SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_A_C2FA3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I


(Mycobacterium
tuberculosis)
PF00809
(Pterin_bind)
4 ASN A  13
ASP A  86
ASN A 105
ASP A 177
MG  A 300 ( 2.9A)
PMM  A 301 (-3.2A)
PMM  A 301 (-2.9A)
PMM  A 301 (-3.1A)
0.78A 5vooA-1eyeA:
18.8
5vooA-1eyeA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Moorella
thermoacetica)
PF00809
(Pterin_bind)
4 ASN A   9
ASP A  75
ASN A  96
ASP A 160
None
0.42A 5vooA-1f6yA:
29.3
5vooA-1f6yA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans)
PF00118
(Cpn60_TCP1)
4 ASN A 401
ASP A 398
ASP A  52
ASN A  82
None
0.94A 5vooA-1iokA:
undetectable
5vooA-1iokA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi)
PF00365
(PFK)
4 ASP A 382
ASN A 386
ASP A 176
ASN A 181
None
None
SO4  A 601 (-3.8A)
None
1.22A 5vooA-1kzhA:
undetectable
5vooA-1kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8f ENDOGLUCANASE

(Melanocarpus
albomyces)
PF02015
(Glyco_hydro_45)
4 ASN A 175
ASP A 177
ASN A 178
ASP A 120
None
1.20A 5vooA-1l8fA:
undetectable
5vooA-1l8fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303


(Haemophilus
influenzae)
PF04452
(Methyltrans_RNA)
4 ASN A  47
ASP A  73
ASP A 242
ASN A 105
None
1.35A 5vooA-1nxzA:
2.5
5vooA-1nxzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
4 ASN A 166
ASP A 255
ASN A  46
ASP A  16
None
RIB  A 311 (-3.1A)
RIB  A 311 (-3.3A)
RIB  A 311 (-2.8A)
1.15A 5vooA-1rk2A:
3.1
5vooA-1rk2A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
4 ASP A 255
ASN A  46
ASP A  16
ASN A 108
RIB  A 311 (-3.1A)
RIB  A 311 (-3.3A)
RIB  A 311 (-2.8A)
None
1.23A 5vooA-1rk2A:
3.1
5vooA-1rk2A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
4 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.47A 5vooA-1ux6A:
undetectable
5vooA-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410


(Thermotoga
maritima)
PF03537
(Glyco_hydro_114)
4 ASN A 203
ASP A 156
ASN A  91
ASP A 118
GOL  A  12 (-3.3A)
GOL  A  14 (-4.0A)
None
None
1.33A 5vooA-2aamA:
6.9
5vooA-2aamA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY


(Thermotoga
maritima)
PF00294
(PfkB)
4 ASP A 261
ASN A  44
ASP A  12
ASN A 110
None
ACT  A 321 (-3.9A)
ACT  A 321 (-3.1A)
None
1.16A 5vooA-2ajrA:
2.1
5vooA-2ajrA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00155
(Aminotran_1_2)
4 ASN A 162
ASP A 138
ASN A 141
ASP A 214
None
None
None
PLG  A 500 (-3.1A)
1.44A 5vooA-2bwpA:
undetectable
5vooA-2bwpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 ASN A 420
ASP A 417
ASP A 520
ASN A 159
None
1.46A 5vooA-2f3oA:
undetectable
5vooA-2f3oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huh PUTATIVE DNA
MISMATCH REPAIR
PROTEIN


(Bacteroides
thetaiotaomicron)
PF09640
(DUF2027)
4 ASN A 145
ASP A 117
ASN A  92
ASP A 219
None
1.12A 5vooA-2huhA:
undetectable
5vooA-2huhA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j42 C2 TOXIN
COMPONENT-II


(Clostridium
botulinum)
PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
4 ASN A 235
ASN A 161
ASP A 191
ASN A 227
None
1.47A 5vooA-2j42A:
undetectable
5vooA-2j42A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ASN A 184
ASP A 186
ASN A 205
ASP A 201
PO4  A   3 (-3.4A)
PO4  A   3 (-3.7A)
PO4  A   3 (-4.1A)
None
1.32A 5vooA-2o5pA:
undetectable
5vooA-2o5pA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE


(Bacillus
anthracis)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 ASN A 121
ASP A 118
ASN A 323
ASN A 331
None
1.43A 5vooA-2pfmA:
undetectable
5vooA-2pfmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v73 PUTATIVE
EXO-ALPHA-SIALIDASE


