SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_F_C2FF3001_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6y | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Moorellathermoacetica) |
PF00809(Pterin_bind) | 5 | ASN A 45ASP A 43LEU A 122GLY A 196ILE A 227 | None | 1.05A | 5vooF-1f6yA:29.3 | 5vooF-1f6yA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6y | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Moorellathermoacetica) |
PF00809(Pterin_bind) | 8 | GLU A 6ASN A 9ASP A 43LEU A 122GLY A 196SER A 198ARG A 207ILE A 227 | None | 0.62A | 5vooF-1f6yA:29.3 | 5vooF-1f6yA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5u | PROFILIN (Heveabrasiliensis) |
PF00235(Profilin) | 5 | GLY A1069VAL A1119LEU A1020GLY A1091ILE A1092 | None | 1.17A | 5vooF-1g5uA:undetectable | 5vooF-1g5uA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 5 | GLY A 341VAL A 404GLY A 313SER A 310PHE A 292 | None | 1.15A | 5vooF-1hcuA:undetectable | 5vooF-1hcuA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | GLU A 301LYS A 353GLY A 260SER A 311ILE A 285 | None | 1.10A | 5vooF-1kb0A:undetectable | 5vooF-1kb0A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 239LYS A 236ASP A 300GLY A 306SER A 259 | None | 1.15A | 5vooF-1lrwA:undetectable | 5vooF-1lrwA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | GLY A 418VAL A 308LEU A 305GLY A 410ILE A 491 | None | 1.18A | 5vooF-1mroA:undetectable | 5vooF-1mroA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oe5 | SINGLE-STRANDSELECTIVEMONOFUNCTIONALURACIL DNAGLYCOSYLASE (Xenopus laevis) |
no annotation | 5 | ASN A 174GLY A 94LEU A 119GLY A 149SER A 148 | URA A1282 (-3.0A)URA A1282 (-3.6A)NoneNoneURA A1282 ( 4.4A) | 1.04A | 5vooF-1oe5A:undetectable | 5vooF-1oe5A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpw | PORCINE HEMOGLOBIN(BETA SUBUNIT) (Sus scrofa) |
PF00042(Globin) | 5 | GLY B 64LYS B 59VAL B 133LEU B 75ILE B 110 | None | 1.17A | 5vooF-1qpwB:undetectable | 5vooF-1qpwB:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v02 | DHURRINASE (Sorghum bicolor) |
PF00232(Glyco_hydro_1) | 5 | ASN A 374GLY A 408VAL A 202LEU A 203GLY A 464 | None | 1.18A | 5vooF-1v02A:3.1 | 5vooF-1v02A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvy | SFUA (Yersiniaenterocolitica) |
PF13343(SBP_bac_6) | 5 | ASN A 60LEU A 258GLY A 97PHE A 56ILE A 227 | None | 1.06A | 5vooF-1xvyA:undetectable | 5vooF-1xvyA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8l | GLUTAMATECARBOXYPEPTIDASE II (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | GLU A 522ASN A 519ASP A 520GLY A 427PHE A 209 | None ZN A1751 (-3.7A)NoneNoneNone | 1.12A | 5vooF-1z8lA:undetectable | 5vooF-1z8lA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztm | FUSION GLYCOPROTEIN (Humanrespirovirus 3) |
PF00523(Fusion_gly) | 5 | GLY A 225VAL A 269LEU A 86GLY A 219ILE A 218 | None | 1.18A | 5vooF-1ztmA:undetectable | 5vooF-1ztmA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaf | ARGININE DEIMINASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 5 | ASN A 233GLY A 234ASP A 417LEU A 338ILE A 416 | None | 1.13A | 5vooF-2aafA:undetectable | 5vooF-2aafA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi7 | UDP-GALACTOPYRANOSEMUTASE (Klebsiellapneumoniae) |
PF03275(GLF)PF13450(NAD_binding_8) | 6 | GLY A 197VAL A 213LEU A 215GLY A 39SER A 42ILE A 202 | NoneNoneNoneNoneFAD A1385 ( 3.8A)None | 1.33A | 5vooF-2bi7A:undetectable | 5vooF-2bi7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7d | UVRABC SYSTEMPROTEIN B (Bacillussubtilis) |
