SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOP_A_C2FA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 751
VAL A 425
VAL A 140
GLY A 142
ILE A 397
 None
 1.05A 5vopA-1dmsA:
undetectable		 5vopA-1dmsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLY A  18
VAL A 350
LEU A   9
VAL A 123
GLY A 102
 None
 1.03A 5vopA-1f0kA:
undetectable		 5vopA-1f0kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		6 ASN A  45
ASP A  43
LEU A 122
VAL A 194
GLY A 196
ILE A 227
 None
 1.08A 5vopA-1f6yA:
30.0		 5vopA-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		9 GLU A   6
ASN A   9
ASP A  43
LEU A 122
VAL A 194
GLY A 196
SER A 198
ARG A 207
ILE A 227
 None
 0.46A 5vopA-1f6yA:
30.0		 5vopA-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 GLY E 226
VAL E  53
GLY E 196
SER E 195
ILE E 212
 None
 1.05A 5vopA-1h9hE:
undetectable		 5vopA-1h9hE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		5 GLY A  13
VAL A  46
VAL A  52
GLY A  54
ILE A   9
 None
 0.76A 5vopA-1hg0A:
2.9		 5vopA-1hg0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 ASN B  20
GLY B  21
VAL B  44
GLY B  46
ASN B  47
 None
 1.05A 5vopA-1k5sB:
undetectable		 5vopA-1k5sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 ASN A 263
GLY A 262
VAL A 416
GLY A 391
ASN A 394
 CA  A 801 ( 2.8A)
None
None
None
PQQ  A1800 (-3.1A)
 1.05A 5vopA-1kb0A:
undetectable		 5vopA-1kb0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocy BACTERIOPHAGE T4
SHORT TAIL FIBRE

(Escherichia
virus T4) 		PF07484
(Collar)
PF14928
(S_tail_recep_bd) 		5 GLY A 435
VAL A 367
VAL A 525
GLY A 344
ILE A 523
 None
 0.97A 5vopA-1ocyA:
undetectable		 5vopA-1ocyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLU A 252
GLY A 259
VAL A 283
VAL A 220
GLY A 246
ILE A 249
 None
 1.45A 5vopA-1ovmA:
2.2		 5vopA-1ovmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 GLU A 190
GLY A 164
LEU A 220
VAL A 332
GLY A 369
 None
3PG  A 451 (-3.8A)
None
None
None
 1.07A 5vopA-1qpgA:
undetectable		 5vopA-1qpgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 GLY A 244
ASP A 455
GLY A 117
ASN A  37
ILE A 122
 None
None
None
SO4  A1003 ( 4.6A)
None
 0.81A 5vopA-1u2xA:
2.8		 5vopA-1u2xA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 GLY A 233
ASP A 440
GLY A 111
ASN A  32
ILE A 116
 None
BGC  A2457 ( 2.7A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.5A)
None
 0.84A 5vopA-1ua4A:
3.3		 5vopA-1ua4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 VAL A  42
LEU A  55
VAL A  20
GLY A  28
ILE A  31
 None
 0.99A 5vopA-1uznA:
2.5		 5vopA-1uznA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyj PROTOCADHERIN BETA
14

(Mus musculus) 		PF08266
(Cadherin_2) 		5 ASP A  33
LEU A  57
VAL A  90
GLY A 101
ILE A  13
 None
 0.92A 5vopA-1wyjA:
undetectable		 5vopA-1wyjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLU A 904
GLY A 830
ASP A 907
VAL A 860
VAL A 895
ILE A 906
 None
 1.48A 5vopA-1zy4A:
undetectable		 5vopA-1zy4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		5 GLY A 108
VAL A 309
VAL A  53
GLY A 261
ILE A 262
 PLP  A 413 (-3.5A)
None
None
None
None
 1.04A 5vopA-2ay9A:
2.6		 5vopA-2ay9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 GLU A  48
VAL A  37
VAL A  90
GLY A  78
SER A  80
 None
 1.03A 5vopA-2b6nA:
undetectable		 5vopA-2b6nA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A 197
VAL A 213
LEU A 215
GLY A  39
SER A  42
 None
None
None
None
FAD  A1385 ( 3.8A)
 1.06A 5vopA-2bi7A:
undetectable		 5vopA-2bi7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbo HYPOTHETICAL PROTEIN
(NP_422103.1)

