SIMILAR PATTERNS OF AMINO ACIDS FOR 5VW5_A_NCAA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE


(Azotobacter
vinelandii)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
FAD  A 259 (-3.8A)
FAD  A 259 (-3.1A)
None
None
FAD  A 259 ( 3.9A)
0.59A 5vw5A-1a8pA:
21.0
5vw5A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE


(Azotobacter
vinelandii)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 THR A 117
GLY A 118
CYH A 219
GLY A 220
GLU A 252
FAD  A 259 (-3.1A)
None
None
None
FAD  A 259 ( 3.9A)
0.72A 5vw5A-1a8pA:
21.0
5vw5A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
4 SER A 457
GLY A 536
CYH A 630
GLY A 631
FAD  A 750 (-3.8A)
None
None
None
0.47A 5vw5A-1amoA:
29.5
5vw5A-1amoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
4 THR A 535
GLY A 536
CYH A 630
GLY A 631
NAP  A 752 (-3.5A)
None
None
None
0.35A 5vw5A-1amoA:
29.5
5vw5A-1amoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
4 GLY A  64
GLY A  33
LEU A  37
ALA A  28
None
0.69A 5vw5A-1aorA:
undetectable
5vw5A-1aorA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 GLY A 268
GLY A 265
LEU A 292
ALA A 263
None
0.73A 5vw5A-1bdgA:
undetectable
5vw5A-1bdgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE


(Talaromyces
purpureogenus)
PF01083
(Cutinase)
4 GLY A  88
GLY A  92
GLU A  12
ALA A  45
None
0.72A 5vw5A-1bs9A:
undetectable
5vw5A-1bs9A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)


(Spinacia
oleracea)
PF00175
(NAD_binding_1)
6 SER A  96
THR A 172
GLY A 173
CYH A 272
GLY A 273
LEU A 274
FAD  A 315 (-3.7A)
FAD  A 315 (-3.4A)
None
None
None
None
0.61A 5vw5A-1bx0A:
40.8
5vw5A-1bx0A:
48.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT


(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
5 SER A 389
THR A 462
GLY A 463
CYH A 552
GLY A 553
FAD  A 600 (-3.2A)
FAD  A 600 ( 3.8A)
None
None
None
0.24A 5vw5A-1ddgA:
29.1
5vw5A-1ddgA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
5 SER A1176
THR A1251
GLY A1252
CYH A1349
GLY A1350
FAD  A1501 (-3.7A)
NAP  A1502 ( 3.9A)
None
None
None
0.51A 5vw5A-1f20A:
29.2
5vw5A-1f20A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLY A 270
CYH A 362
GLY A 363
GLU A 388
None
None
None
FAD  A1397 (-3.6A)
0.69A 5vw5A-1gvhA:
19.8
5vw5A-1gvhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 THR A 181
GLY A 182
CYH A 273
GLY A 274
FAD  A 301 (-3.3A)
None
FAD  A 301 ( 4.0A)
None
0.51A 5vw5A-1i7pA:
19.4
5vw5A-1i7pA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE


(Acinetobacter
sp.)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
6 SER A 159
THR A 220
GLY A 221
CYH A 307
GLY A 308
GLU A 333
FAD  A 501 (-3.1A)
FAD  A 501 (-3.2A)
None
None
None
FAD  A 501 (-3.6A)
0.68A 5vw5A-1krhA:
23.4
5vw5A-1krhA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 THR A 505
GLY A 504
GLY A 501
ALA A 498
None
0.75A 5vw5A-1q8iA:
undetectable
5vw5A-1q8iA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)


(Nostoc sp. PCC
7119)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
6 SER A  80
THR A 157
GLY A 158
CYH A 261
GLY A 262
LEU A 263
FAD  A 304 (-3.4A)
FAD  A 304 (-3.6A)
None
None
None
None
0.26A 5vw5A-1qgzA:
38.9
5vw5A-1qgzA:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN


(Rattus
norvegicus)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 SER A1176
THR A1251
GLY A1252
CYH A1349
GLY A1350
FAD  A1452 (-3.7A)
NAP  A1453 ( 3.4A)
None
None
None
0.53A 5vw5A-1tllA:
28.9
5vw5A-1tllA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP2)