PF00271(Helicase_C)PF02151(UVR)PF04851(ResIII)PF12344(UvrB) | 5 | GLY A 429VAL A 448LEU A 516GLY A 436ILE A 435 | None | 1.14A | 5vooF-2d7dA:2.0 | 5vooF-2d7dA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drh | 361AA LONGHYPOTHETICALD-AMINOPEPTIDASE (Pyrococcushorikoshii) |
PF03576(Peptidase_S58) | 5 | GLU A 213GLY A 223LEU A 266GLY A 210PHE A 181 | None | 1.14A | 5vooF-2drhA:undetectable | 5vooF-2drhA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e1d | TRANSALDOLASE (Mus musculus) |
PF00923(TAL_FSA) | 5 | ASN A 82GLY A 69ASP A 85PHE A 331ILE A 84 | None | 1.16A | 5vooF-2e1dA:6.9 | 5vooF-2e1dA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g39 | ACETYL-COA HYDROLASE (Pseudomonasaeruginosa) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | GLU A 288GLY A 308VAL A 226GLY A 263ILE A 264 | ACY A 901 (-2.6A)NoneNoneNoneACY A 901 (-4.1A) | 1.10A | 5vooF-2g39A:2.6 | 5vooF-2g39A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjx | BETA-HEXOSAMINIDASEALPHA CHAIN (Homo sapiens) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 5 | GLY A 250ASP A 314VAL A 371LEU A 415SER A 112 | None | 1.20A | 5vooF-2gjxA:10.3 | 5vooF-2gjxA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gnp | TRANSCRIPTIONALREGULATOR (Streptococcuspneumoniae) |
PF04198(Sugar-bind) | 5 | GLY A 282VAL A 298LEU A 277GLY A 209ILE A 210 | None | 1.19A | 5vooF-2gnpA:undetectable | 5vooF-2gnpA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5g | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01244(Peptidase_M19) | 5 | GLY A 92VAL A 288LEU A 35GLY A 248SER A 180 | None | 1.13A | 5vooF-2i5gA:4.8 | 5vooF-2i5gA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | GLY A 113VAL A 161LEU A 128GLY A 121ILE A 122 | None | 1.09A | 5vooF-2icsA:4.1 | 5vooF-2icsA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jif | SHORT/BRANCHED CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ASN A 291GLY A 288GLY A 296PHE A 174ILE A 295 | COS A1434 (-3.0A)NoneNoneNoneNone | 1.16A | 5vooF-2jifA:undetectable | 5vooF-2jifA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwh | SUCROSE ISOMERASE ([Pseudomonas]mesoacidophila) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ASN A 59GLY A 63GLY A 29SER A 19ILE A 28 | NoneNone CA A7001 ( 4.6A)NoneNone | 1.13A | 5vooF-2pwhA:9.3 | 5vooF-2pwhA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] SMALL CHAIN (Azospirillumbrasilense) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLU G 219ASN G 408ASP G 411VAL G 236LEU G 237 | FAD G 484 (-2.9A)FAD G 484 (-4.2A)NoneNoneNone | 1.20A | 5vooF-2vdcG:2.3 | 5vooF-2vdcG:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vun | ENAMIDASE (Eubacteriumbarkeri) |
PF01979(Amidohydro_1) | 5 | ASN A 222GLY A 250VAL A 210GLY A 195ILE A 228 | None | 1.18A | 5vooF-2vunA:5.2 | 5vooF-2vunA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLU A 139GLY A 150VAL A 35LEU A 23GLY A 67 | None | 1.15A | 5vooF-2wtbA:4.2 | 5vooF-2wtbA:19.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 6 | ASN A 10LYS A 14ASP A 76GLY A 197SER A 199ARG A 208 | C2F A3000 ( 4.8A)NoneC2F A3000 (-3.4A)C2F A3000 (-3.6A)GOL A1270 ( 3.9A)C2F A3000 ( 2.6A) | 1.44A | 5vooF-2ycjA:29.8 | 5vooF-2ycjA:30.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 5 | ASN A 46ASP A 44LEU A 123GLY A 197ILE A 228 | NoneC2F A3000 ( 4.5A)NoneC2F A3000 (-3.6A)C2F A3000 (-4.6A) | 1.05A | 5vooF-2ycjA:29.8 | 5vooF-2ycjA:30.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 9 | GLU A 7ASN A 10LYS A 14ASP A 44LEU A 123GLY A 197SER A 199ARG A 208ILE A 228 | C2F A3000 ( 4.1A)C2F A3000 ( 4.8A)NoneC2F A3000 ( 4.5A)NoneC2F A3000 (-3.6A)GOL A1270 ( 3.9A)C2F A3000 ( 2.6A)C2F A3000 (-4.6A) | 0.67A | 5vooF-2ycjA:29.8 | 5vooF-2ycjA:30.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjv | REGULATOR OFRIBONUCLEASEACTIVITY A (Escherichiacoli) |
