SIMILAR PATTERNS OF AMINO ACIDS FOR 5VUO_B_MTLB805

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 SER A 181
ASN A 269
GLN A 236
ASP A 234
 None
 1.31A 5vuoB-1c9eA:
0.1		 5vuoB-1c9eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 SER 3  94
GLN 3  87
PHE 3  86
ASN 3  97
 None
 1.16A 5vuoB-1ev13:
undetectable		 5vuoB-1ev13:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 SER A 112
ARG A 212
GLN A 318
ASP A 218
 None
 1.15A 5vuoB-1hn0A:
0.0		 5vuoB-1hn0A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		4 ASN A 211
GLN A 216
PHE A 214
ASN A 101
 None
 1.32A 5vuoB-1iw8A:
0.0		 5vuoB-1iw8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 208
ASN A 241
GLN A 242
ASN A 216
 None
None
None
FAD  A 800 (-4.1A)
 1.29A 5vuoB-1knrA:
0.0		 5vuoB-1knrA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		8 SER A 477
ARG A 481
ASN A 498
GLN A 500
PHE A 501
ASN A 569
ASP A 709
TRP A 711
 None
 0.23A 5vuoB-1lzxA:
62.6		 5vuoB-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		6 SER A 246
ARG A 250
ASN A 267
ASN A 338
ASP A 478
TRP A 480
 None
 0.48A 5vuoB-1m9qA:
59.3		 5vuoB-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		4 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 432 (-3.3A)
None
None
None
 1.28A 5vuoB-1mpoA:
0.0		 5vuoB-1mpoA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 SER A 256
ARG A 260
PHE A 280
ASN A 348
TRP A 490
 None
 0.59A 5vuoB-1qw5A:
58.2		 5vuoB-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.28A 5vuoB-1rrhA:
undetectable		 5vuoB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.08A 5vuoB-1twbA:
undetectable		 5vuoB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 ARG A 253
ASN A 381
PHE A 403
ASP A 397
 None
 1.29A 5vuoB-1vrqA:
undetectable		 5vuoB-1vrqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.32A 5vuoB-1xr4A:
undetectable		 5vuoB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.30A 5vuoB-1yvlA:
undetectable		 5vuoB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 SER A 321
GLN A 329
PHE A 326
ASN A 320
 None
 1.14A 5vuoB-1z3vA:
undetectable		 5vuoB-1z3vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 ASN A 128
GLN A 165
ASN A  54
ASP A 131
 None
 1.27A 5vuoB-2a9vA:
undetectable		 5vuoB-2a9vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 SER A 202
ASN A 207
PHE A 203
ASN A 199
 None
 1.34A 5vuoB-2aqwA:
undetectable		 5vuoB-2aqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.13A 5vuoB-2ckrA:
undetectable		 5vuoB-2ckrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv0 LYSOZYME C

(Pelodiscus
sinensis) 		PF00062
(Lys) 		4 SER A  62
GLN A  51
ASN A  61
ASP A  50
 None
 1.21A 5vuoB-2gv0A:
undetectable		 5vuoB-2gv0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 512
ASN A 368
GLN A 711
ASN A 516
 None
 1.23A 5vuoB-2iujA:
undetectable		 5vuoB-2iujA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 524
ASN A 379
GLN A 723
ASN A 528
 None
 1.20A 5vuoB-2iukA:
undetectable		 5vuoB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcy 30S RIBOSOMAL
PROTEIN S8E

(Methanothermobacter
thermautotrophicus) 		PF01201
(Ribosomal_S8e) 		4 SER A  75
ARG A  76
ASN A  84
ASP A  80
 None
 1.24A 5vuoB-2kcyA:
undetectable		 5vuoB-2kcyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		4 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.00A 5vuoB-2lbfB:
undetectable		 5vuoB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 ARG A 109
GLN A  87
ASN A  63
ASP A  61
 GLC  A 429 ( 3.0A)
None
None
None
 1.22A 5vuoB-2mprA:
undetectable		 5vuoB-2mprA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis) 		PF11258
(DUF3048)
PF17479
(DUF3048_C) 		4 SER A  93
PHE A  96
ASN A  94
ASP A  97
 None
 1.20A 5vuoB-2psbA:
undetectable		 5vuoB-2psbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe9 UNCHARACTERIZED
PROTEIN YIZA