(Cardiovirus B)
PF00073
(Rhv)
4 GLY 2  37
CYH 2  34
GLY 2  35
GLU 2 205
None
0.74A 5vw5A-1tme2:
undetectable
5vw5A-1tme2:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
4 GLY A 244
GLY A 122
GLU A 124
ALA A 118
None
0.75A 5vw5A-1wytA:
undetectable
5vw5A-1wytA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE


(Salmonella
enterica)
PF04223
(CitF)
4 GLY A 174
CYH A 181
GLY A 182
LEU A 333
None
0.62A 5vw5A-1xr4A:
undetectable
5vw5A-1xr4A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b5o FERREDOXIN--NADP
REDUCTASE


(Synechococcus
sp. PCC 7002)
PF00175
(NAD_binding_1)
7 SER A 182
THR A 260
GLY A 261
CYH A 360
GLY A 361
LEU A 362
GLU A 400
FAD  A 403 (-3.1A)
FAD  A 403 (-3.2A)
None
None
None
None
FAD  A 403 (-3.8A)
0.52A 5vw5A-2b5oA:
40.7
5vw5A-2b5oA:
38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE


(Saccharomyces
cerevisiae)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 SER A 442
THR A 543
GLY A 544
CYH A 644
GLY A 645
FAD  A 750 (-3.1A)
NAP  A 753 (-3.7A)
None
None
None
0.36A 5vw5A-2bf4A:
27.5
5vw5A-2bf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A  58
CYH A 369
GLY A 368
ALA A 364
None
None
None
FAD  A1524 (-3.6A)
0.74A 5vw5A-2c3dA:
undetectable
5vw5A-2c3dA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 GLY A 371
GLY A 403
LEU A 406
GLU A 401
None
None
None
ZN  A 700 (-2.1A)
0.67A 5vw5A-2e0pA:
undetectable
5vw5A-2e0pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 THR A 369
GLY A 370
GLY A 364
ALA A 299
None
0.53A 5vw5A-2e0pA:
undetectable
5vw5A-2e0pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eix NADH-CYTOCHROME B5
REDUCTASE


(Physarum
polycephalum)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 THR A 164
GLY A 165
CYH A 255
GLY A 256
FAD  A1301 (-3.3A)
None
FAD  A1301 ( 4.1A)
None
0.44A 5vw5A-2eixA:
20.0
5vw5A-2eixA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A  20
GLY A 329
LEU A 330
ALA A 333
FAD  A8482 (-3.5A)
None
None
None
0.75A 5vw5A-2eq9A:
2.2
5vw5A-2eq9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis)
PF00496
(SBP_bac_5)
4 GLY A 183
GLY A 187
LEU A 188
ALA A 191
None
0.75A 5vw5A-2grvA:
undetectable
5vw5A-2grvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
4 GLY A 180
CYH A 187
GLY A 188
LEU A 339
None
0.64A 5vw5A-2hj0A:
undetectable
5vw5A-2hj0A:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE


(Plasmodium
falciparum)
PF00175
(NAD_binding_1)
4 SER A 104
CYH A 284
GLY A 285
GLU A 314
FAD  A 415 (-3.8A)
None
None
FAD  A 415 ( 3.8A)
0.71A 5vw5A-2ok8A:
30.1
5vw5A-2ok8A:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE


(Plasmodium
falciparum)
PF00175
(NAD_binding_1)
5 SER A 104
THR A 180
GLY A 181
CYH A 284
GLY A 285
FAD  A 415 (-3.8A)
FAD  A 415 (-3.3A)
None
None
None
0.42A 5vw5A-2ok8A:
30.1
5vw5A-2ok8A:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565


(Streptococcus
pneumoniae)
PF01933
(UPF0052)
4 GLY A 208
LEU A 211
GLU A 206
ALA A 210
MLY  A 205 ( 3.6A)
None
None
None
0.75A 5vw5A-2q7xA:
undetectable
5vw5A-2q7xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLY A 118
CYH A 219
GLY A 220
GLU A 252
None
None
None
FAD  A 400 ( 3.9A)
0.63A 5vw5A-2qdxA:
20.8
5vw5A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
FAD  A 400 (-3.7A)
FAD  A 400 (-3.2A)
None
None
FAD  A 400 ( 3.9A)
0.52A 5vw5A-2qdxA:
20.8
5vw5A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC


(Escherichia
coli)
PF01032
(FecCD)
4 GLY A 124
GLY A 100
LEU A 101
ALA A 104
None
0.63A 5vw5A-2qi9A:
undetectable
5vw5A-2qi9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 SER A 454
GLY A 548
CYH A 650
GLY A 651
FAD  A 700 (-3.2A)
None
None
None
0.56A 5vw5A-2qtzA:
28.2
5vw5A-2qtzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 THR A 547
GLY A 548
CYH A 650
GLY A 651
FAD  A 700 ( 4.6A)
None
None
None
0.29A 5vw5A-2qtzA:
28.2
5vw5A-2qtzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3


(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
4 GLY A  38
GLY A 111
LEU A 114
ALA A 113
None
0.70A 5vw5A-2qvbA:
undetectable
5vw5A-2qvbA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rc5 FERREDOXIN-NADP
REDUCTASE


(Leptospira
interrogans)
PF00175
(NAD_binding_1)
6 SER A  97
THR A 175
GLY A 176
CYH A 272
GLY A 273
GLU A 312
FAD  A 415 (-3.1A)
FAD  A 415 (-3.4A)
None
None
None
FAD  A 415 (-3.8A)
0.65A 5vw5A-2rc5A:
34.9
5vw5A-2rc5A:
37.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA


(Homo sapiens)
PF00620
(RhoGAP)
4 THR A 138
GLY A 139
LEU A 170
ALA A 168
None
0.72A 5vw5A-2xs6A:
undetectable
5vw5A-2xs6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3


(Homo sapiens)
PF00638
(Ran_BP1)
4 THR A 325
GLY A 326
LEU A 371
ALA A 364
None
0.73A 5vw5A-2y8fA:
undetectable
5vw5A-2y8fA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA


(Arabidopsis
thaliana)
PF01764
(Lipase_3)
4 GLY A 155
GLY A 238
LEU A 241
ALA A 240
None
0.62A 5vw5A-2yijA:
undetectable
5vw5A-2yijA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiz DODECIN

(Mycobacterium
tuberculosis)
PF07311
(Dodecin)
4 GLY A  12
GLY A  25
LEU A  26
ALA A  29
None
0.65A 5vw5A-2yizA:
undetectable
5vw5A-2yizA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE


(Geobacillus
kaustophilus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 GLY A 405
LEU A 406
GLU A 341
ALA A 333
None
0.66A 5vw5A-2ys6A:
undetectable
5vw5A-2ys6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE


(Bradyrhizobium
japonicum)
PF00561
(Abhydrolase_1)
4 GLY A  37
GLY A 105
LEU A 108
ALA A 107
None
0.75A 5vw5A-3a2lA:
undetectable
5vw5A-3a2lA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Escherichia
coli)
PF00106
(adh_short)
5 THR A   6
GLY A   7
GLY A  31
LEU A  53
ALA A  51
None
0.92A 5vw5A-3asuA:
undetectable
5vw5A-3asuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE


(Saccharomyces
cerevisiae;
Homo sapiens)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 SER A 437
THR A 515
GLY A 516
CYH A 609
GLY A 610
FAD  A 750 (-3.7A)
FAD  A 750 ( 3.9A)
None
None
None
0.56A 5vw5A-3fjoA:
29.4
5vw5A-3fjoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE


(Salmonella
enterica)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 SER A  53
THR A 116
CYH A 212
GLU A 245
FAD  A 301 (-3.6A)
FAD  A 301 (-3.4A)
None
FAD  A 301 ( 4.3A)
0.73A 5vw5A-3fpkA:
21.9
5vw5A-3fpkA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum)
PF01764
(Lipase_3)
4 GLY A  64
GLY A 134
LEU A 137
ALA A 136
None
0.71A 5vw5A-3g7nA:
undetectable
5vw5A-3g7nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 GLY X 264
GLY X 261
LEU X 288
ALA X 259
None
0.73A 5vw5A-3h1vX:
undetectable
5vw5A-3h1vX:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE


(Methylococcus
capsulatus)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 GLY A 149
LEU A 148
GLU A 177
ALA A 175
None
0.73A 5vw5A-3i83A:
undetectable
5vw5A-3i83A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 THR A  69
GLY A  68
GLY A  65
LEU A  61
None
0.74A 5vw5A-3m5hA:
undetectable
5vw5A-3m5hA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC


(Pisum sativum)
PF00175
(NAD_binding_1)
7 SER A  90
THR A 166
GLY A 167
CYH A 266
GLY A 267
LEU A 268
GLU A 306
FAD  A 999 (-3.4A)
FAD  A 999 (-3.3A)
None
None
None
None
FAD  A 999 (-3.6A)
0.71A 5vw5A-3mhpA:
41.7
5vw5A-3mhpA:
46.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus)
PF02126
(PTE)
5 THR A 137
GLY A 138
GLY A 133
GLU A   6
ALA A 141
None
1.16A 5vw5A-3orwA:
undetectable
5vw5A-3orwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd5 PUTATIVE
RIBOSE-5-PHOSPHATE
ISOMERASE


(Coccidioides
immitis)
PF02502
(LacAB_rpiB)
4 GLY A 118
GLY A  79
LEU A  80
ALA A  83
CSO  A  76 ( 3.4A)
CSO  A  76 ( 3.4A)
None
None
0.72A 5vw5A-3qd5A:
undetectable
5vw5A-3qd5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE


(Homo sapiens)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
5 SER A 460
THR A 538
GLY A 539
CYH A 632
GLY A 633
FAD  A 752 (-3.5A)
NAP  A 753 (-3.0A)
None
None
None
0.42A 5vw5A-3qfsA:
29.7
5vw5A-3qfsA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdn ANTIFREEZE PROTEIN
RD3 TYPE III


(Lycodichthys
dearborni)
no annotation 4 GLY A  66
GLY A  71
LEU A  72
GLU A  64
None
0.75A 5vw5A-3rdnA:
undetectable
5vw5A-3rdnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L


(Escherichia
coli)
no annotation 4 GLY L 284
GLY L 324
LEU L 323
ALA L 327
None
0.73A 5vw5A-3rkoL:
undetectable
5vw5A-3rkoL:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 192
GLY A 191
GLY A 229
ALA A 227
None
0.67A 5vw5A-3uk1A:
undetectable
5vw5A-3uk1A:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Zea mays)
PF00175
(NAD_binding_1)
6 SER A  96
THR A 172
GLY A 173
CYH A 272
GLY A 273
GLU A 312
FAD  A 401 (-3.2A)
FAD  A 401 (-3.3A)
None
None
None
FAD  A 401 (-3.8A)
0.47A 5vw5A-3vo2A:
41.3
5vw5A-3vo2A:
49.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2i NADH-CYTOCHROME B5
REDUCTASE 3


(Sus scrofa)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 THR A 153
GLY A 154
CYH A 245
GLY A 246
FAD  A 301 ( 3.5A)
NAD  A 302 (-3.9A)
NAD  A 302 (-3.4A)
NAD  A 302 (-3.8A)
0.55A 5vw5A-3w2iA:
20.6
5vw5A-3w2iA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w5v FERREDOXIN

(Zea mays)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  96
CYH A 272
GLY A 273
LEU A 274
GLU A 312
FAD  A 401 (-3.0A)
None
None
None
FAD  A 401 ( 3.9A)
0.71A 5vw5A-3w5vA:
40.4
5vw5A-3w5vA:
48.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w5v FERREDOXIN

(Zea mays)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
6 SER A  96
THR A 172
GLY A 173
CYH A 272
GLY A 273
LEU A 274
FAD  A 401 (-3.0A)
FAD  A 401 (-2.9A)
None
None
None
None
0.66A 5vw5A-3w5vA:
40.4
5vw5A-3w5vA:
48.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE


(Xanthomonas
citri)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  55
THR A 118
GLY A 119
CYH A 220
GLU A 253
FAD  A1260 (-3.8A)
FAD  A1260 (-3.3A)
None
None
FAD  A1260 ( 4.2A)
0.49A 5vw5A-4b4dA:
20.9
5vw5A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE


(Xanthomonas
citri)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 THR A 118
GLY A 119
CYH A 220
GLY A 221
GLU A 253
FAD  A1260 (-3.3A)
None
None
None
FAD  A1260 ( 4.2A)
0.66A 5vw5A-4b4dA:
20.9
5vw5A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7


(Zobellia
galactanivorans)
PF08787
(Alginate_lyase2)
4 SER A 132
THR A 315
GLY A 316
GLY A 304
None
0.70A 5vw5A-4be3A:
undetectable
5vw5A-4be3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
4 SER A 831
THR A 906
GLY A 907
GLY A1001
FAD  A1101 (-3.3A)
FAD  A1101 (-3.9A)
None
None
0.44A 5vw5A-4dqkA:
29.0
5vw5A-4dqkA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eh1 FLAVOHEMOPROTEIN