(Clostridium
perfringens)
PF02973
(Sialidase)
4 ASN A  61
ASP A  59
ASN A  65
ASP A  88
None
1.25A 5vooA-2v73A:
undetectable
5vooA-2v73A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00809
(Pterin_bind)
4 ASN A  17
ASP A  91
ASN A 110
ASP A 201
None
0.74A 5vooA-2vefA:
6.1
5vooA-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
4 ASN A 384
ASP A 459
ASP A 509
ASN A 390
None
1.10A 5vooA-2xgoA:
2.1
5vooA-2xgoA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
4 ASN A  10
ASP A  44
ASP A 161
ASN A 200
C2F  A3000 ( 4.8A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.1A)
1.47A 5vooA-2ycjA:
29.9
5vooA-2ycjA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
5 ASN A  10
ASP A  76
ASN A  97
ASP A 161
ASN A 200
C2F  A3000 ( 4.8A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.1A)
0.31A 5vooA-2ycjA:
29.9
5vooA-2ycjA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
4 ASN A 323
ASP A 390
ASN A 411
ASP A 473
None
0.37A 5vooA-3bolA:
22.6
5vooA-3bolA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON


(Staphylococcus
saprophyticus)
PF13377
(Peripla_BP_3)
4 ASN A  99
ASP A  68
ASN A  71
ASP A 264
None
None
GOL  A   1 (-3.4A)
GOL  A   1 (-2.6A)
1.45A 5vooA-3e61A:
2.9
5vooA-3e61A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 ASN A 358
ASN A 366
ASP A 205
ASN A 401
None
1.38A 5vooA-3fiiA:
undetectable
5vooA-3fiiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
4 ASN A 169
ASP A 242
ASN A  55
ASP A  25
None
RIB  A 305 (-2.9A)
RIB  A 305 (-3.2A)
RIB  A 305 (-2.8A)
1.05A 5vooA-3go7A:
2.2
5vooA-3go7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus)
PF00168
(C2)
4 ASN A 434
ASP A 402
ASN A 403
ASN A 497
None
1.23A 5vooA-3hn8A:
undetectable
5vooA-3hn8A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE


(Staphylococcus
aureus)
PF00912
(Transgly)
4 ASN A  87
ASP A  86
ASN A 170
ASN A 178
None
1.33A 5vooA-3hzsA:
undetectable
5vooA-3hzsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
4 ASN A  98
ASP A  15
ASP A 260
ASN A 144
None
1.11A 5vooA-3in1A:
2.4
5vooA-3in1A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE


(Bacteroides
thetaiotaomicron)
PF00809
(Pterin_bind)
5 ASN A 361
ASP A 431
ASN A 452
ASP A 519
ASN A 561
GOL  A 643 (-3.1A)
THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.4A)
THH  A 642 ( 3.3A)
0.28A 5vooA-3k13A:
39.0
5vooA-3k13A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Hahella
chejuensis)
PF13407
(Peripla_BP_4)
4 ASN A 106
ASP A  79
ASN A  50
ASP A 259
None
None
BDR  A   1 ( 4.3A)
BDR  A   1 (-2.7A)
1.30A 5vooA-3ksmA:
2.9
5vooA-3ksmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
4 ASN A 194
ASP A 300
ASN A  68
ASP A  18
MG  A 350 ( 4.7A)
B4P  A 349 (-3.4A)
B4P  A 349 (-3.6A)
B4P  A 349 (-2.8A)
1.12A 5vooA-3looA:
undetectable
5vooA-3looA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1


(Saccharomyces
cerevisiae)
PF16499
(Melibiase_2)
4 ASN A  36
ASP A  35
ASN A 263
ASP A 209
None
GOL  A7002 (-3.5A)
GOL  A7002 (-3.1A)
GOL  A7002 ( 3.9A)
1.02A 5vooA-3lrkA:
8.5
5vooA-3lrkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
no annotation 4 ASP B 607
ASN B 432
ASP B 717
ASN B 684
None
1.32A 5vooA-3nr8B:
undetectable
5vooA-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE


(Coxiella
burnetii)
PF00809
(Pterin_bind)
4 ASN A  35
ASP A 111
ASN A 130
ASP A 199
CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
0.76A 5vooA-3tr9A:
8.3
5vooA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
PANCREATIC
RIBONUCLEASE
INHIBITOR


(Mus musculus;
Mus musculus)
PF00074
(RnaseA)
PF13516
(LRR_6)
4 ASN A  45
ASP E 431
ASN E 402
ASP E 399
None
1.40A 5vooA-3tsrA:
undetectable
5vooA-3tsrA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A


