SIMILAR PATTERNS OF AMINO ACIDS FOR 5VYH_A_FOLA409

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoh CELLULOSOMAL-SCAFFOL
DING PROTEIN A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 PRO A  65
PRO A  56
ALA A  85
GLY A  89
THR A  90
None
1.36A 5vyhA-1aohA:
0.0
5vyhA-1aohA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B


(Homo sapiens)
PF00160
(Pro_isomerase)
5 PRO A  92
ALA A 109
GLY A  80
THR A  81
ALA A 111
None
1.33A 5vyhA-1cynA:
undetectable
5vyhA-1cynA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major)
PF01156
(IU_nuc_hydro)
5 PRO A  70
ALA A 176
GLY A 272
THR A 271
ILE A 263
None
1.02A 5vyhA-1ezrA:
0.0
5vyhA-1ezrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE


(Brevibacterium
fuscum)
PF00903
(Glyoxalase)
5 ARG A 117
PRO A 125
GLY A 111
THR A 132
ALA A 115
None
1.17A 5vyhA-1f1xA:
0.0
5vyhA-1f1xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
5 ALA A 494
GLY A 282
THR A 283
ILE A 470
ALA A 289
None
1.16A 5vyhA-1gz4A:
0.0
5vyhA-1gz4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE


(Thermotoga
maritima)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 PRO A  75
HIS A  76
ALA A  55
GLY A  46
ILE A  45
None
CL  A 602 (-4.7A)
None
None
None
1.22A 5vyhA-1o5zA:
0.0
5vyhA-1o5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR


(Salmonella
enterica)
PF00158
(Sigma54_activat)
PF02954
(HTH_8)
5 PRO A 310
ALA A 179
THR A 164
ILE A 278
ALA A 280
None
1.37A 5vyhA-1ojlA:
0.0
5vyhA-1ojlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r75 HYPOTHETICAL PROTEIN

(Leishmania
major)
PF09149
(DUF1935)
5 PRO A  70
ALA A  46
GLY A  23
THR A  24
ILE A  37
None
1.10A 5vyhA-1r75A:
undetectable
5vyhA-1r75A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID


(Primate
erythroparvovirus
1)
PF00740
(Parvo_coat)
5 PRO A 462
HIS A  52
ALA A 482
GLY A 223
ILE A 126
None
1.30A 5vyhA-1s58A:
0.0
5vyhA-1s58A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE


(Geotrichum sp.
M128)
PF15899
(BNR_6)
5 PRO A 162
ALA A 186
GLY A 139
THR A 140
ALA A 188
None
1.34A 5vyhA-1sqjA:
undetectable
5vyhA-1sqjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 PRO A 115
ALA A  70
GLY A 129
THR A 130
ALA A  89
None
1.29A 5vyhA-1tt7A:
undetectable
5vyhA-1tt7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)


(Thermoproteus
tenax)
PF00171
(Aldedh)
5 PRO A 170
PRO A 199
ALA A 118
GLY A 456
ILE A 457
None
1.25A 5vyhA-1uxtA:
undetectable
5vyhA-1uxtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B


(Pyrococcus
horikoshii)
PF01008
(IF-2B)
5 HIS A 208
ALA A 178
THR A 141
ILE A 139
ALA A 181
None
1.19A 5vyhA-1vb5A:
undetectable
5vyhA-1vb5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 PRO A 130
HIS A 129
GLY A 228
ILE A 227
ALA A  56
None
1.25A 5vyhA-1vdkA:
undetectable
5vyhA-1vdkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE


(Thermus
thermophilus)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 PRO A 250
PRO A 248
GLY A 228
THR A 227
ALA A 257
None
1.28A 5vyhA-1wxdA:
undetectable
5vyhA-1wxdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybt HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY


(Mycobacterium
tuberculosis)
PF00211
(Guanylate_cyc)
5 HIS A 331
ALA A 358
GLY A 379
ILE A 380
ALA A 350
None
1.32A 5vyhA-1ybtA:
undetectable
5vyhA-1ybtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT


