SIMILAR PATTERNS OF AMINO ACIDS FOR 5VVA_A_H4BA502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzv | GLUCOSE-6-PHOSPHATEISOMERASE (Sus scrofa) |
PF00342(PGI) | 4 | VAL A 63ARG A 35TRP A 325PHE A 39 | None | 1.30A | 5vvaA-1gzvA:0.05vvaB-1gzvA:0.0 | 5vvaA-1gzvA:23.065vvaB-1gzvA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | ARG A 340TRP A 155PHE A 156GLU A 154 | None | 1.38A | 5vvaA-1l5jA:0.05vvaB-1l5jA:0.0 | 5vvaA-1l5jA:20.215vvaB-1l5jA:20.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 4 | TRP A 306TRP A 676PHE A 691GLU A 694 | None | 0.30A | 5vvaA-1lzxA:59.25vvaB-1lzxA:59.0 | 5vvaA-1lzxA:62.755vvaB-1lzxA:62.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1m9q | ENDOTHELIALNITRIC-OXIDESYNTHASE (Homo sapiens) |
PF02898(NO_synthase) | 4 | TRP A 74TRP A 445PHE A 460GLU A 463 | NoneMPD A 603 (-4.6A)MPD A 603 (-4.2A)None | 0.23A | 5vvaA-1m9qA:32.35vvaB-1m9qA:62.0 | 5vvaA-1m9qA:95.175vvaB-1m9qA:95.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qw5 | NITRIC OXIDESYNTHASE, INDUCIBLE (Mus musculus) |
PF02898(NO_synthase) | 4 | TRP A 84TRP A 455PHE A 470GLU A 473 | None | 0.34A | 5vvaA-1qw5A:56.85vvaB-1qw5A:56.6 | 5vvaA-1qw5A:57.795vvaB-1qw5A:57.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1udd | TRANSCRIPTIONALREGULATOR (Pyrococcushorikoshii) |
PF03070(TENA_THI-4) | 4 | TRP A 208TRP A 17PHE A 21GLU A 204 | None | 1.48A | 5vvaA-1uddA:0.05vvaB-1uddA:0.0 | 5vvaA-1uddA:18.205vvaB-1uddA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4j | SULFATASE MODIFYINGFACTOR 2 (Homo sapiens) |
PF03781(FGE-sulfatase) | 4 | TRP A 235TRP A 169TRP A 237GLU A 236 | NoneNoneNone CA A1004 (-3.6A) | 1.11A | 5vvaA-1y4jA:0.05vvaB-1y4jA:0.0 | 5vvaA-1y4jA:20.315vvaB-1y4jA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d52 | PENTAKETIDE CHROMONESYNTHASE (Aloearborescens) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 4 | VAL A 52ARG A 81PHE A 83GLU A 87 | None | 1.31A | 5vvaA-2d52A:0.65vvaB-2d52A:0.2 | 5vvaA-2d52A:21.895vvaB-2d52A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d9j | REGULATOR OFG-PROTEIN SIGNALLING7 (Homo sapiens) |
PF00615(RGS) | 4 | VAL A 27TRP A 15PHE A 123GLU A 30 | None | 1.36A | 5vvaA-2d9jA:0.05vvaB-2d9jA:0.0 | 5vvaA-2d9jA:17.605vvaB-2d9jA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e9f | ARGININOSUCCINATELYASE (Thermusthermophilus) |
PF00206(Lyase_1)PF14698(ASL_C2) | 4 | ARG A 123TRP A 37PHE A 221GLU A 218 | None | 1.38A | 5vvaA-2e9fA:undetectable5vvaB-2e9fA:undetectable | 5vvaA-2e9fA:22.735vvaB-2e9fA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi8 | SULFATASE-MODIFYINGFACTOR 1 (Homo sapiens) |
PF03781(FGE-sulfatase) | 4 | TRP X 299TRP X 231TRP X 301GLU X 300 | BR X1001 ( 4.4A)NoneNone CA X1016 (-3.3A) | 1.24A | 5vvaA-2hi8X:undetectable5vvaB-2hi8X:undetectable | 5vvaA-2hi8X:21.275vvaB-2hi8X:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2in5 | HYPOTHETICALLIPOPROTEIN YMCC (Escherichiacoli) |
PF11102(YjbF) | 4 | VAL A 154ARG A 75TRP A 163PHE A 167 | None | 1.24A | 5vvaA-2in5A:undetectable5vvaB-2in5A:undetectable | 5vvaA-2in5A:16.705vvaB-2in5A:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inc | TOLUENE, O-XYLENEMONOOXYGENASEOXYGENASE SUBUNIT (Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox)PF04945(YHS) | 4 | VAL A 23ARG A 116PHE A 29GLU A 27 | None | 1.28A | 5vvaA-2incA:undetectable5vvaB-2incA:undetectable | 5vvaA-2incA:20.595vvaB-2incA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q17 | FORMYLGLYCINEGENERATING ENZYME (Streptomycescoelicolor) |
