SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_D_C2FD3001_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6y | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Moorellathermoacetica) |
PF00809(Pterin_bind) | 5 | ASN A 45ASP A 43LEU A 122GLY A 196ILE A 227 | None | 1.03A | 5vooD-1f6yA:29.3 | 5vooD-1f6yA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6y | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Moorellathermoacetica) |
PF00809(Pterin_bind) | 7 | GLU A 6ASN A 9ASP A 43LEU A 122GLY A 196SER A 198ILE A 227 | None | 0.53A | 5vooD-1f6yA:29.3 | 5vooD-1f6yA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5u | PROFILIN (Heveabrasiliensis) |
PF00235(Profilin) | 5 | GLY A1069VAL A1119LEU A1020GLY A1091ILE A1092 | None | 1.12A | 5vooD-1g5uA:undetectable | 5vooD-1g5uA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itu | RENAL DIPEPTIDASE (Homo sapiens) |
PF01244(Peptidase_M19) | 5 | GLY A 61LYS A 117VAL A 267LEU A 271GLY A 286 | None | 1.15A | 5vooD-1ituA:5.4 | 5vooD-1ituA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | GLU A 301LYS A 353GLY A 260SER A 311ILE A 285 | None | 1.13A | 5vooD-1kb0A:undetectable | 5vooD-1kb0A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 6 | MET A 175VAL A 48LEU A 94GLY A 140SER A 139ILE A 153 | None | 1.49A | 5vooD-1ns3A:undetectable | 5vooD-1ns3A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 6 | MET A 175VAL A 48LEU A 94GLY A 141SER A 139ILE A 153 | None | 1.46A | 5vooD-1ns3A:undetectable | 5vooD-1ns3A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oe5 | SINGLE-STRANDSELECTIVEMONOFUNCTIONALURACIL DNAGLYCOSYLASE (Xenopus laevis) |
no annotation | 5 | ASN A 174GLY A 94LEU A 119GLY A 149SER A 148 | URA A1282 (-3.0A)URA A1282 (-3.6A)NoneNoneURA A1282 ( 4.4A) | 1.10A | 5vooD-1oe5A:undetectable | 5vooD-1oe5A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oe5 | SINGLE-STRANDSELECTIVEMONOFUNCTIONALURACIL DNAGLYCOSYLASE (Xenopus laevis) |
no annotation | 5 | VAL A 275LEU A 220GLY A 247PHE A 227ILE A 248 | None | 1.15A | 5vooD-1oe5A:undetectable | 5vooD-1oe5A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1snz | ALDOSE 1-EPIMERASE (Homo sapiens) |
PF01263(Aldose_epim) | 5 | VAL A 260LEU A 306GLY A 303PHE A 285ILE A 189 | None | 1.10A | 5vooD-1snzA:undetectable | 5vooD-1snzA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wni | TRIMERELYSIN II (Protobothropsflavoviridis) |
PF01421(Reprolysin) | 5 | GLU A 9ASN A 92MET A 116SER A 52ILE A 8 | None | 1.13A | 5vooD-1wniA:undetectable | 5vooD-1wniA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xco | PHOSPHATEACETYLTRANSFERASE (Bacillussubtilis) |
PF01515(PTA_PTB) | 5 | GLU A 52ASN A 51VAL A 67GLY A 48ILE A 53 | None | 1.13A | 5vooD-1xcoA:3.3 | 5vooD-1xcoA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvy | SFUA (Yersiniaenterocolitica) |
PF13343(SBP_bac_6) | 5 | ASN A 60LEU A 258GLY A 97PHE A 56ILE A 227 | None | 1.09A | 5vooD-1xvyA:undetectable | 5vooD-1xvyA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ym5 | HYPOTHETICAL 32.6KDA PROTEIN INDAP2-SLT2 INTERGENICREGION (Saccharomycescerevisiae) |
PF02567(PhzC-PhzF) | 5 | GLY A 255LYS A 259LEU A 238GLY A 230PHE A 215 | None | 1.08A | 5vooD-1ym5A:undetectable | 5vooD-1ym5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztm | FUSION GLYCOPROTEIN (Humanrespirovirus 3) |
