SIMILAR PATTERNS OF AMINO ACIDS FOR 5VOO_A_C2FA3001_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eye | DIHYDROPTEROATESYNTHASE I (Mycobacteriumtuberculosis) |
PF00809(Pterin_bind) | 4 | ASN A 13ASP A 86ASN A 105ASP A 177 | MG A 300 ( 2.9A)PMM A 301 (-3.2A)PMM A 301 (-2.9A)PMM A 301 (-3.1A) | 0.78A | 5vooA-1eyeA:18.8 | 5vooA-1eyeA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f6y | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Moorellathermoacetica) |
PF00809(Pterin_bind) | 4 | ASN A 9ASP A 75ASN A 96ASP A 160 | None | 0.42A | 5vooA-1f6yA:29.3 | 5vooA-1f6yA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iok | CHAPERONIN 60 (Paracoccusdenitrificans) |
PF00118(Cpn60_TCP1) | 4 | ASN A 401ASP A 398ASP A 52ASN A 82 | None | 0.94A | 5vooA-1iokA:undetectable | 5vooA-1iokA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kzh | PHOSPHOFRUCTOKINASE (Borreliellaburgdorferi) |
PF00365(PFK) | 4 | ASP A 382ASN A 386ASP A 176ASN A 181 | NoneNoneSO4 A 601 (-3.8A)None | 1.22A | 5vooA-1kzhA:undetectable | 5vooA-1kzhA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l8f | ENDOGLUCANASE (Melanocarpusalbomyces) |
PF02015(Glyco_hydro_45) | 4 | ASN A 175ASP A 177ASN A 178ASP A 120 | None | 1.20A | 5vooA-1l8fA:undetectable | 5vooA-1l8fA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nxz | HYPOTHETICAL PROTEINHI0303 (Haemophilusinfluenzae) |
PF04452(Methyltrans_RNA) | 4 | ASN A 47ASP A 73ASP A 242ASN A 105 | None | 1.35A | 5vooA-1nxzA:2.5 | 5vooA-1nxzA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 4 | ASN A 166ASP A 255ASN A 46ASP A 16 | NoneRIB A 311 (-3.1A)RIB A 311 (-3.3A)RIB A 311 (-2.8A) | 1.15A | 5vooA-1rk2A:3.1 | 5vooA-1rk2A:26.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 4 | ASP A 255ASN A 46ASP A 16ASN A 108 | RIB A 311 (-3.1A)RIB A 311 (-3.3A)RIB A 311 (-2.8A)None | 1.23A | 5vooA-1rk2A:3.1 | 5vooA-1rk2A:26.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 4 | ASP A 933ASN A 931ASP A 874ASN A 855 | None | 1.47A | 5vooA-1ux6A:undetectable | 5vooA-1ux6A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aam | HYPOTHETICAL PROTEINTM1410 (Thermotogamaritima) |
PF03537(Glyco_hydro_114) | 4 | ASN A 203ASP A 156ASN A 91ASP A 118 | GOL A 12 (-3.3A)GOL A 14 (-4.0A)NoneNone | 1.33A | 5vooA-2aamA:6.9 | 5vooA-2aamA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 4 | ASP A 261ASN A 44ASP A 12ASN A 110 | NoneACT A 321 (-3.9A)ACT A 321 (-3.1A)None | 1.16A | 5vooA-2ajrA:2.1 | 5vooA-2ajrA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwp | 5-AMINOLEVULINATESYNTHASE (Rhodobactercapsulatus) |
PF00155(Aminotran_1_2) | 4 | ASN A 162ASP A 138ASN A 141ASP A 214 | NoneNoneNonePLG A 500 (-3.1A) | 1.44A | 5vooA-2bwpA:undetectable | 5vooA-2bwpA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3o | PYRUVATEFORMATE-LYASE 2 (Archaeoglobusfulgidus) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | ASN A 420ASP A 417ASP A 520ASN A 159 | None | 1.46A | 5vooA-2f3oA:undetectable | 5vooA-2f3oA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2huh | PUTATIVE DNAMISMATCH REPAIRPROTEIN (Bacteroidesthetaiotaomicron) |
PF09640(DUF2027) | 4 | ASN A 145ASP A 117ASN A 92ASP A 219 | None | 1.12A | 5vooA-2huhA:undetectable | 5vooA-2huhA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j42 | C2 TOXINCOMPONENT-II (Clostridiumbotulinum) |
