SIMILAR PATTERNS OF AMINO ACIDS FOR 5VUU_A_H4BA802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae)
PF02840
(Prp18)
4 ARG A 123
TRP A 242
PHE A 239
GLU A 241
None
1.49A 5vuuA-1dvkA:
0.0
5vuuB-1dvkA:
1.7
5vuuA-1dvkA:
17.18
5vuuB-1dvkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 ARG A   2
VAL A  87
TRP A  66
GLU A  76
None
1.50A 5vuuA-1fhuA:
0.0
5vuuB-1fhuA:
0.0
5vuuA-1fhuA:
25.23
5vuuB-1fhuA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
None
1.47A 5vuuA-1kexA:
0.0
5vuuB-1kexA:
0.0
5vuuA-1kexA:
16.83
5vuuB-1kexA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
None
1.34A 5vuuA-1kh2A:
0.3
5vuuB-1kh2A:
0.0
5vuuA-1kh2A:
22.65
5vuuB-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
None
1.34A 5vuuA-1l5jA:
0.0
5vuuB-1l5jA:
0.0
5vuuA-1l5jA:
19.28
5vuuB-1l5jA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE


(Rattus
norvegicus)
PF02898
(NO_synthase)
4 MET A 336
ARG A 596
VAL A 677
TRP A 678
H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
0.50A 5vuuA-1lzxA:
17.7
5vuuB-1lzxA:
62.1
5vuuA-1lzxA:
100.00
5vuuB-1lzxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
None
1.03A 5vuuA-1mzbA:
0.6
5vuuB-1mzbA:
0.3
5vuuA-1mzbA:
16.59
5vuuB-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38


(Drosophila
melanogaster)
PF00104
(Hormone_recep)
4 MET A 440
VAL A 401
TRP A 435
PHE A 432
None
0.97A 5vuuA-1pduA:
0.0
5vuuB-1pduA:
0.0
5vuuA-1pduA:
21.05
5vuuB-1pduA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Escherichia
coli)
PF00311
(PEPcase)
4 MET A 249
VAL A 267
PHE A 206
GLU A 201
None
1.15A 5vuuA-1qb4A:
0.0
5vuuB-1qb4A:
0.0
5vuuA-1qb4A:
19.22
5vuuB-1qb4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF09152
(DUF1937)
4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
None
1.45A 5vuuA-1t1jA:
undetectable
5vuuB-1t1jA:
undetectable
5vuuA-1t1jA:
16.38
5vuuB-1t1jA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
None
1.43A 5vuuA-1vmkA:
undetectable
5vuuB-1vmkA:
undetectable
5vuuA-1vmkA:
21.48
5vuuB-1vmkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43


(Homo sapiens)
PF00076
(RRM_1)
4 MET A  17
VAL A  35
PHE A  26
GLU A  21
None
1.14A 5vuuA-1wf0A:
undetectable
5vuuB-1wf0A:
undetectable
5vuuA-1wf0A:
11.85
5vuuB-1wf0A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
None
1.13A 5vuuA-1wqlB:
undetectable
5vuuB-1wqlB:
undetectable
5vuuA-1wqlB:
19.79
5vuuB-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
None
1.10A 5vuuA-2b39A:
undetectable
5vuuB-2b39A:
undetectable
5vuuA-2b39A:
13.58
5vuuB-2b39A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
4 ARG A 194
VAL A 254
PHE A 252
GLU A 106
None
None
None
MG  A1001 ( 3.1A)
1.48A 5vuuA-2eb5A:
undetectable
5vuuB-2eb5A:
undetectable
5vuuA-2eb5A:
21.99
5vuuB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 ARG A 586
VAL A 578
TRP A 579
GLU A 555
None
1.22A 5vuuA-2fjaA:
undetectable
5vuuB-2fjaA:
undetectable
5vuuA-2fjaA:
22.29
5vuuB-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
None
1.36A 5vuuA-2fjaA:
undetectable
5vuuB-2fjaA:
undetectable
5vuuA-2fjaA:
22.29
5vuuB-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
GUN  A 503 (-3.7A)
None
None
None
1.31A 5vuuA-2i9uA:
undetectable
5vuuB-2i9uA:
0.0
5vuuA-2i9uA:
20.97
5vuuB-2i9uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 VAL A 245
TRP A 252
PHE A 254
GLU A 251
None
None
None
MRD  A1301 (-4.3A)
1.43A 5vuuA-2vy0A:
undetectable
5vuuB-2vy0A:
undetectable
5vuuA-2vy0A:
20.00
5vuuB-2vy0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
None
1.46A 5vuuA-2w4oA:
undetectable
5vuuB-2w4oA:
undetectable
5vuuA-2w4oA:
20.26
5vuuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 ARG A 697
VAL A 717
PHE A 698
GLU A 722
None
1.34A 5vuuA-2xvgA:
undetectable
5vuuB-2xvgA:
undetectable
5vuuA-2xvgA:
19.68
5vuuB-2xvgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
None
1.36A 5vuuA-2ywbA:
undetectable
5vuuB-2ywbA:
undetectable
5vuuA-2ywbA:
21.54
5vuuB-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
None
1.45A 5vuuA-2z11A:
undetectable
5vuuB-2z11A:
undetectable
5vuuA-2z11A:
17.58
5vuuB-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR


