SIMILAR PATTERNS OF AMINO ACIDS FOR 5VUS_B_H4BB802
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyo | CYTOCHROME B5 (Bos taurus) |
PF00173(Cyt-b5) | 4 | PHE A 58GLU A 56ARG A 68VAL A 61 | HEM A 201 (-4.8A)NoneNoneNone | 1.32A | 5vusA-1cyoA:0.05vusB-1cyoA:0.0 | 5vusA-1cyoA:12.055vusB-1cyoA:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dvk | PRP18 (Saccharomycescerevisiae) |
PF02840(Prp18) | 4 | TRP A 242PHE A 239GLU A 241ARG A 123 | None | 1.50A | 5vusA-1dvkA:2.55vusB-1dvkA:1.4 | 5vusA-1dvkA:17.185vusB-1dvkA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fhu | O-SUCCINYLBENZOATESYNTHASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 4 | TRP A 66GLU A 76ARG A 2VAL A 87 | None | 1.47A | 5vusA-1fhuA:0.05vusB-1fhuA:0.8 | 5vusA-1fhuA:25.235vusB-1fhuA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | PHE A 501GLU A 519VAL A 41TRP A 521 | None | 1.17A | 5vusA-1flgA:0.05vusB-1flgA:0.0 | 5vusA-1flgA:19.675vusB-1flgA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 4 | PHE C 360GLU C 353MET C 291VAL C 216 | None | 1.41A | 5vusA-1h2tC:0.05vusB-1h2tC:0.0 | 5vusA-1h2tC:19.485vusB-1h2tC:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | PHE A 220GLU A 222ARG A 282VAL A 226 | None | 1.31A | 5vusA-1kh2A:0.35vusB-1kh2A:0.1 | 5vusA-1kh2A:22.655vusB-1kh2A:22.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 4 | MET A 336ARG A 596VAL A 677TRP A 678 | H4B A 760 ( 3.8A)H4B A 760 (-3.5A)H4B A 760 (-4.6A)H4B A 760 ( 3.6A) | 0.48A | 5vusA-1lzxA:62.55vusB-1lzxA:62.1 | 5vusA-1lzxA:100.005vusB-1lzxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | PHE A 79GLU A 36ARG A 69VAL A 54 | None | 1.05A | 5vusA-1mzbA:0.65vusB-1mzbA:0.4 | 5vusA-1mzbA:16.595vusB-1mzbA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdu | NUCLEAR HORMONERECEPTOR HR38 (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 4 | TRP A 435PHE A 432MET A 440VAL A 401 | None | 0.79A | 5vusA-1pduA:0.05vusB-1pduA:0.0 | 5vusA-1pduA:21.055vusB-1pduA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qb4 | PHOSPHOENOLPYRUVATECARBOXYLASE (Escherichiacoli) |
PF00311(PEPcase) | 4 | PHE A 206GLU A 201MET A 249VAL A 267 | None | 1.29A | 5vusA-1qb4A:3.85vusB-1qb4A:0.7 | 5vusA-1qb4A:19.225vusB-1qb4A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1j | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF09152(DUF1937) | 4 | TRP A 110PHE A 117ARG A 2VAL A 28 | None | 1.45A | 5vusA-1t1jA:undetectable5vusB-1t1jA:undetectable | 5vusA-1t1jA:16.385vusB-1t1jA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | TRP A 277PHE A 254GLU A 250VAL A 122 | None | 1.47A | 5vusA-1tkiA:undetectable5vusB-1tkiA:undetectable | 5vusA-1tkiA:20.235vusB-1tkiA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0o | VON WILLEBRANDFACTOR (Mus musculus) |
PF00092(VWA) | 4 | PHE C 536GLU C 542MET C 541VAL C 691 | None | 1.38A | 5vusA-1u0oC:undetectable5vusB-1u0oC:undetectable | 5vusA-1u0oC:21.145vusB-1u0oC:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmk | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermotogamaritima) |
