyhA-1ybtA:undetectable | 5vyhA-1ybtA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yew | PARTICULATE METHANEMONOOXYGENASE, ASUBUNIT (Methylococcuscapsulatus) |
PF02461(AMO) | 5 | HIS B 40GLY B 148THR B 144ILE B 130ALA B 89 | None | 1.33A | 5vyhA-1yewB:undetectable | 5vyhA-1yewB:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7s | PROBABLEPROPIONYL-COACARBOXYLASE BETACHAIN 5 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | PRO A 516PRO A 453GLY A 525THR A 526ILE A 524 | None | 1.10A | 5vyhA-2a7sA:undetectable | 5vyhA-2a7sA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2arc | ARABINOSE OPERONREGULATORY PROTEIN (Escherichiacoli) |
PF02311(AraC_binding) | 5 | PRO A 100ALA A 21GLY A 135ILE A 138ALA A 152 | None | 1.35A | 5vyhA-2arcA:undetectable | 5vyhA-2arcA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayx | SENSOR KINASEPROTEIN RCSC (Escherichiacoli) |
PF00072(Response_reg)PF09456(RcsC) | 5 | PRO A 834ARG A 837HIS A 833THR A 742ALA A 841 | None | 1.23A | 5vyhA-2ayxA:undetectable | 5vyhA-2ayxA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfw | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1) | 5 | PRO A 340ALA A 357GLY A 372THR A 371ALA A 345 | None | 1.37A | 5vyhA-2bfwA:undetectable | 5vyhA-2bfwA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfw | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1) | 5 | PRO A 380ALA A 357GLY A 372ILE A 367ALA A 359 | None | 1.34A | 5vyhA-2bfwA:undetectable | 5vyhA-2bfwA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi0 | HYPOTHETICAL PROTEINRV0216 (Mycobacteriumtuberculosis) |
no annotation | 5 | PRO A 282HIS A 284GLY A 79THR A 230ILE A 78 | None | 1.12A | 5vyhA-2bi0A:undetectable | 5vyhA-2bi0A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6x | (S)-3-O-GERANYLGERANYLGLYCERYL PHOSPHATESYNTHASE (Archaeoglobusfulgidus) |
PF01884(PcrB) | 5 | ARG A1135ALA A1132GLY A1170THR A1171ALA A1134 | NoneNone1GP A3001 (-3.7A)NoneNone | 1.28A | 5vyhA-2f6xA:undetectable | 5vyhA-2f6xA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igw | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Caenorhabditiselegans) |
PF00160(Pro_isomerase) | 5 | PRO A 91ALA A 108GLY A 79THR A 80ALA A 110 | NoneGLY A 201 (-3.1A)NoneNoneNone | 1.32A | 5vyhA-2igwA:undetectable | 5vyhA-2igwA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv2 | FORMATEDEHYDROGENASE H (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | PRO X 510ALA X 515GLY X 539THR X 540ILE X 526 | None | 1.06A | 5vyhA-2iv2X:undetectable | 5vyhA-2iv2X:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og9 | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Polaromonas sp.JS666) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 314PRO A 332ALA A 305GLY A 274ILE A 277 | None | 1.33A | 5vyhA-2og9A:undetectable | 5vyhA-2og9A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | PRO A 170ALA A 228GLY A 192ILE A 193ALA A 232 | None | 1.25A | 5vyhA-2ptzA:undetectable | 5vyhA-2ptzA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rmc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEC (Mus musculus) |
PF00160(Pro_isomerase) | 5 | PRO A 118ALA A 135GLY A 106THR A 107ALA A 137 | None | 1.34A | 5vyhA-2rmcA:undetectable | 5vyhA-2rmcA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6l | COBE (Pseudomonasaeruginosa) |