(Bacillus
subtilis) 		PF05163
(DinB) 		4 SER A  79
ARG A  12
PHE A  82
ASN A  80
 None
 1.32A 5vuoB-2qe9A:
undetectable		 5vuoB-2qe9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN

(Salmonella
enterica) 		PF04962
(KduI) 		4 ARG A 190
ASN A 217
GLN A 195
PHE A 191
 SO4  A 277 (-3.2A)
SO4  A 277 (-3.5A)
None
None
 0.97A 5vuoB-2qjvA:
undetectable		 5vuoB-2qjvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 5vuoB-2r4gA:
undetectable		 5vuoB-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF12202
(OSR1_C) 		4 ARG A 441
GLN A 523
ASN A 448
ASP A 449
 None
 1.28A 5vuoB-2v3sA:
undetectable		 5vuoB-2v3sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.30A 5vuoB-2x63A:
undetectable		 5vuoB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dal PR DOMAIN ZINC
FINGER PROTEIN 1

(Homo sapiens) 		PF00856
(SET) 		4 ARG A  75
PHE A  76
ASN A  26
ASP A  27
 None
 1.13A 5vuoB-3dalA:
undetectable		 5vuoB-3dalA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 ARG A 266
ASN A 283
PHE A 286
ASN A 354
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
None
 1.11A 5vuoB-3e7gA:
57.5		 5vuoB-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		4 ARG A3530
GLN A3582
PHE A3579
ASP A3537
 None
 1.33A 5vuoB-3fzyA:
undetectable		 5vuoB-3fzyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum) 		PF01764
(Lipase_3) 		4 SER A 229
ARG A 224
ASN A 232
ASP A 188
 None
 1.29A 5vuoB-3g7nA:
undetectable		 5vuoB-3g7nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 4 SER A 204
ARG A 175
ASN A 235
ASP A 261
 None
 1.06A 5vuoB-3gozA:
undetectable		 5vuoB-3gozA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASN A 119
GLN A 160
PHE A 104
ASN A 107
 None
 1.34A 5vuoB-3hd8A:
undetectable		 5vuoB-3hd8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN REGULATORY
LIGHT CHAIN LC-2,
MANTLE MUSCLE

(Todarodes
pacificus) 		PF13405
(EF-hand_6) 		4 ASN B 138
GLN B 136
PHE B 137
ASP B  95
 None
 1.30A 5vuoB-3i5gB:
undetectable		 5vuoB-3i5gB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.06A 5vuoB-3ihvA:
undetectable		 5vuoB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.25A 5vuoB-3ij3A:
undetectable		 5vuoB-3ij3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 SER A 109
ARG A 112
ASN A 289
PHE A 294
TRP A 239
 None
 1.36A 5vuoB-3ix1A:
undetectable		 5vuoB-3ix1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 SER A4182
ARG A4238
GLN A4207
ASP A4171
 None
 1.28A 5vuoB-3kciA:
undetectable		 5vuoB-3kciA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		4 ARG B  59
ASN B  56
GLN B 195
ASP B  53
 None
 1.16A 5vuoB-3kydB:
undetectable		 5vuoB-3kydB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrv PRE-MRNA-SPLICING
FACTOR 19

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.28A 5vuoB-3lrvA:
undetectable		 5vuoB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9v UNCHARACTERIZED
PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF10604
(Polyketide_cyc2) 		4 ASN A  10
PHE A 112
ASN A 139
ASP A 143
 None
 1.17A 5vuoB-3p9vA:
undetectable		 5vuoB-3p9vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1