PF01048(PNP_UDP_1) | 4 | TRP A 162PHE A 265GLU A 161VAL A 221 | None | 1.41A | 5vusA-1vmkA:undetectable5vusB-1vmkA:undetectable | 5vusA-1vmkA:21.485vusB-1vmkA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wf0 | TAR DNA-BINDINGPROTEIN-43 (Homo sapiens) |
PF00076(RRM_1) | 4 | PHE A 26GLU A 21MET A 17VAL A 35 | None | 1.20A | 5vusA-1wf0A:undetectable5vusB-1wf0A:undetectable | 5vusA-1wf0A:11.855vusB-1wf0A:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | PHE B 163GLU B 26ARG B 156VAL B 128 | None | 1.20A | 5vusA-1wqlB:undetectable5vusB-1wqlB:undetectable | 5vusA-1wqlB:19.795vusB-1wqlB:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdv | SON OF SEVENLESSPROTEIN HOMOLOG 1 (Homo sapiens) |
PF00169(PH)PF00617(RasGEF)PF00618(RasGEF_N)PF00621(RhoGEF) | 4 | PHE A 648GLU A 646ARG A 722VAL A 685 | None | 1.39A | 5vusA-1xdvA:2.15vusB-1xdvA:undetectable | 5vusA-1xdvA:18.785vusB-1xdvA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | PHE A 722GLU A 693ARG A 708VAL A1424 | None | 1.08A | 5vusA-2b39A:2.55vusB-2b39A:undetectable | 5vusA-2b39A:13.585vusB-2b39A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLU A 555ARG A 586VAL A 578TRP A 579 | None | 1.23A | 5vusA-2fjaA:undetectable5vusB-2fjaA:undetectable | 5vusA-2fjaA:22.295vusB-2fjaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT AADENYLYLSULFATEREDUCTASE, SUBUNIT B (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | TRP B 788GLU A 360ARG A 62VAL A 367 | None | 1.32A | 5vusA-2fjaB:undetectable5vusB-2fjaB:undetectable | 5vusA-2fjaB:18.255vusB-2fjaB:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 4 | PHE A 99GLU A 101ARG A 202TRP A 93 | NoneNoneGUN A 503 (-3.7A)None | 1.31A | 5vusA-2i9uA:undetectable5vusB-2i9uA:0.4 | 5vusA-2i9uA:20.975vusB-2i9uA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obh | CENTRIN-2 (Homo sapiens) |
PF13499(EF-hand_7) | 4 | PHE A 162GLU A 148MET A 145VAL A 157 | NoneNoneNone CA A1001 ( 4.9A) | 1.38A | 5vusA-2obhA:undetectable5vusB-2obhA:undetectable | 5vusA-2obhA:17.095vusB-2obhA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q49 | PROBABLEN-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Arabidopsisthaliana) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | PHE A 61GLU A 58ARG A 199VAL A 33 | None | 1.50A | 5vusA-2q49A:undetectable5vusB-2q49A:undetectable | 5vusA-2q49A:22.975vusB-2q49A:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rik | TITIN (Oryctolaguscuniculus) |
PF07679(I-set) | 4 | PHE A 97GLU A 116VAL A 127TRP A 129 | None | 1.30A | 5vusA-2rikA:undetectable5vusB-2rikA:undetectable | 5vusA-2rikA:22.525vusB-2rikA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 4 | GLU A 34MET A 31ARG A 53VAL A 70 | None | 1.50A | 5vusA-2vdaA:1.55vusB-2vdaA:undetectable | 5vusA-2vdaA:20.585vusB-2vdaA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 4 | TRP A 266PHE A 261ARG A 278VAL A 269 | None | 1.42A | 5vusA-2w4oA:undetectable5vusB-2w4oA:undetectable | 5vusA-2w4oA:20.265vusB-2w4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 4 | PHE A 698GLU A 722ARG A 697VAL A 717 | None | 1.35A | 5vusA-2xvgA:undetectable5vusB-2xvgA:undetectable | 5vusA-2xvgA:19.685vusB-2xvgA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | PHE A 309GLU A 305ARG A 211VAL A 239 | None | 1.31A | 5vusA-2ywbA:undetectable5vusB-2ywbA:undetectable | 5vusA-2ywbA:21.545vusB-2ywbA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z11 | RIBOSOMAL-PROTEIN-ALANINEACETYLTRANSFERASE (Thermusthermophilus) |