(Caulobacter
vibrioides) 		PF03061
(4HBT) 		5 GLY A 136
LEU A  33
VAL A 104
GLY A 106
ILE A 124
 None
 0.81A 5vopA-2hboA:
undetectable		 5vopA-2hboA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A  62
LEU A 133
VAL A  58
SER A  49
ILE A  55
 None
 0.94A 5vopA-2oolA:
undetectable		 5vopA-2oolA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		5 GLU A 257
VAL A 179
VAL A 189
GLY A 187
ILE A 256
 None
 1.01A 5vopA-2q6kA:
undetectable		 5vopA-2q6kA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		6 GLY A 361
VAL A 376
LEU A  72
VAL A 146
SER A 149
ILE A 172
 None
None
None
None
COA  A1383 (-3.5A)
None
 1.25A 5vopA-2vatA:
undetectable		 5vopA-2vatA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY S 226
VAL S  53
GLY S 196
SER S 195
ILE S 212
 None
 1.06A 5vopA-2wpmS:
undetectable		 5vopA-2wpmS:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
 None
 1.07A 5vopA-2wtbA:
2.2		 5vopA-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		5 GLY F  87
ASP F  83
GLY F 144
ASN F 142
ILE F 145
 None
 1.00A 5vopA-2xwbF:
undetectable		 5vopA-2xwbF:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 6 GLU A 208
VAL A 173
LEU A 177
VAL A 204
ARG A 144
ILE A 206
 None
 1.40A 5vopA-2y4lA:
undetectable		 5vopA-2y4lA:
24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		6 ASN A  10
ASP A  76
VAL A 195
GLY A 197
ASN A 200
ARG A 208
 C2F  A3000 ( 4.8A)
C2F  A3000 (-3.4A)
None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.1A)
C2F  A3000 ( 2.6A)
 1.35A 5vopA-2ycjA:
30.6		 5vopA-2ycjA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		7 ASN A  46
ASP A  44
LEU A 123
VAL A 195
GLY A 197
ASN A 200
ILE A 228
 None
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.1A)
C2F  A3000 (-4.6A)
 1.09A 5vopA-2ycjA:
30.6		 5vopA-2ycjA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		10 GLU A   7
ASN A  10
ASP A  44
LEU A 123
VAL A 195
GLY A 197
SER A 199
ASN A 200
ARG A 208
ILE A 228
 C2F  A3000 ( 4.1A)
C2F  A3000 ( 4.8A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-3.1A)
C2F  A3000 ( 2.6A)
C2F  A3000 (-4.6A)
 0.36A 5vopA-2ycjA:
30.6		 5vopA-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 GLY A 173
VAL A 215
VAL A 124
ASN A  98
ILE A 188
 None
 1.02A 5vopA-3a1iA:
undetectable		 5vopA-3a1iA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLU A 275
ASP A 227
VAL A 315
ARG A 412
ILE A 271
 None
 0.98A 5vopA-3abgA:
undetectable		 5vopA-3abgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 0.93A 5vopA-3aqgA:
undetectable		 5vopA-3aqgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 177
VAL A 281
LEU A 277
GLY A 315
ASN A 346
 None
None
GOL  A 500 (-4.2A)
GOL  A 500 ( 3.9A)
None
 1.07A 5vopA-3awkA:
undetectable		 5vopA-3awkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		7 GLU A 320
ASN A 323
ASP A 358
LEU A 437
GLY A 505
SER A 507
ILE A 536
 None
 0.66A 5vopA-3bolA:
23.0		 5vopA-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 ASN A 221
GLY A 224
ASP A 155
VAL A 317
SER A 159
 None
 1.00A 5vopA-3cdxA:
undetectable		 5vopA-3cdxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 172
ASP A 168
GLY A 187
ARG A 179
ILE A 186
 CA  A 303 (-2.8A)
None
None
None
None
 1.02A 5vopA-3dbkA:
undetectable		 5vopA-3dbkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4l PUTATIVE
OXIDOREDUCTASE YHHX

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLU A 145
LEU A 277
VAL A 238
GLY A 240
ILE A 146
 None
 0.85A 5vopA-3f4lA:
undetectable		 5vopA-3f4lA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk9 MUTATOR MUTT PROTEIN