(Homo sapiens) 		PF03031
(NIF) 		4 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.03A 5vuoB-3pglA:
undetectable		 5vuoB-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASN A 175
GLN A 171
PHE A 170
ASN A 303
 None
 1.16A 5vuoB-3to3A:
undetectable		 5vuoB-3to3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ASN A 150
ASN A 228
ASP A 179
TRP A 292
 None
CA  A1201 (-3.2A)
RAM  A1203 ( 2.5A)
None
 1.29A 5vuoB-3w5nA:
undetectable		 5vuoB-3w5nA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.14A 5vuoB-4d0kB:
undetectable		 5vuoB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		4 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.31A 5vuoB-4dq6A:
undetectable		 5vuoB-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ASN B 912
GLN B 980
PHE B 979
ASP B 973
 None
 1.15A 5vuoB-4f92B:
undetectable		 5vuoB-4f92B:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.25A 5vuoB-4fn5A:
undetectable		 5vuoB-4fn5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		4 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.35A 5vuoB-4fvaA:
undetectable		 5vuoB-4fvaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdz UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF14059
(DUF4251) 		4 SER A 181
ASN A  73
ASN A 161
ASP A 160
 None
 1.30A 5vuoB-4gdzA:
undetectable		 5vuoB-4gdzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr6 ATRBCX2

(Arabidopsis
thaliana) 		PF02341
(RcbX) 		4 ARG A  80
PHE A  61
ASN A  21
ASP A  57
 None
 1.25A 5vuoB-4gr6A:
undetectable		 5vuoB-4gr6A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 SER B  62
GLN B  86
ASN B  43
ASP B  60
 None
 1.24A 5vuoB-4hxeB:
undetectable		 5vuoB-4hxeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.20A 5vuoB-4ineA:
undetectable		 5vuoB-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 ASN A 231
GLN A 278
ASN A  45
ASP A 125
 INS  A 401 (-3.9A)
INS  A 401 (-3.1A)
None
INS  A 401 (-2.8A)
 1.23A 5vuoB-4irxA:
undetectable		 5vuoB-4irxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.21A 5vuoB-4m00A:
undetectable		 5vuoB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.20A 5vuoB-4m01A:
undetectable		 5vuoB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 SER A 337
ARG A  53
GLN A  47
ASN A 338
 None
 1.23A 5vuoB-4mhpA:
undetectable		 5vuoB-4mhpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oi3 NICKEL RESPONSIVE
PROTEIN

(Streptomyces
coelicolor) 		PF14026
(DUF4242) 		4 SER A  53
GLN A  62
PHE A   4
ASP A   6
 None
 1.31A 5vuoB-4oi3A:
undetectable		 5vuoB-4oi3A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 SER C 103
ARG C 117
GLN C 110
ASN C 120
 None
 1.23A 5vuoB-4p6vC:
undetectable		 5vuoB-4p6vC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.35A 5vuoB-4pl0A:
undetectable		 5vuoB-4pl0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 ASN A  -6
GLN A  -2
PHE A  -3
TRP A  32
 None
 1.30A 5vuoB-4pviA:
undetectable		 5vuoB-4pviA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 SER C 103
ARG C 117
GLN C 110
ASN C 120
 None
 1.28A 5vuoB-4u9sC:
undetectable		 5vuoB-4u9sC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		4 GLN A 394
PHE A 189
ASN A 191
ASP A 190
 EDO  A 504 (-3.3A)
None
ACR  A 501 (-3.3A)
EDO  A 504 ( 4.2A)
 1.24A 5vuoB-4uacA:
undetectable		 5vuoB-4uacA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.30A 5vuoB-4yzzA:
undetectable		 5vuoB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04939
(RRS1)
PF04427
(Brix) 		4 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 1.01A 5vuoB-5a53C:
undetectable		 5vuoB-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 5vuoB-5aexA:
undetectable		 5vuoB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ARG A  89
GLN A  87
PHE A  88
ASN A 150
 None
None
None
MN  A 501 (-3.4A)
 1.35A 5vuoB-5c3mA:
undetectable		 5vuoB-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 SER A 457
ARG A 455
ASN A 486
ASP A 526
 None
 1.35A 5vuoB-5d6aA:
undetectable		 5vuoB-5d6aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.11A 5vuoB-5dkuA:
undetectable		 5vuoB-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.32A 5vuoB-5du3A:
undetectable		 5vuoB-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 ASN A  72
GLN A  74
PHE A  75
ASN A 288
 None
 1.16A 5vuoB-5ejjA:
undetectable		 5vuoB-5ejjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		4 ARG A 203
GLN A 115
ASP A 152
TRP A 311
 None
None
MG  A 401 (-3.5A)
None
 1.01A 5vuoB-5eqnA:
undetectable		 5vuoB-5eqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.13A 5vuoB-5gs0A:
undetectable		 5vuoB-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 4 ARG A 331
ASN A 327
GLN A 323
PHE A 326
 None
 1.27A 5vuoB-5hafA:
undetectable		 5vuoB-5hafA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		4 SER K 319
ARG K  32
PHE K  31
ASN K 324
 None
 1.25A 5vuoB-5hnzK:
undetectable		 5vuoB-5hnzK:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER A 663
GLN B1065
PHE B1086
ASN A 742
 None
 1.32A 5vuoB-5ip9A:
undetectable		 5vuoB-5ip9A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 ARG A 356
GLN A 417
PHE A 354
ASN A 122
 None
 1.09A 5vuoB-5j55A:
undetectable		 5vuoB-5j55A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 SER A 191
ARG A 189
GLN A 242
ASN A 192
 None
MLA  A 601 (-2.9A)
None
None
 1.32A 5vuoB-5jseA:
undetectable		 5vuoB-5jseA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lii MAJOR CAPSID PROTEIN