PF00523(Fusion_gly) | 5 | GLY A 225VAL A 269LEU A 86GLY A 219ILE A 218 | None | 1.17A | 5vooD-1ztmA:undetectable | 5vooD-1ztmA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaf | ARGININE DEIMINASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 5 | ASN A 233GLY A 234ASP A 417LEU A 338ILE A 416 | None | 1.17A | 5vooD-2aafA:undetectable | 5vooD-2aafA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi7 | UDP-GALACTOPYRANOSEMUTASE (Klebsiellapneumoniae) |
PF03275(GLF)PF13450(NAD_binding_8) | 6 | GLY A 197VAL A 213LEU A 215GLY A 39SER A 42ILE A 202 | NoneNoneNoneNoneFAD A1385 ( 3.8A)None | 1.29A | 5vooD-2bi7A:undetectable | 5vooD-2bi7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi7 | UDP-GALACTOPYRANOSEMUTASE (Klebsiellapneumoniae) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | GLY A 197VAL A 213LEU A 215GLY A 40SER A 42 | NoneNoneNoneFAD A1385 (-3.1A)FAD A1385 ( 3.8A) | 1.18A | 5vooD-2bi7A:undetectable | 5vooD-2bi7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g39 | ACETYL-COA HYDROLASE (Pseudomonasaeruginosa) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | GLU A 288GLY A 308VAL A 226GLY A 263ILE A 264 | ACY A 901 (-2.6A)NoneNoneNoneACY A 901 (-4.1A) | 1.12A | 5vooD-2g39A:undetectable | 5vooD-2g39A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glf | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Thermotogamaritima) |
PF02127(Peptidase_M18) | 5 | GLY A 249LYS A 33VAL A 356LEU A 394SER A 433 | None | 1.18A | 5vooD-2glfA:undetectable | 5vooD-2glfA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5g | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01244(Peptidase_M19) | 5 | GLY A 92VAL A 288LEU A 35GLY A 248SER A 180 | None | 1.14A | 5vooD-2i5gA:5.0 | 5vooD-2i5gA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jif | SHORT/BRANCHED CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 6 | GLU A 292ASN A 291GLY A 288GLY A 296PHE A 174ILE A 295 | NoneCOS A1434 (-3.0A)NoneNoneNoneNone | 1.22A | 5vooD-2jifA:undetectable | 5vooD-2jifA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2or0 | HYDROXYLASE (Rhodococcusjostii) |
PF08028(Acyl-CoA_dh_2) | 5 | GLY A 52VAL A 67GLY A 82PHE A 225ILE A 42 | None | 1.13A | 5vooD-2or0A:undetectable | 5vooD-2or0A:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwh | SUCROSE ISOMERASE ([Pseudomonas]mesoacidophila) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ASN A 59GLY A 63GLY A 29SER A 19ILE A 28 | NoneNone CA A7001 ( 4.6A)NoneNone | 1.12A | 5vooD-2pwhA:10.4 | 5vooD-2pwhA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvb | HALOALKANEDEHALOGENASE 3 (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 5 | GLU A 282MET A 132VAL A 106GLY A 284ILE A 283 | None | 1.16A | 5vooD-2qvbA:undetectable | 5vooD-2qvbA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLU A 139GLY A 150VAL A 35LEU A 23GLY A 67 | None | 1.11A | 5vooD-2wtbA:undetectable | 5vooD-2wtbA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x58 | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLU A 123GLY A 134VAL A 28LEU A 16GLY A 60 | GOL A 770 ( 3.5A)NoneNoneNoneCOA A 760 ( 4.0A) | 1.16A | 5vooD-2x58A:undetectable | 5vooD-2x58A:18.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 5 | ASN A 46ASP A 44LEU A 123GLY A 197ILE A 228 | NoneC2F A3000 ( 4.5A)NoneC2F A3000 (-3.6A)C2F A3000 (-4.6A) | 1.04A | 5vooD-2ycjA:29.9 | 5vooD-2ycjA:30.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 8 | GLU A 7ASN A 10LYS A 14ASP A 44LEU A 123GLY A 197SER A 199ILE A 228 | C2F A3000 ( 4.1A)C2F A3000 ( 4.8A)NoneC2F A3000 ( 4.5A)NoneC2F A3000 (-3.6A)GOL A1270 ( 3.9A)C2F A3000 (-4.6A) | 0.89A | 5vooD-2ycjA:29.9 | 5vooD-2ycjA:30.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjv | REGULATOR OFRIBONUCLEASEACTIVITY A (Escherichiacoli) |
