SIMILAR PATTERNS OF AMINO ACIDS FOR 5VVA_A_H4BA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE


(Sus scrofa)
PF00342
(PGI)
4 VAL A  63
ARG A  35
TRP A 325
PHE A  39
None
1.30A 5vvaA-1gzvA:
0.0
5vvaB-1gzvA:
0.0
5vvaA-1gzvA:
23.06
5vvaB-1gzvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
None
1.38A 5vvaA-1l5jA:
0.0
5vvaB-1l5jA:
0.0
5vvaA-1l5jA:
20.21
5vvaB-1l5jA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF02898
(NO_synthase)
4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
None
0.30A 5vvaA-1lzxA:
59.2
5vvaB-1lzxA:
59.0
5vvaA-1lzxA:
62.75
5vvaB-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE


(Homo sapiens)
PF02898
(NO_synthase)
4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
0.23A 5vvaA-1m9qA:
32.3
5vvaB-1m9qA:
62.0
5vvaA-1m9qA:
95.17
5vvaB-1m9qA:
95.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Mus musculus)
PF02898
(NO_synthase)
4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
None
0.34A 5vvaA-1qw5A:
56.8
5vvaB-1qw5A:
56.6
5vvaA-1qw5A:
57.79
5vvaB-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR


(Pyrococcus
horikoshii)
PF03070
(TENA_THI-4)
4 TRP A 208
TRP A  17
PHE A  21
GLU A 204
None
1.48A 5vvaA-1uddA:
0.0
5vvaB-1uddA:
0.0
5vvaA-1uddA:
18.20
5vvaB-1uddA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2


(Homo sapiens)
PF03781
(FGE-sulfatase)
4 TRP A 235
TRP A 169
TRP A 237
GLU A 236
None
None
None
CA  A1004 (-3.6A)
1.11A 5vvaA-1y4jA:
0.0
5vvaB-1y4jA:
0.0
5vvaA-1y4jA:
20.31
5vvaB-1y4jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE


(Aloe
arborescens)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 VAL A  52
ARG A  81
PHE A  83
GLU A  87
None
1.31A 5vvaA-2d52A:
0.6
5vvaB-2d52A:
0.2
5vvaA-2d52A:
21.89
5vvaB-2d52A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7


(Homo sapiens)
PF00615
(RGS)
4 VAL A  27
TRP A  15
PHE A 123
GLU A  30
None
1.36A 5vvaA-2d9jA:
0.0
5vvaB-2d9jA:
0.0
5vvaA-2d9jA:
17.60
5vvaB-2d9jA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
4 ARG A 123
TRP A  37
PHE A 221
GLU A 218
None
1.38A 5vvaA-2e9fA:
undetectable
5vvaB-2e9fA:
undetectable
5vvaA-2e9fA:
22.73
5vvaB-2e9fA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1


(Homo sapiens)
PF03781
(FGE-sulfatase)
4 TRP X 299
TRP X 231
TRP X 301
GLU X 300
BR  X1001 ( 4.4A)
None
None
CA  X1016 (-3.3A)
1.24A 5vvaA-2hi8X:
undetectable
5vvaB-2hi8X:
undetectable
5vvaA-2hi8X:
21.27
5vvaB-2hi8X:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC


(Escherichia
coli)
PF11102
(YjbF)
4 VAL A 154
ARG A  75
TRP A 163
PHE A 167
None
1.24A 5vvaA-2in5A:
undetectable
5vvaB-2in5A:
undetectable
5vvaA-2in5A:
16.70
5vvaB-2in5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
4 VAL A  23
ARG A 116
PHE A  29
GLU A  27
None
1.28A 5vvaA-2incA:
undetectable
5vvaB-2incA:
undetectable
5vvaA-2incA:
20.59
5vvaB-2incA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME


(Streptomyces
coelicolor)
PF03781
(FGE-sulfatase)
4 TRP A 234
TRP A 166
TRP A 236
GLU A 235
None
1.25A 5vvaA-2q17A:
undetectable
5vvaB-2q17A:
undetectable
5vvaA-2q17A:
23.70
5vvaB-2q17A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 369
ARG A 320
PHE A 381
GLU A 368
None
1.29A 5vvaA-2qluA:
undetectable
5vvaB-2qluA:
undetectable
5vvaA-2qluA:
22.37
5vvaB-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens)
PF00431
(CUB)
PF00754
(F5_F8_type_C)
4 ARG A 405
TRP A 372
PHE A 406
GLU A 370
None
1.47A 5vvaA-2qqoA:
undetectable
5vvaB-2qqoA:
undetectable
5vvaA-2qqoA:
23.53
5vvaB-2qqoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 VAL A 588
TRP A 630
TRP A 635
PHE A 638
None
1.12A 5vvaA-2rdyA:
undetectable
5vvaB-2rdyA:
undetectable
5vvaA-2rdyA:
21.53
5vvaB-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1


(Schizosaccharomyces
pombe)
PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12)
4 VAL A 505
ARG B   4
TRP A 515
PHE A 321
None
1.49A 5vvaA-2xpiA:
undetectable
5vvaB-2xpiA:
undetectable
5vvaA-2xpiA:
21.73
5vvaB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 VAL A 537
TRP A 526
PHE A 564
GLU A 530
None
1.32A 5vvaA-3a2fA:
undetectable
5vvaB-3a2fA:
undetectable
5vvaA-3a2fA:
20.21
5vvaB-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
4 ARG A 437
TRP A 485
PHE A 489
GLU A 484
None
0.94A 5vvaA-3ckbA:
undetectable
5vvaB-3ckbA:
undetectable
5vvaA-3ckbA:
21.88
5vvaB-3ckbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN


(Streptococcus
mutans)
PF12978
(DUF3862)
4 VAL A 151
ARG A  52
TRP A 175
PHE A 127
None
1.26A 5vvaA-3d4eA:
undetectable
5vvaB-3d4eA:
undetectable
5vvaA-3d4eA:
15.51
5vvaB-3d4eA:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
None
0.27A 5vvaA-3e7gA:
55.2
5vvaB-3e7gA:
55.1
5vvaA-3e7gA:
58.03
5vvaB-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1


(Homo sapiens)
PF00632
(HECT)
4 VAL A4019
TRP A4065
PHE A4109
GLU A4033
None
1.34A 5vvaA-3g1nA:
0.1
5vvaB-3g1nA:
undetectable
5vvaA-3g1nA:
21.68
5vvaB-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803)
PF01263
(Aldose_epim)
4 VAL A 241
TRP A 256
PHE A 233
GLU A 254
None
0.97A 5vvaA-3k25A:
undetectable
5vvaB-3k25A:
undetectable
5vvaA-3k25A:
21.71
5vvaB-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE


(Arabidopsis
thaliana)
PF05724
(TPMT)
4 VAL A 120
ARG A  69
PHE A 133
GLU A 122
None
1.33A 5vvaA-3lccA:
undetectable
5vvaB-3lccA:
undetectable
5vvaA-3lccA:
18.04
5vvaB-3lccA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 370
ARG A 321
PHE A 382
GLU A 369
None
1.40A 5vvaA-3q4tA:
undetectable
5vvaB-3q4tA:
undetectable
5vvaA-3q4tA:
23.32
5vvaB-3q4tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN


(Thermosynechococcus
elongatus)
PF01590
(GAF)
4 VAL A  72
TRP A  71
PHE A  67
GLU A  73
None
PVG  A 201 (-3.6A)
None
None
1.05A 5vvaA-3vv4A:
undetectable
5vvaB-3vv4A:
undetectable
5vvaA-3vv4A:
19.96
5vvaB-3vv4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E


(Methylobacterium
extorquens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 VAL A 420
TRP A 183
TRP A   9
GLU A 421
None
1.48A 5vvaA-4gi2A:
undetectable
5vvaB-4gi2A:
undetectable
5vvaA-4gi2A:
21.44
5vvaB-4gi2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae)
PF00264
(Tyrosinase)
4 ARG A 239
TRP A  58
TRP A 143
PHE A 158
None
1.41A 5vvaA-4j3qA:
undetectable
5vvaB-4j3qA:
undetectable
5vvaA-4j3qA:
21.69
5vvaB-4j3qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR


(Bacillus
subtilis)
PF14765
(PS-DH)
4 VAL A  19
TRP A 140
PHE A 144
GLU A 139
None
1.04A 5vvaA-4u3vA:
undetectable
5vvaB-4u3vA:
undetectable
5vvaA-4u3vA:
19.47
5vvaB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB


(Mycolicibacterium
thermoresistibile)
PF03781
(FGE-sulfatase)
PF12867
(DinB_2)
4 TRP A 359
TRP A 299
TRP A 361
GLU A 360
None
None
None
CA  A 517 (-3.9A)
1.10A 5vvaA-4x8dA:
undetectable
5vvaB-4x8dA:
undetectable
5vvaA-4x8dA:
22.89
5vvaB-4x8dA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Bacillus
pumilus)
PF02011
(Glyco_hydro_48)
4 ARG A 644
TRP A 185
PHE A 640
GLU A 186
None
None
None
CA  A 801 (-2.3A)
1.31A 5vvaA-5bv9A:
undetectable
5vvaB-5bv9A:
undetectable
5vvaA-5bv9A:
21.37
5vvaB-5bv9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN


(Caenorhabditis
remanei)
no annotation 4 VAL A 409
TRP A 407
PHE A 404
GLU A 410
None
1.33A 5vvaA-5cowA:
undetectable
5vvaB-5cowA:
undetectable
5vvaA-5cowA:
20.90
5vvaB-5cowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage)
PF12708
(Pectate_lyase_3)
4 VAL A 341
TRP A 323
TRP A 347
PHE A 290
None
1.11A 5vvaA-5jseA:
undetectable
5vvaB-5jseA:
undetectable
5vvaA-5jseA:
19.31
5vvaB-5jseA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B


(Homo sapiens)
PF00076
(RRM_1)
PF08662
(eIF2A)
4 VAL B 570
TRP B 607
TRP B 562
GLU B 561
None
1.32A 5vvaA-5k1hB:
undetectable
5vvaB-5k1hB:
undetectable
5vvaA-5k1hB:
22.41
5vvaB-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
4 VAL A 329
TRP A 324
TRP A 251
GLU A 254
None
None
FAD  A 901 (-3.9A)
None
1.31A 5vvaA-5l46A:
undetectable
5vvaB-5l46A:
undetectable
5vvaA-5l46A:
20.70
5vvaB-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1


(Homo sapiens)
no annotation 4 VAL B4019
TRP B4065
PHE B4109
GLU B4033
None
1.26A 5vvaA-5lp8B:
undetectable
5vvaB-5lp8B:
undetectable
5vvaA-5lp8B:
21.31
5vvaB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
None
1.09A 5vvaA-5m8tA:
undetectable
5vvaB-5m8tA:
undetectable
5vvaA-5m8tA:
21.75
5vvaB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE


(Thermomonospora
curvata)
PF03781
(FGE-sulfatase)
4 TRP A 228
TRP A 160
TRP A 230
GLU A 229
ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
1.10A 5vvaA-5nyyA:
undetectable
5vvaB-5nyyA:
undetectable
5vvaA-5nyyA:
21.27
5vvaB-5nyyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN


(Burkholderia
pseudomallei)
no annotation 4 VAL A  57
TRP A  56
PHE A  49
GLU A  54
None
0.97A 5vvaA-5vyoA:
undetectable
5vvaB-5vyoA:
undetectable
5vvaA-5vyoA:
9.71
5vvaB-5vyoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
UNCHARACTERIZED
PROTEIN


(Trichomonas
vaginalis)
PF00177
(Ribosomal_S7)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
4 VAL c  16
ARG F  49
PHE F  50
GLU c  51
None
C  21421 ( 4.4A)
None
None
0.93A 5vvaA-5xyic:
undetectable
5vvaB-5xyic:
undetectable
5vvaA-5xyic:
12.84
5vvaB-5xyic:
12.84