SIMILAR PATTERNS OF AMINO ACIDS FOR 5VW5_A_NCAA403_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8p | NADPH:FERREDOXINOXIDOREDUCTASE (Azotobactervinelandii) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 54THR A 117GLY A 118CYH A 219GLU A 252 | FAD A 259 (-3.8A)FAD A 259 (-3.1A)NoneNoneFAD A 259 ( 3.9A) | 0.59A | 5vw5A-1a8pA:21.0 | 5vw5A-1a8pA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8p | NADPH:FERREDOXINOXIDOREDUCTASE (Azotobactervinelandii) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | THR A 117GLY A 118CYH A 219GLY A 220GLU A 252 | FAD A 259 (-3.1A)NoneNoneNoneFAD A 259 ( 3.9A) | 0.72A | 5vw5A-1a8pA:21.0 | 5vw5A-1a8pA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amo | NADPH-CYTOCHROMEP450 REDUCTASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 4 | SER A 457GLY A 536CYH A 630GLY A 631 | FAD A 750 (-3.8A)NoneNoneNone | 0.47A | 5vw5A-1amoA:29.5 | 5vw5A-1amoA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amo | NADPH-CYTOCHROMEP450 REDUCTASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 4 | THR A 535GLY A 536CYH A 630GLY A 631 | NAP A 752 (-3.5A)NoneNoneNone | 0.35A | 5vw5A-1amoA:29.5 | 5vw5A-1amoA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 4 | GLY A 64GLY A 33LEU A 37ALA A 28 | None | 0.69A | 5vw5A-1aorA:undetectable | 5vw5A-1aorA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bdg | HEXOKINASE (Schistosomamansoni) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 4 | GLY A 268GLY A 265LEU A 292ALA A 263 | None | 0.73A | 5vw5A-1bdgA:undetectable | 5vw5A-1bdgA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bs9 | ACETYL XYLANESTERASE (Talaromycespurpureogenus) |
PF01083(Cutinase) | 4 | GLY A 88GLY A 92GLU A 12ALA A 45 | None | 0.72A | 5vw5A-1bs9A:undetectable | 5vw5A-1bs9A:22.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bx0 | PROTEIN(FERREDOXIN:NADP+OXIDOREDUCTASE) (Spinaciaoleracea) |
PF00175(NAD_binding_1) | 6 | SER A 96THR A 172GLY A 173CYH A 272GLY A 273LEU A 274 | FAD A 315 (-3.7A)FAD A 315 (-3.4A)NoneNoneNoneNone | 0.61A | 5vw5A-1bx0A:40.8 | 5vw5A-1bx0A:48.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddg | SULFITE REDUCTASE(NADPH) FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | SER A 389THR A 462GLY A 463CYH A 552GLY A 553 | FAD A 600 (-3.2A)FAD A 600 ( 3.8A)NoneNoneNone | 0.24A | 5vw5A-1ddgA:29.1 | 5vw5A-1ddgA:28.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | SER A1176THR A1251GLY A1252CYH A1349GLY A1350 | FAD A1501 (-3.7A)NAP A1502 ( 3.9A)NoneNoneNone | 0.51A | 5vw5A-1f20A:29.2 | 5vw5A-1f20A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gvh | FLAVOHEMOPROTEIN (Escherichiacoli) |
PF00042(Globin)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLY A 270CYH A 362GLY A 363GLU A 388 | NoneNoneNoneFAD A1397 (-3.6A) | 0.69A | 5vw5A-1gvhA:19.8 | 5vw5A-1gvhA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7p | NADH-CYTOCHROME B5REDUCTASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | THR A 181GLY A 182CYH A 273GLY A 274 | FAD A 301 (-3.3A)NoneFAD A 301 ( 4.0A)None | 0.51A | 5vw5A-1i7pA:19.4 | 5vw5A-1i7pA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krh | BENZOATE1,2-DIOXYGENASEREDUCTASE (Acinetobactersp.) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 6 | SER A 159THR A 220GLY A 221CYH A 307GLY A 308GLU A 333 | FAD A 501 (-3.1A)FAD A 501 (-3.2A)NoneNoneNoneFAD A 501 (-3.6A) | 0.68A | 5vw5A-1krhA:23.4 | 5vw5A-1krhA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8i | DNA POLYMERASE II (Escherichiacoli) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | THR A 505GLY A 504GLY A 501ALA A 498 | None | 0.75A | 5vw5A-1q8iA:undetectable | 5vw5A-1q8iA:17.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 6 | SER A 80THR A 157GLY A 158CYH A 261GLY A 262LEU A 263 | FAD A 304 (-3.4A)FAD A 304 (-3.6A)NoneNoneNoneNone | 0.26A | 5vw5A-1qgzA:38.9 | 5vw5A-1qgzA:44.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tll | NITRIC-OXIDESYNTHASE, BRAIN (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | SER A1176THR A1251GLY A1252CYH A1349GLY A1350 | FAD A1452 (-3.7A)NAP A1453 ( 3.4A)NoneNoneNone | 0.53A | 5vw5A-1tllA:28.9 | 5vw5A-1tllA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tme | THEILER'S MURINEENCEPHALOMYELITISVIRUS (SUBUNIT VP2) (Cardiovirus B) |
PF00073(Rhv) | 4 | GLY 2 37CYH 2 34GLY 2 35GLU 2 205 | None | 0.74A | 5vw5A-1tme2:undetectable | 5vw5A-1tme2:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 4 | GLY A 244GLY A 122GLU A 124ALA A 118 | None | 0.75A | 5vw5A-1wytA:undetectable | 5vw5A-1wytA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr4 | PUTATIVE CITRATELYASE ALPHACHAIN/CITRATE-ACPTRANSFERASE (Salmonellaenterica) |
PF04223(CitF) | 4 | GLY A 174CYH A 181GLY A 182LEU A 333 | None | 0.62A | 5vw5A-1xr4A:undetectable | 5vw5A-1xr4A:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2b5o | FERREDOXIN--NADPREDUCTASE (Synechococcussp. PCC 7002) |
PF00175(NAD_binding_1) | 7 | SER A 182THR A 260GLY A 261CYH A 360GLY A 361LEU A 362GLU A 400 | FAD A 403 (-3.1A)FAD A 403 (-3.2A)NoneNoneNoneNoneFAD A 403 (-3.8A) | 0.52A | 5vw5A-2b5oA:40.7 | 5vw5A-2b5oA:38.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf4 | NADPH-CYTOCHROMEP450 REDUCTASE (Saccharomycescerevisiae) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | SER A 442THR A 543GLY A 544CYH A 644GLY A 645 | FAD A 750 (-3.1A)NAP A 753 (-3.7A)NoneNoneNone | 0.36A | 5vw5A-2bf4A:27.5 | 5vw5A-2bf4A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3d | 2-OXOPROPYL-COMREDUCTASE (Xanthobacterautotrophicus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 58CYH A 369GLY A 368ALA A 364 | NoneNoneNoneFAD A1524 (-3.6A) | 0.74A | 5vw5A-2c3dA:undetectable | 5vw5A-2c3dA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 4 | GLY A 371GLY A 403LEU A 406GLU A 401 | NoneNoneNone ZN A 700 (-2.1A) | 0.67A | 5vw5A-2e0pA:undetectable | 5vw5A-2e0pA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 4 | THR A 369GLY A 370GLY A 364ALA A 299 | None | 0.53A | 5vw5A-2e0pA:undetectable | 5vw5A-2e0pA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eix | NADH-CYTOCHROME B5REDUCTASE (Physarumpolycephalum) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | THR A 164GLY A 165CYH A 255GLY A 256 | FAD A1301 (-3.3A)NoneFAD A1301 ( 4.1A)None | 0.44A | 5vw5A-2eixA:20.0 | 5vw5A-2eixA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eq9 | PYRUVATEDEHYDROGENASECOMPLEX,DIHYDROLIPOAMIDEDEHYDROGENASE E3COMPONENT (Thermusthermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 20GLY A 329LEU A 330ALA A 333 | FAD A8482 (-3.5A)NoneNoneNone | 0.75A | 5vw5A-2eq9A:2.2 | 5vw5A-2eq9A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grv | LPQW (Mycolicibacteriumsmegmatis) |
