SIMILAR PATTERNS OF AMINO ACIDS FOR 5VW3_A_ACTA404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkp PYST1

(Homo sapiens) 		PF00782
(DSPc) 		4 GLN A 270
LEU A 268
ASN A 267
GLN A 339
 None
 1.24A 5vw3A-1mkpA:
2.5		 5vw3A-1mkpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3q THAUMATIN-LIKE
PROTEIN

(Musa acuminata) 		PF00314
(Thaumatin) 		4 GLN A  24
LEU A  25
ASN A  26
GLN A  29
 None
 0.83A 5vw3A-1z3qA:
0.0		 5vw3A-1z3qA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLN A 831
LEU A 930
ASN A 835
GLN A 837
 None
 1.50A 5vw3A-2jgdA:
2.1		 5vw3A-2jgdA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		4 GLN A 143
LEU A 141
ASN A 144
GLN A 146
 None
 1.05A 5vw3A-2lknA:
0.0		 5vw3A-2lknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 GLN A 246
LEU A 310
ASN A 307
GLN A 306
 None
 1.43A 5vw3A-4fgvA:
0.5		 5vw3A-4fgvA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		4 GLN A 152
LEU A 146
ASN A 147
GLN A 143
 None
 1.25A 5vw3A-4p58A:
2.4		 5vw3A-4p58A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2e DUAL SPECIFICITY
PROTEIN PHOSPHATASE
7

(Homo sapiens) 		PF00782
(DSPc) 		4 GLN A 209
LEU A 207
ASN A 206
GLN A 278
 None
 1.31A 5vw3A-4y2eA:
0.0		 5vw3A-4y2eA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 459
LEU A 460
ASN A 530
GLN A 534
 None
 1.04A 5vw3A-4yffA:
0.0		 5vw3A-4yffA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		4 GLN A 305
LEU A 306
ASN A 309
GLN A 311
 None
 0.28A 5vw3A-5h5jA:
49.4		 5vw3A-5h5jA:
97.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqy TYROSINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		no annotation 4 GLN A 200
LEU A 204
ASN A 203
GLN A 182
 None
None
None
EDO  A 501 (-3.4A)
 1.44A 5vw3A-6bqyA:
2.6		 5vw3A-6bqyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f PROTEASOME-INTERACTI
NG PROTEIN CIC1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN K 233
LEU K 100
ASN K 101
GLN K 269
 None
None
U  6  19 ( 4.9A)
None
 1.32A 5vw3A-6c0fK:
undetectable		 5vw3A-6c0fK:
undetectable