SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_E_C2FE3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Moorella
thermoacetica)
PF00809
(Pterin_bind)
4 ASN A   9
ASP A  75
ASN A  96
ASP A 160
None
0.45A 5vooE-1f6yA:
29.1
5vooE-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi)
PF00365
(PFK)
4 ASP A 382
ASN A 386
ASP A 176
ASN A 181
None
None
SO4  A 601 (-3.8A)
None
1.23A 5vooE-1kzhA:
undetectable
5vooE-1kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303


(Haemophilus
influenzae)
PF04452
(Methyltrans_RNA)
4 ASN A  47
ASP A  73
ASP A 242
ASN A 105
None
1.28A 5vooE-1nxzA:
undetectable
5vooE-1nxzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdk MANNOSE-BINDING
PROTEIN-C


(Rattus rattus)
PF00059
(Lectin_C)
4 ASN 1 171
ASP 1 166
ASN 1 199
ASN 1 192
None
CA  1 227 ( 2.4A)
CA  1 227 (-3.4A)
GAL  1   1 (-2.7A)
1.47A 5vooE-1rdk1:
undetectable
5vooE-1rdk1:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
4 ASP A 255
ASN A  46
ASP A  16
ASN A 108
RIB  A 311 (-3.1A)
RIB  A 311 (-3.3A)
RIB  A 311 (-2.8A)
None
1.24A 5vooE-1rk2A:
2.8
5vooE-1rk2A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE


(Salmonella
enterica)
PF00294
(PfkB)
4 ASN A 160
ASP A 252
ASN A  35
ASP A  16
ACP  A 401 (-2.7A)
AIS  A 402 (-3.0A)
AIS  A 402 (-3.9A)
AIS  A 402 (-2.5A)
1.12A 5vooE-1tz6A:
undetectable
5vooE-1tz6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
4 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.49A 5vooE-1ux6A:
undetectable
5vooE-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori)
PF14529
(Exo_endo_phos_2)
4 ASN A  29
ASP A 157
ASN A 159
ASP A 130
PO4  A 249 (-3.7A)
PO4  A 249 (-3.7A)
PO4  A 249 (-3.3A)
None
1.33A 5vooE-1wduA:
undetectable
5vooE-1wduA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY


(Thermotoga
maritima)
PF00294
(PfkB)
4 ASP A 261
ASN A  44
ASP A  12
ASN A 110
None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
1.13A 5vooE-2ajrA:
undetectable
5vooE-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00155
(Aminotran_1_2)
4 ASN A 162
ASP A 138
ASN A 141
ASP A 214
None
None
None
PLG  A 500 (-3.1A)
1.45A 5vooE-2bwpA:
undetectable
5vooE-2bwpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ASN A 184
ASP A 186
ASN A 205
ASP A 201
PO4  A   3 (-3.4A)
PO4  A   3 (-3.7A)
PO4  A   3 (-4.1A)
None
1.26A 5vooE-2o5pA:
undetectable
5vooE-2o5pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v73 PUTATIVE
EXO-ALPHA-SIALIDASE


(Clostridium
perfringens)
PF02973
(Sialidase)
4 ASN A  61
ASP A  59
ASN A  65
ASP A  88
None
1.26A 5vooE-2v73A:
undetectable
5vooE-2v73A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00809
(Pterin_bind)
4 ASN A  17
ASP A  91
ASN A 110
ASP A 201
None
0.84A 5vooE-2vefA:
18.6
5vooE-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
4 ASN A 384
ASP A 459
ASP A 509
ASN A 390
None
1.15A 5vooE-2xgoA:
2.4
5vooE-2xgoA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
4 ASN A  10
ASP A  44
ASP A 161
ASN A 200
C2F  A3000 ( 4.8A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.1A)
1.40A 5vooE-2ycjA:
29.8
5vooE-2ycjA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
5 ASN A  10
ASP A  76
ASN A  97
ASP A 161
ASN A 200
C2F  A3000 ( 4.8A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.1A)
0.38A 5vooE-2ycjA:
29.8
5vooE-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Mus musculus)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 ASN B 363
ASN B 359
ASP B 409
ASN B 413
None
NAG  B 951 (-1.7A)
NDG  B 971 ( 4.1A)
None
1.43A 5vooE-3a79B:
2.1
5vooE-3a79B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
5 ASN A 323
ASP A 390
ASN A 411
ASP A 473
ASN A 508
None
0.89A 5vooE-3bolA:
22.5
5vooE-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 ASN A 358
ASN A 366
ASP A 205
ASN A 401
None
1.40A 5vooE-3fiiA:
undetectable
5vooE-3fiiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
4 ASN A 169
ASP A 242
ASN A  55
ASP A  25
None
RIB  A 305 (-2.9A)
RIB  A 305 (-3.2A)
RIB  A 305 (-2.8A)
1.08A 5vooE-3go7A:
2.2
5vooE-3go7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus)
PF00168
(C2)
4 ASN A 434
ASP A 402
ASN A 403
ASN A 497
None
1.20A 5vooE-3hn8A:
undetectable
5vooE-3hn8A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE


(Staphylococcus
aureus)
PF00912
(Transgly)
4 ASN A  87
ASP A  86
ASN A 170
ASN A 178
None
1.31A 5vooE-3hzsA:
undetectable
5vooE-3hzsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY


(Rhodospirillum
rubrum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 ASN A 180
ASP A 287
ASN A 298
ASP A 270
None
PO4  A 509 ( 4.4A)
PO4  A 509 (-3.6A)
None
1.49A 5vooE-3ifrA:
undetectable
5vooE-3ifrA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
4 ASN A  98
ASP A  15
ASP A 260
ASN A 144
None
1.07A 5vooE-3in1A:
2.5
5vooE-3in1A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE


(Bacteroides
thetaiotaomicron)
PF00809
(Pterin_bind)
5 ASN A 361
ASP A 431
ASN A 452
ASP A 519
ASN A 561
GOL  A 643 (-3.1A)
THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
THH  A 642 ( 3.3A)
0.28A 5vooE-3k13A:
38.5
5vooE-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Hahella
chejuensis)
PF13407
(Peripla_BP_4)
4 ASN A 106
ASP A  79
ASN A  50
ASP A 259
None
None
BDR  A   1 ( 4.3A)
BDR  A   1 (-2.7A)
1.30A 5vooE-3ksmA:
undetectable
5vooE-3ksmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1


(Saccharomyces
cerevisiae)
PF16499
(Melibiase_2)
4 ASN A  36
ASP A  35
ASN A 263
ASP A 209
None
GOL  A7002 (-3.5A)
GOL  A7002 (-3.1A)
GOL  A7002 ( 3.9A)
1.04A 5vooE-3lrkA:
8.4
5vooE-3lrkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqw CG11900

(Drosophila
melanogaster)
PF13328
(HD_4)
4 ASN A 127
ASP A 126
ASN A  39
ASN A 134
MN  A 300 ( 4.2A)
None
None
None
1.41A 5vooE-3nqwA:
undetectable
5vooE-3nqwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
no annotation 4 ASP B 607
ASN B 432
ASP B 717
ASN B 684
None
1.34A 5vooE-3nr8B:
undetectable
5vooE-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
4 ASN A  45
ASP A  15
ASN A  18
ASN A 383
None
None
None
HX2  A 397 (-3.7A)
1.47A 5vooE-3oftA:
undetectable
5vooE-3oftA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE


(Coxiella
burnetii)
PF00809
(Pterin_bind)
4 ASN A  35
ASP A 111
ASN A 130
ASP A 199
CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
0.87A 5vooE-3tr9A:
19.3
5vooE-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
PANCREATIC
RIBONUCLEASE
INHIBITOR


(Mus musculus;
Mus musculus)
PF00074
(RnaseA)
PF13516
(LRR_6)
4 ASN A  45
ASP E 431
ASN E 402
ASP E 399
None
1.45A 5vooE-3tsrA:
undetectable
5vooE-3tsrA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A


(Butyrivibrio
proteoclasticus)
PF13472
(Lipase_GDSL_2)
4 ASP A 259
ASN A 257
ASP A 198
ASN A 108
None
1.17A 5vooE-3u37A:
2.4
5vooE-3u37A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
4 ASN A 989
ASP A 986
ASN A1602
ASN A 948
None
1.42A 5vooE-4amcA:
2.6
5vooE-4amcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
4 ASN A 379
ASP A 414
ASP A 537
ASN A 579
THG  A1652 (-4.6A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
1.43A 5vooE-4cczA:
38.6
5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
0.25A 5vooE-4cczA:
38.6
5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A  20
ASP A 401
ASP A  51
ASN A 318
PO4  A 501 (-3.6A)
None
None
PO4  A 501 ( 4.8A)
1.24A 5vooE-4dhgA:
5.4
5vooE-4dhgA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE


(Caenorhabditis
elegans)
PF03372
(Exo_endo_phos)
4 ASN A 273
ASP A 271
ASN A 126
ASP A 128
MLI  A 403 (-3.2A)
MLI  A 403 ( 4.5A)
MLI  A 403 (-4.2A)
MG  A 402 (-3.3A)
1.23A 5vooE-4fvaA:
undetectable
5vooE-4fvaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2