PF13302(Acetyltransf_3) | 4 | TRP A 66PHE A 4GLU A 6VAL A 64 | None | 1.41A | 5vusA-2z11A:undetectable5vusB-2z11A:undetectable | 5vusA-2z11A:17.585vusB-2z11A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zf8 | COMPONENT OFSODIUM-DRIVEN POLARFLAGELLAR MOTOR (Vibrioalginolyticus) |
PF00691(OmpA) | 4 | TRP A 15PHE A 137GLU A 16MET A 17 | None | 1.22A | 5vusA-2zf8A:undetectable5vusB-2zf8A:undetectable | 5vusA-2zf8A:21.355vusB-2zf8A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | TRP A 374GLU A 372VAL A 314TRP A 293 | NoneEDO A 404 ( 3.8A)NoneNone | 1.42A | 5vusA-3b7fA:undetectable5vusB-3b7fA:undetectable | 5vusA-3b7fA:20.875vusB-3b7fA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxz | PREPROTEINTRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF07517(SecA_DEAD) | 4 | GLU A 34MET A 31ARG A 53VAL A 70 | None | 1.49A | 5vusA-3bxzA:undetectable5vusB-3bxzA:undetectable | 5vusA-3bxzA:20.855vusB-3bxzA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2w | TAR DNA-BINDINGPROTEIN 43 (Mus musculus) |
PF00076(RRM_1) | 4 | PHE A 211GLU A 206MET A 202VAL A 220 | None | 0.92A | 5vusA-3d2wA:undetectable5vusB-3d2wA:undetectable | 5vusA-3d2wA:12.225vusB-3d2wA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddl | XANTHORHODOPSIN (Salinibacterruber) |
PF01036(Bac_rhodopsin) | 4 | TRP A 70PHE A 88GLU A 71VAL A 16 | None | 1.44A | 5vusA-3ddlA:1.45vusB-3ddlA:undetectable | 5vusA-3ddlA:20.145vusB-3ddlA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 4 | TRP A 248PHE A 243GLU A 245ARG A 260 | None | 1.35A | 5vusA-3f3zA:undetectable5vusB-3f3zA:undetectable | 5vusA-3f3zA:21.035vusB-3f3zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | TRP B 88GLU A 380ARG A 66VAL A 387 | None | 1.25A | 5vusA-3gyxB:undetectable5vusB-3gyxB:undetectable | 5vusA-3gyxB:16.675vusB-3gyxB:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzp | NTF2-LIKE PROTEIN OFUNKNOWN FUNCTION (Prochlorococcusmarinus) |
PF12707(DUF3804) | 4 | PHE A 34MET A 20ARG A 118TRP A 51 | 1PE A 131 (-4.5A)1PE A 131 ( 3.8A)1PE A 131 (-3.7A)None | 1.40A | 5vusA-3hzpA:undetectable5vusB-3hzpA:undetectable | 5vusA-3hzpA:14.185vusB-3hzpA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lew | SUSD-LIKECARBOHYDRATE BINDINGPROTEIN (Bacteroidesvulgatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | TRP A 275GLU A 274ARG A 215VAL A 363 | NoneNone2PE A 4 ( 4.6A)None | 1.41A | 5vusA-3lewA:undetectable5vusB-3lewA:undetectable | 5vusA-3lewA:19.365vusB-3lewA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | TRP A 257PHE A 252ARG A 269VAL A 260 | None | 1.41A | 5vusA-3ma6A:undetectable5vusB-3ma6A:undetectable | 5vusA-3ma6A:21.555vusB-3ma6A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3k | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Homo sapiens) |