PF03495(Binary_toxB)PF07691(PA14)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 4 | ASN A 235ASN A 161ASP A 191ASN A 227 | None | 1.47A | 5vooA-2j42A:undetectable | 5vooA-2j42A:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | ASN A 184ASP A 186ASN A 205ASP A 201 | PO4 A 3 (-3.4A)PO4 A 3 (-3.7A)PO4 A 3 (-4.1A)None | 1.32A | 5vooA-2o5pA:undetectable | 5vooA-2o5pA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfm | ADENYLOSUCCINATELYASE (Bacillusanthracis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | ASN A 121ASP A 118ASN A 323ASN A 331 | None | 1.43A | 5vooA-2pfmA:undetectable | 5vooA-2pfmA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v73 | PUTATIVEEXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF02973(Sialidase) | 4 | ASN A 61ASP A 59ASN A 65ASP A 88 | None | 1.25A | 5vooA-2v73A:undetectable | 5vooA-2v73A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vef | DIHYDROPTEROATESYNTHASE (Streptococcuspneumoniae) |
PF00809(Pterin_bind) | 4 | ASN A 17ASP A 91ASN A 110ASP A 201 | None | 0.74A | 5vooA-2vefA:6.1 | 5vooA-2vefA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 4 | ASN A 384ASP A 459ASP A 509ASN A 390 | None | 1.10A | 5vooA-2xgoA:2.1 | 5vooA-2xgoA:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 4 | ASN A 10ASP A 44ASP A 161ASN A 200 | C2F A3000 ( 4.8A)C2F A3000 ( 4.5A)C2F A3000 (-3.5A)C2F A3000 (-3.1A) | 1.47A | 5vooA-2ycjA:29.9 | 5vooA-2ycjA:30.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 5 | ASN A 10ASP A 76ASN A 97ASP A 161ASN A 200 | C2F A3000 ( 4.8A)C2F A3000 (-3.4A)C2F A3000 (-3.0A)C2F A3000 (-3.5A)C2F A3000 (-3.1A) | 0.31A | 5vooA-2ycjA:29.9 | 5vooA-2ycjA:30.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 4 | ASN A 323ASP A 390ASN A 411ASP A 473 | None | 0.37A | 5vooA-3bolA:22.6 | 5vooA-3bolA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e61 | PUTATIVETRANSCRIPTIONALREPRESSOR OF RIBOSEOPERON (Staphylococcussaprophyticus) |
PF13377(Peripla_BP_3) | 4 | ASN A 99ASP A 68ASN A 71ASP A 264 | NoneNoneGOL A 1 (-3.4A)GOL A 1 (-2.6A) | 1.45A | 5vooA-3e61A:2.9 | 5vooA-3e61A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fii | BOTULINUM NEUROTOXINTYPE F (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | ASN A 358ASN A 366ASP A 205ASN A 401 | None | 1.38A | 5vooA-3fiiA:undetectable | 5vooA-3fiiA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3go7 | RIBOKINASE RBSK (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 4 | ASN A 169ASP A 242ASN A 55ASP A 25 | NoneRIB A 305 (-2.9A)RIB A 305 (-3.2A)RIB A 305 (-2.8A) | 1.05A | 5vooA-3go7A:2.2 | 5vooA-3go7A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn8 | SYNAPTOTAGMIN-3 (Rattusnorvegicus) |
PF00168(C2) | 4 | ASN A 434ASP A 402ASN A 403ASN A 497 | None | 1.23A | 5vooA-3hn8A:undetectable | 5vooA-3hn8A:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzs | MONOFUNCTIONALGLYCOSYLTRANSFERASE (Staphylococcusaureus) |
PF00912(Transgly) | 4 | ASN A 87ASP A 86ASN A 170ASN A 178 | None | 1.33A | 5vooA-3hzsA:undetectable | 5vooA-3hzsA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 4 | ASN A 98ASP A 15ASP A 260ASN A 144 | None | 1.11A | 5vooA-3in1A:2.4 | 5vooA-3in1A:22.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 5 | ASN A 361ASP A 431ASN A 452ASP A 519ASN A 561 | GOL A 643 (-3.1A)THH A 642 (-3.3A)THH A 642 (-3.0A)THH A 642 (-3.4A)THH A 642 ( 3.3A) | 0.28A | 5vooA-3k13A:39.0 | 5vooA-3k13A:34.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksm | ABC-TYPE SUGARTRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Hahellachejuensis) |