PF03737(RraA-like) | 5 | GLU A 43GLY A 118ASP A 44GLY A 65SER A 68 | None | 1.14A | 5vooF-2yjvA:undetectable | 5vooF-2yjvA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv5 | YJEQ PROTEIN (Aquifexaeolicus) |
PF03193(RsgA_GTPase) | 5 | GLY A 208VAL A 50LEU A 10GLY A 20ILE A 19 | None | 1.18A | 5vooF-2yv5A:2.2 | 5vooF-2yv5A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abg | BILIRUBIN OXIDASE (Albifimbriaverrucaria) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLU A 275ASP A 227VAL A 315ARG A 412ILE A 271 | None | 0.99A | 5vooF-3abgA:undetectable | 5vooF-3abgA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au9 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | GLY A 186LEU A 219GLY A 212SER A 210ILE A 208 | None | 1.17A | 5vooF-3au9A:2.4 | 5vooF-3au9A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 7 | GLU A 320ASN A 323ASP A 358LEU A 437GLY A 505SER A 507ILE A 536 | None | 0.66A | 5vooF-3bolA:22.3 | 5vooF-3bolA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5y | RIBOSE/GALACTOSEISOMERASE (Novosphingobiumaromaticivorans) |
PF02502(LacAB_rpiB)PF12408(DUF3666) | 5 | GLU A 8GLY A 77LEU A 127SER A 10ILE A 7 | None | 1.17A | 5vooF-3c5yA:undetectable | 5vooF-3c5yA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7l | LIN1944 PROTEIN (Listeriainnocua) |
PF13561(adh_short_C2) | 5 | GLY A 122VAL A 174LEU A 157GLY A 112ILE A 113 | None | 1.10A | 5vooF-3d7lA:2.5 | 5vooF-3d7lA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbk | ELASTASE (Pseudomonasaeruginosa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | GLU A 172ASP A 168GLY A 187ARG A 179ILE A 186 | CA A 303 (-2.8A)NoneNoneNoneNone | 1.06A | 5vooF-3dbkA:undetectable | 5vooF-3dbkA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebv | CHINITASE A (Streptomycescoelicolor) |
PF00704(Glyco_hydro_18) | 5 | GLY A 9ASP A 31LEU A 294GLY A 288SER A 284 | None | 1.11A | 5vooF-3ebvA:7.4 | 5vooF-3ebvA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoz | PUTATIVEPHOSPHOGLYCERATEMUTASE (Plasmodiumfalciparum) |
PF00300(His_Phos_1) | 5 | GLY A 183VAL A 69LEU A 64GLY A 57ILE A 87 | None | 1.10A | 5vooF-3eozA:undetectable | 5vooF-3eozA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbd | SUCROSE ISOMERASESMUA FROMPROTAMINOBACTERRUBRUM (Serratiaplymuthica) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASN A 73GLY A 77GLY A 43SER A 33ILE A 42 | None | 1.17A | 5vooF-3gbdA:9.5 | 5vooF-3gbdA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfb | L-THREONINE3-DEHYDROGENASE (Thermococcuskodakarensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 164ASP A 159VAL A 110GLY A 290ILE A 291 | None | 1.20A | 5vooF-3gfbA:2.4 | 5vooF-3gfbA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqs | ADENYLATECYCLASE-LIKE PROTEIN (Chlamydiatrachomatis) |
PF16697(Yop-YscD_cpl) | 5 | GLY A 70VAL A 9LEU A 7GLY A 30ILE A 45 | None | 1.17A | 5vooF-3gqsA:undetectable | 5vooF-3gqsA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbn | UDP-SUGAR HYDROLASE (Campylobacterjejuni) |
