SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOP_B_C2FB3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad1 DIHYDROPTEROATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00809
(Pterin_bind) 		3 ASP A  84
ASN A 103
ASP A 167
 None
 0.84A 5vopB-1ad1A:
8.7		 5vopB-1ad1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 None
 0.75A 5vopB-1ajzA:
7.9		 5vopB-1ajzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP B 226
ASN A  96
ASP A  94
 None
 0.75A 5vopB-1bplB:
3.8		 5vopB-1bplB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 ASP A 318
ASN A  73
ASP A  24
 ADN  A 375 ( 3.1A)
ADN  A 375 ( 4.9A)
ADN  A 375 (-2.9A)
 0.83A 5vopB-1dgmA:
2.2		 5vopB-1dgmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		3 ASP A  86
ASN A 105
ASP A 177
 PMM  A 301 (-3.2A)
PMM  A 301 (-2.9A)
PMM  A 301 (-3.1A)
 0.17A 5vopB-1eyeA:
8.7		 5vopB-1eyeA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		3 ASP A  75
ASN A  96
ASP A 160
 None
 0.45A 5vopB-1f6yA:
29.3		 5vopB-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		3 ASP A 501
ASN A 499
ASP A 544
 None
 0.80A 5vopB-1g7rA:
undetectable		 5vopB-1g7rA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		3 ASP A  45
ASN A  44
ASP A  36
 CA  A1102 (-2.8A)
CA  A1102 ( 4.5A)
None
 0.82A 5vopB-1hdfA:
undetectable		 5vopB-1hdfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		3 ASP A  45
ASN A  44
ASP A  64
 CA  A1102 (-2.8A)
CA  A1102 ( 4.5A)
None
 0.74A 5vopB-1hdfA:
undetectable		 5vopB-1hdfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP X 225
ASN X 245
ASP X 297
 None
 0.81A 5vopB-1jpdX:
8.3		 5vopB-1jpdX:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 ASP A1081
ASN A1084
ASP A 979
 None
SO4  A 251 ( 3.5A)
SO4  A 251 ( 3.9A)
 0.85A 5vopB-1k7yA:
2.6		 5vopB-1k7yA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		3 ASP A 125
ASN A 133
ASP A 102
 UPG  A 334 (-4.1A)
UPG  A 334 (-3.4A)
MN  A 333 ( 3.1A)
 0.82A 5vopB-1ll2A:
undetectable		 5vopB-1ll2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 ASP A1081
ASN A1084
ASP A 979
 None
 0.76A 5vopB-1mskA:
undetectable		 5vopB-1mskA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		3 ASP A 164
ASN A  46
ASP A  49
 None
 0.84A 5vopB-1qmyA:
undetectable		 5vopB-1qmyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 244
ASN A 266
ASP A 321
 MG  A1601 ( 3.2A)
GLU  A2471 ( 4.7A)
ALA  A2470 (-2.7A)
 0.73A 5vopB-1tkkA:
3.7		 5vopB-1tkkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		3 ASP A 101
ASN A 120
ASP A 184
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
 0.36A 5vopB-1twwA:
19.6		 5vopB-1twwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ASP A  87
ASN A 104
ASP A 112
 None
 0.83A 5vopB-1un1A:
undetectable		 5vopB-1un1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 226
ASN A  96
ASP A  94
 None
 0.80A 5vopB-1vjsA:
9.6		 5vopB-1vjsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS013

(Pyrococcus
horikoshii) 		PF05016
(ParE_toxin) 		3 ASP A  74
ASN A  71
ASP A  53
 None
 0.80A 5vopB-1wmiA:
undetectable		 5vopB-1wmiA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A1239
ASN A1261
ASP A1316
 None
 0.87A 5vopB-1wueA:
5.2		 5vopB-1wueA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A1239
ASN A1261
ASP A1316
 MG  A5001 (-3.5A)
None
None
 0.76A 5vopB-1wufA:
8.8		 5vopB-1wufA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 ASP A 334
ASN A 331
ASP A 363
 None
 0.84A 5vopB-1xdpA:
undetectable		 5vopB-1xdpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 ASP A 261
ASN A  44
ASP A  12
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
 0.80A 5vopB-2ajrA:
2.6		 5vopB-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 ASP A 127
ASN A 157
ASP A 166
 None
 0.89A 5vopB-2azqA:
undetectable		 5vopB-2azqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		3 ASP A 636
ASN A 655
ASP A 755
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
 0.28A 5vopB-2bmbA:
7.6		 5vopB-2bmbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		3 ASP A 255
ASN A  41
ASP A  12
 ATP  A 411 (-4.1A)
None
None
 0.71A 5vopB-2f02A:
3.1		 5vopB-2f02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF04430
(DUF498) 		3 ASP A  63
ASN A  64
ASP A  40
 None
 0.79A 5vopB-2fvtA:
undetectable		 5vopB-2fvtA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 245
ASN A 267
ASP A 322
 None
 0.90A 5vopB-2ggjA:
5.2		 5vopB-2ggjA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqk NIFU-LIKE PROTEIN