(Vibrio cholerae)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLY A 126
CYH A 208
GLY A 209
GLU A 234
None
None
None
FAD  A 301 (-3.6A)
0.48A 5vw5A-4eh1A:
22.8
5vw5A-4eh1A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk8 FERREDOXIN--NADP
REDUCTASE


(Burkholderia
thailandensis)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  69
THR A 132
GLY A 133
CYH A 234
GLU A 266
FAD  A 301 (-3.8A)
FAD  A 301 (-3.0A)
None
None
FAD  A 301 ( 3.9A)
0.64A 5vw5A-4fk8A:
18.1
5vw5A-4fk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwb HALOALKANE
DEHALOGENASE


(Rhodococcus
rhodochrous)
PF00561
(Abhydrolase_1)
4 GLY A  40
GLY A 108
LEU A 111
ALA A 110
None
0.71A 5vw5A-4fwbA:
undetectable
5vw5A-4fwbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLY A 283
CYH A 362
GLY A 363
GLU A 388
None
None
None
FAD  A 402 (-3.6A)
0.56A 5vw5A-4g1bA:
21.5
5vw5A-4g1bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 SER A 210
GLY A 283
CYH A 362
GLU A 388
FAD  A 402 (-3.6A)
None
None
FAD  A 402 (-3.6A)
0.74A 5vw5A-4g1bA:
21.5
5vw5A-4g1bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE


(Rhodobacter
capsulatus)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  67
THR A 130
GLY A 131
CYH A 232
GLY A 233
FAD  A 301 (-3.1A)
FAD  A 301 (-2.8A)
None
None
None
0.61A 5vw5A-4k1xA:
20.7
5vw5A-4k1xA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE


(Xanthomonas
oryzae)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 GLY A 134
CYH A 295
GLY A 294
ALA A 292
None
0.64A 5vw5A-4l1kA:
undetectable
5vw5A-4l1kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE


(Lactobacillus
casei)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 THR A 323
GLY A 322
GLU A 317
ALA A 316
None
0.72A 5vw5A-4n54A:
undetectable
5vw5A-4n54A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 SER A 492
GLY A 513
GLY A 516
ALA A 518
None
0.71A 5vw5A-4qq1A:
undetectable
5vw5A-4qq1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE


(Sphingobium
japonicum)
PF00561
(Abhydrolase_1)
4 GLY A  37
GLY A 110
LEU A 113
ALA A 112
None
0.74A 5vw5A-4wdrA:
undetectable
5vw5A-4wdrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT


(Pseudomonas
mendocina)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 SER A 149
GLY A 210
CYH A 296
GLY A 297
FAD  A 402 (-3.0A)
None
None
None
0.55A 5vw5A-4wqmA:
22.6
5vw5A-4wqmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 THR A  15
GLY A  14
GLY A  88
ALA A  82
FAD  A 601 (-3.2A)
FAD  A 601 (-3.4A)
FAD  A 601 (-3.0A)
FAD  A 601 ( 4.8A)
0.70A 5vw5A-4ynuA:
2.8
5vw5A-4ynuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqu CDII TOXIN

(Salmonella
enterica)
PF07262
(CdiI)
4 GLY B  51
GLY B 165
LEU B 168
GLU B 163
None
0.74A 5vw5A-4zquB:
undetectable
5vw5A-4zquB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE


(Lactobacillus
plantarum)
PF00291
(PALP)
4 THR A  73
GLY A  76
GLY A  46
LEU A  49
SO4  A 404 (-3.7A)
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
None
0.68A 5vw5A-5b1hA:
undetectable
5vw5A-5b1hA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus)
no annotation 4 THR A 413
GLY A 412
LEU A 374
ALA A 370
None
0.71A 5vw5A-5dn7A:
undetectable
5vw5A-5dn7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2


(Arabidopsis
thaliana)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 SER A 492
THR A 570
GLY A 571
CYH A 664
GLY A 665
FAD  A 802 (-3.3A)
FAD  A 802 (-3.9A)
None
None
None
0.45A 5vw5A-5gxuA:
30.1
5vw5A-5gxuA:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h5j FERREDOXIN--NADP
REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
5 SER A  95
CYH A 275
GLY A 276
LEU A 277
GLU A 315
FAD  A 401 (-3.5A)
None
None
None
FAD  A 401 (-3.5A)
0.72A 5vw5A-5h5jA:
49.6
5vw5A-5h5jA:
97.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h5j FERREDOXIN--NADP
REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
6 SER A  95
THR A 176
GLY A 177
CYH A 275
GLY A 276
LEU A 277
FAD  A 401 (-3.5A)
FAD  A 401 (-3.3A)
None
None
None
None
0.15A 5vw5A-5h5jA:
49.6
5vw5A-5h5jA:
97.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN


(Stenotrophomonas
maltophilia)
PF12849
(PBP_like_2)
4 THR A  37
GLY A  38
GLY A   8
ALA A  31
None
0.67A 5vw5A-5j1dA:
undetectable
5vw5A-5j1dA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE


(Amycolatopsis
methanolica)
no annotation 4 SER A 148
GLY A 216
CYH A 302
GLY A 303
FAD  A 401 (-3.2A)
None
None
None
0.47A 5vw5A-5ogxA:
23.4
5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE


(Amycolatopsis
methanolica)
no annotation 4 SER A 148
THR A 215
CYH A 302
GLU A 328
FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
FAD  A 401 ( 4.0A)
0.70A 5vw5A-5ogxA:
23.4
5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE


(Amycolatopsis
methanolica)
no annotation 4 SER A 148
THR A 215
GLY A 216
CYH A 302
FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
None
0.41A 5vw5A-5ogxA:
23.4
5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB


(Escherichia
coli)
no annotation 4 GLY B 144
GLY B 184
LEU B 185
ALA B 188
None
0.68A 5vw5A-5sv0B:
undetectable
5vw5A-5sv0B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t96 HE PROTEIN

(Salmon isavirus)
PF06215
(ISAV_HA)
4 THR A 217
GLY A 120
GLY A 116
LEU A 115
None
0.69A 5vw5A-5t96A:
undetectable
5vw5A-5t96A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE


(Neisseria
gonorrhoeae)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
FAD  A 303 (-3.8A)
FAD  A 303 (-3.1A)
None
None
FAD  A 303 ( 4.0A)
0.58A 5vw5A-5thxA:
20.8
5vw5A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE


(Neisseria
gonorrhoeae)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 THR A 117
GLY A 118
CYH A 219
GLY A 220
GLU A 252
FAD  A 303 (-3.1A)
None
None
None
FAD  A 303 ( 4.0A)
0.68A 5vw5A-5thxA:
20.8
5vw5A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE


(Neisseria
gonorrhoeae)
PF00175
(NAD_binding_1)
4 GLY A 131
CYH A 232
GLY A 233
GLU A 264
None
None
None
FAD  A 301 ( 4.6A)
0.65A 5vw5A-5tr9A:
21.5
5vw5A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE


(Neisseria
gonorrhoeae)
PF00175
(NAD_binding_1)
4 SER A  67
GLY A 131
CYH A 232
GLU A 264
FAD  A 301 (-3.9A)
None
None
FAD  A 301 ( 4.6A)
0.66A 5vw5A-5tr9A:
21.5
5vw5A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Homo sapiens)
PF07034
(ORC3_N)
4 SER A  80
CYH A 272
GLU A 274
ALA A 103
None
0.74A 5vw5A-5uj8A:
undetectable
5vw5A-5uj8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE


(Mycobacteroides
abscessus)
PF00561
(Abhydrolase_1)
4 SER A  67
THR A 112
GLY A 111
ALA A  21
None
None
GOL  A 407 (-3.5A)
None
0.66A 5vw5A-5w8pA:
undetectable
5vw5A-5w8pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S9,
CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 4 GLY i  74
GLY i 149
LEU i 148
ALA i 145
None
0.76A 5vw5A-5x8ri:
undetectable
5vw5A-5x8ri:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yly NITRATE REDUCTASE

(Ulva prolifera)
no annotation 4 THR A 743
GLY A 744
CYH A 835
GLY A 836
FAD  A1001 (-3.4A)
None
FAD  A1001 ( 4.5A)
None
0.45A 5vw5A-5ylyA:
19.8
5vw5A-5ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-)
no annotation 4 THR A  45
GLY A  44
LEU A 294
ALA A 297
None
0.74A 5vw5A-5zovA:
undetectable
5vw5A-5zovA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA


(Acinetobacter
baumannii)
no annotation 4 THR A 130
GLY A 129
GLY A 224
ALA A 198
None
0.67A 5vw5A-6ap4A:
undetectable
5vw5A-6ap4A:
undetectable