no annotation | 5 | GLU A 85ASP A 84LEU A 53SER A 98ILE A 80 | None | 1.16A | 5vooF-3hbnA:4.7 | 5vooF-3hbnA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hje | 704AA LONGHYPOTHETICALGLYCOSYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 5 | GLU A 468LEU A 535SER A 548PHE A 552ILE A 472 | None | 1.14A | 5vooF-3hjeA:6.5 | 5vooF-3hjeA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifr | CARBOHYDRATE KINASE,FGGY (Rhodospirillumrubrum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ASN A 298GLY A 299ASP A 287LEU A 138GLY A 131 | PO4 A 509 (-3.6A)NonePO4 A 509 ( 4.4A)NoneNone | 1.11A | 5vooF-3ifrA:undetectable | 5vooF-3ifrA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 5 | GLU A 210VAL A 245LEU A 227GLY A 212ILE A 211 | None | 1.15A | 5vooF-3iuuA:2.4 | 5vooF-3iuuA:23.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 9 | GLU A 358ASN A 361GLY A 364ASP A 396VAL A 478GLY A 558SER A 560ARG A 573ILE A 593 | THH A 642 ( 3.5A)GOL A 643 (-3.1A)THH A 642 (-3.7A)THH A 642 ( 4.7A)NoneTHH A 642 (-3.3A) K A 644 ( 3.4A)THH A 642 (-3.1A)THH A 642 (-4.2A) | 0.35A | 5vooF-3k13A:38.2 | 5vooF-3k13A:34.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p24 | BFT-3 (Bacteroidesfragilis) |
PF13583(Reprolysin_4)PF16376(fragilysinNterm) | 5 | ASN A 275GLY A 274ASP A 277GLY A 315ILE A 316 | None | 1.05A | 5vooF-3p24A:undetectable | 5vooF-3p24A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqv | RCL1 PROTEIN (Kluyveromyceslactis) |
PF01137(RTC)PF05189(RTC_insert) | 5 | GLY A 119LEU A 103GLY A 128SER A 122ILE A 129 | None | 1.16A | 5vooF-3pqvA:undetectable | 5vooF-3pqvA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rf7 | IRON-CONTAININGALCOHOLDEHYDROGENASE (Shewanelladenitrificans) |
PF00465(Fe-ADH) | 5 | GLY A 100ASP A 194GLY A 246SER A 149PHE A 170 | NAD A 358 (-3.2A) FE A 360 (-2.0A)NoneNAD A 358 (-2.5A)None | 1.19A | 5vooF-3rf7A:undetectable | 5vooF-3rf7A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3riq | TAILSPIKE PROTEIN (Salmonellavirus 9NA) |
PF09251(PhageP22-tail) | 5 | ASN A 413VAL A 467GLY A 409SER A 376ILE A 410 | None | 1.20A | 5vooF-3riqA:undetectable | 5vooF-3riqA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 302VAL A 122LEU A 126GLY A 280ILE A 108 | None | 1.17A | 5vooF-3sjnA:9.3 | 5vooF-3sjnA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4v | INTEGRIN BETA-7 (Homo sapiens) |
PF00362(Integrin_beta) | 5 | GLU B 240GLY B 241LEU B 193GLY B 234SER B 142 | 0DU B4000 (-3.3A)NoneNone0DU B4000 (-3.4A) MG B2001 ( 2.9A) | 1.15A | 5vooF-3v4vB:2.8 | 5vooF-3v4vB:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnk | XYLOSE ISOMERASEDOMAIN PROTEIN TIMBARREL ([Clostridium]cellulolyticum) |
PF01261(AP_endonuc_2) | 5 | GLU A 227GLY A 196VAL A 241GLY A 229ILE A 228 | None | 1.16A | 5vooF-3vnkA:6.9 | 5vooF-3vnkA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aah | METHANOLDEHYDROGENASE (Methylophilusmethylotrophus) |