PF00443(UCH) | 4 | TRP A1001PHE A 946GLU A 908ARG A 944 | None | 1.48A | 5vusA-3n3kA:undetectable5vusB-3n3kA:undetectable | 5vusA-3n3kA:19.835vusB-3n3kA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | PHE A 121GLU A 119ARG A 175VAL A 92 | None | 1.22A | 5vusA-3owcA:undetectable5vusB-3owcA:undetectable | 5vusA-3owcA:16.475vusB-3owcA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pf7 | BENZOYL-COAOXYGENASE COMPONENTB (Azoarcusevansii) |
no annotation | 4 | TRP A 27GLU A 174ARG A 188VAL A 158 | None | 1.36A | 5vusA-3pf7A:undetectable5vusB-3pf7A:undetectable | 5vusA-3pf7A:21.555vusB-3pf7A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q63 | MLL2253 PROTEIN (Mesorhizobiumjaponicum) |
PF08327(AHSA1) | 4 | PHE A 113GLU A 109MET A 108TRP A 128 | None | 1.36A | 5vusA-3q63A:undetectable5vusB-3q63A:undetectable | 5vusA-3q63A:13.715vusB-3q63A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | TRP A 146PHE A 162GLU A 187VAL A 149 | None | 1.29A | 5vusA-3rjyA:1.45vusB-3rjyA:undetectable | 5vusA-3rjyA:21.275vusB-3rjyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxf | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | TRP A 274PHE A 269ARG A 286VAL A 277 | NoneDMS A 711 (-3.9A)DMS A 711 (-4.1A)None | 1.45A | 5vusA-3sxfA:undetectable5vusB-3sxfA:undetectable | 5vusA-3sxfA:20.775vusB-3sxfA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | PHE A 305GLU A 265VAL A 240TRP A 239 | None | 1.39A | 5vusA-3ti8A:undetectable5vusB-3ti8A:undetectable | 5vusA-3ti8A:22.645vusB-3ti8A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqu | NON-CANONICAL PURINENTP PYROPHOSPHATASE (Coxiellaburnetii) |
PF01725(Ham1p_like) | 4 | TRP A 140PHE A 118GLU A 141VAL A 162 | None | 1.26A | 5vusA-3tquA:undetectable5vusB-3tquA:undetectable | 5vusA-3tquA:19.055vusB-3tquA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxm | THYMIDYLATE KINASE (Pseudomonasaeruginosa) |
PF02223(Thymidylate_kin) | 4 | PHE A 162GLU A 156ARG A 109VAL A 166 | None MG A 213 (-3.2A)NoneNone | 1.27A | 5vusA-3uxmA:0.95vusB-3uxmA:undetectable | 5vusA-3uxmA:20.295vusB-3uxmA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6u | OMEGA TRANSAMINASE (Chromobacteriumviolaceum) |
PF00202(Aminotran_3) | 4 | PHE A 223GLU A 246ARG A 149VAL A 257 | None | 1.47A | 5vusA-4a6uA:0.85vusB-4a6uA:undetectable | 5vusA-4a6uA:21.595vusB-4a6uA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgd | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT) | 4 | TRP C2314PHE C2329GLU C2310VAL C2274 | None | 1.28A | 5vusA-4bgdC:undetectable5vusB-4bgdC:undetectable | 5vusA-4bgdC:20.995vusB-4bgdC:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bs2 | TAR DNA-BINDINGPROTEIN 43 (Homo sapiens) |
PF00076(RRM_1) | 4 | PHE A 211GLU A 206MET A 202VAL A 220 | None | 1.03A | 5vusA-4bs2A:undetectable5vusB-4bs2A:undetectable | 5vusA-4bs2A:15.875vusB-4bs2A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d8o | ANKYRIN-2 (Homo sapiens) |