PF01890(CbiG_C) | 5 | ARG A 82PRO A 81ALA A 116GLY A 113ALA A 106 | None | 1.14A | 5vyhA-2w6lA:undetectable | 5vyhA-2w6lA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | TRP A 148PRO A 147ALA A 195GLY A 332ILE A 259 | None | 1.23A | 5vyhA-2wskA:undetectable | 5vyhA-2wskA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt0 | HALOALKANEDEHALOGENASE (Plesiocystispacifica) |
PF00561(Abhydrolase_1) | 5 | ARG A 63PRO A 18GLY A 185ILE A 186ALA A 189 | None | 1.16A | 5vyhA-2xt0A:undetectable | 5vyhA-2xt0A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6b | BASEPLATE STRUCTURALPROTEIN GP27 (Escherichiavirus T4) |
PF09096(Phage-tail_2)PF09097(Phage-tail_1) | 5 | PRO D 210GLY D 314THR D 353ILE D 313ALA D 231 | None | 1.12A | 5vyhA-2z6bD:undetectable | 5vyhA-2z6bD:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyj | ALPHA-AMINODIPATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | PRO A 253HIS A 252GLY A 75THR A 73ALA A 249 | None | 1.31A | 5vyhA-2zyjA:undetectable | 5vyhA-2zyjA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg7 | MUCONATECYCLOISOMERASE (Mycolicibacteriumsmegmatis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 98GLY A 61THR A 60ILE A 62ALA A 8 | None | 1.34A | 5vyhA-3dg7A:undetectable | 5vyhA-3dg7A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eck | PROTEIN(HOMOPROTOCATECHUATE2,3-DIOXYGENASE) (Brevibacteriumfuscum) |
PF00903(Glyoxalase) | 5 | ARG A 117PRO A 125GLY A 111THR A 132ALA A 115 | None | 1.20A | 5vyhA-3eckA:undetectable | 5vyhA-3eckA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eei | 5-METHYLTHIOADENOSINENUCLEOSIDASE/S-ADENOSYLHOMOCYSTEINENUCLEOSIDASE (Neisseriameningitidis) |
PF01048(PNP_UDP_1) | 5 | ALA A 179GLY A 95THR A 96ILE A 195ALA A 183 | None | 1.12A | 5vyhA-3eeiA:undetectable | 5vyhA-3eeiA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fay | RASGTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 (Homo sapiens) |
PF00616(RasGAP) | 5 | PRO A1157ALA A1164GLY A1188ILE A1187ALA A1269 | None | 0.85A | 5vyhA-3fayA:undetectable | 5vyhA-3fayA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gm8 | GLYCOSIDE HYDROLASEFAMILY 2, CANDIDATEBETA-GLYCOSIDASE (Bacteroidesvulgatus) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | PRO A 631HIS A 632ALA A 613GLY A 602ILE A 603 | None | 0.98A | 5vyhA-3gm8A:undetectable | 5vyhA-3gm8A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0l | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Aquifexaeolicus) |
PF01425(Amidase) | 5 | PRO A 267ALA A 272GLY A 445THR A 396ILE A 436 | None | 1.32A | 5vyhA-3h0lA:undetectable | 5vyhA-3h0lA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hfw | PROTEINADP-RIBOSYLARGININEHYDROLASE (Homo sapiens) |
PF03747(ADP_ribosyl_GH) | 5 | PRO A 166HIS A 165ALA A 174THR A 306ALA A 132 | NoneADP A 358 (-3.8A)NoneNoneNone | 1.19A | 5vyhA-3hfwA:undetectable | 5vyhA-3hfwA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hfw | PROTEINADP-RIBOSYLARGININEHYDROLASE (Homo sapiens) |
PF03747(ADP_ribosyl_GH) | 5 | TRP A 227PRO A 166HIS A 165GLY A 192ALA A 174 | NoneNoneADP A 358 (-3.8A)NoneNone | 0.94A | 5vyhA-3hfwA:undetectable | 5vyhA-3hfwA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6e | MUCONATECYCLOISOMERASE I (Ruegeriapomeroyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 66HIS A 17GLY A 312ILE A 274ALA A 109 | None | 0.92A | 5vyhA-3i6eA:undetectable | 5vyhA-3i6eA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifr | CARBOHYDRATE KINASE,FGGY (Rhodospirillumrubrum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | PRO