PF03737(RraA-like) | 5 | GLU A 43GLY A 118ASP A 44GLY A 65SER A 68 | None | 1.16A | 5vooD-2yjvA:undetectable | 5vooD-2yjvA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au9 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | GLY A 186LEU A 219GLY A 212SER A 210ILE A 208 | None | 1.10A | 5vooD-3au9A:undetectable | 5vooD-3au9A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A 474MET A 508VAL A 428GLY A 484ILE A 483 | None | 1.13A | 5vooD-3av6A:undetectable | 5vooD-3av6A:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 5 | ASN A 360ASP A 358LEU A 437GLY A 505ILE A 536 | None | 1.15A | 5vooD-3bolA:22.5 | 5vooD-3bolA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 7 | GLU A 320ASN A 323ASP A 358LEU A 437GLY A 505SER A 507ILE A 536 | None | 0.70A | 5vooD-3bolA:22.5 | 5vooD-3bolA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebv | CHINITASE A (Streptomycescoelicolor) |
PF00704(Glyco_hydro_18) | 5 | GLY A 9ASP A 31LEU A 294GLY A 288SER A 284 | None | 1.15A | 5vooD-3ebvA:9.5 | 5vooD-3ebvA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoz | PUTATIVEPHOSPHOGLYCERATEMUTASE (Plasmodiumfalciparum) |
PF00300(His_Phos_1) | 5 | GLY A 183VAL A 69LEU A 64GLY A 57ILE A 87 | None | 1.05A | 5vooD-3eozA:undetectable | 5vooD-3eozA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbd | SUCROSE ISOMERASESMUA FROMPROTAMINOBACTERRUBRUM (Serratiaplymuthica) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASN A 73GLY A 77GLY A 43SER A 33ILE A 42 | None | 1.17A | 5vooD-3gbdA:10.2 | 5vooD-3gbdA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqs | ADENYLATECYCLASE-LIKE PROTEIN (Chlamydiatrachomatis) |
PF16697(Yop-YscD_cpl) | 5 | GLY A 70VAL A 9LEU A 7GLY A 30ILE A 45 | None | 1.10A | 5vooD-3gqsA:undetectable | 5vooD-3gqsA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hje | 704AA LONGHYPOTHETICALGLYCOSYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 5 | GLU A 468LEU A 535SER A 548PHE A 552ILE A 472 | None | 1.11A | 5vooD-3hjeA:7.1 | 5vooD-3hjeA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifr | CARBOHYDRATE KINASE,FGGY (Rhodospirillumrubrum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ASN A 298GLY A 299ASP A 287LEU A 138GLY A 131 | PO4 A 509 (-3.6A)NonePO4 A 509 ( 4.4A)NoneNone | 1.14A | 5vooD-3ifrA:undetectable | 5vooD-3ifrA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 5 | GLU A 210VAL A 245LEU A 227GLY A 212ILE A 211 | None | 1.12A | 5vooD-3iuuA:2.4 | 5vooD-3iuuA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixq | RIBOSE-5-PHOSPHATEISOMERASE A (Methanocaldococcusjannaschii) |
PF06026(Rib_5-P_isom_A) | 5 | GLU A 138GLY A 175GLY A 101PHE A 57ILE A 178 | NoneNone CL A 231 (-4.4A)NoneNone | 1.12A | 5vooD-3ixqA:2.2 | 5vooD-3ixqA:23.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 7 | ASN A 361MET A 429VAL A 478GLY A 558SER A 560PHE A 564ILE A 593 | GOL A 643 (-3.1A)NoneNoneTHH A 642 (-3.3A) K A 644 ( 3.4A)NoneTHH A 642 (-4.2A) | 0.73A | 5vooD-3k13A:38.4 | 5vooD-3k13A:34.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 5 | ASN A 398ASP A 396MET A 429GLY A 558ILE A 593 | NoneTHH A 642 ( 4.7A)NoneTHH A 642 (-3.3A)THH A 642 (-4.2A) | 0.97A | 5vooD-3k13A:38.4 | 5vooD-3k13A:34.