PF03781(FGE-sulfatase) | 4 | TRP A 234TRP A 166TRP A 236GLU A 235 | None | 1.25A | 5vvaA-2q17A:undetectable5vvaB-2q17A:undetectable | 5vvaA-2q17A:23.705vvaB-2q17A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 369ARG A 320PHE A 381GLU A 368 | None | 1.29A | 5vvaA-2qluA:undetectable5vvaB-2qluA:undetectable | 5vvaA-2qluA:22.375vvaB-2qluA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqo | NEUROPILIN-2 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 4 | ARG A 405TRP A 372PHE A 406GLU A 370 | None | 1.47A | 5vvaA-2qqoA:undetectable5vvaB-2qqoA:undetectable | 5vvaA-2qqoA:23.535vvaB-2qqoA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | VAL A 588TRP A 630TRP A 635PHE A 638 | None | 1.12A | 5vvaA-2rdyA:undetectable5vvaB-2rdyA:undetectable | 5vvaA-2rdyA:21.535vvaB-2rdyA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xpi | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT CUT9ANAPHASE-PROMOTINGCOMPLEX SUBUNIT HCN1HCN1/CDC26,20SCYCLOSOME/APCCOMPLEX PROTEINHCN1, CHAPERONE-LIKEPROTEIN HCN1, HIGHCOPY SUPPRESSOR OFCUT9 PROTEIN 1 (Schizosaccharomycespombe) |
PF10471(ANAPC_CDC26)PF12895(ANAPC3)PF13181(TPR_8)PF13424(TPR_12) | 4 | VAL A 505ARG B 4TRP A 515PHE A 321 | None | 1.49A | 5vvaA-2xpiA:undetectable5vvaB-2xpiA:undetectable | 5vvaA-2xpiA:21.735vvaB-2xpiA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2f | DNA POLYMERASE (Pyrococcusfuriosus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | VAL A 537TRP A 526PHE A 564GLU A 530 | None | 1.32A | 5vvaA-3a2fA:undetectable5vvaB-3a2fA:undetectable | 5vvaA-3a2fA:20.215vvaB-3a2fA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckb | SUSD (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB) | 4 | ARG A 437TRP A 485PHE A 489GLU A 484 | None | 0.94A | 5vvaA-3ckbA:undetectable5vvaB-3ckbA:undetectable | 5vvaA-3ckbA:21.885vvaB-3ckbA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d4e | PUTATIVEBETA-LACTAMASEINHIBITOR PROTEIN (Streptococcusmutans) |
PF12978(DUF3862) | 4 | VAL A 151ARG A 52TRP A 175PHE A 127 | None | 1.26A | 5vvaA-3d4eA:undetectable5vvaB-3d4eA:undetectable | 5vvaA-3d4eA:15.515vvaB-3d4eA:15.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e7g | NITRIC OXIDESYNTHASE, INDUCIBLE (Homo sapiens) |
PF02898(NO_synthase) | 4 | TRP A 90TRP A 461PHE A 476GLU A 479 | None | 0.27A | 5vvaA-3e7gA:55.25vvaB-3e7gA:55.1 | 5vvaA-3e7gA:58.035vvaB-3e7gA:58.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1n | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
PF00632(HECT) | 4 | VAL A4019TRP A4065PHE A4109GLU A4033 | None | 1.34A | 5vvaA-3g1nA:0.15vvaB-3g1nA:undetectable | 5vvaA-3g1nA:21.685vvaB-3g1nA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k25 | SLR1438 PROTEIN (Synechocystissp. PCC 6803) |
PF01263(Aldose_epim) | 4 | VAL A 241TRP A 256PHE A 233GLU A 254 | None | 0.97A | 5vvaA-3k25A:undetectable5vvaB-3k25A:undetectable | 5vvaA-3k25A:21.715vvaB-3k25A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lcc | PUTATIVE METHYLCHLORIDE TRANSFERASE (Arabidopsisthaliana) |
PF05724(TPMT) | 4 | VAL A 120ARG A 69PHE A 133GLU A 122 | None | 1.33A | 5vvaA-3lccA:undetectable5vvaB-3lccA:undetectable | 5vvaA-3lccA:18.045vvaB-3lccA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 370ARG A 321PHE A 382GLU A 369 | None | 1.40A | 5vvaA-3q4tA:undetectable5vvaB-3q4tA:undetectable | 5vvaA-3q4tA:23.325vvaB-3q4tA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vv4 | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN (Thermosynechococcuselongatus) |