PF00531(Death)PF00791(ZU5) | 4 | PHE A1118GLU A1032ARG A1065VAL A1046 | None | 1.30A | 5vusA-4d8oA:undetectable5vusB-4d8oA:undetectable | 5vusA-4d8oA:19.445vusB-4d8oA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 4 | TRP A 62PHE A 85MET A 258VAL A 265 | None | 1.30A | 5vusA-4g76A:undetectable5vusB-4g76A:undetectable | 5vusA-4g76A:19.865vusB-4g76A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgn | RNA SILENCINGSUPPRESSOR P19 (Tomato bushystunt virus) |
PF03220(Tombus_P19) | 4 | PHE A 94GLU A 121ARG A 56VAL A 97 | None | 1.46A | 5vusA-4jgnA:undetectable5vusB-4jgnA:undetectable | 5vusA-4jgnA:17.465vusB-4jgnA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l37 | ARYLPHORIN (Bombyx mori) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | PHE B 327GLU B 424VAL B 351TRP B 355 | None | 0.99A | 5vusA-4l37B:undetectable5vusB-4l37B:undetectable | 5vusA-4l37B:20.695vusB-4l37B:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mln | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | PHE A 93GLU A 183MET A 180VAL A 9 | None | 1.12A | 5vusA-4mlnA:undetectable5vusB-4mlnA:undetectable | 5vusA-4mlnA:16.555vusB-4mlnA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6w | PREDICTED HDPHOSPHOHYDROLASEPHNZ (unculturedbacteriumHF130_AEPn_1) |
PF01966(HD) | 4 | PHE A 93GLU A 183MET A 180VAL A 9 | None | 1.19A | 5vusA-4n6wA:undetectable5vusB-4n6wA:undetectable | 5vusA-4n6wA:19.625vusB-4n6wA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p8b | TRAP-TYPETRANSPORTER,PERIPLASMICCOMPONENT (Cupriavidusnecator) |
PF03480(DctP) | 4 | TRP A 45ARG A 155VAL A 38TRP A 199 | NoneX2X A 403 (-3.0A)X2X A 403 ( 4.5A)X2X A 403 (-4.4A) | 1.47A | 5vusA-4p8bA:undetectable5vusB-4p8bA:undetectable | 5vusA-4p8bA:20.815vusB-4p8bA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 4 | PHE A 141GLU A 162ARG A 75VAL A 79 | None | 1.32A | 5vusA-4pneA:undetectable5vusB-4pneA:undetectable | 5vusA-4pneA:21.365vusB-4pneA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj5 | CYCLIC AMP-GMPSYNTHASE (Vibrio cholerae) |
no annotation | 4 | TRP A 267PHE A 268ARG A 280VAL A 309 | None | 1.15A | 5vusA-4xj5A:2.05vusB-4xj5A:undetectable | 5vusA-4xj5A:22.455vusB-4xj5A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | PHE A 264GLU A 266ARG A 276VAL A 305 | None | 1.16A | 5vusA-4xj6A:undetectable5vusB-4xj6A:undetectable | 5vusA-4xj6A:21.065vusB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | TRP A 263PHE A 264GLU A 266VAL A 305 | None | 1.06A | 5vusA-4xj6A:undetectable5vusB-4xj6A:undetectable | 5vusA-4xj6A:21.065vusB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylr | TUBULINPOLYGLUTAMYLASETTLL7 (Homo sapiens) |
PF03133(TTL) | 4 | PHE A 277GLU A 279VAL A 288TRP A 292 | None | 1.44A | 5vusA-4ylrA:undetectable5vusB-4ylrA:undetectable | 5vusA-4ylrA:22.815vusB-4ylrA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zva | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | TRP A 12GLU A 11MET A 8VAL A 84 | None | 1.38A | 5vusA-4zvaA:undetectable5vusB-4zvaA:undetectable | 5vusA-4zvaA:18.865vusB-4zvaA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs1 | CRRBCX-IIA (Chlamydomonasreinhardtii) |