PF13360(PQQ_2) | 5 | GLY A 233LYS A 230ASP A 294GLY A 300SER A 253 | None | 1.14A | 5vooF-4aahA:undetectable | 5vooF-4aahA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b90 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | GLY A 93ASP A 401LEU A 385GLY A 392PHE A 373 | None | 1.14A | 5vooF-4b90A:5.2 | 5vooF-4b90A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b92 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | GLY A 93ASP A 401LEU A 385GLY A 392PHE A 373 | None | 1.14A | 5vooF-4b92A:8.4 | 5vooF-4b92A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccz | METHIONINE SYNTHASE (Homo sapiens) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 6 | GLU A 376ASN A 379GLY A 382ASP A 414PHE A 582ARG A 591 | THG A1652 (-3.5A)THG A1652 (-4.6A)THG A1652 (-3.8A)NoneTHG A1652 (-4.5A)THG A1652 (-3.0A) | 0.76A | 5vooF-4cczA:38.6 | 5vooF-4cczA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccz | METHIONINE SYNTHASE (Homo sapiens) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 9 | GLU A 376ASN A 379GLY A 382ASP A 414VAL A 496GLY A 576SER A 578ARG A 591ILE A 611 | THG A1652 (-3.5A)THG A1652 (-4.6A)THG A1652 (-3.8A)NoneNoneTHG A1652 (-3.6A)THG A1652 (-4.2A)THG A1652 (-3.0A)THG A1652 (-4.2A) | 0.44A | 5vooF-4cczA:38.6 | 5vooF-4cczA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci0 | F420-REDUCINGHYDROGENASE, SUBUNITBETA (Methanothermobactermarburgensis) |
PF04422(FrhB_FdhB_N)PF04432(FrhB_FdhB_C) | 5 | GLY C 226LEU C 68GLY C 98ARG C 110ILE C 42 | None | 1.11A | 5vooF-4ci0C:undetectable | 5vooF-4ci0C:25.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4r | PHOSPHATEACETYLTRANSFERASE (Staphylococcusaureus) |
PF01515(PTA_PTB) | 5 | GLY A 177VAL A 133LEU A 299GLY A 151ILE A 169 | EDO A 502 (-3.7A)NoneNoneNoneNone | 1.15A | 5vooF-4e4rA:undetectable | 5vooF-4e4rA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgw | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(+)] 1 (Saccharomycescerevisiae) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | GLY A 298VAL A 347GLY A 280SER A 287ILE A 240 | None | 1.15A | 5vooF-4fgwA:3.9 | 5vooF-4fgwA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fys | AMINOPEPTIDASE N (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | GLU A 523LEU A 487GLY A 499SER A 502PHE A 507 | NAG A1010 (-3.9A)NoneNAG A1010 ( 4.4A)NAG A1010 (-4.1A)None | 0.66A | 5vooF-4fysA:undetectable | 5vooF-4fysA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifd | EXOSOME COMPLEXCOMPONENT RRP43 (Saccharomycescerevisiae) |
PF01138(RNase_PH) | 5 | GLU C 339GLY C 224GLY C 298ARG C 44ILE C 343 | None | 1.18A | 5vooF-4ifdC:undetectable | 5vooF-4ifdC:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jer | HEMOPHORE HASA (Yersinia pestis) |
PF06438(HasA) | 5 | GLY A 149LEU A 109GLY A 58SER A 60ILE A 57 | None | 0.95A | 5vooF-4jerA:undetectable | 5vooF-4jerA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz6 | SALICYLALDEHYDEDEHYDROGENASE NAHF (Pseudomonasputida) |
PF00171(Aldedh) | 5 | GLY A 150VAL A 169LEU A 198GLY A 173SER A 174 | NK A 501 (-3.1A)NoneNoneNoneNone | 1.05A | 5vooF-4jz6A:undetectable | 5vooF-4jz6A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nen | INTEGRIN BETA-2 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF17205(PSI_integrin) | 5 | GLU B 212GLY B 213LEU B 165GLY B 206SER B 114 | CA B 705 ( 3.2A)NoneNoneNone MG B 707 (-2.1A) | 1.14A | 5vooF-4nenB:2.5 | 5vooF-4nenB:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 5 | ASN A 10LEU A 123GLY A 196ARG A 207ILE A 227 | C2F A3000 ( 4.5A)NoneC2F A3000 (-3.5A)NoneC2F A3000 (-4.3A) | 1.13A | 5vooF-4o1eA:27.8 | 5vooF-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 6 | GLU A 7ASN A 10ASP A 44LEU A 123GLY A 196ILE A 227 | C2F A3000 (-3.6A)C2F A3000 ( 4.5A)NoneNoneC2F A3000 (-3.5A)C2F A3000 (-4.3A) | 0.60A | 5vooF-4o1eA:27.8 | 5vooF-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 5 | GLU A 7ASN A 10LEU A 163GLY A 196ILE A 227 | C2F A3000 (-3.6A)C2F A3000 ( 4.5A)NoneC2F A3000 (-3.5A)C2F A3000 (-4.3A) | 1.17A | 5vooF-4o1eA:27.8 | 5vooF-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou2 | 2-AMINOMUCONATE6-SEMIALDEHYDEDEHYDROGENASE (Pseudomonasfluorescens) |