(Mus musculus)
PF03372
(Exo_endo_phos)
4 ASN A 274
ASP A 272
ASN A 130
ASP A 132
None
None
MG  A 402 ( 4.3A)
MG  A 402 (-2.9A)
1.23A 5vooE-4gz2A:
undetectable
5vooE-4gz2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE


(Rhizomucor
miehei)
PF03639
(Glyco_hydro_81)
4 ASN A 515
ASP A 520
ASN A  14
ASP A  16
None
1.49A 5vooE-4k35A:
undetectable
5vooE-4k35A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
4 ASN A 103
ASP A 104
ASN A 318
ASP A 319
PG4  A 404 ( 4.9A)
None
None
None
1.45A 5vooE-4n91A:
undetectable
5vooE-4n91A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
4 ASN A  10
ASP A  76
ASN A  97
ASP A 161
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
0.29A 5vooE-4o1eA:
27.8
5vooE-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
4 ASP A  76
ASN A  97
ASP A 161
ASN A 199
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
0.80A 5vooE-4o1eA:
27.8
5vooE-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica)
PF12468
(TTSSLRR)
4 ASN A 363
ASN A 359
ASP A 399
ASN A 403
None
1.39A 5vooE-4ow2A:
undetectable
5vooE-4ow2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae)
PF01633
(Choline_kinase)
4 ASN A  32
ASN A  88
ASP A  73
ASN A 181
None
1.46A 5vooE-4r7bA:
undetectable
5vooE-4r7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 ASN A2693
ASP A2170
ASN A2801
ASN A2182
CA  A3000 (-3.1A)
CA  A3000 (-2.2A)
None
None
1.40A 5vooE-4tvcA:
3.0
5vooE-4tvcA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii)
PF07367
(FB_lectin)
4 ASN A  59
ASP A  14
ASN A  12
ASN A 116
None
1.20A 5vooE-4z2qA:
undetectable
5vooE-4z2qA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 ASN A 538
ASP A 533
ASN A 570
ASN A 662
None
1.23A 5vooE-4zgvA:
undetectable
5vooE-4zgvA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 ASN A 540
ASP A 533
ASN A 570
ASN A 662
None
1.11A 5vooE-4zgvA:
undetectable
5vooE-4zgvA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1


(Gallus gallus)
PF03493
(BK_channel_a)
4 ASN C 838
ASP C 837
ASN C 877
ASP C 857
None
1.34A 5vooE-5a6fC:
undetectable
5vooE-5a6fC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED


(Cupriavidus
metallidurans)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK)
4 ASN A  44
ASP A  40
ASN A 743
ASP A 739
None
B12  A1101 (-3.5A)
B12  A1101 ( 4.6A)
None
1.19A 5vooE-5cjuA:
8.1
5vooE-5cjuA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE


(Cryptococcus
neoformans)
PF02358
(Trehalose_PPase)
4 ASP A 214
ASN A  24
ASP A  26
ASN A 178
T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
1.22A 5vooE-5dx9A:
undetectable
5vooE-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
4 ASN A 174
ASP A 266
ASN A  49
ASP A  30
None
1.18A 5vooE-5ey7A:
2.5
5vooE-5ey7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
4 ASN A 218
ASP A 217
ASP A 144
ASN A 161
None
1.43A 5vooE-5m60A:
undetectable
5vooE-5m60A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.30A 5vooE-5okoA:
undetectable
5vooE-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 4 ASN A 376
ASP A 411
ASP A 531
ASN A 573
NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
1.32A 5vooE-5vopA:
46.1
5vooE-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 5 ASN A 376
ASP A 443
ASN A 464
ASP A 531
ASN A 573
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
0.18A 5vooE-5vopA:
46.1
5vooE-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN


(Ornithorhynchus
anatinus)
no annotation 4 ASN A  45
ASP A  60
ASN A  57
ASP A 119
None
1.46A 5vooE-6b4mA:
2.4
5vooE-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM


(Saccharomyces
cerevisiae)
no annotation 4 ASN A 136
ASP A 137
ASN A 259
ASP A 257
None
1.20A 5vooE-6c6lA:
undetectable
5vooE-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans)
no annotation 4 ASN A 163
ASP A 273
ASN A  46
ASP A  16
None
None
GOL  A 400 (-3.3A)
GOL  A 400 (-2.8A)
1.09A 5vooE-6cw5A:
2.5
5vooE-6cw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44


(Homo sapiens)
no annotation 4 ASP K 488
ASN K 487
ASP K 784
ASN K 671
A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
1.28A 5vooE-6d6qK:
undetectable
5vooE-6d6qK:
undetectable