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 5 | ASP A 396MET A 429VAL A 478GLY A 592ILE A 356 | THH A 642 ( 4.7A)NoneNoneNoneNone | 1.15A | 5vooD-3k13A:38.4 | 5vooD-3k13A:34.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 9 | GLU A 358ASN A 361GLY A 364ASP A 396MET A 429VAL A 478GLY A 558SER A 560ILE A 593 | THH A 642 ( 3.5A)GOL A 643 (-3.1A)THH A 642 (-3.7A)THH A 642 ( 4.7A)NoneNoneTHH A 642 (-3.3A) K A 644 ( 3.4A)THH A 642 (-4.2A) | 0.35A | 5vooD-3k13A:38.4 | 5vooD-3k13A:34.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p24 | BFT-3 (Bacteroidesfragilis) |
PF13583(Reprolysin_4)PF16376(fragilysinNterm) | 5 | ASN A 275GLY A 274ASP A 277GLY A 315ILE A 316 | None | 1.06A | 5vooD-3p24A:undetectable | 5vooD-3p24A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqv | RCL1 PROTEIN (Kluyveromyceslactis) |
PF01137(RTC)PF05189(RTC_insert) | 5 | GLY A 119LEU A 103GLY A 128SER A 122ILE A 129 | None | 1.10A | 5vooD-3pqvA:undetectable | 5vooD-3pqvA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 302VAL A 122LEU A 126GLY A 280ILE A 108 | None | 1.15A | 5vooD-3sjnA:7.2 | 5vooD-3sjnA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4v | INTEGRIN BETA-7 (Homo sapiens) |
PF00362(Integrin_beta) | 5 | GLU B 240GLY B 241LEU B 193GLY B 234SER B 142 | 0DU B4000 (-3.3A)NoneNone0DU B4000 (-3.4A) MG B2001 ( 2.9A) | 1.09A | 5vooD-3v4vB:2.8 | 5vooD-3v4vB:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aah | METHANOLDEHYDROGENASE (Methylophilusmethylotrophus) |
PF13360(PQQ_2) | 5 | GLY A 233LYS A 230ASP A 294GLY A 300SER A 253 | None | 1.16A | 5vooD-4aahA:undetectable | 5vooD-4aahA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b90 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | GLY A 93ASP A 401LEU A 385GLY A 392PHE A 373 | None | 1.13A | 5vooD-4b90A:8.3 | 5vooD-4b90A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b92 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | GLY A 93ASP A 401LEU A 385GLY A 392PHE A 373 | None | 1.13A | 5vooD-4b92A:8.4 | 5vooD-4b92A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cab | CATALASE (Deinococcusradiodurans) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | GLU A 248GLY A 252MET A 327VAL A 122GLY A 225 | None | 1.12A | 5vooD-4cabA:undetectable | 5vooD-4cabA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccz | METHIONINE SYNTHASE (Homo sapiens) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 8 | GLU A 376ASN A 379GLY A 382ASP A 414VAL A 496GLY A 576SER A 578ILE A 611 | THG A1652 (-3.5A)THG A1652 (-4.6A)THG A1652 (-3.8A)NoneNoneTHG A1652 (-3.6A)THG A1652 (-4.2A)THG A1652 (-4.2A) | 0.43A | 5vooD-4cczA:38.6 | 5vooD-4cczA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4r | PHOSPHATEACETYLTRANSFERASE (Staphylococcusaureus) |
PF01515(PTA_PTB) | 5 | GLY A 177VAL A 133LEU A 299GLY A 151ILE A 169 | EDO A 502 (-3.7A)NoneNoneNoneNone | 1.11A | 5vooD-4e4rA:undetectable | 5vooD-4e4rA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgw | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(+)] 1 (Saccharomycescerevisiae) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | GLY A 298VAL A 347GLY A 280SER A 287ILE A 240 | None | 1.17A | 5vooD-4fgwA:undetectable | 5vooD-4fgwA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fys | AMINOPEPTIDASE N (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | GLU A 523LEU A 487GLY A 499SER A 502PHE A 507 | NAG A1010 (-3.9A)NoneNAG A1010 ( 4.4A)NAG A1010 (-4.1A)None | 0.70A | 5vooD-4fysA:undetectable | 5vooD-4fysA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1s | 5'-NUCLEOTIDASE (Homo sapiens) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | ASN A 362LEU A 415GLY A 348SER A 352PHE A 449 | None | 1.15A | 5vooD-4h1sA:3.6 | 5vooD-4h1sA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i04 | CATHEPSIN B-LIKEPEPTIDASE (C01FAMILY) (Schistosomamansoni) |