PF01590(GAF) | 4 | VAL A 72TRP A 71PHE A 67GLU A 73 | NonePVG A 201 (-3.6A)NoneNone | 1.05A | 5vvaA-3vv4A:undetectable5vvaB-3vv4A:undetectable | 5vvaA-3vv4A:19.965vvaB-3vv4A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gi2 | CROTONYL-COACARBOXYLASE/REDUCTASE (Methylobacteriumextorquens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | VAL A 420TRP A 183TRP A 9GLU A 421 | None | 1.48A | 5vvaA-4gi2A:undetectable5vvaB-4gi2A:undetectable | 5vvaA-4gi2A:21.445vvaB-4gi2A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 4 | ARG A 239TRP A 58TRP A 143PHE A 158 | None | 1.41A | 5vvaA-4j3qA:undetectable5vvaB-4j3qA:undetectable | 5vvaA-4j3qA:21.695vvaB-4j3qA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3v | POLYKETIDE SYNTHASEPKSR (Bacillussubtilis) |
PF14765(PS-DH) | 4 | VAL A 19TRP A 140PHE A 144GLU A 139 | None | 1.04A | 5vvaA-4u3vA:undetectable5vvaB-4u3vA:undetectable | 5vvaA-4u3vA:19.475vvaB-4u3vA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8d | SULFOXIDE SYNTHASEEGTB (Mycolicibacteriumthermoresistibile) |
PF03781(FGE-sulfatase)PF12867(DinB_2) | 4 | TRP A 359TRP A 299TRP A 361GLU A 360 | NoneNoneNone CA A 517 (-3.9A) | 1.10A | 5vvaA-4x8dA:undetectable5vvaB-4x8dA:undetectable | 5vvaA-4x8dA:22.895vvaB-4x8dA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bv9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Bacilluspumilus) |
PF02011(Glyco_hydro_48) | 4 | ARG A 644TRP A 185PHE A 640GLU A 186 | NoneNoneNone CA A 801 (-2.3A) | 1.31A | 5vvaA-5bv9A:undetectable5vvaB-5bv9A:undetectable | 5vvaA-5bv9A:21.375vvaB-5bv9A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cow | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditisremanei) |
no annotation | 4 | VAL A 409TRP A 407PHE A 404GLU A 410 | None | 1.33A | 5vvaA-5cowA:undetectable5vvaB-5cowA:undetectable | 5vvaA-5cowA:20.905vvaB-5cowA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jse | PHIAB6 TAILSPIKE (unidentifiedphage) |
PF12708(Pectate_lyase_3) | 4 | VAL A 341TRP A 323TRP A 347PHE A 290 | None | 1.11A | 5vvaA-5jseA:undetectable5vvaB-5jseA:undetectable | 5vvaA-5jseA:19.315vvaB-5jseA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1h | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT B (Homo sapiens) |
PF00076(RRM_1)PF08662(eIF2A) | 4 | VAL B 570TRP B 607TRP B 562GLU B 561 | None | 1.32A | 5vvaA-5k1hB:undetectable5vvaB-5k1hB:undetectable | 5vvaA-5k1hB:22.415vvaB-5k1hB:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 4 | VAL A 329TRP A 324TRP A 251GLU A 254 | NoneNoneFAD A 901 (-3.9A)None | 1.31A | 5vvaA-5l46A:undetectable5vvaB-5l46A:undetectable | 5vvaA-5l46A:20.705vvaB-5l46A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp8 | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
no annotation | 4 | VAL B4019TRP B4065PHE B4109GLU B4033 | None | 1.26A | 5vvaA-5lp8B:undetectable5vvaB-5lp8B:undetectable | 5vvaA-5lp8B:21.315vvaB-5lp8B:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | ARG A 225TRP A 414PHE A 411GLU A 413 | None | 1.09A | 5vvaA-5m8tA:undetectable5vvaB-5m8tA:undetectable | 5vvaA-5m8tA:21.755vvaB-5m8tA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyy | NON-SPECIFICSERINE/THREONINEPROTEIN KINASE (Thermomonosporacurvata) |
PF03781(FGE-sulfatase) | 4 | TRP A 228TRP A 160TRP A 230GLU A 229 | ACT A 405 (-3.9A)NoneNone CA A 407 (-3.9A) | 1.10A | 5vvaA-5nyyA:undetectable5vvaB-5nyyA:undetectable | 5vvaA-5nyyA:21.275vvaB-5nyyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyo | THIOL:DISULFIDEINTERCHANGE PROTEIN (Burkholderiapseudomallei) |
no annotation | 4 | VAL A 57TRP A 56PHE A 49GLU A 54 | None | 0.97A | 5vvaA-5vyoA:undetectable5vvaB-5vyoA:undetectable | 5vvaA-5vyoA:9.715vvaB-5vyoA:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S5-B,PUTATIVEUNCHARACTERIZEDPROTEIN (Trichomonasvaginalis) |
PF00177(Ribosomal_S7)PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 4 | VAL c 16ARG F 49PHE F 50GLU c 51 | None C 21421 ( 4.4A)NoneNone | 0.93A | 5vvaA-5xyic:undetectable5vvaB-5xyic:undetectable | 5vvaA-5xyic:12.845vvaB-5xyic:12.84 |