SIMILAR PATTERNS OF AMINO ACIDS FOR 5VV1_A_H4BA802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyo CYTOCHROME B5

(Bos taurus)
PF00173
(Cyt-b5)
4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
None
None
HEM  A 201 (-4.8A)
None
1.34A 5vv1A-1cyoA:
0.0
5vv1B-1cyoA:
0.0
5vv1A-1cyoA:
12.82
5vv1B-1cyoA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 ARG A   2
VAL A  87
TRP A  66
GLU A  76
None
1.46A 5vv1A-1fhuA:
0.0
5vv1B-1fhuA:
0.0
5vv1A-1fhuA:
23.29
5vv1B-1fhuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)


(Pseudomonas
aeruginosa)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 VAL A  41
TRP A 521
PHE A 501
GLU A 519
None
1.22A 5vv1A-1flgA:
0.0
5vv1B-1flgA:
0.0
5vv1A-1flgA:
20.20
5vv1B-1flgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
None
1.42A 5vv1A-1kexA:
undetectable
5vv1B-1kexA:
undetectable
5vv1A-1kexA:
17.18
5vv1B-1kexA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
None
1.32A 5vv1A-1kh2A:
0.0
5vv1B-1kh2A:
0.1
5vv1A-1kh2A:
23.65
5vv1B-1kh2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
None
1.35A 5vv1A-1l5jA:
0.0
5vv1B-1l5jA:
0.0
5vv1A-1l5jA:
19.93
5vv1B-1l5jA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
4 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.41A 5vv1A-1mhzD:
0.0
5vv1B-1mhzD:
0.0
5vv1A-1mhzD:
20.77
5vv1B-1mhzD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
None
1.01A 5vv1A-1mzbA:
0.3
5vv1B-1mzbA:
0.4
5vv1A-1mzbA:
14.73
5vv1B-1mzbA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF09152
(DUF1937)
4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
None
1.45A 5vv1A-1t1jA:
0.0
5vv1B-1t1jA:
0.0
5vv1A-1t1jA:
15.63
5vv1B-1t1jA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 122
TRP A 277
PHE A 254
GLU A 250
None
1.48A 5vv1A-1tkiA:
undetectable
5vv1B-1tkiA:
undetectable
5vv1A-1tkiA:
20.51
5vv1B-1tkiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
None
1.38A 5vv1A-1vmkA:
undetectable
5vv1B-1vmkA:
undetectable
5vv1A-1vmkA:
21.38
5vv1B-1vmkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
None
1.14A 5vv1A-1wqlB:
undetectable
5vv1B-1wqlB:
undetectable
5vv1A-1wqlB:
17.80
5vv1B-1wqlB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
None
1.06A 5vv1A-2b39A:
undetectable
5vv1B-2b39A:
2.5
5vv1A-2b39A:
13.24
5vv1B-2b39A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
4 ARG A 194
VAL A 254
PHE A 252
GLU A 106
None
None
None
MG  A1001 ( 3.1A)
1.46A 5vv1A-2eb5A:
undetectable
5vv1B-2eb5A:
undetectable
5vv1A-2eb5A:
20.33
5vv1B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 ARG A 586
VAL A 578
TRP A 579
GLU A 555
None
1.24A 5vv1A-2fjaA:
undetectable
5vv1B-2fjaA:
undetectable
5vv1A-2fjaA:
22.42
5vv1B-2fjaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
None
1.36A 5vv1A-2fjaA:
undetectable
5vv1B-2fjaA:
undetectable
5vv1A-2fjaA:
22.42
5vv1B-2fjaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Thermotoga
maritima)
PF02127
(Peptidase_M18)
4 ARG A 261
VAL A 443
PHE A  21
GLU A  17
None
1.27A 5vv1A-2glfA:
undetectable
5vv1B-2glfA:
undetectable
5vv1A-2glfA:
23.30
5vv1B-2glfA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
GUN  A 503 (-3.7A)
None
None
None
1.32A 5vv1A-2i9uA:
undetectable
5vv1B-2i9uA:
0.4
5vv1A-2i9uA:
21.46
5vv1B-2i9uA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus)
PF07679
(I-set)
4 VAL A 127
TRP A 129
PHE A  97
GLU A 116
None
1.37A 5vv1A-2rikA:
undetectable
5vv1B-2rikA:
undetectable
5vv1A-2rikA:
23.01
5vv1B-2rikA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 VAL A 245
TRP A 252
PHE A 254
GLU A 251
None
None
None
MRD  A1301 (-4.3A)
1.43A 5vv1A-2vy0A:
undetectable
5vv1B-2vy0A:
undetectable
5vv1A-2vy0A:
20.05
5vv1B-2vy0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
None
1.42A 5vv1A-2w4oA:
undetectable
5vv1B-2w4oA:
undetectable
5vv1A-2w4oA:
21.36
5vv1B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA


(Escherichia
coli)
PF00232
(Glyco_hydro_1)
4 ARG A 159
VAL A 164
PHE A  98
GLU A 108
None
1.49A 5vv1A-2xhyA:
undetectable
5vv1B-2xhyA:
0.2
5vv1A-2xhyA:
20.68
5vv1B-2xhyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
None
1.30A 5vv1A-2ywbA:
undetectable
5vv1B-2ywbA:
undetectable
5vv1A-2ywbA:
22.74
5vv1B-2ywbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
None
1.44A 5vv1A-2z11A:
undetectable
5vv1B-2z11A:
undetectable
5vv1A-2z11A:
19.21
5vv1B-2z11A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
None
None
None
EDO  A 404 ( 3.8A)
1.39A 5vv1A-3b7fA:
undetectable
5vv1B-3b7fA:
undetectable
5vv1A-3b7fA:
20.22
5vv1B-3b7fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
None
1.46A 5vv1A-3ddlA:
undetectable
5vv1B-3ddlA:
2.2
5vv1A-3ddlA:
20.14
5vv1B-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
4 ARG A 260
TRP A 248
PHE A 243
GLU A 245
None
1.32A 5vv1A-3f3zA:
undetectable
5vv1B-3f3zA:
undetectable
5vv1A-3f3zA:
20.84
5vv1B-3f3zA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
4 ARG A  27
VAL A  56
PHE A  67
GLU A  65
None
1.49A 5vv1A-3gs3A:
undetectable
5vv1B-3gs3A:
undetectable
5vv1A-3gs3A:
19.86
5vv1B-3gs3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
None
1.30A 5vv1A-3gyxA:
undetectable
5vv1B-3gyxA:
2.9
5vv1A-3gyxA:
20.86
5vv1B-3gyxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
None
1.42A 5vv1A-3ma6A:
undetectable
5vv1B-3ma6A:
undetectable
5vv1A-3ma6A:
21.21
5vv1B-3ma6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF00443
(UCH)
4 ARG A 944
TRP A1001
PHE A 946
GLU A 908
None
1.46A 5vv1A-3n3kA:
undetectable
5vv1B-3n3kA:
undetectable
5vv1A-3n3kA:
20.09
5vv1B-3n3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
None
1.24A 5vv1A-3owcA:
undetectable
5vv1B-3owcA:
1.6
5vv1A-3owcA:
17.73
5vv1B-3owcA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
None
1.28A 5vv1A-3rjyA:
undetectable
5vv1B-3rjyA:
1.3
5vv1A-3rjyA:
20.54
5vv1B-3rjyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 ARG A 286
VAL A 277
TRP A 274
PHE A 269
DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
1.44A 5vv1A-3sxfA:
undetectable
5vv1B-3sxfA:
undetectable
5vv1A-3sxfA:
19.81
5vv1B-3sxfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
None
1.39A 5vv1A-3ti8A:
undetectable
5vv1B-3ti8A:
undetectable
5vv1A-3ti8A:
21.75
5vv1B-3ti8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE


(Coxiella
burnetii)
PF01725
(Ham1p_like)
4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
None
1.27A 5vv1A-3tquA:
undetectable
5vv1B-3tquA:
undetectable
5vv1A-3tquA:
19.76
5vv1B-3tquA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa)
PF02223
(Thymidylate_kin)
4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
None
None
None
MG  A 213 (-3.2A)
1.26A 5vv1A-3uxmA:
undetectable
5vv1B-3uxmA:
undetectable
5vv1A-3uxmA:
20.53
5vv1B-3uxmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
None
1.33A 5vv1A-4bgdC:
undetectable
5vv1B-4bgdC:
undetectable
5vv1A-4bgdC:
20.63
5vv1B-4bgdC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens)
PF00531
(Death)
PF00791
(ZU5)
4 ARG A1065
VAL A1046
PHE A1118
GLU A1032
None
1.31A 5vv1A-4d8oA:
undetectable
5vv1B-4d8oA:
2.1
5vv1A-4d8oA:
20.13
5vv1B-4d8oA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 373
VAL A 412
TRP A 383
PHE A 370
None
1.49A 5vv1A-4fnqA:
undetectable
5vv1B-4fnqA:
undetectable
5vv1A-4fnqA:
20.57
5vv1B-4fnqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
None
1.05A 5vv1A-4l37B:
undetectable
5vv1B-4l37B:
undetectable
5vv1A-4l37B:
19.86
5vv1B-4l37B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE


(Phanerochaete
chrysosporium)
PF13417
(GST_N_3)
4 ARG A  29
VAL A  73
PHE A   7
GLU A  42
None
FLC  A 300 (-4.1A)
None
None
1.09A 5vv1A-4lmvA:
undetectable
5vv1B-4lmvA:
undetectable
5vv1A-4lmvA:
21.09
5vv1B-4lmvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
4 ARG A 385
TRP A 387
TRP A 218
PHE A 286
None
1.39A 5vv1A-4mh1A:
undetectable
5vv1B-4mh1A:
undetectable
5vv1A-4mh1A:
21.09
5vv1B-4mh1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Cupriavidus
necator)
PF03480
(DctP)
4 ARG A 155
VAL A  38
TRP A 199
TRP A  45
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
1.49A 5vv1A-4p8bA:
undetectable
5vv1B-4p8bA:
undetectable
5vv1A-4p8bA:
20.87
5vv1B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
None
1.30A 5vv1A-4pneA:
undetectable
5vv1B-4pneA:
undetectable
5vv1A-4pneA:
21.10
5vv1B-4pneA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
None
1.14A 5vv1A-4xj6A:
undetectable
5vv1B-4xj6A:
2.2
5vv1A-4xj6A:
20.42
5vv1B-4xj6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
None
1.10A 5vv1A-4xj6A:
undetectable
5vv1B-4xj6A:
2.2
5vv1A-4xj6A:
20.42
5vv1B-4xj6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
None
1.42A 5vv1A-4ylrA:
undetectable
5vv1B-4ylrA:
undetectable
5vv1A-4ylrA:
23.05
5vv1B-4ylrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs1 CRRBCX-IIA

(Chlamydomonas
reinhardtii)
PF02341
(RcbX)
4 ARG A 123
VAL A 108
TRP A 104
GLU A 103
ARG  A 123 ( 0.6A)
VAL  A 108 ( 0.6A)
TRP  A 104 ( 0.5A)
GLU  A 103 ( 0.6A)
1.29A 5vv1A-5bs1A:
undetectable
5vv1B-5bs1A:
undetectable
5vv1A-5bs1A:
15.97
5vv1B-5bs1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
None
1.38A 5vv1A-5by3A:
undetectable
5vv1B-5by3A:
2.0
5vv1A-5by3A:
19.67
5vv1B-5by3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
4 VAL B  28
TRP A 401
PHE A 397
GLU A 402
None
1.49A 5vv1A-5c6gB:
undetectable
5vv1B-5c6gB:
undetectable
5vv1A-5c6gB:
18.16
5vv1B-5c6gB:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE


(Geobacillus
stearothermophilus)
PF00633
(HHH)
PF00730
(HhH-GPD)
4 VAL A  92
TRP A  83
PHE A  61
GLU A  84
None
1.35A 5vv1A-5kn8A:
undetectable
5vv1B-5kn8A:
undetectable
5vv1A-5kn8A:
21.21
5vv1B-5kn8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
4 ARG A  84
TRP A  73
PHE A 318
GLU A 317
None
1.39A 5vv1A-5m7rA:
undetectable
5vv1B-5m7rA:
undetectable
5vv1A-5m7rA:
17.01
5vv1B-5m7rA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
None
1.10A 5vv1A-5m8tA:
undetectable
5vv1B-5m8tA:
undetectable
5vv1A-5m8tA:
20.25
5vv1B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN


(Homo sapiens)
PF07555
(NAGidase)
4 ARG A  84
TRP A  73
PHE A 318
GLU A 317
None
1.44A 5vv1A-5uhkA:
undetectable
5vv1B-5uhkA:
undetectable
5vv1A-5uhkA:
21.65
5vv1B-5uhkA:
21.65