(Methylococcus
capsulatus)
PF02461
(AMO)
5 HIS B  40
GLY B 148
THR B 144
ILE B 130
ALA B  89
None
1.33A 5vyhA-1yewB:
undetectable
5vyhA-1yewB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5


(Mycobacterium
tuberculosis)
PF01039
(Carboxyl_trans)
5 PRO A 516
PRO A 453
GLY A 525
THR A 526
ILE A 524
None
1.10A 5vyhA-2a7sA:
undetectable
5vyhA-2a7sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arc ARABINOSE OPERON
REGULATORY PROTEIN


(Escherichia
coli)
PF02311
(AraC_binding)
5 PRO A 100
ALA A  21
GLY A 135
ILE A 138
ALA A 152
None
1.35A 5vyhA-2arcA:
undetectable
5vyhA-2arcA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC


(Escherichia
coli)
PF00072
(Response_reg)
PF09456
(RcsC)
5 PRO A 834
ARG A 837
HIS A 833
THR A 742
ALA A 841
None
1.23A 5vyhA-2ayxA:
undetectable
5vyhA-2ayxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
5 PRO A 340
ALA A 357
GLY A 372
THR A 371
ALA A 345
None
1.37A 5vyhA-2bfwA:
undetectable
5vyhA-2bfwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
5 PRO A 380
ALA A 357
GLY A 372
ILE A 367
ALA A 359
None
1.34A 5vyhA-2bfwA:
undetectable
5vyhA-2bfwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216


(Mycobacterium
tuberculosis)
no annotation 5 PRO A 282
HIS A 284
GLY A  79
THR A 230
ILE A  78
None
1.12A 5vyhA-2bi0A:
undetectable
5vyhA-2bi0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE


(Archaeoglobus
fulgidus)
PF01884
(PcrB)
5 ARG A1135
ALA A1132
GLY A1170
THR A1171
ALA A1134
None
None
1GP  A3001 (-3.7A)
None
None
1.28A 5vyhA-2f6xA:
undetectable
5vyhA-2f6xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3


(Caenorhabditis
elegans)
PF00160
(Pro_isomerase)
5 PRO A  91
ALA A 108
GLY A  79
THR A  80
ALA A 110
None
GLY  A 201 (-3.1A)
None
None
None
1.32A 5vyhA-2igwA:
undetectable
5vyhA-2igwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 PRO X 510
ALA X 515
GLY X 539
THR X 540
ILE X 526
None
1.06A 5vyhA-2iv2X:
undetectable
5vyhA-2iv2X:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Polaromonas sp.
JS666)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PRO A 314
PRO A 332
ALA A 305
GLY A 274
ILE A 277
None
1.33A 5vyhA-2og9A:
undetectable
5vyhA-2og9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 PRO A 170
ALA A 228
GLY A 192
ILE A 193
ALA A 232
None
1.25A 5vyhA-2ptzA:
undetectable
5vyhA-2ptzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C


(Mus musculus)
PF00160
(Pro_isomerase)
5 PRO A 118
ALA A 135
GLY A 106
THR A 107
ALA A 137
None
1.34A 5vyhA-2rmcA:
undetectable
5vyhA-2rmcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa)
PF01890
(CbiG_C)
5 ARG A  82
PRO A  81
ALA A 116
GLY A 113
ALA A 106
None
1.14A 5vyhA-2w6lA:
undetectable
5vyhA-2w6lA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 TRP A 148
PRO A 147
ALA A 195
GLY A 332
ILE A 259
None
1.23A 5vyhA-2wskA:
undetectable
5vyhA-2wskA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE


(Plesiocystis
pacifica)
PF00561
(Abhydrolase_1)
5 ARG A  63
PRO A  18
GLY A 185
ILE A 186
ALA A 189
None
1.16A 5vyhA-2xt0A:
undetectable
5vyhA-2xt0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27


(Escherichia
virus T4)
PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1)
5 PRO D 210
GLY D 314
THR D 353
ILE D 313
ALA D 231
None
1.12A 5vyhA-2z6bD:
undetectable
5vyhA-2z6bD:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 PRO A 253
HIS A 252
GLY A  75
THR A  73
ALA A 249
None
1.31A 5vyhA-2zyjA:
undetectable
5vyhA-2zyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE


(Mycolicibacterium
smegmatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  98
GLY A  61
THR A  60
ILE A  62
ALA A   8
None
1.34A 5vyhA-3dg7A:
undetectable
5vyhA-3dg7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)


(Brevibacterium
fuscum)
PF00903
(Glyoxalase)
5 ARG A 117
PRO A 125
GLY A 111
THR A 132
ALA A 115
None
1.20A 5vyhA-3eckA:
undetectable
5vyhA-3eckA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE


(Neisseria
meningitidis)
PF01048
(PNP_UDP_1)
5 ALA A 179
GLY A  95
THR A  96
ILE A 195
ALA A 183
None
1.12A 5vyhA-3eeiA:
undetectable
5vyhA-3eeiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1


(Homo sapiens)
PF00616
(RasGAP)
5 PRO A1157
ALA A1164
GLY A1188
ILE A1187
ALA A1269
None
0.85A 5vyhA-3fayA:
undetectable
5vyhA-3fayA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE


(Bacteroides
vulgatus)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 PRO A 631
HIS A 632
ALA A 613
GLY A 602
ILE A 603
None
0.98A 5vyhA-3gm8A:
undetectable
5vyhA-3gm8A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Aquifex
aeolicus)
PF01425
(Amidase)
5 PRO A 267
ALA A 272
GLY A 445
THR A 396
ILE A 436
None
1.32A 5vyhA-3h0lA:
undetectable
5vyhA-3h0lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE


(Homo sapiens)
PF03747
(ADP_ribosyl_GH)
5 PRO A 166
HIS A 165
ALA A 174
THR A 306
ALA A 132
None
ADP  A 358 (-3.8A)
None
None
None
1.19A 5vyhA-3hfwA:
undetectable
5vyhA-3hfwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE


(Homo sapiens)
PF03747
(ADP_ribosyl_GH)
5 TRP A 227
PRO A 166
HIS A 165
GLY A 192
ALA A 174
None
None
ADP  A 358 (-3.8A)
None
None
0.94A 5vyhA-3hfwA:
undetectable
5vyhA-3hfwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I


(Ruegeria
pomeroyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PRO A  66
HIS A  17
GLY A 312
ILE A 274
ALA A 109
None
0.92A 5vyhA-3i6eA:
undetectable
5vyhA-3i6eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY


(Rhodospirillum
rubrum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 PRO A 292
HIS A 217
ALA A 278
GLY A 131
THR A 130
None
1.37A 5vyhA-3ifrA:
undetectable
5vyhA-3ifrA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 PRO A 340
ALA A 357
GLY A 372
THR A 371
ALA A 345
K  A5600 ( 4.8A)
None
None
None
None
1.30A 5vyhA-3l01A:
undetectable
5vyhA-3l01A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 PRO A 380
ALA A 357
GLY A 372
ILE A 367
ALA A 359
None
1.33A 5vyhA-3l01A:
undetectable
5vyhA-3l01A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni)
PF14622
(Ribonucleas_3_3)
5 HIS A  57
ALA A 131
GLY A 120
ILE A 122
ALA A 135
None
1.32A 5vyhA-3n3wA:
undetectable
5vyhA-3n3wA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 HIS A 135
ALA A 314
GLY A 283
THR A 285
ILE A 112
None
1.25A 5vyhA-3ozyA:
undetectable
5vyhA-3ozyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE


(Aliivibrio
fischeri)
PF02719
(Polysacc_synt_2)
5 PRO A 305
HIS A 283
ALA A 223
GLY A 210
ALA A 271
None
1.28A 5vyhA-3pvzA:
undetectable
5vyhA-3pvzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II


(Bacillus
anthracis)
PF01116
(F_bP_aldolase)
5 PRO A  44
PRO A  79
ALA A  37
GLY A 274
ILE A 273
None
1.35A 5vyhA-3q94A:
undetectable
5vyhA-3q94A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli;
Escherichia
coli)
no annotation
no annotation
5 PRO K   3
HIS K   6
ALA N 179
GLY N 206
ALA K  45
None
1.05A 5vyhA-3rkoK:
undetectable
5vyhA-3rkoK:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II


