SIMILAR PATTERNS OF AMINO ACIDS FOR 5VW9_A_ACTA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		4 THR A 222
TYR A 158
LEU A 232
MET A 161
 None
 1.39A 5vw9A-1yt8A:
0.8		 5vw9A-1yt8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b85 PHOSPHATE
STARVATION-INDUCIBLE
PROTEIN

(Corynebacterium
glutamicum) 		PF02562
(PhoH) 		4 THR A 170
TYR A 227
LEU A 225
MET A 228
 None
None
SO4  A 408 ( 4.7A)
None
 1.35A 5vw9A-3b85A:
0.0		 5vw9A-3b85A:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		4 THR A 170
TYR A 246
LEU A 274
MET A 277
 None
 0.78A 5vw9A-3vo2A:
41.7		 5vw9A-3vo2A:
49.38