(Escherichia
coli) 		PF01592
(NifU_N) 		3 ASP A  24
ASN A  26
ASP A  49
 None
 0.82A 5vopB-2kqkA:
undetectable		 5vopB-2kqkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 ASP A 203
ASN A  61
ASP A  63
 None
None
PB  A 402 (-3.3A)
 0.80A 5vopB-2o3cA:
2.4		 5vopB-2o3cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		3 ASP A  91
ASN A 110
ASP A 201
 None
 0.24A 5vopB-2vefA:
8.2		 5vopB-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp8 DIHYDROPTEROATE
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		3 ASP A 123
ASN A 142
ASP A 217
 None
 0.53A 5vopB-2vp8A:
16.9		 5vopB-2vp8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		3 ASP A 101
ASN A 120
ASP A 191
 None
 0.62A 5vopB-2y5jA:
7.9		 5vopB-2y5jA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.16A 5vopB-2ycjA:
30.0		 5vopB-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		3 ASP A 232
ASN A 230
ASP A 204
 None
 0.88A 5vopB-3aw9A:
2.6		 5vopB-3aw9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 178
ASN A 179
ASP A 174
 None
 0.77A 5vopB-3b9eA:
4.7		 5vopB-3b9eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk6 PH STOMATIN

(Pyrococcus
horikoshii) 		PF01145
(Band_7) 		3 ASP A 165
ASN A  88
ASP A  71
 None
 0.87A 5vopB-3bk6A:
undetectable		 5vopB-3bk6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ASP A 390
ASN A 411
ASP A 473
 None
 0.35A 5vopB-3bolA:
22.5		 5vopB-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		3 ASP A 165
ASN A 184
ASP A 227
 None
 0.89A 5vopB-3bz5A:
undetectable		 5vopB-3bz5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 ASP A 128
ASN A 146
ASP A 186
 None
 0.78A 5vopB-3cvrA:
undetectable		 5vopB-3cvrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 241
ASN A 263
ASP A 317
 MG  A 401 (-3.0A)
None
None
 0.81A 5vopB-3dfyA:
3.5		 5vopB-3dfyA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 ASP X 127
ASN X 124
ASP X 230
 None
 0.75A 5vopB-3e13X:
undetectable		 5vopB-3e13X:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A 294
ASN A 154
ASP A 157
 CO  A 502 (-1.9A)
CO  A 502 (-3.9A)
None
 0.69A 5vopB-3gb4A:
undetectable		 5vopB-3gb4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ASP A 115
ASN A 144
ASP A 202
 None
 0.78A 5vopB-3gozA:
undetectable		 5vopB-3gozA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASP A  65
ASN A  66
ASP A 101
 None
 0.82A 5vopB-3hdxA:
undetectable		 5vopB-3hdxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 ASP A 347
ASN A 277
ASP A 272
 None
 0.85A 5vopB-3i04A:
undetectable		 5vopB-3i04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 244
ASN A 266
ASP A 320
 K  A 364 (-3.9A)
None
None
 0.77A 5vopB-3ik4A:
3.9		 5vopB-3ik4A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		3 ASP A1612
ASN A1563
ASP A1582
 None
 0.89A 5vopB-3jzyA:
undetectable		 5vopB-3jzyA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		3 ASP A 431
ASN A 452
ASP A 519
 THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
 0.10A 5vopB-3k13A:
39.0		 5vopB-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgl CRUCIFERIN