PF00496(SBP_bac_5) | 4 | GLY A 183GLY A 187LEU A 188ALA A 191 | None | 0.75A | 5vw5A-2grvA:undetectable | 5vw5A-2grvA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj0 | PUTATIVE CITRATELYASE, ALFA SUBUNIT (Streptococcusmutans) |
PF04223(CitF) | 4 | GLY A 180CYH A 187GLY A 188LEU A 339 | None | 0.64A | 5vw5A-2hj0A:undetectable | 5vw5A-2hj0A:21.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ok8 | PUTATIVEFERREDOXIN--NADPREDUCTASE (Plasmodiumfalciparum) |
PF00175(NAD_binding_1) | 4 | SER A 104CYH A 284GLY A 285GLU A 314 | FAD A 415 (-3.8A)NoneNoneFAD A 415 ( 3.8A) | 0.71A | 5vw5A-2ok8A:30.1 | 5vw5A-2ok8A:32.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ok8 | PUTATIVEFERREDOXIN--NADPREDUCTASE (Plasmodiumfalciparum) |
PF00175(NAD_binding_1) | 5 | SER A 104THR A 180GLY A 181CYH A 284GLY A 285 | FAD A 415 (-3.8A)FAD A 415 (-3.3A)NoneNoneNone | 0.42A | 5vw5A-2ok8A:30.1 | 5vw5A-2ok8A:32.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7x | UPF0052 PROTEINSP_1565 (Streptococcuspneumoniae) |
PF01933(UPF0052) | 4 | GLY A 208LEU A 211GLU A 206ALA A 210 | MLY A 205 ( 3.6A)NoneNoneNone | 0.75A | 5vw5A-2q7xA:undetectable | 5vw5A-2q7xA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdx | FERREDOXIN REDUCTASE (Pseudomonasaeruginosa) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLY A 118CYH A 219GLY A 220GLU A 252 | NoneNoneNoneFAD A 400 ( 3.9A) | 0.63A | 5vw5A-2qdxA:20.8 | 5vw5A-2qdxA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdx | FERREDOXIN REDUCTASE (Pseudomonasaeruginosa) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 54THR A 117GLY A 118CYH A 219GLU A 252 | FAD A 400 (-3.7A)FAD A 400 (-3.2A)NoneNoneFAD A 400 ( 3.9A) | 0.52A | 5vw5A-2qdxA:20.8 | 5vw5A-2qdxA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qi9 | VITAMIN B12 IMPORTSYSTEM PERMEASEPROTEIN BTUC (Escherichiacoli) |
PF01032(FecCD) | 4 | GLY A 124GLY A 100LEU A 101ALA A 104 | None | 0.63A | 5vw5A-2qi9A:undetectable | 5vw5A-2qi9A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtz | METHIONINE SYNTHASEREDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | SER A 454GLY A 548CYH A 650GLY A 651 | FAD A 700 (-3.2A)NoneNoneNone | 0.56A | 5vw5A-2qtzA:28.2 | 5vw5A-2qtzA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtz | METHIONINE SYNTHASEREDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | THR A 547GLY A 548CYH A 650GLY A 651 | FAD A 700 ( 4.6A)NoneNoneNone | 0.29A | 5vw5A-2qtzA:28.2 | 5vw5A-2qtzA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvb | HALOALKANEDEHALOGENASE 3 (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 4 | GLY A 38GLY A 111LEU A 114ALA A 113 | None | 0.70A | 5vw5A-2qvbA:undetectable | 5vw5A-2qvbA:21.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rc5 | FERREDOXIN-NADPREDUCTASE (Leptospirainterrogans) |