A 292HIS A 217ALA A 278GLY A 131THR A 130 | None | 1.37A | 5vyhA-3ifrA:undetectable | 5vyhA-3ifrA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l01 | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | PRO A 340ALA A 357GLY A 372THR A 371ALA A 345 | K A5600 ( 4.8A)NoneNoneNoneNone | 1.30A | 5vyhA-3l01A:undetectable | 5vyhA-3l01A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l01 | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | PRO A 380ALA A 357GLY A 372ILE A 367ALA A 359 | None | 1.33A | 5vyhA-3l01A:undetectable | 5vyhA-3l01A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3w | RIBONUCLEASE III (Campylobacterjejuni) |
PF14622(Ribonucleas_3_3) | 5 | HIS A 57ALA A 131GLY A 120ILE A 122ALA A 135 | None | 1.32A | 5vyhA-3n3wA:undetectable | 5vyhA-3n3wA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozy | PUTATIVE MANDELATERACEMASE (Bordetellabronchiseptica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | HIS A 135ALA A 314GLY A 283THR A 285ILE A 112 | None | 1.25A | 5vyhA-3ozyA:undetectable | 5vyhA-3ozyA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvz | UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (Aliivibriofischeri) |
PF02719(Polysacc_synt_2) | 5 | PRO A 305HIS A 283ALA A 223GLY A 210ALA A 271 | None | 1.28A | 5vyhA-3pvzA:undetectable | 5vyhA-3pvzA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q94 | FRUCTOSE-BISPHOSPHATE ALDOLASE, CLASS II (Bacillusanthracis) |
PF01116(F_bP_aldolase) | 5 | PRO A 44PRO A 79ALA A 37GLY A 274ILE A 273 | None | 1.35A | 5vyhA-3q94A:undetectable | 5vyhA-3q94A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli;Escherichiacoli) |
no annotationno annotation | 5 | PRO K 3HIS K 6ALA N 179GLY N 206ALA K 45 | None | 1.05A | 5vyhA-3rkoK:undetectable | 5vyhA-3rkoK:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rq1 | AMINOTRANSFERASECLASS I AND II (Veillonellaparvula) |
PF00155(Aminotran_1_2) | 5 | TRP A 133PRO A 189ALA A 224GLY A 108THR A 109 | OAA A 422 (-3.9A)NoneNoneNoneNone | 1.22A | 5vyhA-3rq1A:undetectable | 5vyhA-3rq1A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrw | THYLAKOID LUMENAL 29KDA PROTEIN,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00141(peroxidase) | 5 | ARG A 60ALA A 154GLY A 54THR A 45ALA A 157 | NoneNone CA A 271 (-4.4A) CA A 271 (-4.0A)None | 1.34A | 5vyhA-3rrwA:undetectable | 5vyhA-3rrwA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwb | PYRIDOXAL4-DEHYDROGENASE (Mesorhizobiumloti) |
PF13561(adh_short_C2) | 5 | HIS A 197ALA A 89GLY A 115THR A 114ILE A 62 | 4PL A 252 (-3.6A)NAD A 251 (-3.5A)NoneNoneNAD A 251 (-3.9A) | 1.35A | 5vyhA-3rwbA:undetectable | 5vyhA-3rwbA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3th6 | TRIOSEPHOSPHATEISOMERASE (Rhipicephalusmicroplus) |
PF00121(TIM) | 5 | PRO A 44PRO A 46ALA A 62GLY A 9ILE A 40 | None | 1.28A | 5vyhA-3th6A:undetectable | 5vyhA-3th6A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay2 | PROBABLEATP-DEPENDENT RNAHELICASE DDX58 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | HIS A 444ALA A 254GLY A 407ILE A 406ALA A 251 | None | 1.32A | 5vyhA-4ay2A:undetectable | 5vyhA-4ay2A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | PRO B2971HIS B2972ALA B3107GLY B2993ILE B2994 | None | 1.27A | 5vyhA-4bedB:undetectable | 5vyhA-4bedB:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 5 | HIS A 127ALA A 539GLY A 50THR A 51ILE A 401 | None | 1.03A | 5vyhA-4c3oA:undetectable | 5vyhA-4c3oA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfi | FLAGELLIN (Burkholderiapseudomallei) |