(Vibrio
alginolyticus)
PF00691
(OmpA)
4 MET A  17
TRP A  15
PHE A 137
GLU A  16
None
1.33A 5vuuA-2zf8A:
undetectable
5vuuB-2zf8A:
undetectable
5vuuA-2zf8A:
21.35
5vuuB-2zf8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL H  37
TRP H  47
PHE H  69
GLU H  95
None
1.34A 5vuuA-2zpkH:
undetectable
5vuuB-2zpkH:
undetectable
5vuuA-2zpkH:
20.10
5vuuB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
None
None
None
EDO  A 404 ( 3.8A)
1.41A 5vuuA-3b7fA:
undetectable
5vuuB-3b7fA:
undetectable
5vuuA-3b7fA:
20.87
5vuuB-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43


(Mus musculus)
PF00076
(RRM_1)
4 MET A 202
VAL A 220
PHE A 211
GLU A 206
None
0.96A 5vuuA-3d2wA:
undetectable
5vuuB-3d2wA:
undetectable
5vuuA-3d2wA:
12.22
5vuuB-3d2wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
None
1.46A 5vuuA-3ddlA:
undetectable
5vuuB-3ddlA:
undetectable
5vuuA-3ddlA:
20.14
5vuuB-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
4 ARG A 260
TRP A 248
PHE A 243
GLU A 245
None
1.31A 5vuuA-3f3zA:
undetectable
5vuuB-3f3zA:
undetectable
5vuuA-3f3zA:
21.03
5vuuB-3f3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
4 ARG A  27
VAL A  56
PHE A  67
GLU A  65
None
1.50A 5vuuA-3gs3A:
undetectable
5vuuB-3gs3A:
undetectable
5vuuA-3gs3A:
20.28
5vuuB-3gs3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
None
1.30A 5vuuA-3gyxA:
undetectable
5vuuB-3gyxA:
undetectable
5vuuA-3gyxA:
20.98
5vuuB-3gyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION


(Prochlorococcus
marinus)
PF12707
(DUF3804)
4 MET A  20
ARG A 118
TRP A  51
PHE A  34
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
1.43A 5vuuA-3hzpA:
undetectable
5vuuB-3hzpA:
undetectable
5vuuA-3hzpA:
14.18
5vuuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN


(Bacteroides
vulgatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 ARG A 215
VAL A 363
TRP A 275
GLU A 274
2PE  A   4 ( 4.6A)
None
None
None
1.41A 5vuuA-3lewA:
undetectable
5vuuB-3lewA:
0.0
5vuuA-3lewA:
19.36
5vuuB-3lewA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
None
1.44A 5vuuA-3ma6A:
undetectable
5vuuB-3ma6A:
undetectable
5vuuA-3ma6A:
21.55
5vuuB-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF00443
(UCH)
4 ARG A 944
TRP A1001
PHE A 946
GLU A 908
None
1.49A 5vuuA-3n3kA:
undetectable
5vuuB-3n3kA:
undetectable
5vuuA-3n3kA:
19.83
5vuuB-3n3kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkz FLAGELLAR PROTEIN
FLIT