PF00175(NAD_binding_1) | 6 | SER A 97THR A 175GLY A 176CYH A 272GLY A 273GLU A 312 | FAD A 415 (-3.1A)FAD A 415 (-3.4A)NoneNoneNoneFAD A 415 (-3.8A) | 0.65A | 5vw5A-2rc5A:34.9 | 5vw5A-2rc5A:37.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xs6 | PHOSPHATIDYLINOSITOL3-KINASE REGULATORYSUBUNIT BETA (Homo sapiens) |
PF00620(RhoGAP) | 4 | THR A 138GLY A 139LEU A 170ALA A 168 | None | 0.72A | 5vw5A-2xs6A:undetectable | 5vw5A-2xs6A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8f | RAN-BINDING PROTEIN3 (Homo sapiens) |
PF00638(Ran_BP1) | 4 | THR A 325GLY A 326LEU A 371ALA A 364 | None | 0.73A | 5vw5A-2y8fA:undetectable | 5vw5A-2y8fA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yij | PHOSPHOLIPASEA1-IIGAMMA (Arabidopsisthaliana) |
PF01764(Lipase_3) | 4 | GLY A 155GLY A 238LEU A 241ALA A 240 | None | 0.62A | 5vw5A-2yijA:undetectable | 5vw5A-2yijA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yiz | DODECIN (Mycobacteriumtuberculosis) |
PF07311(Dodecin) | 4 | GLY A 12GLY A 25LEU A 26ALA A 29 | None | 0.65A | 5vw5A-2yizA:undetectable | 5vw5A-2yizA:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ys6 | PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE (Geobacilluskaustophilus) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 4 | GLY A 405LEU A 406GLU A 341ALA A 333 | None | 0.66A | 5vw5A-2ys6A:undetectable | 5vw5A-2ys6A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2l | HALOALKANEDEHALOGENASE (Bradyrhizobiumjaponicum) |
PF00561(Abhydrolase_1) | 4 | GLY A 37GLY A 105LEU A 108ALA A 107 | None | 0.75A | 5vw5A-3a2lA:undetectable | 5vw5A-3a2lA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asu | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Escherichiacoli) |
PF00106(adh_short) | 5 | THR A 6GLY A 7GLY A 31LEU A 53ALA A 51 | None | 0.92A | 5vw5A-3asuA:undetectable | 5vw5A-3asuA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fjo | NADPH-CYTOCHROMEP450 REDUCTASE (Saccharomycescerevisiae;Homo sapiens) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | SER A 437THR A 515GLY A 516CYH A 609GLY A 610 | FAD A 750 (-3.7A)FAD A 750 ( 3.9A)NoneNoneNone | 0.56A | 5vw5A-3fjoA:29.4 | 5vw5A-3fjoA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpk | FERREDOXIN-NADPREDUCTASE (Salmonellaenterica) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | SER A 53THR A 116CYH A 212GLU A 245 | FAD A 301 (-3.6A)FAD A 301 (-3.4A)NoneFAD A 301 ( 4.3A) | 0.73A | 5vw5A-3fpkA:21.9 | 5vw5A-3fpkA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7n | LIPASE (Penicilliumexpansum) |
PF01764(Lipase_3) | 4 | GLY A 64GLY A 134LEU A 137ALA A 136 | None | 0.71A | 5vw5A-3g7nA:undetectable | 5vw5A-3g7nA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1v | GLUCOKINASE (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 4 | GLY X 264GLY X 261LEU X 288ALA X 259 | None | 0.73A | 5vw5A-3h1vX:undetectable | 5vw5A-3h1vX:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i83 | 2-DEHYDROPANTOATE2-REDUCTASE (Methylococcuscapsulatus) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | GLY A 149LEU A 148GLU A 177ALA A 175 | None | 0.73A | 5vw5A-3i83A:undetectable | 5vw5A-3i83A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m5h | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | THR A 69GLY A 68GLY A 65LEU A 61 | None | 0.74A | 5vw5A-3m5hA:undetectable | 5vw5A-3m5hA:20.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mhp | FERREDOXIN--NADPREDUCTASE, LEAFISOZYME,CHLOROPLASTIC (Pisum sativum) |