PF02341(RcbX) | 4 | TRP A 104GLU A 103ARG A 123VAL A 108 | TRP A 104 ( 0.5A)GLU A 103 ( 0.6A)ARG A 123 ( 0.6A)VAL A 108 ( 0.6A) | 1.32A | 5vusA-5bs1A:undetectable5vusB-5bs1A:undetectable | 5vusA-5bs1A:14.455vusB-5bs1A:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5v | ACIDOCALCISOMALPYROPHOSPHATASE (Trypanosomabrucei) |
PF00719(Pyrophosphatase) | 4 | PHE A 136GLU A 123MET A 120VAL A 101 | None | 1.16A | 5vusA-5c5vA:3.25vusB-5c5vA:undetectable | 5vusA-5c5vA:20.845vusB-5c5vA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6g | AGR133CPSISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF10345(Cohesin_load)no annotation | 4 | TRP A 401PHE A 397GLU A 402VAL B 28 | None | 1.45A | 5vusA-5c6gA:2.75vusB-5c6gA:undetectable | 5vusA-5c6gA:21.865vusB-5c6gA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqi | CATALASE-PEROXIDASE (Burkholderiapseudomallei) |
PF00141(peroxidase) | 4 | TRP A 736PHE A 732GLU A 560VAL A 481 | None | 1.49A | 5vusA-5kqiA:undetectable5vusB-5kqiA:undetectable | 5vusA-5kqiA:20.855vusB-5kqiA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m7r | PROTEIN O-GLCNACASE (Homo sapiens) |
PF07555(NAGidase) | 4 | TRP A 73PHE A 318GLU A 317ARG A 84 | None | 1.41A | 5vusA-5m7rA:undetectable5vusB-5m7rA:0.0 | 5vusA-5m7rA:18.135vusB-5m7rA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | TRP A 414PHE A 411GLU A 413ARG A 225 | None | 1.08A | 5vusA-5m8tA:undetectable5vusB-5m8tA:undetectable | 5vusA-5m8tA:20.005vusB-5m8tA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wq3 | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Corynebacteriumglutamicum) |
PF03641(Lysine_decarbox) | 4 | PHE A 159MET A 112ARG A 155VAL A 104 | None | 1.47A | 5vusA-5wq3A:undetectable5vusB-5wq3A:undetectable | 5vusA-5wq3A:24.235vusB-5wq3A:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x89 | ENDA-LIKEPROTEIN,TRNA-SPLICING ENDONUCLEASE (Methanopyruskandleri) |
no annotation | 4 | PHE A 258GLU A 253MET A 249VAL A 231 | None | 1.08A | 5vusA-5x89A:undetectable5vusB-5x89A:undetectable | 5vusA-5x89A:12.705vusB-5x89A:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xct | VH(S112C)-SARAHCHIMERA (Homo sapiens;Mus musculus) |
PF07686(V-set)PF11629(Mst1_SARAH) | 4 | PHE A 69GLU A 95VAL A 37TRP A 47 | None | 1.34A | 5vusA-5xctA:undetectable5vusB-5xctA:undetectable | 5vusA-5xctA:16.715vusB-5xctA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwd | VH CHAIN OF 059-152VL CHAIN OF 059-152 (Homo sapiens) |
no annotation | 4 | TRP H 49MET H 105VAL D 98TRP D 91 | None | 1.18A | 5vusA-5xwdH:undetectable5vusB-5xwdH:undetectable | 5vusA-5xwdH:9.595vusB-5xwdH:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyo | DUAL SPECIFICITYPROTEIN KINASE CLK1 (Homo sapiens) |
no annotation | 4 | TRP A 419GLU A 392MET A 391VAL A 429 | None | 1.49A | 5vusA-6fyoA:undetectable5vusB-6fyoA:undetectable | 5vusA-6fyoA:undetectable5vusB-6fyoA:undetectable |