PF13407(Peripla_BP_4) | 4 | ASN A 106ASP A 79ASN A 50ASP A 259 | NoneNoneBDR A 1 ( 4.3A)BDR A 1 (-2.7A) | 1.30A | 5vooA-3ksmA:2.9 | 5vooA-3ksmA:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 4 | ASN A 194ASP A 300ASN A 68ASP A 18 | MG A 350 ( 4.7A)B4P A 349 (-3.4A)B4P A 349 (-3.6A)B4P A 349 (-2.8A) | 1.12A | 5vooA-3looA:undetectable | 5vooA-3looA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrk | ALPHA-GALACTOSIDASE1 (Saccharomycescerevisiae) |
PF16499(Melibiase_2) | 4 | ASN A 36ASP A 35ASN A 263ASP A 209 | NoneGOL A7002 (-3.5A)GOL A7002 (-3.1A)GOL A7002 ( 3.9A) | 1.02A | 5vooA-3lrkA:8.5 | 5vooA-3lrkA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nr8 | PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
no annotation | 4 | ASP B 607ASN B 432ASP B 717ASN B 684 | None | 1.32A | 5vooA-3nr8B:undetectable | 5vooA-3nr8B:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr9 | DIHYDROPTEROATESYNTHASE (Coxiellaburnetii) |
PF00809(Pterin_bind) | 4 | ASN A 35ASP A 111ASN A 130ASP A 199 | CL A 315 (-3.6A)PT1 A1001 ( 3.4A)PT1 A1001 ( 2.9A)PT1 A1001 (-3.3A) | 0.76A | 5vooA-3tr9A:8.3 | 5vooA-3tr9A:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsr | RIBONUCLEASEPANCREATICRIBONUCLEASEINHIBITOR (Mus musculus;Mus musculus) |
PF00074(RnaseA)PF13516(LRR_6) | 4 | ASN A 45ASP E 431ASN E 402ASP E 399 | None | 1.40A | 5vooA-3tsrA:undetectable | 5vooA-3tsrA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u37 | ACETYL-XYLANESTERASE EST2A (Butyrivibrioproteoclasticus) |
PF13472(Lipase_GDSL_2) | 4 | ASP A 259ASN A 257ASP A 198ASN A 108 | None | 1.17A | 5vooA-3u37A:3.4 | 5vooA-3u37A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccz | METHIONINE SYNTHASE (Homo sapiens) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 5 | ASN A 379ASP A 449ASN A 470ASP A 537ASN A 579 | THG A1652 (-4.6A)THG A1652 (-3.4A)THG A1652 (-3.2A)THG A1652 (-3.4A)THG A1652 (-3.1A) | 0.23A | 5vooA-4cczA:38.6 | 5vooA-4cczA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 20ASP A 401ASP A 51ASN A 318 | PO4 A 501 (-3.6A)NoneNonePO4 A 501 ( 4.8A) | 1.22A | 5vooA-4dhgA:3.3 | 5vooA-4dhgA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 4 | ASN A 10ASP A 76ASN A 97ASP A 161 | C2F A3000 ( 4.5A)C2F A3000 (-3.6A)C2F A3000 (-3.0A)C2F A3000 (-3.5A) | 0.25A | 5vooA-4o1eA:27.8 | 5vooA-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 4 | ASP A 76ASN A 97ASP A 161ASN A 199 | C2F A3000 (-3.6A)C2F A3000 (-3.0A)C2F A3000 (-3.5A)C2F A3000 ( 4.3A) | 0.83A | 5vooA-4o1eA:27.8 | 5vooA-4o1eA:28.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ow2 | YOP EFFECTOR YOPM (Yersiniaenterocolitica) |
PF12468(TTSSLRR) | 4 | ASN A 363ASN A 359ASP A 399ASN A 403 | None | 1.40A | 5vooA-4ow2A:undetectable | 5vooA-4ow2A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj3 | INTRON-BINDINGPROTEIN AQUARIUS (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12)PF16399(Aquarius_N) | 4 | ASN A 314ASP A 315ASN A 271ASP A 275 | None | 1.23A | 5vooA-4pj3A:3.1 | 5vooA-4pj3A:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7b | CHOLINE KINASE (Streptococcuspneumoniae) |