PF00175(NAD_binding_1) | 7 | SER A 90THR A 166GLY A 167CYH A 266GLY A 267LEU A 268GLU A 306 | FAD A 999 (-3.4A)FAD A 999 (-3.3A)NoneNoneNoneNoneFAD A 999 (-3.6A) | 0.71A | 5vw5A-3mhpA:41.7 | 5vw5A-3mhpA:46.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3orw | PHOSPHOTRIESTERASE (Geobacilluskaustophilus) |
PF02126(PTE) | 5 | THR A 137GLY A 138GLY A 133GLU A 6ALA A 141 | None | 1.16A | 5vw5A-3orwA:undetectable | 5vw5A-3orwA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd5 | PUTATIVERIBOSE-5-PHOSPHATEISOMERASE (Coccidioidesimmitis) |
PF02502(LacAB_rpiB) | 4 | GLY A 118GLY A 79LEU A 80ALA A 83 | CSO A 76 ( 3.4A)CSO A 76 ( 3.4A)NoneNone | 0.72A | 5vw5A-3qd5A:undetectable | 5vw5A-3qd5A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfs | NADPH--CYTOCHROMEP450 REDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | SER A 460THR A 538GLY A 539CYH A 632GLY A 633 | FAD A 752 (-3.5A)NAP A 753 (-3.0A)NoneNoneNone | 0.42A | 5vw5A-3qfsA:29.7 | 5vw5A-3qfsA:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rdn | ANTIFREEZE PROTEINRD3 TYPE III (Lycodichthysdearborni) |
no annotation | 4 | GLY A 66GLY A 71LEU A 72GLU A 64 | None | 0.75A | 5vw5A-3rdnA:undetectable | 5vw5A-3rdnA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) |
no annotation | 4 | GLY L 284GLY L 324LEU L 323ALA L 327 | None | 0.73A | 5vw5A-3rkoL:undetectable | 5vw5A-3rkoL:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | THR A 192GLY A 191GLY A 229ALA A 227 | None | 0.67A | 5vw5A-3uk1A:undetectable | 5vw5A-3uk1A:18.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vo2 | PUTATIVEUNCHARACTERIZEDPROTEIN (Zea mays) |
PF00175(NAD_binding_1) | 6 | SER A 96THR A 172GLY A 173CYH A 272GLY A 273GLU A 312 | FAD A 401 (-3.2A)FAD A 401 (-3.3A)NoneNoneNoneFAD A 401 (-3.8A) | 0.47A | 5vw5A-3vo2A:41.3 | 5vw5A-3vo2A:49.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w2i | NADH-CYTOCHROME B5REDUCTASE 3 (Sus scrofa) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | THR A 153GLY A 154CYH A 245GLY A 246 | FAD A 301 ( 3.5A)NAD A 302 (-3.9A)NAD A 302 (-3.4A)NAD A 302 (-3.8A) | 0.55A | 5vw5A-3w2iA:20.6 | 5vw5A-3w2iA:22.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w5v | FERREDOXIN (Zea mays) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 96CYH A 272GLY A 273LEU A 274GLU A 312 | FAD A 401 (-3.0A)NoneNoneNoneFAD A 401 ( 3.9A) | 0.71A | 5vw5A-3w5vA:40.4 | 5vw5A-3w5vA:48.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w5v | FERREDOXIN (Zea mays) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 6 | SER A 96THR A 172GLY A 173CYH A 272GLY A 273LEU A 274 | FAD A 401 (-3.0A)FAD A 401 (-2.9A)NoneNoneNoneNone | 0.66A | 5vw5A-3w5vA:40.4 | 5vw5A-3w5vA:48.