PF00669(Flagellin_N)PF12613(FliC_SP) | 5 | PRO A 102ALA A 98GLY A 297ILE A 292ALA A 108 | None | 1.11A | 5vyhA-4cfiA:undetectable | 5vyhA-4cfiA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cja | BURRH (Paraburkholderiarhizoxinica) |
PF03377(TAL_effector) | 5 | PRO A 438HIS A 410ALA A 460GLY A 425ALA A 454 | None | 1.28A | 5vyhA-4cjaA:undetectable | 5vyhA-4cjaA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d6v | G PROTEIN BETASUBUNIT GIB2 (Cryptococcusneoformans) |
PF00400(WD40) | 5 | HIS A 60GLY A 301THR A 287ILE A 21ALA A 34 | None | 1.30A | 5vyhA-4d6vA:undetectable | 5vyhA-4d6vA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3v | ESX-1 SECRETIONSYSTEM PROTEIN ECCA1 (Mycobacteriumtuberculosis) |
no annotation | 5 | TRP A 137PRO A 163ALA A 200GLY A 90ALA A 171 | None | 1.22A | 5vyhA-4f3vA:undetectable | 5vyhA-4f3vA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 5 | PRO A 350HIS A 344GLY A 208ILE A 127ALA A 133 | None | 1.22A | 5vyhA-4g4iA:undetectable | 5vyhA-4g4iA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ARG A 110HIS A 112THR A 515ILE A 140ALA A 507 | None | 1.37A | 5vyhA-4ha6A:undetectable | 5vyhA-4ha6A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hb9 | SIMILARITIES WITHPROBABLEMONOOXYGENASE (Photorhabduslaumondii) |
PF01494(FAD_binding_3) | 5 | ALA A 160GLY A 4THR A 27ILE A 5ALA A 8 | NoneNoneNoneNoneEDO A 511 (-4.1A) | 1.36A | 5vyhA-4hb9A:undetectable | 5vyhA-4hb9A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ida | RIPENING-INDUCEDPROTEIN (Fragaria vesca) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 5 | ALA A 194GLY A 208THR A 206ILE A 180ALA A 172 | NoneNoneNoneNoneSO4 A 402 ( 3.8A) | 1.25A | 5vyhA-4idaA:undetectable | 5vyhA-4idaA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jbd | PROLINE RACEMASE (Pseudomonasputida) |
PF05544(Pro_racemase) | 5 | PRO A 107GLY A 286THR A 285ILE A 93ALA A 121 | None | 1.05A | 5vyhA-4jbdA:undetectable | 5vyhA-4jbdA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jvz | CARBON DIOXIDECONCENTRATINGMECHANISM PROTEIN (Thermosynechococcuselongatus) |
PF03319(EutN_CcmL) | 5 | ALA A 77GLY A 69THR A 70ILE A 66ALA A 62 | None | 1.11A | 5vyhA-4jvzA:undetectable | 5vyhA-4jvzA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwg | PUTATIVEDIHYDROMETHANOPTERINREDUCTASE (AFPA) (Paraburkholderiaxenovorans) |
PF02441(Flavoprotein) | 5 | PRO A 114ALA A 121GLY A 128THR A 169ALA A 119 | None | 1.27A | 5vyhA-4mwgA:undetectable | 5vyhA-4mwgA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o89 | RNA 3'-TERMINALPHOSPHATE CYCLASE (Pyrococcushorikoshii) |
PF01137(RTC)PF05189(RTC_insert) | 5 | PRO A 258ALA A 206GLY A 190ILE A 222ALA A 202 | None | 1.35A | 5vyhA-4o89A:undetectable | 5vyhA-4o89A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9u | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Thermusthermophilus) |