PF00112(Peptidase_C1)PF08127(Propeptide_C1) | 5 | LYS A 233LEU A 125GLY A 218SER A 220ILE A 322 | None | 1.13A | 5vooD-4i04A:undetectable | 5vooD-4i04A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i05 | CATHEPSIN B-LIKEPEPTIDASE (C01FAMILY) (Schistosomamansoni) |
PF00112(Peptidase_C1) | 5 | LYS A 233LEU A 125GLY A 218SER A 220ILE A 322 | None | 1.16A | 5vooD-4i05A:undetectable | 5vooD-4i05A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jer | HEMOPHORE HASA (Yersinia pestis) |
PF06438(HasA) | 5 | GLY A 149LEU A 109GLY A 58SER A 60ILE A 57 | None | 0.90A | 5vooD-4jerA:undetectable | 5vooD-4jerA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz6 | SALICYLALDEHYDEDEHYDROGENASE NAHF (Pseudomonasputida) |
PF00171(Aldedh) | 5 | GLY A 150VAL A 169LEU A 198GLY A 173SER A 174 | NK A 501 (-3.1A)NoneNoneNoneNone | 1.06A | 5vooD-4jz6A:2.8 | 5vooD-4jz6A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myn | FORMIMINOGLUTAMASE (Trypanosomacruzi) |
PF00491(Arginase) | 5 | GLU A 273GLY A 112LYS A 46VAL A 134LEU A 161 | None | 1.18A | 5vooD-4mynA:2.4 | 5vooD-4mynA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myn | FORMIMINOGLUTAMASE (Trypanosomacruzi) |
PF00491(Arginase) | 5 | GLU A 273GLY A 112LYS A 46VAL A 134SER A 154 | None | 0.99A | 5vooD-4mynA:2.4 | 5vooD-4mynA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nen | INTEGRIN BETA-2 (Homo sapiens) |
PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF17205(PSI_integrin) | 5 | GLU B 212GLY B 213LEU B 165GLY B 206SER B 114 | CA B 705 ( 3.2A)NoneNoneNone MG B 707 (-2.1A) | 1.11A | 5vooD-4nenB:2.6 | 5vooD-4nenB:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk6 | POLY(BETA-D-MANNURONATE) C5 EPIMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13229(Beta_helix) | 5 | ASN A 306GLY A 305MET A 246VAL A 231ILE A 241 | MLY A 304 ( 3.4A)MLY A 304 ( 2.4A)NoneNoneNone | 1.11A | 5vooD-4nk6A:undetectable | 5vooD-4nk6A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 6 | GLU A 7ASN A 10ASP A 44LEU A 123GLY A 196ILE A 227 | C2F A3000 (-3.6A)C2F A3000 ( 4.5A)NoneNoneC2F A3000 (-3.5A)C2F A3000 (-4.3A) | 0.57A | 5vooD-4o1eA:27.9 | 5vooD-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 5 | GLU A 7ASN A 10LEU A 163GLY A 196ILE A 227 | C2F A3000 (-3.6A)C2F A3000 ( 4.5A)NoneC2F A3000 (-3.5A)C2F A3000 (-4.3A) | 1.05A | 5vooD-4o1eA:27.9 | 5vooD-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovq | TRAP DICARBOXYLATEABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Roseobacterdenitrificans) |
PF03480(DctP) | 5 | GLU A 84ASN A 240GLY A 81GLY A 29ILE A 85 | None | 1.17A | 5vooD-4ovqA:undetectable | 5vooD-4ovqA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozy | POLY(BETA-D-MANNURONATE) C5 EPIMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13229(Beta_helix) | 5 | ASN A 306GLY A 305MET A 246VAL A 231ILE A 241 | None | 1.15A | 5vooD-4ozyA:undetectable | 5vooD-4ozyA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | ASN A 131GLY A 244LEU A 116GLY A 249SER A 143 | None | 1.00A | 5vooD-4q0cA:undetectable | 5vooD-4q0cA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7o | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PUTATIVE (Bacillusanthracis) |