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4d | FERREDOXIN-NADPREDUCTASE (Xanthomonascitri) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 55THR A 118GLY A 119CYH A 220GLU A 253 | FAD A1260 (-3.8A)FAD A1260 (-3.3A)NoneNoneFAD A1260 ( 4.2A) | 0.49A | 5vw5A-4b4dA:20.9 | 5vw5A-4b4dA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b4d | FERREDOXIN-NADPREDUCTASE (Xanthomonascitri) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | THR A 118GLY A 119CYH A 220GLY A 221GLU A 253 | FAD A1260 (-3.3A)NoneNoneNoneFAD A1260 ( 4.2A) | 0.66A | 5vw5A-4b4dA:20.9 | 5vw5A-4b4dA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4be3 | ALGINATE LYASE,FAMILY PL7 (Zobelliagalactanivorans) |
PF08787(Alginate_lyase2) | 4 | SER A 132THR A 315GLY A 316GLY A 304 | None | 0.70A | 5vw5A-4be3A:undetectable | 5vw5A-4be3A:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqk | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | SER A 831THR A 906GLY A 907GLY A1001 | FAD A1101 (-3.3A)FAD A1101 (-3.9A)NoneNone | 0.44A | 5vw5A-4dqkA:29.0 | 5vw5A-4dqkA:26.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eh1 | FLAVOHEMOPROTEIN (Vibrio cholerae) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLY A 126CYH A 208GLY A 209GLU A 234 | NoneNoneNoneFAD A 301 (-3.6A) | 0.48A | 5vw5A-4eh1A:22.8 | 5vw5A-4eh1A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk8 | FERREDOXIN--NADPREDUCTASE (Burkholderiathailandensis) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 69THR A 132GLY A 133CYH A 234GLU A 266 | FAD A 301 (-3.8A)FAD A 301 (-3.0A)NoneNoneFAD A 301 ( 3.9A) | 0.64A | 5vw5A-4fk8A:18.1 | 5vw5A-4fk8A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwb | HALOALKANEDEHALOGENASE (Rhodococcusrhodochrous) |
PF00561(Abhydrolase_1) | 4 | GLY A 40GLY A 108LEU A 111ALA A 110 | None | 0.71A | 5vw5A-4fwbA:undetectable | 5vw5A-4fwbA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1b | FLAVOHEMOGLOBIN (Saccharomycescerevisiae) |
PF00042(Globin)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLY A 283CYH A 362GLY A 363GLU A 388 | NoneNoneNoneFAD A 402 (-3.6A) | 0.56A | 5vw5A-4g1bA:21.5 | 5vw5A-4g1bA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1b | FLAVOHEMOGLOBIN (Saccharomycescerevisiae) |
PF00042(Globin)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | SER A 210GLY A 283CYH A 362GLU A 388 | FAD A 402 (-3.6A)NoneNoneFAD A 402 (-3.6A) | 0.74A | 5vw5A-4g1bA:21.5 | 5vw5A-4g1bA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k1x | NADPH:FERREDOXINREDUCTASE (Rhodobactercapsulatus) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 67THR A 130GLY A 131CYH A 232GLY A 233 | FAD A 301 (-3.1A)FAD A 301 (-2.8A)NoneNoneNone | 0.61A | 5vw5A-4k1xA:20.7 | 5vw5A-4k1xA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1k | D-ALANINE--D-ALANINELIGASE (Xanthomonasoryzae) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | GLY A 134CYH A 295GLY A 294ALA A 292 | None | 0.64A | 5vw5A-4l1kA:undetectable | 5vw5A-4l1kA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n54 | INOSITOLDEHYDROGENASE (Lactobacilluscasei) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | THR A 323GLY A 322GLU A 317ALA A 316 | None | 0.72A | 5vw5A-4n54A:undetectable | 5vw5A-4n54A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qq1 | TRANSFERRIN-BINDINGPROTEIN 2 (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 4 | SER A 492GLY A 513GLY A 516ALA A 518 | None | 0.71A | 5vw5A-4qq1A:undetectable | 5vw5A-4qq1A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wdr | HALOALKANEDEHALOGENASE (Sphingobiumjaponicum) |
