SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_C_C2FC702_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 GLY P 100
VAL P  47
LEU P 123
GLY P 211
ILE P 212
 None
 1.19A 5vooC-1bruP:
undetectable		 5vooC-1bruP:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		7 GLU A   6
ASP A  43
LEU A 122
GLY A 196
SER A 198
ARG A 207
ILE A 227
 None
 0.49A 5vooC-1f6yA:
29.4		 5vooC-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5u PROFILIN

(Hevea
brasiliensis) 		PF00235
(Profilin) 		5 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.10A 5vooC-1g5uA:
undetectable		 5vooC-1g5uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A 193
VAL A 207
LEU A 209
GLY A  37
ILE A 198
 None
 1.16A 5vooC-1i8tA:
undetectable		 5vooC-1i8tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 ARG A 201
GLY A  53
LEU A 231
GLY A 228
ILE A 198
 None
 1.06A 5vooC-1jcfA:
2.9		 5vooC-1jcfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 GLU A 301
LYS A 353
GLY A 260
SER A 311
ILE A 285
 None
 1.10A 5vooC-1kb0A:
undetectable		 5vooC-1kb0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A

(Homo sapiens) 		PF02301
(HORMA) 		5 GLY A  38
VAL A  70
SER A  32
PHE A  45
ILE A  30
 None
 1.15A 5vooC-1klqA:
undetectable		 5vooC-1klqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 GLY A 245
VAL A 380
LEU A 383
GLY A 172
SER A 167
 None
 1.19A 5vooC-1lbqA:
3.0		 5vooC-1lbqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 GLU A 355
ARG A 357
LEU A 495
GLY A 318
SER A 345
 None
SO4  A 904 (-4.3A)
None
None
None
 1.15A 5vooC-1o99A:
undetectable		 5vooC-1o99A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLU A  42
GLY A  51
VAL A  64
GLY A  58
SER A  54
 None
 1.16A 5vooC-1r2jA:
undetectable		 5vooC-1r2jA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLU A 496
GLY A 499
VAL A 477
LEU A 433
SER A 492
 None
 1.18A 5vooC-1r9jA:
undetectable		 5vooC-1r9jA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		5 VAL A   9
LEU A 122
GLY A 228
SER A 224
PHE A 132
 None
 1.10A 5vooC-1rptA:
undetectable		 5vooC-1rptA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 GLU A 505
ARG A  34
GLY A 501
SER A 512
ILE A 502
 None
 1.14A 5vooC-1rqgA:
undetectable		 5vooC-1rqgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		5 GLY A  49
LEU A  24
GLY A 145
SER A 120
ILE A 169
 None
 1.17A 5vooC-1tk9A:
undetectable		 5vooC-1tk9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 ARG A 336
GLY A 335
LEU A 359
GLY A 339
ILE A 319
 None
 1.11A 5vooC-1w61A:
undetectable		 5vooC-1w61A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 GLY A  59
VAL A 313
LEU A 305
GLY A  73
ILE A  74
 None
 1.11A 5vooC-1wkyA:
5.7		 5vooC-1wkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 GLU A 357
ARG A 408
GLY A 405
GLY A 361
ARG A 211
 MG  A2001 (-2.6A)
PO4  A3001 ( 3.2A)
NSS  A3002 (-3.2A)
NSS  A3002 ( 4.2A)
NSS  A3002 (-2.9A)
 1.14A 5vooC-1x55A:
undetectable		 5vooC-1x55A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 153
VAL A 112
LEU A 105
GLY A  38
ARG A 173
 FAD  A 999 (-3.3A)
None
None
None
None
 1.16A 5vooC-1xdiA:
undetectable		 5vooC-1xdiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		5 GLY A 225
VAL A 269
LEU A  86
GLY A 219
ILE A 218
 None
 1.12A 5vooC-1ztmA:
undetectable		 5vooC-1ztmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY A 485
ASP A 269
LEU A 443
GLY A 458
PHE A 425
 None
 1.09A 5vooC-2aeyA:
undetectable		 5vooC-2aeyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		5 GLU A 102
ARG A 133
GLY A 135
ASP A 103
GLY A  57
 None
 1.06A 5vooC-2b4eA:
undetectable		 5vooC-2b4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		6 GLY A 197
VAL A 213
LEU A 215
GLY A  39
SER A  42
ILE A 202
 None
None
None
None
FAD  A1385 ( 3.8A)
None
 1.25A 5vooC-2bi7A:
undetectable		 5vooC-2bi7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 ARG A1774
VAL A1595
LEU A1592
GLY A1766
ILE A1769
 None
 1.18A 5vooC-2fr1A:
3.0		 5vooC-2fr1A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 GLU A 288
GLY A 308
VAL A 226
GLY A 263
ILE A 264
 ACY  A 901 (-2.6A)
None
None
None
ACY  A 901 (-4.1A)
 1.16A 5vooC-2g39A:
undetectable		 5vooC-2g39A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		5 VAL A1009
LEU A1122
GLY A1228
SER A1224
PHE A1132
 None
 1.09A 5vooC-2hpaA:
undetectable		 5vooC-2hpaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 GLY A 502
LYS A 509
LEU A 580
SER A 467
ILE A 462
 None
 1.18A 5vooC-2qqmA:
undetectable		 5vooC-2qqmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY 1 292
VAL 1 125
LEU 1 123
SER 1 195
ILE 1 193
 None
 1.13A 5vooC-2r6r1:
2.6		 5vooC-2r6r1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ARG B 336
GLY B 338
GLY B 202
SER B 199
ILE B 201
 SH0  A 503 (-3.0A)
None
None
None
None
 1.19A 5vooC-2v4jB:
undetectable		 5vooC-2v4jB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wja PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		5 GLY A  42
ASP A 119
VAL A 131
LEU A 135
SER A  89
 None
PO4  A1148 (-3.3A)
None
None
None
 1.20A 5vooC-2wjaA:
undetectable		 5vooC-2wjaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
 None
 1.07A 5vooC-2wtbA:
undetectable		 5vooC-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.10A 5vooC-2x58A:
undetectable		 5vooC-2x58A:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		8 GLU A   7
LYS A  14
ASP A  44
LEU A 123
GLY A 197
SER A 199
ARG A 208
ILE A 228
 C2F  A3000 ( 4.1A)
None
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 ( 2.6A)
C2F  A3000 (-4.6A)
 0.75A 5vooC-2ycjA:
30.2		 5vooC-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Escherichia
coli) 		PF03737
(RraA-like) 		5 ARG A  71
GLY A 118
LEU A  61
GLY A  65
SER A  68
 None
 1.12A 5vooC-2yjvA:
undetectable		 5vooC-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Escherichia
coli) 		PF03737
(RraA-like) 		6 GLU A  43
ARG A  71
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.28A 5vooC-2yjvA:
undetectable		 5vooC-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		5 GLY A  14
ASP A   8
VAL A 132
LEU A 114
ARG A 153
 ADP  A 210 (-3.1A)
None
None
None
CDP  A 209 ( 3.0A)
 1.13A 5vooC-3akcA:
undetectable		 5vooC-3akcA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 0.95A 5vooC-3aqgA:
undetectable		 5vooC-3aqgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.12A 5vooC-3au9A:
undetectable		 5vooC-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 GLU A 320
ASP A 358
LEU A 437
GLY A 505
SER A 507
ILE A 536
 None
 0.75A 5vooC-3bolA:
8.3		 5vooC-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.20A 5vooC-3c5yA:
undetectable		 5vooC-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 GLY A 642
VAL A 171
LEU A 175
PHE A 106
ARG A 663
 None
 1.18A 5vooC-3cf4A:
undetectable		 5vooC-3cf4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 172
ASP A 168
GLY A 187
ARG A 179
ILE A 186
 CA  A 303 (-2.8A)
None
None
None
None
 1.00A 5vooC-3dbkA:
undetectable		 5vooC-3dbkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 GLY A   9
ASP A  31
LEU A 294
GLY A 288
SER A 284
 None
 1.16A 5vooC-3ebvA:
3.0		 5vooC-3ebvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 371
VAL A 267
LEU A 250
GLY A 307
ILE A 311
 None
 1.09A 5vooC-3euoA:
undetectable		 5vooC-3euoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqs ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF16697
(Yop-YscD_cpl) 		5 GLY A  70
VAL A   9
LEU A   7
GLY A  30
ILE A  45
 None
 1.16A 5vooC-3gqsA:
undetectable		 5vooC-3gqsA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 5 GLU A  53
GLY A  80
LEU A  41
GLY A  34
ILE A  62
 None
 1.03A 5vooC-3hm2A:
undetectable		 5vooC-3hm2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		5 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.12A 5vooC-3iuuA:
3.3		 5vooC-3iuuA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		8 GLU A 358
GLY A 364
ASP A 396
VAL A 478
GLY A 558
SER A 560
ARG A 573
ILE A 593
 THH  A 642 ( 3.5A)
THH  A 642 (-3.7A)
THH  A 642 ( 4.7A)
None
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 (-3.1A)
THH  A 642 (-4.2A)
 0.37A 5vooC-3k13A:
38.9		 5vooC-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 GLY A 138
LEU A  54
GLY A  45
SER A  11
ILE A  46
 None
 1.16A 5vooC-3k2qA:
2.6		 5vooC-3k2qA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 302
VAL A 122