(Brassica napus) 		PF00190
(Cupin_1) 		3 ASP A 362
ASN A 361
ASP A  10
 None
 0.76A 5vopB-3kglA:
undetectable		 5vopB-3kglA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 240
ASN A 262
ASP A 318
 MG  A 357 ( 3.3A)
None
ARG  A 355 (-2.8A)
 0.84A 5vopB-3kumA:
3.4		 5vopB-3kumA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		3 ASP A  90
ASN A  87
ASP A  29
 None
None
MLY  A  32 ( 3.8A)
 0.70A 5vopB-3kv0A:
undetectable		 5vopB-3kv0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG

(Haemophilus
influenzae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A  18
ASN A  16
ASP A  42
 None
 0.89A 5vopB-3lykA:
undetectable		 5vopB-3lykA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Salmonella
enterica) 		no annotation 3 ASP A  47
ASN A  48
ASP A  12
 None
 0.89A 5vopB-3mk3A:
undetectable		 5vopB-3mk3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		3 ASP A 116
ASN A  85
ASP A  89
 None
 0.85A 5vopB-3n94A:
undetectable		 5vopB-3n94A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 241
ASN A 263
ASP A 318
 MG  A1602 ( 3.0A)
MG  A1602 ( 4.7A)
DAL  A2472 ( 2.4A)
 0.83A 5vopB-3q4dA:
6.4		 5vopB-3q4dA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 241
ASN A 264
ASP A 319
 MG  A 365 ( 3.8A)
None
ARG  A 363 (-3.0A)
 0.81A 5vopB-3ritA:
8.8		 5vopB-3ritA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		3 ASP A 125
ASN A 133
ASP A 102
 None
None
MN  A 263 ( 3.0A)
 0.73A 5vopB-3rmvA:
undetectable		 5vopB-3rmvA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 221
ASN A 218
ASP A 201
 None
 0.86A 5vopB-3s2gA:
undetectable		 5vopB-3s2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 247
ASN A 269
ASP A 323
 None
 0.77A 5vopB-3s5sA:
5.1		 5vopB-3s5sA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 ASP A 605
ASN A 475
ASP A 310
 None
 0.60A 5vopB-3t5oA:
undetectable		 5vopB-3t5oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.21A 5vopB-3tr9A:
19.3		 5vopB-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1w HYPOTHETICAL
PERIPLASMIC PROTEIN

(Parabacteroides
distasonis) 		PF11396
(PepSY_like) 		3 ASP A 158
ASN A 157
ASP A 153
 None
 0.86A 5vopB-3u1wA:
undetectable		 5vopB-3u1wA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vol AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ASP A 231
ASN A 229
ASP A 192
 None
 0.84A 5vopB-3volA:
undetectable		 5vopB-3volA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 267
ASN A 270
ASP A 277
 None
 0.89A 5vopB-4c2tA:
undetectable		 5vopB-4c2tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.15A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		3 ASP A  11
ASN A   8
ASP A  96
 None
 0.76A 5vopB-4f3eA:
undetectable		 5vopB-4f3eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		3 ASP A 271
ASN A 126
ASP A 128
 MLI  A 403 ( 4.5A)
MLI  A 403 (-4.2A)
MG  A 402 (-3.3A)
 0.88A 5vopB-4fvaA:
undetectable		 5vopB-4fvaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 224
ASN A 244
ASP A 296
 NA  A 401 ( 3.3A)
GLU  A 403 ( 4.4A)
ALA  A 402 (-2.5A)
 0.82A 5vopB-4gfiA:
4.3		 5vopB-4gfiA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		3 ASP A 272
ASN A 130
ASP A 132
 None
MG  A 402 ( 4.3A)
MG  A 402 (-2.9A)
 0.84A 5vopB-4gz2A:
2.1		 5vopB-4gz2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ASP A 231
ASN A 229
ASP A 192
 None
 0.89A 5vopB-4hi4A:
undetectable		 5vopB-4hi4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		3 ASP A  44
ASN A  43
ASP A 123
 None
 0.88A 5vopB-4jisA:
2.1		 5vopB-4jisA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ASP A 100
ASN A  13
ASP A 284
 None
 0.84A 5vopB-4lbwA:
3.1		 5vopB-4lbwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASP A1306
ASN A1230
ASP A 974
 None
 0.80A 5vopB-4lnvA:
undetectable		 5vopB-4lnvA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.27A 5vopB-4o1eA:
27.9		 5vopB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 ASP A 143
ASN A  75
ASP A 364
 UNL  A 400 ( 3.0A)
UNL  A 400 ( 3.1A)
UNL  A 400 ( 3.0A)
 0.85A 5vopB-4onzA:
undetectable		 5vopB-4onzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		3 ASP A 214
ASN A 215
ASP A  37
 None
 0.86A 5vopB-4ovrA:
undetectable		 5vopB-4ovrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		3 ASP A 195
ASN A 250
ASP A  69
 None
 0.75A 5vopB-4pagA:
undetectable		 5vopB-4pagA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		3 ASP A 254
ASN A 276
ASP A 345
 None
 0.54A 5vopB-4pzvA:
8.2		 5vopB-4pzvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05207
(zf-CSL)
PF00415
(RCC1) 		3 ASP B  62
ASN B  46
ASP A  29
 None
 0.84A 5vopB-4x33B:
undetectable		 5vopB-4x33B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1g UNCHARACTERIZED
PROTEIN SAV1875