(Veillonella
parvula)
PF00155
(Aminotran_1_2)
5 TRP A 133
PRO A 189
ALA A 224
GLY A 108
THR A 109
OAA  A 422 (-3.9A)
None
None
None
None
1.22A 5vyhA-3rq1A:
undetectable
5vyhA-3rq1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00141
(peroxidase)
5 ARG A  60
ALA A 154
GLY A  54
THR A  45
ALA A 157
None
None
CA  A 271 (-4.4A)
CA  A 271 (-4.0A)
None
1.34A 5vyhA-3rrwA:
undetectable
5vyhA-3rrwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE


(Mesorhizobium
loti)
PF13561
(adh_short_C2)
5 HIS A 197
ALA A  89
GLY A 115
THR A 114
ILE A  62
4PL  A 252 (-3.6A)
NAD  A 251 (-3.5A)
None
None
NAD  A 251 (-3.9A)
1.35A 5vyhA-3rwbA:
undetectable
5vyhA-3rwbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE


(Rhipicephalus
microplus)
PF00121
(TIM)
5 PRO A  44
PRO A  46
ALA A  62
GLY A   9
ILE A  40
None
1.28A 5vyhA-3th6A:
undetectable
5vyhA-3th6A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58


(Homo sapiens)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 HIS A 444
ALA A 254
GLY A 407
ILE A 406
ALA A 251
None
1.32A 5vyhA-4ay2A:
undetectable
5vyhA-4ay2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
5 PRO B2971
HIS B2972
ALA B3107
GLY B2993
ILE B2994
None
1.27A 5vyhA-4bedB:
undetectable
5vyhA-4bedB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
5 HIS A 127
ALA A 539
GLY A  50
THR A  51
ILE A 401
None
1.03A 5vyhA-4c3oA:
undetectable
5vyhA-4c3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei)
PF00669
(Flagellin_N)
PF12613
(FliC_SP)
5 PRO A 102
ALA A  98
GLY A 297
ILE A 292
ALA A 108
None
1.11A 5vyhA-4cfiA:
undetectable
5vyhA-4cfiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 PRO A 438
HIS A 410
ALA A 460
GLY A 425
ALA A 454
None
1.28A 5vyhA-4cjaA:
undetectable
5vyhA-4cjaA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2


(Cryptococcus
neoformans)
PF00400
(WD40)
5 HIS A  60
GLY A 301
THR A 287
ILE A  21
ALA A  34
None
1.30A 5vyhA-4d6vA:
undetectable
5vyhA-4d6vA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1


(Mycobacterium
tuberculosis)
no annotation 5 TRP A 137
PRO A 163
ALA A 200
GLY A  90
ALA A 171
None
1.22A 5vyhA-4f3vA:
undetectable
5vyhA-4f3vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 5 PRO A 350
HIS A 344
GLY A 208
ILE A 127
ALA A 133
None
1.22A 5vyhA-4g4iA:
undetectable
5vyhA-4g4iA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ARG A 110
HIS A 112
THR A 515
ILE A 140
ALA A 507
None
1.37A 5vyhA-4ha6A:
undetectable
5vyhA-4ha6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE


(Photorhabdus
laumondii)
PF01494
(FAD_binding_3)
5 ALA A 160
GLY A   4
THR A  27
ILE A   5
ALA A   8
None
None
None
None
EDO  A 511 (-4.1A)
1.36A 5vyhA-4hb9A:
undetectable
5vyhA-4hb9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN


(Fragaria vesca)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
5 ALA A 194
GLY A 208
THR A 206
ILE A 180
ALA A 172
None
None
None
None
SO4  A 402 ( 3.8A)
1.25A 5vyhA-4idaA:
undetectable
5vyhA-4idaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida)
PF05544
(Pro_racemase)
5 PRO A 107
GLY A 286
THR A 285
ILE A  93
ALA A 121
None
1.05A 5vyhA-4jbdA:
undetectable
5vyhA-4jbdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvz CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN


(Thermosynechococcus
elongatus)
PF03319
(EutN_CcmL)
5 ALA A  77
GLY A  69
THR A  70
ILE A  66
ALA A  62
None
1.11A 5vyhA-4jvzA:
undetectable
5vyhA-4jvzA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)


(Paraburkholderia
xenovorans)
PF02441
(Flavoprotein)
5 PRO A 114
ALA A 121
GLY A 128
THR A 169
ALA A 119
None
1.27A 5vyhA-4mwgA:
undetectable
5vyhA-4mwgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE


(Pyrococcus
horikoshii)
PF01137
(RTC)
PF05189
(RTC_insert)
5 PRO A 258
ALA A 206
GLY A 190
ILE A 222
ALA A 202
None
1.35A 5vyhA-4o89A:
undetectable
5vyhA-4o89A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA


(Thermus
thermophilus)
PF02233
(PNTB)
5 PRO B  82
ALA B 206
GLY B 199
ILE B 198
ALA B 135
None
1.08A 5vyhA-4o9uB:
undetectable
5vyhA-4o9uB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
5 PRO A 131
ALA A 239
GLY A 177
THR A 179
ILE A 236
None
None
FAD  A 601 (-3.5A)
FAD  A 601 (-4.6A)
FAD  A 601 (-3.9A)
1.32A 5vyhA-4oalA:
undetectable
5vyhA-4oalA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 HIS A 444
ALA A 254
GLY A 407
ILE A 406
ALA A 251
None
1.35A 5vyhA-4on9A:
undetectable
5vyhA-4on9A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
5 PRO A 189
ALA A 199
GLY A  51
THR A  52
ALA A 201
None
1.37A 5vyhA-4r27A:
undetectable
5vyhA-4r27A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Atopobium
parvulum)
PF00905
(Transpeptidase)
5 PRO A 797
ALA A 790
GLY A 715
THR A 716
ILE A 712
None
1.34A 5vyhA-4ra7A:
undetectable
5vyhA-4ra7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
5 PRO A1163
ALA A1140
GLY A1155
ILE A1150
ALA A1142
None
1.35A 5vyhA-4s0vA:
undetectable
5vyhA-4s0vA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
5 PRO L 234
HIS L 235
ALA L 222
THR L 434
ALA L 118
None
SF4  S2001 (-4.4A)
None
None
None
1.37A 5vyhA-4u9iL:
undetectable
5vyhA-4u9iL:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2v AVIDIN FAMILY

(Hoeflea
phototrophica)
PF01382
(Avidin)
5 PRO A  39
GLY A  96
THR A  95
ILE A  75
ALA A  67
None
1.10A 5vyhA-4z2vA:
undetectable
5vyhA-4z2vA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
5 PRO A1163
ALA A1140
GLY A1155
ILE A1150
ALA A1142
None
1.29A 5vyhA-4zj8A:
undetectable
5vyhA-4zj8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX


(Streptomyces
atroolivaceus)
PF02585
(PIG-L)
5 PRO A 229
ARG A 230
ALA A 179
GLY A 175
ALA A 182
None
1.15A 5vyhA-5bmoA:
undetectable
5vyhA-5bmoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR


(Ovis aries)
PF01109
(GM_CSF)
5 PRO B 118
ALA B  18
GLY B  75
THR B  74
ALA B  22
None
1.17A 5vyhA-5d28B:
undetectable
5vyhA-5d28B:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE


(Microbispora
corallina)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
5 PRO A 634
GLY A 629
THR A 628
ILE A 804
ALA A 566
None
1.27A 5vyhA-5ehkA:
undetectable
5vyhA-5ehkA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE


(Gaeumannomyces
avenae)
PF00305
(Lipoxygenase)
5 PRO A 494
HIS A 496
GLY A 127
ILE A 122
ALA A 529
None
1.15A 5vyhA-5fx8A:
undetectable
5vyhA-5fx8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
5 TRP A 270
HIS A 267
ALA A 179
GLY A 190
THR A 252
None
MLY  A 222 ( 2.7A)
None
None
None
1.37A 5vyhA-5jh8A:
undetectable
5vyhA-5jh8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ARG B 918
PRO B 919
ALA B 833
ILE B 836
ALA B 859
None
1.34A 5vyhA-5kkrB:
undetectable
5vyhA-5kkrB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93