LEU A 126
GLY A 280
ILE A 108
 None
 1.15A 5vooC-3sjnA:
4.5		 5vooC-3sjnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		5 GLU A  69
ARG A  91
VAL A  22
LEU A 126
GLY A  29
 None
SKZ  A 290 (-3.0A)
None
None
None
 1.14A 5vooC-3tnyA:
undetectable		 5vooC-3tnyA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		5 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.06A 5vooC-3v4vB:
2.4		 5vooC-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 5 VAL A  88
LEU A 365
SER A 435
ARG A 439
ILE A 328
 None
 1.20A 5vooC-3w36A:
undetectable		 5vooC-3w36A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		9 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.60A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		5 ARG A 534
GLY A 553
VAL A 572
GLY A 549
SER A 582
 None
 1.06A 5vooC-4chbA:
undetectable		 5vooC-4chbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		5 GLU B 258
GLY B 226
GLY B  96
PHE B 111
ILE B 259
 None
 1.09A 5vooC-4dhiB:
undetectable		 5vooC-4dhiB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.09A 5vooC-4e4rA:
undetectable		 5vooC-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 521
VAL A 532
GLY A 505
PHE A 693
ILE A 491
 None
 1.05A 5vooC-4g9iA:
2.0		 5vooC-4g9iA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		5 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.16A 5vooC-4ifdC:
undetectable		 5vooC-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		5 GLU A 361
VAL A  91
LEU A  89
GLY A 192
ARG A 454
 None
 1.18A 5vooC-4j7hA:
undetectable		 5vooC-4j7hA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		5 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.88A 5vooC-4jerA:
undetectable		 5vooC-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 150
VAL A 169
LEU A 198
GLY A 173
SER A 174
 NK  A 501 (-3.1A)
None
None
None
None
 1.04A 5vooC-4jz6A:
undetectable		 5vooC-4jz6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ARG A 779
ASP A 778
VAL A 817
LEU A 769
ILE A 793
 None
 1.17A 5vooC-4n3nA:
2.5		 5vooC-4n3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		6 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
 F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
 1.37A 5vooC-4n6fA:
3.5		 5vooC-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ARG A  92
VAL A  41
LEU A  39
ARG A 412
ILE A  94
 None
 1.16A 5vooC-4nbqA:
undetectable		 5vooC-4nbqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		5 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 CA  B 705 ( 3.2A)
None
None
None
MG  B 707 (-2.1A)
 1.09A 5vooC-4nenB:
2.1		 5vooC-4nenB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		5 GLU A   7
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.56A 5vooC-4o1eA:
28.0		 5vooC-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLU A  75
GLY A 101
VAL A 149
LEU A 158
GLY A 118
 None
 1.02A 5vooC-4psdA:
undetectable		 5vooC-4psdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 GLU A 349
ARG A 351
LEU A 489
GLY A 312
SER A 339
 None
 1.14A 5vooC-4qaxA:
2.1		 5vooC-4qaxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		5 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
 None
 0.80A 5vooC-4rxmA:
2.3		 5vooC-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		5 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.14A 5vooC-4s1iB:
3.0		 5vooC-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk0 INTEGRIN BETA-1

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 GLU B 229
GLY B 230
LEU B 183
GLY B 223
SER B 132
 MG  B 501 ( 3.1A)
None
None
None
MG  B 501 (-2.1A)
 1.15A 5vooC-4wk0B:
undetectable		 5vooC-4wk0B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 GLU A 639
ARG A 647
GLY A 588
GLY A 641
SER A 643
 None
 1.12A 5vooC-4wrnA:
undetectable		 5vooC-4wrnA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 VAL A 530
LEU A 543
GLY A 548
SER A 514
ILE A 550
 None
 1.18A 5vooC-4yplA:
undetectable		 5vooC-4yplA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE

(Colwellia
psychrerythraea) 		PF13580
(SIS_2) 		5 GLY A  48
LEU A  23
GLY A 144
SER A 119
ILE A 171
 None
 1.13A 5vooC-5by2A:
undetectable		 5vooC-5by2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 1.04A 5vooC-5c6uA:
undetectable		 5vooC-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 GLU A 297
VAL A 175
LEU A 173
SER A 483
ILE A 163
 None
 1.15A 5vooC-5ck7A:
3.3		 5vooC-5ck7A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 GLU A 529
ARG A 162
GLY A 158
LEU A 256
ILE A 530
 SN5  A 604 (-3.9A)
None
None
None
None
 1.14A 5vooC-5df0A:
4.2		 5vooC-5df0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.01A 5vooC-5e6sB:
undetectable		 5vooC-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 GLY A 154
VAL A  88
LEU A  92
GLY A  62
SER A 196
 None
 1.13A 5vooC-5gkxA:
undetectable		 5vooC-5gkxA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 GLY B 166
LYS B 142
LEU B 237
GLY B 186
ILE B 185
 None
 1.01A 5vooC-5hz1B:
undetectable		 5vooC-5hz1B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 GLU A 480
VAL A 532
LEU A 461
SER A 427
ARG A 413
 None
 1.12A 5vooC-5j7xA:
undetectable		 5vooC-5j7xA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 GLU A 440
GLY A 437
VAL A 479
LEU A 481
SER A 548
 None
None
None
EDO  A1009 ( 3.5A)
None
 1.18A 5vooC-5kdxA:
undetectable		 5vooC-5kdxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 GLU A 343
GLY A  95
VAL A 326
LEU A 279
GLY A 269
 6S6  A 613 (-1.9A)
None
None
None
None
 1.17A 5vooC-5la7A:
2.9		 5vooC-5la7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 5 GLY B 329
VAL B 476
LEU B 386
GLY B 380
ILE B 379
 None
 1.12A 5vooC-5ltmB:
undetectable		 5vooC-5ltmB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 GLU B 291
GLY B 294
LEU B 276
GLY B 389
ILE B 390
 None
 1.19A 5vooC-5my0B:
undetectable		 5vooC-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		5 GLY A 261
ASP A 159
GLY A 166
SER A 152
PHE A 253
 None
 1.10A 5vooC-5o30A:
undetectable		 5vooC-5o30A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.13A 5vooC-5oe5A:
undetectable		 5vooC-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 5 GLY A 231
VAL A 170
LEU A 266
GLY A 149
ILE A 102
 None
 1.10A 5vooC-5ofnA:
undetectable		 5vooC-5ofnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.01A 5vooC-5t6oA:
undetectable		 5vooC-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE

(uncultured
bacterium) 		PF13561
(adh_short_C2) 		5 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.10A 5vooC-5tiiA:
2.9		 5vooC-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 ARG A 118
GLY A 244
VAL A 211
LEU A 221
ILE A 120
 NAP  A 407 (-3.8A)
NAP  A 407 (-3.2A)
None
None
NAP  A 407 ( 4.6A)
 1.18A 5vooC-5u63A:
undetectable		 5vooC-5u63A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.94A 5vooC-5v4bB:
undetectable		 5vooC-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 10 GLU A 373
GLY A 379
LYS A 381
ASP A 411
VAL A 490
LEU A 492
GLY A 570
SER A 572
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-3.3A)
None
C2F  A3001 ( 3.8A)
C2F  A3001 ( 4.7A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.37A 5vooC-5vopA:
47.6		 5vooC-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vy3 PROTEASOME SUBUNIT
ALPHA

(Thermoplasma
acidophilum) 		no annotation 6 GLY A 168
LYS A  32
VAL A 229
LEU A 233
GLY A 193
ILE A  49
 None
 1.38A 5vooC-5vy3A:
undetectable		 5vooC-5vy3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLU B 108
GLY B  98
VAL B 116
GLY B  93
SER B  95
 None
GDP  B 501 (-4.4A)
None
None
None
 1.15A 5vooC-5w3jB:
2.3		 5vooC-5w3jB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 5 GLU A  95
VAL A 126
LEU A 155
SER A 135
PHE A 216
 None
 1.20A 5vooC-5z43A:
undetectable		 5vooC-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.92A 5vooC-6c8zA:
2.3		 5vooC-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 ARG A 594
GLY A 523
LEU A 977
GLY A 918
ARG A 960
 None
 1.17A 5vooC-6etzA:
5.1		 5vooC-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 GLY A 206
VAL A 229
LEU A 233
GLY A 106
ILE A 213
 None
None
HEM  A 401 ( 4.4A)
None
None
 1.14A 5vooC-6fshA:
undetectable		 5vooC-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 5 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.14A 5vooC-6gunA:
undetectable		 5vooC-6gunA:
undetectable