(Bacillus
halodurans) 		PF00293
(NUDIX) 		5 GLY A  62
VAL A 109
VAL A  15
ASN A   6
ILE A   8
 None
 1.04A 5vopA-3fk9A:
undetectable		 5vopA-3fk9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 VAL A 256
LEU A 240
VAL A 262
GLY A 247
ILE A 248
 None
 1.04A 5vopA-3fsxA:
undetectable		 5vopA-3fsxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 5 GLU A  53
GLY A  80
LEU A  41
GLY A  34
ILE A  62
 None
 1.06A 5vopA-3hm2A:
2.1		 5vopA-3hm2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij5 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Yersinia pestis) 		PF08282
(Hydrolase_3) 		5 GLY A  39
VAL A 168
LEU A  28
VAL A 139
GLY A 123
 None
 1.07A 5vopA-3ij5A:
undetectable		 5vopA-3ij5A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		6 ASN A 361
GLY A 364
ASP A 431
VAL A 478
GLY A 558
ASN A 561
 GOL  A 643 (-3.1A)
THH  A 642 (-3.7A)
THH  A 642 (-3.3A)
None
THH  A 642 (-3.3A)
THH  A 642 ( 3.3A)
 1.43A 5vopA-3k13A:
39.5		 5vopA-3k13A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		5 ASN A 398
ASP A 396
GLY A 558
ASN A 561
ILE A 593
 None
THH  A 642 ( 4.7A)
THH  A 642 (-3.3A)
THH  A 642 ( 3.3A)
THH  A 642 (-4.2A)
 0.93A 5vopA-3k13A:
39.5		 5vopA-3k13A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		10 GLU A 358
ASN A 361
GLY A 364
ASP A 396
VAL A 478
GLY A 558
SER A 560
ASN A 561
ARG A 573
ILE A 593
 THH  A 642 ( 3.5A)
GOL  A 643 (-3.1A)
THH  A 642 (-3.7A)
THH  A 642 ( 4.7A)
None
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 ( 3.3A)
THH  A 642 (-3.1A)
THH  A 642 (-4.2A)
 0.35A 5vopA-3k13A:
39.5		 5vopA-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 VAL A  32
LEU A  45
VAL A  10
GLY A  18
ILE A  21
 None
 0.99A 5vopA-3m1aA:
2.0		 5vopA-3m1aA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m21 PROBABLE TAUTOMERASE
HP_0924

(Helicobacter
pylori) 		PF01361
(Tautomerase) 		5 GLU A  47
GLY A  13
VAL A  26
VAL A  43
ILE A  45
 None
 0.78A 5vopA-3m21A:
undetectable		 5vopA-3m21A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 VAL A  31
LEU A  73
VAL A  10
GLY A  17
ILE A  20
 None
 1.07A 5vopA-3mogA:
undetectable		 5vopA-3mogA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwu SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 GLY A 295
LEU A 265
GLY A 341
ASN A 343
ILE A 340
 None
 1.07A 5vopA-3nwuA:
undetectable		 5vopA-3nwuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY B 807
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 0.99A 5vopA-3ohmB:
4.6		 5vopA-3ohmB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		5 GLY A 120
VAL A 206
VAL A 218
GLY A 149
ASN A 147
 None
 0.95A 5vopA-3om5A:
undetectable		 5vopA-3om5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otd TRNA(HIS)
GUANYLYLTRANSFERASE

(Homo sapiens) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 GLU A 189
LEU A 170
VAL A 160
SER A 193
ILE A 190
 None
 1.03A 5vopA-3otdA:
undetectable		 5vopA-3otdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r20 CYTIDYLATE KINASE

(Mycolicibacterium
smegmatis) 		PF02224
(Cytidylate_kin) 		5 GLY A  17
VAL A 221
LEU A  29
VAL A 144
ILE A 146
 DPO  A 230 (-3.1A)
None
None
None
None
 0.84A 5vopA-3r20A:
undetectable		 5vopA-3r20A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 453
VAL A 328
LEU A 325
GLY A 297
ASN A 302
 None
 1.07A 5vopA-3v4cA:
undetectable		 5vopA-3v4cA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		5 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.07A 5vopA-3v4vB:
undetectable		 5vopA-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 GLU A 116
LEU A 139
VAL A  72
GLY A 110
ILE A 117
 None
NAI  A1400 (-4.5A)
None
None
None
 1.06A 5vopA-3zu4A:
undetectable		 5vopA-3zu4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 232
VAL A 104
LEU A 102
VAL A  15
ILE A 190
 None
 1.04A 5vopA-4b46A:
undetectable		 5vopA-4b46A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 GLY A 241
ASP A 451
GLY A 119
ASN A  40
ILE A 124
 None
GLC  A 468 (-2.9A)
GLC  A 468 (-3.5A)
GLC  A 468 ( 4.1A)
None
 0.76A 5vopA-4b8sA:
3.0		 5vopA-4b8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4biz SENSOR PROTEIN CPXA

(Escherichia
coli) 		PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c) 		5 GLY A 339
VAL A 358
LEU A 332
VAL A 384
GLY A 372
 None
 0.86A 5vopA-4bizA:
undetectable		 5vopA-4bizA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4biz SENSOR PROTEIN CPXA