(Porphyromonas
gingivalis)
no annotation 5 PRO A 401
ALA A 395
GLY A 407
THR A 408
ILE A 445
CAC  A 813 ( 4.7A)
None
None
None
None
1.33A 5vyhA-5m11A:
undetectable
5vyhA-5m11A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC


(Spinacia
oleracea)
PF01245
(Ribosomal_L19)
5 ALA R 130
GLY R 176
THR R 179
ILE R 177
ALA R 134
None
1.26A 5vyhA-5mlcR:
undetectable
5vyhA-5mlcR:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ney FUCOSE-BINDING
LECTIN II (PA-IIL)


(Pseudomonas
aeruginosa)
PF07472
(PA-IIL)
5 PRO A  73
GLY A  51
THR A  17
ILE A  50
ALA A 105
None
1.15A 5vyhA-5neyA:
undetectable
5vyhA-5neyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL


(Rhodopseudomonas
palustris)
no annotation 5 TRP A 262
GLY A 103
THR A 264
ILE A 107
ALA A 109
None
1.29A 5vyhA-5oeiA:
undetectable
5vyhA-5oeiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8y EPOXYQUEUOSINE
REDUCTASE


(Bacillus
subtilis)
PF08331
(DUF1730)
PF13484
(Fer4_16)
PF13646
(HEAT_2)
5 HIS A 106
ALA A  76
GLY A 164
THR A 159
ALA A  74
PO4  A 505 ( 4.6A)
None
None
None
None
1.33A 5vyhA-5t8yA:
undetectable
5vyhA-5t8yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Aliivibrio
fischeri)
PF01048
(PNP_UDP_1)
5 ALA A  55
GLY A   7
THR A  74
ILE A   6
ALA A 176
None
1.34A 5vyhA-5ue1A:
undetectable
5vyhA-5ue1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 HIS A 827
ALA A 726
GLY A 874
ILE A 875
ALA A 695
None
1.30A 5vyhA-5ux5A:
undetectable
5vyhA-5ux5A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 PRO A 265
ALA A 239
GLY A  21
ILE A  19
ALA A 258
None
1.29A 5vyhA-5wi5A:
undetectable
5vyhA-5wi5A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
no annotation 10 TRP A  44
PRO A  45
ARG A  46
PRO A  47
HIS A  81
ALA A 123
GLY A 128
THR A 129
ILE A 140
ALA A 312
None
0.39A 5vyhA-5x4rA:
54.9
5vyhA-5x4rA:
98.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
10 TRP A  44
PRO A  45
ARG A  46
PRO A  47
HIS A  81
ALA A 123
GLY A 128
THR A 129
ILE A 140
ALA A 312
None
0.42A 5vyhA-5x59A:
53.5
5vyhA-5x59A:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC


(Spinacia
oleracea)
PF01245
(Ribosomal_L19)
5 ALA Q 130
GLY Q 176
THR Q 179
ILE Q 177
ALA Q 134
None
1.13A 5vyhA-5x8tQ:
undetectable
5vyhA-5x8tQ:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT


(Methylobacillus
sp. KY4400)
no annotation 5 ARG C 442
GLY C 650
THR C 651
ILE C 774
ALA C 759
SO4  C 804 (-4.1A)
None
None
None
None
1.27A 5vyhA-5y6qC:
undetectable
5vyhA-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE


(Escherichia
coli)
no annotation 5 PRO A 223
ALA A 227
GLY A 170
THR A 171
ILE A 196
None
1.32A 5vyhA-5z03A:
undetectable
5vyhA-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN


(Rhinocladiella
mackenziei)
no annotation 5 PRO A 198
ALA A 229
GLY A 237
THR A 238
ILE A 236
None
1.23A 5vyhA-5z97A:
undetectable
5vyhA-5z97A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-)
no annotation 5 PRO A 874
ARG A 860
GLY A 908
THR A 909
ALA A 903
None
1.31A 5vyhA-6c13A:
undetectable
5vyhA-6c13A:
undetectable