SIMILAR PATTERNS OF AMINO ACIDS FOR 5VUO_A_ACTA804_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 GLY A 417
GLN A 420
TRP A 587
VAL A 649
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
 0.11A 5vuoA-1lzxA:
63.3		 5vuoA-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 186
GLN A 189
TRP A 356
VAL A 418
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
 0.14A 5vuoA-1m9qA:
59.7		 5vuoA-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 GLY A  86
GLN A  88
TRP A  85
VAL A  74
 None
 1.22A 5vuoA-3d0qA:
0.0		 5vuoA-3d0qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzm DNA POLYMERASE III
SUBUNIT ALPHA

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A 142
GLN A  46
TRP A  47
VAL A  22
 None
 1.19A 5vuoA-3nzmA:
0.0		 5vuoA-3nzmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.20A 5vuoA-3ps9A:
0.1		 5vuoA-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A 309
GLN A 308
TRP A 408
VAL A 502
 CL  A 691 (-3.5A)
None
None
None
 1.12A 5vuoA-3pvcA:
0.2		 5vuoA-3pvcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		4 GLY A 721
GLN A 821
TRP A 823
VAL A 865
 None
 1.42A 5vuoA-4b9wA:
0.0		 5vuoA-4b9wA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.40A 5vuoA-4fblA:
0.3		 5vuoA-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxs PROTEIN RIBT

(Bacillus
subtilis) 		no annotation 4 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.26A 5vuoA-5xxsA:
0.0		 5vuoA-5xxsA:
undetectable