(Escherichia
coli) 		PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c) 		5 GLY A 339
VAL A 358
LEU A 332
VAL A 384
ILE A 382
 None
 1.02A 5vopA-4bizA:
undetectable		 5vopA-4bizA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
 1.32A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		10 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 GLY A 216
LEU A 257
GLY A 212
ASN A 200
ILE A 213
 None
 1.04A 5vopA-4drtA:
undetectable		 5vopA-4drtA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		5 GLY A 366
VAL A 312
VAL A  37
GLY A  33
ILE A  34
 None
 1.07A 5vopA-4dteA:
undetectable		 5vopA-4dteA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.08A 5vopA-4e4rA:
undetectable		 5vopA-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLY A 396
VAL A 412
VAL A 475
GLY A 409
ILE A 472
 None
 1.01A 5vopA-4fnqA:
7.7		 5vopA-4fnqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 GLY A  66
VAL A 227
LEU A 231
VAL A 259
ILE A  53
 None
 0.91A 5vopA-4fqdA:
undetectable		 5vopA-4fqdA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLU A 523
LEU A 487
VAL A 495
GLY A 499
SER A 502
 NAG  A1010 (-3.9A)
None
None
NAG  A1010 ( 4.4A)
NAG  A1010 (-4.1A)
 0.81A 5vopA-4fysA:
undetectable		 5vopA-4fysA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		5 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.88A 5vopA-4jerA:
undetectable		 5vopA-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		5 ASN A 222
GLY A 232
VAL A 177
VAL A 195
ILE A 240
 None
 0.97A 5vopA-4jqpA:
2.5		 5vopA-4jqpA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 150
VAL A 169
LEU A 198
GLY A 173
SER A 174
 NK  A 501 (-3.1A)
None
None
None
None
 1.07A 5vopA-4jz6A:
2.7		 5vopA-4jz6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		5 GLY A  41
VAL A 461
LEU A 351
VAL A 449
ILE A 439
 None
 1.00A 5vopA-4kjdA:
undetectable		 5vopA-4kjdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 VAL A  35
LEU A  52
VAL A  13
GLY A  21
ILE A  24
 None
 1.05A 5vopA-4m8sA:
2.7		 5vopA-4m8sA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ASN A 219
VAL A  33
VAL A  11
GLY A  19
ILE A  22
 None
 1.03A 5vopA-4mowA:
undetectable		 5vopA-4mowA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		6 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
 F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
 1.35A 5vopA-4n6fA:
7.2		 5vopA-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 ASN A  10
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.94A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.54A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.95A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 1.05A 5vopA-4psdA:
undetectable		 5vopA-4psdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 ASN A 131
GLY A 244
LEU A 116
GLY A 249
SER A 143
 None
 1.01A 5vopA-4q0cA:
undetectable		 5vopA-4q0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		5 ASN A 221
VAL A  34
VAL A  12
GLY A  20
ILE A  23
 None
 1.01A 5vopA-4rf3A:
undetectable		 5vopA-4rf3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 GLY A  16
VAL A  54
LEU A  48
VAL A  36
ILE A  79
 None
 1.00A 5vopA-4rv0A:
undetectable		 5vopA-4rv0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		5 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
 None
 0.77A 5vopA-4rxmA:
2.6		 5vopA-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.98A 5vopA-4yh2A:
undetectable		 5vopA-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY H 226
LEU H 121
VAL H  53
SER H 195
ILE H 212
 0Z7  H 501 (-3.0A)
None
None
0Z7  H 501 (-1.4A)
None
 1.06A 5vopA-4ylqH:
undetectable		 5vopA-4ylqH:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLU A 194
VAL A  72
LEU A  68
VAL A  96
ILE A 193
 None
 0.84A 5vopA-4zemA:
2.4		 5vopA-4zemA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A  68
LEU A  28
VAL A 246
GLY A 244
ARG A  46
 None
 1.06A 5vopA-5bp1A:
undetectable		 5vopA-5bp1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 1.02A 5vopA-5c6uA:
undetectable		 5vopA-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Yersinia pestis) 		PF13561
(adh_short_C2) 		5 VAL A  32
LEU A  49
VAL A  10
GLY A  18
ILE A  21
 None
 1.07A 5vopA-5cejA:
2.6		 5vopA-5cejA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.04A 5vopA-5e6sB:
undetectable		 5vopA-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		5 LEU A 284
VAL A 263
GLY A 280
ASN A 281
ILE A 254
 None
 0.86A 5vopA-5i1tA:
undetectable		 5vopA-5i1tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 GLY A 236
ASP A 443
GLY A 114
ASN A  35
ILE A 119
 None
GLC  A 503 (-2.6A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.4A)
None
 0.85A 5vopA-5o0jA:
3.3		 5vopA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 GLY A 233
ASP A 442
GLY A 106
ASN A  26
ILE A 111
 None
GLC  A 501 ( 2.6A)
GLC  A 501 (-3.2A)
GLC  A 501 (-3.8A)
None
 0.83A 5vopA-5od2A:
3.0		 5vopA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A  50
LEU A  63
VAL A  28
GLY A  36
ILE A  39
 None
 0.96A 5vopA-5ovkA:
3.0		 5vopA-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A  50
LEU A  63
VAL A  28
GLY A  36
ILE A  39
 None
 1.08A 5vopA-5ovlA:
undetectable		 5vopA-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 GLY A 234
LEU A 275
GLY A 230
ASN A 218
ILE A 231
 None
 1.02A 5vopA-5tr7A:
undetectable		 5vopA-5tr7A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.92A 5vopA-5v4bB:
undetectable		 5vopA-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 7 ASN A 376
GLY A 379
ASP A 443
VAL A 490
VAL A 568
GLY A 570
ASN A 573
 NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 (-2.5A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 (-2.6A)
 1.35A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 12 GLU A 373
ASN A 376
GLY A 379
ASP A 411
VAL A 490
LEU A 492
VAL A 568
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-3.3A)
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.00A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 6 GLY A 242
ASP A 471
GLY A 114
SER A  33
ASN A  34
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
None
 0.87A 5vopA-6c8zA:
2.6		 5vopA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad1 DIHYDROPTEROATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00809
(Pterin_bind) 		3 ASP A  84
ASN A 103
ASP A 167
 None
 0.83A 5vopA-1ad1A:
8.7		 5vopA-1ad1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 None
 0.74A 5vopA-1ajzA:
18.7		 5vopA-1ajzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP B 226
ASN A  96
ASP A  94
 None
 0.81A 5vopA-1bplB:
3.8		 5vopA-1bplB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 ASP A 318
ASN A  73
ASP A  24
 ADN  A 375 ( 3.1A)
ADN  A 375 ( 4.9A)
ADN  A 375 (-2.9A)
 0.81A 5vopA-1dgmA:
2.4		 5vopA-1dgmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		3 ASP A  86
ASN A 105
ASP A 177
 PMM  A 301 (-3.2A)
PMM  A 301 (-2.9A)
PMM  A 301 (-3.1A)
 0.25A 5vopA-1eyeA:
19.0		 5vopA-1eyeA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		3 ASP A  75
ASN A  96
ASP A 160
 None
 0.43A 5vopA-1f6yA:
30.0		 5vopA-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fgg GLUCURONYLTRANSFERAS
E I