PF00561(Abhydrolase_1) | 4 | GLY A 37GLY A 110LEU A 113ALA A 112 | None | 0.74A | 5vw5A-4wdrA:undetectable | 5vw5A-4wdrA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wqm | TOLUENE-4-MONOOXYGENASE ELECTRONTRANSFER COMPONENT (Pseudomonasmendocina) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | SER A 149GLY A 210CYH A 296GLY A 297 | FAD A 402 (-3.0A)NoneNoneNone | 0.55A | 5vw5A-4wqmA:22.6 | 5vw5A-4wqmA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | THR A 15GLY A 14GLY A 88ALA A 82 | FAD A 601 (-3.2A)FAD A 601 (-3.4A)FAD A 601 (-3.0A)FAD A 601 ( 4.8A) | 0.70A | 5vw5A-4ynuA:2.8 | 5vw5A-4ynuA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqu | CDII TOXIN (Salmonellaenterica) |
PF07262(CdiI) | 4 | GLY B 51GLY B 165LEU B 168GLU B 163 | None | 0.74A | 5vw5A-4zquB:undetectable | 5vw5A-4zquB:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1h | CYSTATHIONINEBETA-SYNTHASE (Lactobacillusplantarum) |
PF00291(PALP) | 4 | THR A 73GLY A 76GLY A 46LEU A 49 | SO4 A 404 (-3.7A)LLP A 42 ( 3.5A)LLP A 42 ( 3.8A)None | 0.68A | 5vw5A-5b1hA:undetectable | 5vw5A-5b1hA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn7 | PROTEIN FAM179B (Mus musculus) |
no annotation | 4 | THR A 413GLY A 412LEU A 374ALA A 370 | None | 0.71A | 5vw5A-5dn7A:undetectable | 5vw5A-5dn7A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxu | NADPH--CYTOCHROMEP450 REDUCTASE 2 (Arabidopsisthaliana) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | SER A 492THR A 570GLY A 571CYH A 664GLY A 665 | FAD A 802 (-3.3A)FAD A 802 (-3.9A)NoneNoneNone | 0.45A | 5vw5A-5gxuA:30.1 | 5vw5A-5gxuA:18.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h5j | FERREDOXIN--NADPREDUCTASE (Zea mays) |
PF00175(NAD_binding_1) | 5 | SER A 95CYH A 275GLY A 276LEU A 277GLU A 315 | FAD A 401 (-3.5A)NoneNoneNoneFAD A 401 (-3.5A) | 0.72A | 5vw5A-5h5jA:49.6 | 5vw5A-5h5jA:97.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h5j | FERREDOXIN--NADPREDUCTASE (Zea mays) |
PF00175(NAD_binding_1) | 6 | SER A 95THR A 176GLY A 177CYH A 275GLY A 276LEU A 277 | FAD A 401 (-3.5A)FAD A 401 (-3.3A)NoneNoneNoneNone | 0.15A | 5vw5A-5h5jA:49.6 | 5vw5A-5h5jA:97.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1d | PHOSPHATE BINDINGPROTEIN (Stenotrophomonasmaltophilia) |
PF12849(PBP_like_2) | 4 | THR A 37GLY A 38GLY A 8ALA A 31 | None | 0.67A | 5vw5A-5j1dA:undetectable | 5vw5A-5j1dA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogx | CYTOCHROME P450REDUCTASE (Amycolatopsismethanolica) |
no annotation | 4 | SER A 148GLY A 216CYH A 302GLY A 303 | FAD A 401 (-3.2A)NoneNoneNone | 0.47A | 5vw5A-5ogxA:23.4 | 5vw5A-5ogxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogx | CYTOCHROME P450REDUCTASE (Amycolatopsismethanolica) |
no annotation | 4 | SER A 148THR A 215CYH A 302GLU A 328 | FAD A 401 (-3.2A)FAD A 401 (-3.5A)NoneFAD A 401 ( 4.0A) | 0.70A | 5vw5A-5ogxA:23.4 | 5vw5A-5ogxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogx | CYTOCHROME P450REDUCTASE (Amycolatopsismethanolica) |