(Staphylococcus
phage 812) 		no annotation 4 ASN P 247
GLN P 237
ASN P 242
ASP P 241
 None
 1.31A 5vuoB-5liiP:
undetectable		 5vuoB-5liiP:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 188
ARG A 160
PHE A 192
ASN A 187
 None
 1.26A 5vuoB-5oqrA:
undetectable		 5vuoB-5oqrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.30A 5vuoB-5t4yD:
undetectable		 5vuoB-5t4yD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 SER A 498
ASN A 355
GLN A 697
ASN A 502
 None
 1.25A 5vuoB-5tr0A:
undetectable		 5vuoB-5tr0A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubw DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 4 ARG A 331
ASN A 327
GLN A 323
PHE A 326
 None
 1.21A 5vuoB-5ubwA:
undetectable		 5vuoB-5ubwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 SER A 686
ARG A 521
ASN A 518
ASP A 730
 None
 1.29A 5vuoB-5uowA:
undetectable		 5vuoB-5uowA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)

(Neisseria
meningitidis;
Neisseria
meningitidis) 		PF13395
(HNH_4)
no annotation 		4 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.13A 5vuoB-5vgbA:
undetectable		 5vuoB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.15A 5vuoB-5w3fA:
undetectable		 5vuoB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 SER C 503
ASN C 238
GLN C 236
PHE C 237
 None
 1.16A 5vuoB-5wqlC:
undetectable		 5vuoB-5wqlC:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY

(Escherichia
coli) 		no annotation 4 SER A 146
ARG A 149
ASN A 143
ASP A 261
 None
 1.35A 5vuoB-5xb6A:
undetectable		 5vuoB-5xb6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg8 GALACTOSIDE-BINDING
SOLUBLE LECTIN 13

(Homo sapiens) 		no annotation 4 SER A  29
PHE A  30
ASN A  32
ASP A  33
 None
 1.34A 5vuoB-5xg8A:
undetectable		 5vuoB-5xg8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00514
(Arm)
no annotation 		4 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.84A 5vuoB-5xjgA:
undetectable		 5vuoB-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii;
Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.29A 5vuoB-5xogA:
undetectable		 5vuoB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 4 ARG M 240
ASN M  56
GLN M  54
ASN M 242
 None
 1.13A 5vuoB-5xu1M:
undetectable		 5vuoB-5xu1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 ASN A 450
GLN A 130
ASN A 310
ASP A 308
 None
 1.24A 5vuoB-5yh5A:
undetectable		 5vuoB-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 SER A 569
ARG A 565
PHE A 351
TRP A 576
 EDO  A 802 (-2.6A)
EDO  A 802 (-3.7A)
EDO  A 802 (-4.0A)
None
 1.31A 5vuoB-6b6lA:
undetectable		 5vuoB-6b6lA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 4 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.24A 5vuoB-6b7kA:
undetectable		 5vuoB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 SER B 345
ARG B 316
ASN B 314
ASN B 346
 None
 1.19A 5vuoB-6evjB:
undetectable		 5vuoB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 SER A 507
ASN A 581
ASN A 508
ASP A 467
 None
 1.31A 5vuoB-6fikA:
undetectable		 5vuoB-6fikA:
undetectable