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		3 ASP A 196
ASN A 197
ASP A 252
 MN  A 336 ( 1.8A)
MN  A 336 ( 4.5A)
GAL  A   1 ( 3.5A)
 0.85A 5vopA-1fggA:
3.4		 5vopA-1fggA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		3 ASP A 501
ASN A 499
ASP A 544
 None
 0.80A 5vopA-1g7rA:
3.4		 5vopA-1g7rA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		3 ASP A  45
ASN A  44
ASP A  36
 CA  A1102 (-2.8A)
CA  A1102 ( 4.5A)
None
 0.85A 5vopA-1hdfA:
undetectable		 5vopA-1hdfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		3 ASP A  45
ASN A  44
ASP A  64
 CA  A1102 (-2.8A)
CA  A1102 ( 4.5A)
None
 0.76A 5vopA-1hdfA:
undetectable		 5vopA-1hdfA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP X 225
ASN X 245
ASP X 297
 None
 0.83A 5vopA-1jpdX:
5.4		 5vopA-1jpdX:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 ASP A1081
ASN A1084
ASP A 979
 None
SO4  A 251 ( 3.5A)
SO4  A 251 ( 3.9A)
 0.83A 5vopA-1k7yA:
undetectable		 5vopA-1k7yA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ASP A 329
ASN A 419
ASP A 412
 None
 0.85A 5vopA-1lamA:
3.1		 5vopA-1lamA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		3 ASP A 125
ASN A 133
ASP A 102
 UPG  A 334 (-4.1A)
UPG  A 334 (-3.4A)
MN  A 333 ( 3.1A)
 0.82A 5vopA-1ll2A:
undetectable		 5vopA-1ll2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 ASP D 170
ASN D 169
ASP D 164
 None
 0.85A 5vopA-1mhzD:
undetectable		 5vopA-1mhzD:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 ASP A1081
ASN A1084
ASP A 979
 None
 0.72A 5vopA-1mskA:
undetectable		 5vopA-1mskA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s79 LUPUS LA PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP A 107
ASN A 110
ASP A 186
 None
 0.84A 5vopA-1s79A:
undetectable		 5vopA-1s79A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 244
ASN A 266
ASP A 321
 MG  A1601 ( 3.2A)
GLU  A2471 ( 4.7A)
ALA  A2470 (-2.7A)
 0.78A 5vopA-1tkkA:
6.7		 5vopA-1tkkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		3 ASP A 101
ASN A 120
ASP A 184
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-3.1A)
 0.33A 5vopA-1twwA:
19.8		 5vopA-1twwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ASP A  87
ASN A 104
ASP A 112
 None
 0.81A 5vopA-1un1A:
undetectable		 5vopA-1un1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		3 ASP A 197
ASN A 198
ASP A 254
 MN  A 501 ( 2.0A)
MN  A 501 ( 4.6A)
GAL  A 505 (-3.7A)
 0.83A 5vopA-1v84A:
undetectable		 5vopA-1v84A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 226
ASN A  96
ASP A  94
 None
 0.85A 5vopA-1vjsA:
2.4		 5vopA-1vjsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS013

