SIMILAR PATTERNS OF AMINO ACIDS FOR 5VV9_A_H4BA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 VAL A  63
ARG A  35
TRP A 325
PHE A  39
 None
 1.28A 5vv9A-1gzvA:
0.0
5vv9B-1gzvA:
0.0		 5vv9A-1gzvA:
23.06
5vv9B-1gzvA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.30A 5vv9A-1lzxA:
58.9
5vv9B-1lzxA:
58.7		 5vv9A-1lzxA:
62.75
5vv9B-1lzxA:
62.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.28A 5vv9A-1m9qA:
61.7
5vv9B-1m9qA:
61.8		 5vv9A-1m9qA:
95.17
5vv9B-1m9qA:
95.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.35A 5vv9A-1qw5A:
56.6
5vv9B-1qw5A:
56.5		 5vv9A-1qw5A:
57.79
5vv9B-1qw5A:
57.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.11A 5vv9A-1y4jA:
0.0
5vv9B-1y4jA:
0.0		 5vv9A-1y4jA:
20.31
5vv9B-1y4jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A  52
ARG A  81
PHE A  83
GLU A  87
 None
 1.36A 5vv9A-2d52A:
0.8
5vv9B-2d52A:
0.9		 5vv9A-2d52A:
21.89
5vv9B-2d52A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP X 299
TRP X 231
TRP X 301
GLU X 300
 BR  X1001 ( 4.4A)
None
None
CA  X1016 (-3.3A)
 1.25A 5vv9A-2hi8X:
0.0
5vv9B-2hi8X:
0.0		 5vv9A-2hi8X:
21.27
5vv9B-2hi8X:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC

(Escherichia
coli) 		PF11102
(YjbF) 		4 VAL A 154
ARG A  75
TRP A 163
PHE A 167
 None
 1.33A 5vv9A-2in5A:
0.0
5vv9B-2in5A:
0.0		 5vv9A-2in5A:
16.70
5vv9B-2in5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 VAL A  23
ARG A 116
PHE A  29
GLU A  27
 None
 1.28A 5vv9A-2incA:
0.0
5vv9B-2incA:
0.0		 5vv9A-2incA:
20.59
5vv9B-2incA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 369
ARG A 320
PHE A 381
GLU A 368
 None
 1.41A 5vv9A-2qluA:
undetectable
5vv9B-2qluA:
undetectable		 5vv9A-2qluA:
22.37
5vv9B-2qluA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.12A 5vv9A-2rdyA:
undetectable
5vv9B-2rdyA:
undetectable		 5vv9A-2rdyA:
21.53
5vv9B-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 VAL A  37
TRP A  22
PHE A  41
GLU A  38
 None
 1.46A 5vv9A-2rttA:
undetectable
5vv9B-2rttA:
undetectable		 5vv9A-2rttA:
15.25
5vv9B-2rttA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 5vv9A-2xpiA:
undetectable
5vv9B-2xpiA:
undetectable		 5vv9A-2xpiA:
21.73
5vv9B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF07679
(I-set) 		4 VAL A 124
ARG A  77
PHE A  78
GLU A 102
 None
 1.47A 5vv9A-2yd3A:
undetectable
5vv9B-2yd3A:
undetectable		 5vv9A-2yd3A:
19.46
5vv9B-2yd3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 537
TRP A 526
PHE A 564
GLU A 530
 None
 1.39A 5vv9A-3a2fA:
undetectable
5vv9B-3a2fA:
4.1		 5vv9A-3a2fA:
20.21
5vv9B-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN

(Streptococcus
mutans) 		PF12978
(DUF3862) 		4 VAL A 151
ARG A  52
TRP A 175
PHE A 127
 None
 1.27A 5vv9A-3d4eA:
undetectable
5vv9B-3d4eA:
undetectable		 5vv9A-3d4eA:
15.51
5vv9B-3d4eA:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.27A 5vv9A-3e7gA:
55.2
5vv9B-3e7gA:
19.4		 5vv9A-3e7gA:
58.03
5vv9B-3e7gA:
58.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 VAL A4019
TRP A4065
PHE A4109
GLU A4033
 None
 1.34A 5vv9A-3g1nA:
undetectable
5vv9B-3g1nA:
undetectable		 5vv9A-3g1nA:
21.68
5vv9B-3g1nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.98A 5vv9A-3k25A:
undetectable
5vv9B-3k25A:
undetectable		 5vv9A-3k25A:
21.71
5vv9B-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		4 VAL A  89
ARG A 109
PHE A  93
GLU A  69
 None
 1.45A 5vv9A-3k77A:
undetectable
5vv9B-3k77A:
undetectable		 5vv9A-3k77A:
15.35
5vv9B-3k77A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 VAL A 120
ARG A  69
PHE A 133
GLU A 122
 None
 1.28A 5vv9A-3lccA:
undetectable
5vv9B-3lccA:
undetectable		 5vv9A-3lccA:
18.04
5vv9B-3lccA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 VAL A  72
TRP A  71
PHE A  67
GLU A  73
 None
PVG  A 201 (-3.6A)
None
None
 1.03A 5vv9A-3vv4A:
undetectable
5vv9B-3vv4A:
undetectable		 5vv9A-3vv4A:
19.96
5vv9B-3vv4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.35A 5vv9A-4j3qA:
undetectable
5vv9B-4j3qA:
undetectable		 5vv9A-4j3qA:
21.69
5vv9B-4j3qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8c HSC70-INTERACTING
PROTEIN