PF00171(Aldedh) | 5 | GLY A 472VAL A 258LEU A 242GLY A 251SER A 248 | None | 1.18A | 5vooF-4ou2A:undetectable | 5vooF-4ou2A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovq | TRAP DICARBOXYLATEABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Roseobacterdenitrificans) |
PF03480(DctP) | 5 | GLU A 84ASN A 240GLY A 81GLY A 29ILE A 85 | None | 1.17A | 5vooF-4ovqA:undetectable | 5vooF-4ovqA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | ASN A 131GLY A 244LEU A 116GLY A 249SER A 143 | None | 0.99A | 5vooF-4q0cA:undetectable | 5vooF-4q0cA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxm | POSSIBLE SUGAR ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Mannheimiahaemolytica) |
PF13407(Peripla_BP_4) | 5 | GLY A 154VAL A 139LEU A 259GLY A 132ILE A 168 | None | 0.84A | 5vooF-4rxmA:2.6 | 5vooF-4rxmA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1i | PYRIDOXAL KINASE (Entamoebahistolytica) |
PF08543(Phos_pyr_kin) | 5 | GLY B 215LEU B 109GLY B 82SER B 10ILE B 113 | NoneNoneNonePLP B 302 (-2.4A)PLP B 302 ( 4.7A) | 1.15A | 5vooF-4s1iB:2.7 | 5vooF-4s1iB:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yh2 | GLUTATHIONE STRANSFERASE E6 (Drosophilamelanogaster) |
PF13417(GST_N_3)PF14497(GST_C_3) | 5 | GLU A 193ASN A 202GLY A 203VAL A 142ILE A 189 | None | 0.92A | 5vooF-4yh2A:undetectable | 5vooF-4yh2A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp1 | MYCOCEROSIC ACIDSYNTHASE (Mycolicibacteriumsmegmatis) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 68LYS A 66LEU A 28GLY A 244ARG A 46 | None | 1.19A | 5vooF-5bp1A:undetectable | 5vooF-5bp1A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxp | LACTO-N-BIOSIDASE (Bifidobacteriumbifidum) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF14200(RicinB_lectin_2) | 5 | ASN A 357GLY A 354LEU A 404GLY A 376ILE A 372 | None | 1.14A | 5vooF-5bxpA:3.7 | 5vooF-5bxpA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by2 | PHOSPHOHEPTOSEISOMERASE (Colwelliapsychrerythraea) |
PF13580(SIS_2) | 5 | GLY A 48LEU A 23GLY A 144SER A 119ILE A 171 | None | 1.18A | 5vooF-5by2A:undetectable | 5vooF-5by2A:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN BETA-2 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | GLU B 212GLY B 213ASP B 209GLY B 206SER B 114 | NoneNone CA B2003 (-3.0A)NoneNone | 1.18A | 5vooF-5e6sB:2.5 | 5vooF-5e6sB:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN BETA-2 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | GLU B 212GLY B 213LEU B 165GLY B 206SER B 114 | None | 1.06A | 5vooF-5e6sB:2.5 | 5vooF-5e6sB:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 74ASP A 303GLY A 375SER A 373ARG A 406 | NonePO4 A1716 (-2.8A)NoneNoneNone | 1.20A | 5vooF-5fp1A:undetectable | 5vooF-5fp1A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | GLU A 564LEU A 484GLY A 504SER A 502PHE A 455 | None | 1.08A | 5vooF-5h8wA:3.0 | 5vooF-5h8wA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hz1 | PROBABLE LRRRECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASEAT4G26540 (Arabidopsisthaliana) |