PF02233(PNTB) | 5 | PRO B 82ALA B 206GLY B 199ILE B 198ALA B 135 | None | 1.08A | 5vyhA-4o9uB:undetectable | 5vyhA-4o9uB:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oal | CYTOKININDEHYDROGENASE 4 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | PRO A 131ALA A 239GLY A 177THR A 179ILE A 236 | NoneNoneFAD A 601 (-3.5A)FAD A 601 (-4.6A)FAD A 601 (-3.9A) | 1.32A | 5vyhA-4oalA:undetectable | 5vyhA-4oalA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4on9 | PROBABLEATP-DEPENDENT RNAHELICASE DDX58 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | HIS A 444ALA A 254GLY A 407ILE A 406ALA A 251 | None | 1.35A | 5vyhA-4on9A:undetectable | 5vyhA-4on9A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 5 | PRO A 189ALA A 199GLY A 51THR A 52ALA A 201 | None | 1.37A | 5vyhA-4r27A:undetectable | 5vyhA-4r27A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ra7 | PEPTIDOGLYCANGLYCOSYLTRANSFERASE (Atopobiumparvulum) |
PF00905(Transpeptidase) | 5 | PRO A 797ALA A 790GLY A 715THR A 716ILE A 712 | None | 1.34A | 5vyhA-4ra7A:undetectable | 5vyhA-4ra7A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s0v | HUMAN OREXINRECEPTOR TYPE 2FUSION PROTEIN TO P.ABYSII GLYCOGENSYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 5 | PRO A1163ALA A1140GLY A1155ILE A1150ALA A1142 | None | 1.35A | 5vyhA-4s0vA:undetectable | 5vyhA-4s0vA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9i | PERIPLASMIC [NIFE]HYDROGENASE LARGESUBUNIT (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases) | 5 | PRO L 234HIS L 235ALA L 222THR L 434ALA L 118 | NoneSF4 S2001 (-4.4A)NoneNoneNone | 1.37A | 5vyhA-4u9iL:undetectable | 5vyhA-4u9iL:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z2v | AVIDIN FAMILY (Hoefleaphototrophica) |
PF01382(Avidin) | 5 | PRO A 39GLY A 96THR A 95ILE A 75ALA A 67 | None | 1.10A | 5vyhA-4z2vA:undetectable | 5vyhA-4z2vA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zj8 | HUMAN OX1R FUSIONPROTEIN TO P.ABYSIIGLYCOGEN SYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 5 | PRO A1163ALA A1140GLY A1155ILE A1150ALA A1142 | None | 1.29A | 5vyhA-4zj8A:undetectable | 5vyhA-4zj8A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bmo | PUTATIVEUNCHARACTERIZEDPROTEIN LNMX (Streptomycesatroolivaceus) |
PF02585(PIG-L) | 5 | PRO A 229ARG A 230ALA A 179GLY A 175ALA A 182 | None | 1.15A | 5vyhA-5bmoA:undetectable | 5vyhA-5bmoA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d28 | GRANULOCYTE-MACROPHAGECOLONY-STIMULATINGFACTOR (Ovis aries) |
PF01109(GM_CSF) | 5 | PRO B 118ALA B 18GLY B 75THR B 74ALA B 22 | None | 1.17A | 5vyhA-5d28B:undetectable | 5vyhA-5d28B:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ehk | LANTIBIOTICDEHYDRATASE (Microbisporacorallina) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 5 | PRO A 634GLY A 629THR A 628ILE A 804ALA A 566 | None | 1.27A | 5vyhA-5ehkA:undetectable | 5vyhA-5ehkA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fx8 | LINOLEATE11-LIPOXYGENASE (Gaeumannomycesavenae) |
PF00305(Lipoxygenase) | 5 | PRO A 494HIS A 496GLY A 127ILE A 122ALA A 529 | None | 1.15A | 5vyhA-5fx8A:undetectable | 5vyhA-5fx8A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jh8 | PROBABLE CHITINASE (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18) | 5 | TRP A 270HIS A 267ALA A 179GLY A 190THR A 252 | NoneMLY A 222 ( 2.7A)NoneNoneNone | 1.37A | 5vyhA-5jh8A:undetectable | 5vyhA-5jh8A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkr | KINASE SUPPRESSOR OFRAS 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ARG B 918PRO B 919ALA B 833ILE B 836ALA B 859 | None | 1.34A | 5vyhA-5kkrB:undetectable | 5vyhA-5kkrB:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m11 | IMMUNOREACTIVE 84KDANTIGEN PG93 (Porphyromonasgingivalis) |