(Rattus
norvegicus) 		no annotation 4 VAL A  35
TRP A  34
PHE A  30
GLU A  36
 None
 1.46A 5vv9A-4j8cA:
undetectable
5vv9B-4j8cA:
undetectable		 5vv9A-4j8cA:
8.45
5vv9B-4j8cA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 VAL A  71
ARG A  58
PHE A  28
GLU A  25
 None
 1.20A 5vv9A-4o6xA:
undetectable
5vv9B-4o6xA:
undetectable		 5vv9A-4o6xA:
13.54
5vv9B-4o6xA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.42A 5vv9A-4okdA:
undetectable
5vv9B-4okdA:
undetectable		 5vv9A-4okdA:
19.91
5vv9B-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 VAL C 123
ARG C  76
PHE C  77
GLU C 101
 None
 1.48A 5vv9A-4pbvC:
undetectable
5vv9B-4pbvC:
undetectable		 5vv9A-4pbvC:
20.73
5vv9B-4pbvC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ARG A   9
TRP A 428
PHE A 431
GLU A 429
 None
 1.48A 5vv9A-4qbuA:
undetectable
5vv9B-4qbuA:
0.9		 5vv9A-4qbuA:
21.53
5vv9B-4qbuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5vv9A-4u3vA:
undetectable
5vv9B-4u3vA:
undetectable		 5vv9A-4u3vA:
19.47
5vv9B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.12A 5vv9A-4x8dA:
undetectable
5vv9B-4x8dA:
2.5		 5vv9A-4x8dA:
22.89
5vv9B-4x8dA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 4 VAL A 409
TRP A 407
PHE A 404
GLU A 410
 None
 1.33A 5vv9A-5cowA:
undetectable
5vv9B-5cowA:
1.5		 5vv9A-5cowA:
20.90
5vv9B-5cowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		4 TRP A 179
TRP A 141
PHE A 147
GLU A 143
 None
None
None
GOL  A 402 (-2.9A)
 1.48A 5vv9A-5i2uA:
undetectable
5vv9B-5i2uA:
undetectable		 5vv9A-5i2uA:
21.73
5vv9B-5i2uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 VAL A 341
TRP A 323
TRP A 347
PHE A 290
 None
 1.07A 5vv9A-5jseA:
undetectable
5vv9B-5jseA:
undetectable		 5vv9A-5jseA:
19.31
5vv9B-5jseA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 VAL B 570
TRP B 607
TRP B 562
GLU B 561
 None
 1.31A 5vv9A-5k1hB:
undetectable
5vv9B-5k1hB:
undetectable		 5vv9A-5k1hB:
22.41
5vv9B-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 VAL A 329
TRP A 324
TRP A 251
GLU A 254
 None
None
FAD  A 901 (-3.9A)
None
 1.36A 5vv9A-5l46A:
undetectable
5vv9B-5l46A:
undetectable		 5vv9A-5l46A:
20.70
5vv9B-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 5vv9A-5lp8B:
undetectable
5vv9B-5lp8B:
undetectable		 5vv9A-5lp8B:
21.31
5vv9B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vv9A-5m8tA:
undetectable
5vv9B-5m8tA:
0.6		 5vv9A-5m8tA:
21.75
5vv9B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.11A 5vv9A-5nyyA:
undetectable
5vv9B-5nyyA:
undetectable		 5vv9A-5nyyA:
21.27
5vv9B-5nyyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 VAL A  57
TRP A  56
PHE A  49
GLU A  54
 None
 1.03A 5vv9A-5vyoA:
undetectable
5vv9B-5vyoA:
undetectable		 5vv9A-5vyoA:
9.71
5vv9B-5vyoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 VAL c  16
ARG F  49
PHE F  50
GLU c  51
 None
C  21421 ( 4.4A)
None
None
 0.98A 5vv9A-5xyic:
undetectable
5vv9B-5xyic:
undetectable		 5vv9A-5xyic:
12.84
5vv9B-5xyic:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 VAL A 310
TRP A 323
PHE A 280
GLU A 324
 None
 1.38A 5vv9A-5yfbA:
undetectable
5vv9B-5yfbA:
undetectable		 5vv9A-5yfbA:
11.79
5vv9B-5yfbA:
11.79