PF03009(GDPD) | 5 | GLY A 45MET A 186VAL A 208LEU A 210ILE A 41 | NoneNoneNoneGOL A 405 ( 4.7A)None | 1.16A | 5vooD-4r7oA:11.2 | 5vooD-4r7oA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxm | POSSIBLE SUGAR ABCSUPERFAMILY ATPBINDING CASSETTETRANSPORTER, BINDINGPROTEIN (Mannheimiahaemolytica) |
PF13407(Peripla_BP_4) | 5 | GLY A 154VAL A 139LEU A 259GLY A 132ILE A 168 | None | 0.78A | 5vooD-4rxmA:undetectable | 5vooD-4rxmA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1i | PYRIDOXAL KINASE (Entamoebahistolytica) |
PF08543(Phos_pyr_kin) | 5 | GLY B 215LEU B 109GLY B 82SER B 10ILE B 113 | NoneNoneNonePLP B 302 (-2.4A)PLP B 302 ( 4.7A) | 1.09A | 5vooD-4s1iB:2.8 | 5vooD-4s1iB:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk0 | INTEGRIN BETA-1 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | GLU B 229GLY B 230LEU B 183GLY B 223SER B 132 | MG B 501 ( 3.1A)NoneNoneNone MG B 501 (-2.1A) | 1.18A | 5vooD-4wk0B:3.1 | 5vooD-4wk0B:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xiv | CHEMOTAXIS PROTEINCHEA (Thermotogamaritima) |
PF02518(HATPase_c)PF02895(H-kinase_dim) | 5 | GLU A 416GLY A 453VAL A 369GLY A 430ILE A 415 | NoneACP A 601 (-4.7A)NoneNoneNone | 1.16A | 5vooD-4xivA:undetectable | 5vooD-4xivA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yh2 | GLUTATHIONE STRANSFERASE E6 (Drosophilamelanogaster) |
PF13417(GST_N_3)PF14497(GST_C_3) | 5 | GLU A 193ASN A 202GLY A 203VAL A 142ILE A 189 | None | 0.93A | 5vooD-4yh2A:undetectable | 5vooD-4yh2A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 5 | GLY A 235LYS A 230LEU A 366GLY A 274ILE A 305 | None | 1.07A | 5vooD-4zhjA:undetectable | 5vooD-4zhjA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxp | LACTO-N-BIOSIDASE (Bifidobacteriumbifidum) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF14200(RicinB_lectin_2) | 5 | ASN A 357GLY A 354LEU A 404GLY A 376ILE A 372 | None | 1.17A | 5vooD-5bxpA:7.0 | 5vooD-5bxpA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by2 | PHOSPHOHEPTOSEISOMERASE (Colwelliapsychrerythraea) |
PF13580(SIS_2) | 5 | GLY A 48LEU A 23GLY A 144SER A 119ILE A 171 | None | 1.17A | 5vooD-5by2A:undetectable | 5vooD-5by2A:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN BETA-2 (Homo sapiens) |
PF00362(Integrin_beta)PF17205(PSI_integrin) | 5 | GLU B 212GLY B 213LEU B 165GLY B 206SER B 114 | None | 1.01A | 5vooD-5e6sB:2.6 | 5vooD-5e6sB:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | GLU A 564LEU A 484GLY A 504SER A 502PHE A 455 | None | 0.97A | 5vooD-5h8wA:undetectable | 5vooD-5h8wA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hz1 | PROBABLE LRRRECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASEAT4G26540 (Arabidopsisthaliana) |
PF13855(LRR_8) | 5 | GLY B 166LYS B 142LEU B 237GLY B 186ILE B 185 | None | 1.08A | 5vooD-5hz1B:undetectable | 5vooD-5hz1B:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjc | CYSTEINE SYNTHASE (Brucellaabortus) |
PF00291(PALP) | 5 | GLY A 233LEU A 111GLY A 74PHE A 150ILE A 75 | LLP A 42 ( 4.0A)NoneNoneNoneNone | 1.05A | 5vooD-5jjcA:2.4 | 5vooD-5jjcA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhf | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Mus musculus) |
no annotation | 5 | VAL A 456LEU A 392GLY A 398PHE A 103ILE A 399 | None | 1.11A | 5vooD-5mhfA:undetectable | 5vooD-5mhfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o6y | PEPTIDOGLYCANN-ACETYLGLUCOSAMINEDEACETYLASE (Bacillus cereus) |