no annotation | 5 | PRO A 401ALA A 395GLY A 407THR A 408ILE A 445 | CAC A 813 ( 4.7A)NoneNoneNoneNone | 1.33A | 5vyhA-5m11A:undetectable | 5vyhA-5m11A:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlc | 50S RIBOSOMALPROTEIN L19,CHLOROPLASTIC (Spinaciaoleracea) |
PF01245(Ribosomal_L19) | 5 | ALA R 130GLY R 176THR R 179ILE R 177ALA R 134 | None | 1.26A | 5vyhA-5mlcR:undetectable | 5vyhA-5mlcR:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ney | FUCOSE-BINDINGLECTIN II (PA-IIL) (Pseudomonasaeruginosa) |
PF07472(PA-IIL) | 5 | PRO A 73GLY A 51THR A 17ILE A 50ALA A 105 | None | 1.15A | 5vyhA-5neyA:undetectable | 5vyhA-5neyA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oei | UNCHARACTERIZEDPROTEIN FAMILYUPF0065:TAT PATHWAYSIGNAL (Rhodopseudomonaspalustris) |
no annotation | 5 | TRP A 262GLY A 103THR A 264ILE A 107ALA A 109 | None | 1.29A | 5vyhA-5oeiA:undetectable | 5vyhA-5oeiA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8y | EPOXYQUEUOSINEREDUCTASE (Bacillussubtilis) |
PF08331(DUF1730)PF13484(Fer4_16)PF13646(HEAT_2) | 5 | HIS A 106ALA A 76GLY A 164THR A 159ALA A 74 | PO4 A 505 ( 4.6A)NoneNoneNoneNone | 1.33A | 5vyhA-5t8yA:undetectable | 5vyhA-5t8yA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ue1 | 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Aliivibriofischeri) |
PF01048(PNP_UDP_1) | 5 | ALA A 55GLY A 7THR A 74ILE A 6ALA A 176 | None | 1.34A | 5vyhA-5ue1A:undetectable | 5vyhA-5ue1A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | HIS A 827ALA A 726GLY A 874ILE A 875ALA A 695 | None | 1.30A | 5vyhA-5ux5A:undetectable | 5vyhA-5ux5A:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wi5 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | PRO A 265ALA A 239GLY A 21ILE A 19ALA A 258 | None | 1.29A | 5vyhA-5wi5A:undetectable | 5vyhA-5wi5A:21.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x4r | S PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
no annotation | 10 | TRP A 44PRO A 45ARG A 46PRO A 47HIS A 81ALA A 123GLY A 128THR A 129ILE A 140ALA A 312 | None | 0.39A | 5vyhA-5x4rA:54.9 | 5vyhA-5x4rA:98.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x59 | S PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind) | 10 | TRP A 44PRO A 45ARG A 46PRO A 47HIS A 81ALA A 123GLY A 128THR A 129ILE A 140ALA A 312 | None | 0.42A | 5vyhA-5x59A:53.5 | 5vyhA-5x59A:42.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8t | 50S RIBOSOMALPROTEIN L19,CHLOROPLASTIC (Spinaciaoleracea) |
PF01245(Ribosomal_L19) | 5 | ALA Q 130GLY Q 176THR Q 179ILE Q 177ALA Q 134 | None | 1.13A | 5vyhA-5x8tQ:undetectable | 5vyhA-5x8tQ:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASELARGE SUBUNIT (Methylobacillussp. KY4400) |
no annotation | 5 | ARG C 442GLY C 650THR C 651ILE C 774ALA C 759 | SO4 C 804 (-4.1A)NoneNoneNoneNone | 1.27A | 5vyhA-5y6qC:undetectable | 5vyhA-5y6qC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z03 | MUREIN TETRAPEPTIDECARBOXYPEPTIDASE (Escherichiacoli) |
no annotation | 5 | PRO A 223ALA A 227GLY A 170THR A 171ILE A 196 | None | 1.32A | 5vyhA-5z03A:undetectable | 5vyhA-5z03A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z97 | LACTONASE FORPROTEIN (Rhinocladiellamackenziei) |
no annotation | 5 | PRO A 198ALA A 229GLY A 237THR A 238ILE A 236 | None | 1.23A | 5vyhA-5z97A:undetectable | 5vyhA-5z97A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c13 | - (-) |
no annotation | 5 | PRO A 874ARG A 860GLY A 908THR A 909ALA A 903 | None | 1.31A | 5vyhA-6c13A:undetectable | 5vyhA-6c13A:undetectable |