(Staphylococcus
aureus) 		PF01965
(DJ-1_PfpI) 		3 ASP A  98
ASN A 149
ASP A 147
 None
 0.89A 5vopB-4y1gA:
undetectable		 5vopB-4y1gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		3 ASP A2114
ASN A2115
ASP A2049
 None
 0.82A 5vopB-4zwjA:
undetectable		 5vopB-4zwjA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		3 ASP C 262
ASN C 297
ASP C 294
 None
 0.87A 5vopB-5d04C:
3.9		 5vopB-5d04C:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ASP A 392
ASN A 386
ASP A 382
 None
 0.78A 5vopB-5eufA:
undetectable		 5vopB-5eufA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 306
ASN A 332
ASP A 413
 C8E  A1725 (-4.4A)
None
None
 0.84A 5vopB-5fokA:
undetectable		 5vopB-5fokA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxy TYROSINE RECOMBINASE
XERA

(Thermoplasma
acidophilum) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		3 ASP A 147
ASN A 156
ASP A 165
 None
 0.83A 5vopB-5hxyA:
undetectable		 5vopB-5hxyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
immunodeficiency
virus 1;
Human
coronavirus
HKU1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 ASP A 837
ASN A 840
ASP A 813
 None
 0.66A 5vopB-5i08A:
undetectable		 5vopB-5i08A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		3 ASP A 201
ASN B 113
ASP A 523
 None
 0.79A 5vopB-5ivaA:
undetectable		 5vopB-5ivaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
 0.30A 5vopB-5jq9A:
8.3		 5vopB-5jq9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		3 ASP A 173
ASN A 205
ASP A 207
 None
 0.80A 5vopB-5knnA:
undetectable		 5vopB-5knnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASP A  71
ASN A 190
ASP A 193
 None
 0.78A 5vopB-5na7A:
undetectable		 5vopB-5na7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 None
 0.71A 5vopB-5umgA:
8.3		 5vopB-5umgA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usw DIHYDROPTEROATE
SYNTHASE

(Aliivibrio
fischeri) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
 0.36A 5vopB-5uswA:
2.9		 5vopB-5uswA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 3 ASP A 443
ASN A 464
ASP A 531
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
 0.13A 5vopB-5vopA:
46.9		 5vopB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 ASP A 200
ASN A 197
ASP A 363
 None
 0.84A 5vopB-5xccA:
undetectable		 5vopB-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 3 ASP A 376
ASN A  98
ASP A  43
 None
PGE  A 503 (-4.3A)
PGE  A 503 ( 4.4A)
 0.90A 5vopB-6anvA:
undetectable		 5vopB-6anvA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 ASP A 100
ASN A  12
ASP A 372
 None
 0.74A 5vopB-6bk7A:
undetectable		 5vopB-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo0 MDBA PROTEIN

(Corynebacterium
matruchotii) 		no annotation 3 ASP A  84
ASN A 117
ASP A  66
 None
 0.84A 5vopB-6bo0A:
undetectable		 5vopB-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 137
ASN A 259
ASP A 257
 None
 0.74A 5vopB-6c6lA:
undetectable		 5vopB-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6day DIHYDROPTEROATE
SYNTHASE

(Xanthomonas
albilineans) 		no annotation 3 ASP A 101
ASN A 120
ASP A 190
 None
 0.41A 5vopB-6dayA:
19.1		 5vopB-6dayA:
undetectable