no annotation | 5 | GLU B 74GLY B 219LEU B 95SER B 258PHE B 260 | None | 1.18A | 5vooD-5o6yB:2.3 | 5vooD-5o6yB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oe5 | ANTHRANILATE--COALIGASE (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 5 | VAL A 239LEU A 243GLY A 253SER A 277ILE A 257 | None | 1.14A | 5vooD-5oe5A:undetectable | 5vooD-5oe5A:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t6o | POLY-BETA-HYDROXYBUTERATE POLYMERASE (Cupriavidusnecator) |
PF07167(PhaC_N) | 5 | GLY A 206ASP A 254VAL A 266LEU A 231GLY A 214 | None | 1.05A | 5vooD-5t6oA:undetectable | 5vooD-5t6oA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnu | DNA-DEPENDENT ATPASEXPBII (Sulfurisphaeratokodaii) |
no annotation | 5 | GLU A 143GLY A 141ASP A 144LEU A 112GLY A 137 | NoneSO4 A 505 ( 4.8A)NoneNoneNone | 1.06A | 5vooD-5tnuA:undetectable | 5vooD-5tnuA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 288LEU A 316GLY A 293SER A 294ILE A 244 | None | 0.97A | 5vooD-5u2aA:undetectable | 5vooD-5u2aA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4b | F-BOX/WDREPEAT-CONTAININGPROTEIN 7 (Homo sapiens) |
PF00400(WD40)PF12937(F-box-like) | 5 | GLU B2569GLY B2571LEU B2589GLY B2551ILE B2552 | None | 0.97A | 5vooD-5v4bB:undetectable | 5vooD-5v4bB:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vop | 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 8 | ASN A 376GLY A 379LYS A 381ASP A 443MET A 441VAL A 490GLY A 570PHE A 576 | NA A3005 (-3.0A)C2F A3001 (-3.3A)NoneC2F A3001 (-2.5A)C2F A3001 ( 4.8A)C2F A3001 ( 4.7A)C2F A3001 (-3.5A)C2F A3001 (-4.7A) | 1.46A | 5vooD-5vopA:46.4 | 5vooD-5vopA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vop | 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 12 | GLU A 373ASN A 376GLY A 379LYS A 381ASP A 411MET A 441VAL A 490LEU A 492GLY A 570SER A 572PHE A 576ILE A 603 | C2F A3001 (-3.7A) NA A3005 (-3.0A)C2F A3001 (-3.3A)NoneC2F A3001 ( 3.8A)C2F A3001 ( 4.8A)C2F A3001 ( 4.7A)NoneC2F A3001 (-3.5A)C2F A3001 ( 4.5A)C2F A3001 (-4.7A)C2F A3001 (-3.5A) | 0.54A | 5vooD-5vopA:46.4 | 5vooD-5vopA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vy3 | PROTEASOME SUBUNITALPHA (Thermoplasmaacidophilum) |
no annotation | 5 | LYS A 32VAL A 229LEU A 233GLY A 193ILE A 49 | None | 1.08A | 5vooD-5vy3A:undetectable | 5vooD-5vy3A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | GLU B 108GLY B 98VAL B 116GLY B 93SER B 95 | NoneGDP B 501 (-4.4A)NoneNoneNone | 1.18A | 5vooD-5w3jB:undetectable | 5vooD-5w3jB:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4s | SPIKE GLYCOPROTEIN (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF16451(Spike_NTD) | 5 | GLY A 39LEU A 194GLY A 86PHE A 59ILE A 87 | None | 1.13A | 5vooD-5x4sA:undetectable | 5vooD-5x4sA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z7r | SHORT-CHAIN-ENOYL-COA HYDRATASE (Clostridiumacetobutylicum) |
no annotation | 5 | GLY A 65MET A 36GLY A 56PHE A 107ILE A 19 | None | 1.18A | 5vooD-5z7rA:2.6 | 5vooD-5z7rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8z | ADP-DEPENDENTPHOSPHOFRUCTOKINASE (Methanosarcinales) |
no annotation | 5 | GLY A 242ASP A 471GLY A 114SER A 33ILE A 119 | NoneADP A 501 (-3.6A)NoneNoneNone | 0.97A | 5vooD-6c8zA:2.6 | 5vooD-6c8zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | GLY A 104ASP A 57LEU A 151GLY A 158SER A 181 | None | 1.10A | 5vooD-6gunA:undetectable | 5vooD-6gunA:undetectable |