PF01633(Choline_kinase) | 4 | ASN A 32ASN A 88ASP A 73ASN A 181 | None | 1.46A | 5vooA-4r7bA:undetectable | 5vooA-4r7bA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 4 | ASN A 157ASP A 249ASN A 34ASP A 11 | ANP A 401 (-3.6A)ANP A 401 ( 4.3A)NoneNone | 1.11A | 5vooA-4wjmA:2.3 | 5vooA-4wjmA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z2q | LECTIN (Athelia rolfsii) |
PF07367(FB_lectin) | 4 | ASN A 59ASP A 14ASN A 12ASN A 116 | None | 1.13A | 5vooA-4z2qA:undetectable | 5vooA-4z2qA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 4 | ASN A 538ASP A 533ASN A 570ASN A 662 | None | 1.29A | 5vooA-4zgvA:undetectable | 5vooA-4zgvA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 4 | ASN A 540ASP A 533ASN A 570ASN A 662 | None | 1.07A | 5vooA-4zgvA:undetectable | 5vooA-4zgvA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 4 | ASN A 44ASP A 40ASN A 743ASP A 739 | NoneB12 A1101 (-3.5A)B12 A1101 ( 4.6A)None | 1.25A | 5vooA-5cjuA:3.1 | 5vooA-5cjuA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx9 | TREHALOSE-6-PHOSPHATE PHOSPHATASE (Cryptococcusneoformans) |
PF02358(Trehalose_PPase) | 4 | ASP A 214ASN A 24ASP A 26ASN A 178 | T6P A 402 ( 4.3A) MG A 401 ( 2.5A)T6P A 402 ( 2.9A)T6P A 402 (-3.5A) | 1.25A | 5vooA-5dx9A:undetectable | 5vooA-5dx9A:24.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey7 | FRUCTOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 4 | ASN A 174ASP A 266ASN A 49ASP A 30 | None | 1.18A | 5vooA-5ey7A:2.4 | 5vooA-5ey7A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxd | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Dinoroseobactershibae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 4 | ASN A 39ASP A 38ASP A 48ASN A 231 | None | 1.48A | 5vooA-5gxdA:4.4 | 5vooA-5gxdA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oko | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | ASP A 607ASN A 432ASP A 717ASN A 684 | None | 1.28A | 5vooA-5okoA:undetectable | 5vooA-5okoA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vop | 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 4 | ASN A 376ASP A 411ASP A 531ASN A 573 | NA A3005 (-3.0A)C2F A3001 ( 3.8A)C2F A3001 (-2.5A)C2F A3001 (-2.6A) | 1.41A | 5vooA-5vopA:48.1 | 5vooA-5vopA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vop | 5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 5 | ASN A 376ASP A 443ASN A 464ASP A 531ASN A 573 | NA A3005 (-3.0A)C2F A3001 (-2.5A)C2F A3001 (-2.2A)C2F A3001 (-2.5A)C2F A3001 (-2.6A) | 0.09A | 5vooA-5vopA:48.1 | 5vooA-5vopA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4m | MONOTREME LACTATIONPROTEIN (Ornithorhynchusanatinus) |
no annotation | 4 | ASN A 45ASP A 60ASN A 57ASP A 119 | None | 1.43A | 5vooA-6b4mA:undetectable | 5vooA-6b4mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 4 | ASN A 163ASP A 273ASN A 46ASP A 16 | NoneNoneGOL A 400 (-3.3A)GOL A 400 (-2.8A) | 1.04A | 5vooA-6cw5A:2.6 | 5vooA-6cw5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME COMPLEXEXONUCLEASE RRP44 (Homo sapiens) |
no annotation | 4 | ASP K 488ASN K 487ASP K 784ASN K 671 | A O 61 ( 3.3A) A O 62 ( 3.2A)NoneNone | 1.21A | 5vooA-6d6qK:undetectable | 5vooA-6d6qK:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gct | NEUTRAL AMINO ACIDTRANSPORTER B(0) (Homo sapiens) |
no annotation | 4 | ASN A 190ASP A 186ASP A 410ASN A 447 | None | 1.44A | 5vooA-6gctA:undetectable | 5vooA-6gctA:undetectable |