(Pyrococcus
horikoshii) 		PF05016
(ParE_toxin) 		3 ASP A  74
ASN A  71
ASP A  53
 None
 0.77A 5vopA-1wmiA:
undetectable		 5vopA-1wmiA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A1239
ASN A1261
ASP A1316
 MG  A5001 (-3.5A)
None
None
 0.80A 5vopA-1wufA:
9.6		 5vopA-1wufA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		3 ASP A 235
ASN A 213
ASP A 210
 None
CME  A 214 ( 4.8A)
None
 0.84A 5vopA-1wz9A:
undetectable		 5vopA-1wz9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		3 ASP A 124
ASN A 121
ASP A 372
 None
 0.77A 5vopA-1x9yA:
undetectable		 5vopA-1x9yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 ASP A 334
ASN A 331
ASP A 363
 None
 0.81A 5vopA-1xdpA:
undetectable		 5vopA-1xdpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 ASP A 261
ASN A  44
ASP A  12
 None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
 0.80A 5vopA-2ajrA:
undetectable		 5vopA-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ams HIGH POTENTIAL
IRON-SULFUR PROTEIN

(Allochromatium
vinosum) 		PF01355
(HIPIP) 		3 ASP A  57
ASN A  70
ASP A  22
 None
 0.83A 5vopA-2amsA:
undetectable		 5vopA-2amsA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		3 ASP A 636
ASN A 655
ASP A 755
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 (-3.2A)
 0.32A 5vopA-2bmbA:
17.8		 5vopA-2bmbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		3 ASP A 255
ASN A  41
ASP A  12
 ATP  A 411 (-4.1A)
None
None
 0.69A 5vopA-2f02A:
3.0		 5vopA-2f02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF04430
(DUF498) 		3 ASP A  63
ASN A  64
ASP A  40
 None
 0.72A 5vopA-2fvtA:
undetectable		 5vopA-2fvtA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqk NIFU-LIKE PROTEIN

(Escherichia
coli) 		PF01592
(NifU_N) 		3 ASP A  24
ASN A  26
ASP A  49
 None
 0.78A 5vopA-2kqkA:
undetectable		 5vopA-2kqkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 ASP A 203
ASN A  61
ASP A  63
 None
None
PB  A 402 (-3.3A)
 0.83A 5vopA-2o3cA:
undetectable		 5vopA-2o3cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		3 ASP A 147
ASN A 110
ASP A  70
 None
None
PG4  A 337 (-3.6A)
 0.83A 5vopA-2r44A:
undetectable		 5vopA-2r44A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		3 ASP A  91
ASN A 110
ASP A 201
 None
 0.27A 5vopA-2vefA:
18.6		 5vopA-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		3 ASP A 101
ASN A  68
ASP A  80
 None
 0.84A 5vopA-2verA:
undetectable		 5vopA-2verA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp8 DIHYDROPTEROATE
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		3 ASP A 123
ASN A 142
ASP A 217
 None
 0.49A 5vopA-2vp8A:
17.2		 5vopA-2vp8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		3 ASP A 101
ASN A 120
ASP A 191
 None
 0.61A 5vopA-2y5jA:
17.6		 5vopA-2y5jA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.15A 5vopA-2ycjA:
30.6		 5vopA-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		3 ASP A 232
ASN A 230
ASP A 204
 None
 0.82A 5vopA-3aw9A:
2.2		 5vopA-3aw9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ASP A 178
ASN A 179
ASP A 174
 None
 0.73A 5vopA-3b9eA:
7.4		 5vopA-3b9eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk6 PH STOMATIN