(Yersinia
enterocolitica)
PF05400
(FliT)
4 MET A  38
ARG A  69
VAL A  44
GLU A  37
None
None
PG4  A 122 ( 4.2A)
None
1.36A 5vuuA-3nkzA:
undetectable
5vuuB-3nkzA:
undetectable
5vuuA-3nkzA:
15.33
5vuuB-3nkzA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
None
1.24A 5vuuA-3owcA:
undetectable
5vuuB-3owcA:
undetectable
5vuuA-3owcA:
16.47
5vuuB-3owcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE


(Bacillus
licheniformis)
PF00171
(Aldedh)
4 ARG A 459
VAL A 295
PHE A 431
GLU A 433
None
None
None
CD  A 542 (-2.3A)
1.44A 5vuuA-3rjlA:
undetectable
5vuuB-3rjlA:
undetectable
5vuuA-3rjlA:
22.66
5vuuB-3rjlA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
None
1.32A 5vuuA-3rjyA:
undetectable
5vuuB-3rjyA:
undetectable
5vuuA-3rjyA:
21.27
5vuuB-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 ARG A 286
VAL A 277
TRP A 274
PHE A 269
DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
1.47A 5vuuA-3sxfA:
undetectable
5vuuB-3sxfA:
undetectable
5vuuA-3sxfA:
20.77
5vuuB-3sxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
None
1.41A 5vuuA-3ti8A:
undetectable
5vuuB-3ti8A:
undetectable
5vuuA-3ti8A:
22.64
5vuuB-3ti8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE


(Coxiella
burnetii)
PF01725
(Ham1p_like)
4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
None
1.26A 5vuuA-3tquA:
undetectable
5vuuB-3tquA:
undetectable
5vuuA-3tquA:
19.05
5vuuB-3tquA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa)
PF02223
(Thymidylate_kin)
4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
None
None
None
MG  A 213 (-3.2A)
1.32A 5vuuA-3uxmA:
undetectable
5vuuB-3uxmA:
undetectable
5vuuA-3uxmA:
20.29
5vuuB-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
None
1.32A 5vuuA-4bgdC:
undetectable
5vuuB-4bgdC:
undetectable
5vuuA-4bgdC:
20.99
5vuuB-4bgdC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens)
PF00531
(Death)
PF00791
(ZU5)
4 ARG A1065
VAL A1046
PHE A1118
GLU A1032
None
1.39A 5vuuA-4d8oA:
undetectable
5vuuB-4d8oA:
undetectable
5vuuA-4d8oA:
19.44
5vuuB-4d8oA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa)
PF14859
(Colicin_M)
4 MET A 258
VAL A 265
TRP A  62
PHE A  85
None
1.31A 5vuuA-4g76A:
undetectable
5vuuB-4g76A:
undetectable
5vuuA-4g76A:
19.86
5vuuB-4g76A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
None
1.01A 5vuuA-4l37B:
undetectable
5vuuB-4l37B:
undetectable
5vuuA-4l37B:
20.69
5vuuB-4l37B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
4 ARG A 385
TRP A 387
TRP A 218
PHE A 286
None
1.40A 5vuuA-4mh1A:
undetectable
5vuuB-4mh1A:
undetectable
5vuuA-4mh1A:
21.16
5vuuB-4mh1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


(uncultured
bacterium
HF130_AEPn_1)
PF01966
(HD)
4 MET A 180
VAL A   9
PHE A  93
GLU A 183
None
1.16A 5vuuA-4mlnA:
undetectable
5vuuB-4mlnA:
undetectable
5vuuA-4mlnA:
16.55
5vuuB-4mlnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


(uncultured
bacterium
HF130_AEPn_1)
PF01966
(HD)
4 MET A 180
VAL A   9
PHE A  93
GLU A 183
None
1.23A 5vuuA-4n6wA:
undetectable
5vuuB-4n6wA:
undetectable
5vuuA-4n6wA:
19.62
5vuuB-4n6wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
None
1.33A 5vuuA-4pneA:
undetectable
5vuuB-4pneA:
undetectable
5vuuA-4pneA:
21.36
5vuuB-4pneA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE


(Vibrio cholerae)
no annotation 4 ARG A 280
VAL A 309
TRP A 267
PHE A 268
None
1.16A 5vuuA-4xj5A:
undetectable
5vuuB-4xj5A:
undetectable
5vuuA-4xj5A:
22.45
5vuuB-4xj5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
None
1.15A 5vuuA-4xj6A:
undetectable
5vuuB-4xj6A:
undetectable
5vuuA-4xj6A:
21.06
5vuuB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
None
1.13A 5vuuA-4xj6A:
undetectable
5vuuB-4xj6A:
undetectable
5vuuA-4xj6A:
21.06
5vuuB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
None
1.42A 5vuuA-4ylrA:
undetectable
5vuuB-4ylrA:
undetectable
5vuuA-4ylrA:
22.81
5vuuB-4ylrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zva DIGUANYLATE CYCLASE
DOSC


(Escherichia
coli)
PF11563
(Protoglobin)
4 MET A   8
VAL A  84
TRP A  12
GLU A  11
None
1.27A 5vuuA-4zvaA:
undetectable
5vuuB-4zvaA:
undetectable
5vuuA-4zvaA:
18.86
5vuuB-4zvaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
None
1.40A 5vuuA-5by3A:
undetectable
5vuuB-5by3A:
undetectable
5vuuA-5by3A:
19.82
5vuuB-5by3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
4 VAL B  28
TRP A 401
PHE A 397
GLU A 402
None
1.47A 5vuuA-5c6gB:
undetectable
5vuuB-5c6gB:
undetectable
5vuuA-5c6gB:
18.69
5vuuB-5c6gB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE


(Cosenzaea
myxofaciens)
PF01266
(DAO)
4 ARG A 316
VAL A 438
TRP A 439
GLU A 418
BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
None
1.34A 5vuuA-5fjnA:
undetectable
5vuuB-5fjnA:
undetectable
5vuuA-5fjnA:
23.27
5vuuB-5fjnA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE


(Geobacillus
stearothermophilus)
PF00633
(HHH)
PF00730
(HhH-GPD)
4 VAL A  92
TRP A  83
PHE A  61
GLU A  84
None
1.33A 5vuuA-5kn8A:
undetectable
5vuuB-5kn8A:
undetectable
5vuuA-5kn8A:
22.28
5vuuB-5kn8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
4 ARG A  84
TRP A  73
PHE A 318
GLU A 317
None
1.39A 5vuuA-5m7rA:
undetectable
5vuuB-5m7rA:
undetectable
5vuuA-5m7rA:
18.13
5vuuB-5m7rA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
None
1.07A 5vuuA-5m8tA:
undetectable
5vuuB-5m8tA:
undetectable
5vuuA-5m8tA:
20.00
5vuuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE


(Corynebacterium
glutamicum)
PF03641
(Lysine_decarbox)
4 MET A 112
ARG A 155
VAL A 104
PHE A 159
None
1.43A 5vuuA-5wq3A:
undetectable
5vuuB-5wq3A:
undetectable
5vuuA-5wq3A:
24.23
5vuuB-5wq3A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE


(Methanopyrus
kandleri)
no annotation 4 MET A 249
VAL A 231
PHE A 258
GLU A 253
None
0.97A 5vuuA-5x89A:
undetectable
5vuuB-5x89A:
undetectable
5vuuA-5x89A:
12.70
5vuuB-5x89A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA


(Homo sapiens;
Mus musculus)
PF07686
(V-set)
PF11629
(Mst1_SARAH)
4 VAL A  37
TRP A  47
PHE A  69
GLU A  95
None
1.35A 5vuuA-5xctA:
undetectable
5vuuB-5xctA:
undetectable
5vuuA-5xctA:
16.71
5vuuB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152


(Homo sapiens)
no annotation 4 MET H 105
VAL D  98
TRP D  91
TRP H  49
None
1.23A 5vuuA-5xwdH:
undetectable
5vuuB-5xwdH:
undetectable
5vuuA-5xwdH:
9.59
5vuuB-5xwdH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79


(Oryza sativa)
no annotation 4 ARG A 331
VAL A 317
TRP A 316
GLU A 322
None
UDP  A 501 ( 4.8A)
None
None
1.29A 5vuuA-6bk1A:
undetectable
5vuuB-6bk1A:
undetectable
5vuuA-6bk1A:
13.48
5vuuB-6bk1A:
13.48