PF13855(LRR_8) | 5 | GLY B 166LYS B 142LEU B 237GLY B 186ILE B 185 | None | 1.06A | 5vooF-5hz1B:undetectable | 5vooF-5hz1B:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k66 | NTA1P (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 5 | ASN A 151GLY A 154GLY A 185PHE A 207ILE A 186 | None | 1.06A | 5vooF-5k66A:undetectable | 5vooF-5k66A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oe5 | ANTHRANILATE--COALIGASE (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 5 | VAL A 239LEU A 243GLY A 253SER A 277ILE A 257 | None | 1.09A | 5vooF-5oe5A:undetectable | 5vooF-5oe5A:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t6o | POLY-BETA-HYDROXYBUTERATE POLYMERASE (Cupriavidusnecator) |
PF07167(PhaC_N) | 5 | GLY A 206ASP A 254VAL A 266LEU A 231GLY A 214 | None | 1.03A | 5vooF-5t6oA:undetectable | 5vooF-5t6oA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tii | 3-OXOACYL-ACPREDUCTASE (unculturedbacterium) |
PF13561(adh_short_C2) | 5 | GLY A 188GLY A 150SER A 147ARG A 165ILE A 151 | None | 1.10A | 5vooF-5tiiA:3.1 | 5vooF-5tiiA:25.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnu | DNA-DEPENDENT ATPASEXPBII (Sulfurisphaeratokodaii) |
no annotation | 5 | GLU A 143GLY A 141ASP A 144LEU A 112GLY A 137 | NoneSO4 A 505 ( 4.8A)NoneNoneNone | 1.09A | 5vooF-5tnuA:undetectable | 5vooF-5tnuA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tov | ADENOSYLHOMOCYSTEINASE (Thermotogamaritima) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLY A 143VAL A 129LEU A 130SER A 137ILE A 111 | None | 1.03A | 5vooF-5tovA:undetectable | 5vooF-5tovA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 288LEU A 316GLY A 293SER A 294ILE A 244 | None | 1.01A | 5vooF-5u2aA:3.2 | 5vooF-5u2aA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4b | F-BOX/WDREPEAT-CONTAININGPROTEIN 7 (Homo sapiens) |
PF00400(WD40)PF12937(F-box-like) | 5 | GLU B2569GLY B2571LEU B2589GLY B2551ILE B2552 | None | 1.01A | 5vooF-5v4bB:undetectable | 5vooF-5v4bB:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vop | 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 12 | GLU A 373ASN A 376GLY A 379LYS A 381ASP A 411VAL A 490LEU A 492GLY A 570SER A 572PHE A 576ARG A 583ILE A 603 | C2F A3001 (-3.7A) NA A3005 (-3.0A)C2F A3001 (-3.3A)NoneC2F A3001 ( 3.8A)C2F A3001 ( 4.7A)NoneC2F A3001 (-3.5A)C2F A3001 ( 4.5A)C2F A3001 (-4.7A)C2F A3001 (-3.0A)C2F A3001 (-3.5A) | 0.52A | 5vooF-5vopA:45.7 | 5vooF-5vopA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | GLU B 108GLY B 98VAL B 116GLY B 93SER B 95 | NoneGDP B 501 (-4.4A)NoneNoneNone | 1.19A | 5vooF-5w3jB:2.1 | 5vooF-5w3jB:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfn | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 1 (Homo sapiens) |
no annotation | 5 | GLY A 222VAL A 272LEU A 356GLY A 360SER A 255 | NoneDL1 A 601 ( 4.8A)NoneNoneNone | 1.14A | 5vooF-6bfnA:undetectable | 5vooF-6bfnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8z | ADP-DEPENDENTPHOSPHOFRUCTOKINASE (Methanosarcinales) |
no annotation | 5 | GLY A 242ASP A 471GLY A 114SER A 33ILE A 119 | NoneADP A 501 (-3.6A)NoneNoneNone | 0.97A | 5vooF-6c8zA:2.4 | 5vooF-6c8zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dhi | - (-) |
no annotation | 5 | GLY A 167LYS A 439VAL A 187LEU A 188ILE A 179 | None | 1.19A | 5vooF-6dhiA:undetectable | 5vooF-6dhiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | GLY A 104ASP A 57LEU A 151GLY A 158SER A 181 | None | 1.07A | 5vooF-6gunA:undetectable | 5vooF-6gunA:undetectable |