(Pyrococcus
horikoshii) 		PF01145
(Band_7) 		3 ASP A 165
ASN A  88
ASP A  71
 None
 0.77A 5vopA-3bk6A:
undetectable		 5vopA-3bk6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ASP A 390
ASN A 411
ASP A 473
 None
 0.39A 5vopA-3bolA:
23.0		 5vopA-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		3 ASP A 165
ASN A 184
ASP A 227
 None
 0.82A 5vopA-3bz5A:
undetectable		 5vopA-3bz5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 ASP A 128
ASN A 146
ASP A 186
 None
 0.70A 5vopA-3cvrA:
undetectable		 5vopA-3cvrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 241
ASN A 263
ASP A 317
 MG  A 401 (-3.0A)
None
None
 0.84A 5vopA-3dfyA:
9.1		 5vopA-3dfyA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 ASP X 127
ASN X 124
ASP X 230
 None
 0.76A 5vopA-3e13X:
undetectable		 5vopA-3e13X:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASP A 294
ASN A 154
ASP A 157
 CO  A 502 (-1.9A)
CO  A 502 (-3.9A)
None
 0.69A 5vopA-3gb4A:
undetectable		 5vopA-3gb4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ASP A 115
ASN A 144
ASP A 202
 None
 0.81A 5vopA-3gozA:
2.4		 5vopA-3gozA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASP A  65
ASN A  66
ASP A 101
 None
 0.77A 5vopA-3hdxA:
undetectable		 5vopA-3hdxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 ASP A 347
ASN A 277
ASP A 272
 None
 0.83A 5vopA-3i04A:
undetectable		 5vopA-3i04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 244
ASN A 266
ASP A 320
 K  A 364 (-3.9A)
None
None
 0.78A 5vopA-3ik4A:
9.8		 5vopA-3ik4A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		3 ASP A1612
ASN A1563
ASP A1582
 None
 0.83A 5vopA-3jzyA:
undetectable		 5vopA-3jzyA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		3 ASP A 431
ASN A 452
ASP A 519
 THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
 0.14A 5vopA-3k13A:
39.5		 5vopA-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgl CRUCIFERIN

(Brassica napus) 		PF00190
(Cupin_1) 		3 ASP A 362
ASN A 361
ASP A  10
 None
 0.76A 5vopA-3kglA:
undetectable		 5vopA-3kglA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		3 ASP A  90
ASN A  87
ASP A  29
 None
None
MLY  A  32 ( 3.8A)
 0.67A 5vopA-3kv0A:
undetectable		 5vopA-3kv0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG

(Haemophilus
influenzae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A  18
ASN A  16
ASP A  42
 None
 0.85A 5vopA-3lykA:
undetectable		 5vopA-3lykA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Salmonella
enterica) 		no annotation 3 ASP A  47
ASN A  48
ASP A  12
 None
 0.81A 5vopA-3mk3A:
undetectable		 5vopA-3mk3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		3 ASP A 116
ASN A  85
ASP A  89
 None
 0.80A 5vopA-3n94A:
undetectable		 5vopA-3n94A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 241
ASN A 264
ASP A 319
 MG  A 365 ( 3.8A)
None
ARG  A 363 (-3.0A)
 0.85A 5vopA-3ritA:
8.9		 5vopA-3ritA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		3 ASP A 125
ASN A 133
ASP A 102
 None
None
MN  A 263 ( 3.0A)
 0.75A 5vopA-3rmvA:
undetectable		 5vopA-3rmvA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 221
ASN A 218
ASP A 201
 None
 0.84A 5vopA-3s2gA:
undetectable		 5vopA-3s2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 247
ASN A 269
ASP A 323
 None
 0.82A 5vopA-3s5sA:
10.1		 5vopA-3s5sA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 ASP A 605
ASN A 475
ASP A 310
 None
 0.54A 5vopA-3t5oA:
undetectable		 5vopA-3t5oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.26A 5vopA-3tr9A:
19.4		 5vopA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 ASP A 293
ASN A 294
ASP A 254
 None
 0.82A 5vopA-3vm7A:
3.1		 5vopA-3vm7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vol AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ASP A 231
ASN A 229
ASP A 192
 None
 0.83A 5vopA-3volA:
undetectable		 5vopA-3volA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 267
ASN A 270
ASP A 277
 None
 0.85A 5vopA-4c2tA:
undetectable		 5vopA-4c2tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.20A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		3 ASP A  11
ASN A   8
ASP A  96
 None
 0.71A 5vopA-4f3eA:
undetectable		 5vopA-4f3eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 224
ASN A 244
ASP A 296
 NA  A 401 ( 3.3A)
GLU  A 403 ( 4.4A)
ALA  A 402 (-2.5A)
 0.85A 5vopA-4gfiA:
6.8		 5vopA-4gfiA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		3 ASP A  99
ASN A 178
ASP A 182
 None
 0.82A 5vopA-4ho4A:
undetectable		 5vopA-4ho4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		3 ASP A  44
ASN A  43
ASP A 123
 None
 0.80A 5vopA-4jisA:
undetectable		 5vopA-4jisA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ASP A 100
ASN A  13
ASP A 284
 None
 0.86A 5vopA-4lbwA:
2.6		 5vopA-4lbwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASP A1306
ASN A1230
ASP A 974
 None
 0.83A 5vopA-4lnvA:
undetectable		 5vopA-4lnvA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.26A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		3 ASP A 143
ASN A  75
ASP A 364
 UNL  A 400 ( 3.0A)
UNL  A 400 ( 3.1A)
UNL  A 400 ( 3.0A)
 0.82A 5vopA-4onzA:
undetectable		 5vopA-4onzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		3 ASP A 214
ASN A 215
ASP A  37
 None
 0.86A 5vopA-4ovrA:
undetectable		 5vopA-4ovrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		3 ASP A 195
ASN A 250
ASP A  69
 None
 0.73A 5vopA-4pagA:
2.4		 5vopA-4pagA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		3 ASP A 254
ASN A 276
ASP A 345
 None
 0.54A 5vopA-4pzvA:
16.8		 5vopA-4pzvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 141
ASN A  90
ASP A 168
 None
 0.81A 5vopA-4usfA:
undetectable		 5vopA-4usfA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uww STRUTHIOCALCIN-1