no annotation | 4 | SER A 148THR A 215GLY A 216CYH A 302 | FAD A 401 (-3.2A)FAD A 401 (-3.5A)NoneNone | 0.41A | 5vw5A-5ogxA:23.4 | 5vw5A-5ogxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sv0 | BIOPOLYMER TRANSPORTPROTEIN EXBB (Escherichiacoli) |
no annotation | 4 | GLY B 144GLY B 184LEU B 185ALA B 188 | None | 0.68A | 5vw5A-5sv0B:undetectable | 5vw5A-5sv0B:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t96 | HE PROTEIN (Salmon isavirus) |
PF06215(ISAV_HA) | 4 | THR A 217GLY A 120GLY A 116LEU A 115 | None | 0.69A | 5vw5A-5t96A:undetectable | 5vw5A-5t96A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thx | FERREDOXIN--NADPREDUCTASE (Neisseriagonorrhoeae) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 54THR A 117GLY A 118CYH A 219GLU A 252 | FAD A 303 (-3.8A)FAD A 303 (-3.1A)NoneNoneFAD A 303 ( 4.0A) | 0.58A | 5vw5A-5thxA:20.8 | 5vw5A-5thxA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thx | FERREDOXIN--NADPREDUCTASE (Neisseriagonorrhoeae) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | THR A 117GLY A 118CYH A 219GLY A 220GLU A 252 | FAD A 303 (-3.1A)NoneNoneNoneFAD A 303 ( 4.0A) | 0.68A | 5vw5A-5thxA:20.8 | 5vw5A-5thxA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr9 | FERREDOXIN-NADPREDUCTASE (Neisseriagonorrhoeae) |
PF00175(NAD_binding_1) | 4 | GLY A 131CYH A 232GLY A 233GLU A 264 | NoneNoneNoneFAD A 301 ( 4.6A) | 0.65A | 5vw5A-5tr9A:21.5 | 5vw5A-5tr9A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr9 | FERREDOXIN-NADPREDUCTASE (Neisseriagonorrhoeae) |
PF00175(NAD_binding_1) | 4 | SER A 67GLY A 131CYH A 232GLU A 264 | FAD A 301 (-3.9A)NoneNoneFAD A 301 ( 4.6A) | 0.66A | 5vw5A-5tr9A:21.5 | 5vw5A-5tr9A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj8 | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Homo sapiens) |
PF07034(ORC3_N) | 4 | SER A 80CYH A 272GLU A 274ALA A 103 | None | 0.74A | 5vw5A-5uj8A:undetectable | 5vw5A-5uj8A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8p | HOMOSERINEO-ACETYLTRANSFERASE (Mycobacteroidesabscessus) |
PF00561(Abhydrolase_1) | 4 | SER A 67THR A 112GLY A 111ALA A 21 | NoneNoneGOL A 407 (-3.5A)None | 0.66A | 5vw5A-5w8pA:undetectable | 5vw5A-5w8pA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8r | 30S RIBOSOMALPROTEIN S9,CHLOROPLASTIC (Spinaciaoleracea) |
no annotation | 4 | GLY i 74GLY i 149LEU i 148ALA i 145 | None | 0.76A | 5vw5A-5x8ri:undetectable | 5vw5A-5x8ri:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yly | NITRATE REDUCTASE (Ulva prolifera) |
no annotation | 4 | THR A 743GLY A 744CYH A 835GLY A 836 | FAD A1001 (-3.4A)NoneFAD A1001 ( 4.5A)None | 0.45A | 5vw5A-5ylyA:19.8 | 5vw5A-5ylyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zov | - (-) |
no annotation | 4 | THR A 45GLY A 44LEU A 294ALA A 297 | None | 0.74A | 5vw5A-5zovA:undetectable | 5vw5A-5zovA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ap4 | DNA POLYMERASE IIISUBUNIT BETA (Acinetobacterbaumannii) |
no annotation | 4 | THR A 130GLY A 129GLY A 224ALA A 198 | None | 0.67A | 5vw5A-6ap4A:undetectable | 5vw5A-6ap4A:undetectable |