(Butyrivibrio
proteoclasticus)
PF13472
(Lipase_GDSL_2)
4 ASP A 259
ASN A 257
ASP A 198
ASN A 108
None
1.17A 5vooA-3u37A:
3.4
5vooA-3u37A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
0.23A 5vooA-4cczA:
38.6
5vooA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A  20
ASP A 401
ASP A  51
ASN A 318
PO4  A 501 (-3.6A)
None
None
PO4  A 501 ( 4.8A)
1.22A 5vooA-4dhgA:
3.3
5vooA-4dhgA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
4 ASN A  10
ASP A  76
ASN A  97
ASP A 161
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
0.25A 5vooA-4o1eA:
27.8
5vooA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
4 ASP A  76
ASN A  97
ASP A 161
ASN A 199
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
0.83A 5vooA-4o1eA:
27.8
5vooA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica)
PF12468
(TTSSLRR)
4 ASN A 363
ASN A 359
ASP A 399
ASN A 403
None
1.40A 5vooA-4ow2A:
undetectable
5vooA-4ow2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
4 ASN A 314
ASP A 315
ASN A 271
ASP A 275
None
1.23A 5vooA-4pj3A:
3.1
5vooA-4pj3A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae)
PF01633
(Choline_kinase)
4 ASN A  32
ASN A  88
ASP A  73
ASN A 181
None
1.46A 5vooA-4r7bA:
undetectable
5vooA-4r7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
4 ASN A 157
ASP A 249
ASN A  34
ASP A  11
ANP  A 401 (-3.6A)
ANP  A 401 ( 4.3A)
None
None
1.11A 5vooA-4wjmA:
2.3
5vooA-4wjmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii)
PF07367
(FB_lectin)
4 ASN A  59
ASP A  14
ASN A  12
ASN A 116
None
1.13A 5vooA-4z2qA:
undetectable
5vooA-4z2qA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 ASN A 538
ASP A 533
ASN A 570
ASN A 662
None
1.29A 5vooA-4zgvA:
undetectable
5vooA-4zgvA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 ASN A 540
ASP A 533
ASN A 570
ASN A 662
None
1.07A 5vooA-4zgvA:
undetectable
5vooA-4zgvA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED


(Cupriavidus
metallidurans)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK)
4 ASN A  44
ASP A  40
ASN A 743
ASP A 739
None
B12  A1101 (-3.5A)
B12  A1101 ( 4.6A)
None
1.25A 5vooA-5cjuA:
3.1
5vooA-5cjuA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE


(Cryptococcus
neoformans)
PF02358
(Trehalose_PPase)
4 ASP A 214
ASN A  24
ASP A  26
ASN A 178
T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
1.25A 5vooA-5dx9A:
undetectable
5vooA-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
4 ASN A 174
ASP A 266
ASN A  49
ASP A  30
None
1.18A 5vooA-5ey7A:
2.4
5vooA-5ey7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Dinoroseobacter
shibae)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
4 ASN A  39
ASP A  38
ASP A  48
ASN A 231
None
1.48A 5vooA-5gxdA:
4.4
5vooA-5gxdA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.28A 5vooA-5okoA:
undetectable
5vooA-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 4 ASN A 376
ASP A 411
ASP A 531
ASN A 573
NA  A3005 (-3.0A)
C2F  A3001 ( 3.8A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
1.41A 5vooA-5vopA:
48.1
5vooA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE


(Thermus
thermophilus)
no annotation 5 ASN A 376
ASP A 443
ASN A 464
ASP A 531
ASN A 573
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.6A)
0.09A 5vooA-5vopA:
48.1
5vooA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN


(Ornithorhynchus
anatinus)
no annotation 4 ASN A  45
ASP A  60
ASN A  57
ASP A 119
None
1.43A 5vooA-6b4mA:
undetectable
5vooA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans)
no annotation 4 ASN A 163
ASP A 273
ASN A  46
ASP A  16
None
None
GOL  A 400 (-3.3A)
GOL  A 400 (-2.8A)
1.04A 5vooA-6cw5A:
2.6
5vooA-6cw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44


(Homo sapiens)
no annotation 4 ASP K 488
ASN K 487
ASP K 784
ASN K 671
A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
1.21A 5vooA-6d6qK:
undetectable
5vooA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)


(Homo sapiens)
no annotation 4 ASN A 190
ASP A 186
ASP A 410
ASN A 447
None
1.44A 5vooA-6gctA:
undetectable
5vooA-6gctA:
undetectable