(Struthio
camelus) 		PF00059
(Lectin_C) 		3 ASP A 116
ASN A 117
ASP A  96
 None
 0.84A 5vopA-4uwwA:
undetectable		 5vopA-4uwwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05207
(zf-CSL)
PF00415
(RCC1) 		3 ASP B  62
ASN B  46
ASP A  29
 None
 0.79A 5vopA-4x33B:
undetectable		 5vopA-4x33B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		3 ASP A2114
ASN A2115
ASP A2049
 None
 0.82A 5vopA-4zwjA:
undetectable		 5vopA-4zwjA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		3 ASP C 262
ASN C 297
ASP C 294
 None
 0.83A 5vopA-5d04C:
10.4		 5vopA-5d04C:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxy TYROSINE RECOMBINASE
XERA

(Thermoplasma
acidophilum) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		3 ASP A 147
ASN A 156
ASP A 165
 None
 0.80A 5vopA-5hxyA:
undetectable		 5vopA-5hxyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
immunodeficiency
virus 1;
Human
coronavirus
HKU1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 ASP A 837
ASN A 840
ASP A 813
 None
 0.60A 5vopA-5i08A:
undetectable		 5vopA-5i08A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		3 ASP A 201
ASN B 113
ASP A 523
 None
 0.76A 5vopA-5ivaA:
undetectable		 5vopA-5ivaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 6MB  A 301 (-3.2A)
6MB  A 301 (-2.9A)
6MB  A 301 (-3.2A)
 0.32A 5vopA-5jq9A:
18.8		 5vopA-5jq9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		3 ASP A 173
ASN A 205
ASP A 207
 None
 0.80A 5vopA-5knnA:
undetectable		 5vopA-5knnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASP A  71
ASN A 190
ASP A 193
 None
 0.75A 5vopA-5na7A:
undetectable		 5vopA-5na7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 None
 0.69A 5vopA-5umgA:
8.5		 5vopA-5umgA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usw DIHYDROPTEROATE
SYNTHASE

(Aliivibrio
fischeri) 		PF00809
(Pterin_bind) 		3 ASP A  96
ASN A 115
ASP A 185
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
 0.33A 5vopA-5uswA:
17.9		 5vopA-5uswA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 3 ASP A 443
ASN A 464
ASP A 531
 C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
 0.03A 5vopA-5vopA:
50.8		 5vopA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 ASP A 200
ASN A 197
ASP A 363
 None
 0.80A 5vopA-5xccA:
undetectable		 5vopA-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 ASP A 100
ASN A  12
ASP A 372
 None
 0.78A 5vopA-6bk7A:
undetectable		 5vopA-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo0 MDBA PROTEIN

(Corynebacterium
matruchotii) 		no annotation 3 ASP A  84
ASN A 117
ASP A  66
 None
 0.85A 5vopA-6bo0A:
undetectable		 5vopA-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 137
ASN A 259
ASP A 257
 None
 0.65A 5vopA-6c6lA:
undetectable		 5vopA-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6day DIHYDROPTEROATE
SYNTHASE

(Xanthomonas
albilineans) 		no annotation 3 ASP A 101
ASN A 120
ASP A 190
 None
 0.47A 5vopA-6dayA:
19.2		 5vopA-6dayA:
undetectable