SIMILAR PATTERNS OF AMINO ACIDS FOR 5VNC_C_GCSC801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		7 GLY A 114
HIS A 345
VAL A 420
ASN A 449
LYS A 539
GLU A 637
GLY A 640
 PLP  A 999 ( 3.6A)
GLC  A 998 (-4.3A)
None
GLC  A 998 (-3.3A)
GLC  A 998 (-4.0A)
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.73A 5vncC-1e4oA:
16.8		 5vncC-1e4oA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLY A  18
HIS A 163
VAL A 213
ASN A 246
PRO A 377
 None
 0.75A 5vncC-1rzvA:
6.1		 5vncC-1rzvA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 VAL A 213
ASN A 246
LYS A 304
GLU A 376
PRO A 377
GLY A 379
 None
 0.83A 5vncC-1rzvA:
6.1		 5vncC-1rzvA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		5 VAL A  92
ASN A  67
GLU A  64
PRO A  65
GLY A  69
 None
 1.27A 5vncC-1xuvA:
undetectable		 5vncC-1xuvA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 GLY A 135
HIS A 377
VAL A 455
ASN A 484
GLY A 675
 PLP  A 860 ( 3.3A)
None
None
None
PLP  A 860 ( 4.1A)
 0.68A 5vncC-1ygpA:
15.1		 5vncC-1ygpA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
 PLP  A 860 ( 3.3A)
None
None
None
PO4  A1900 ( 3.7A)
 0.72A 5vncC-1ygpA:
15.1		 5vncC-1ygpA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 GLY A 135
HIS A 377
VAL A 455
LYS A 574
GLU A 672
 PLP  A 860 ( 3.3A)
None
None
PO4  A1900 ( 3.7A)
None
 0.89A 5vncC-1ygpA:
15.1		 5vncC-1ygpA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		6 GLY A 114
HIS A 334
VAL A 408
ASN A 437
LYS A 528
GLU A 626
 PO4  A1794 (-3.4A)
FMT  A1799 (-3.9A)
None
FMT  A1799 (-3.5A)
PO4  A1794 ( 3.9A)
None
 0.91A 5vncC-2c4mA:
17.1		 5vncC-2c4mA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		6 GLY A 114
HIS A 334
VAL A 408
ASN A 437
LYS A 528
GLY A 629
 PO4  A1794 (-3.4A)
FMT  A1799 (-3.9A)
None
FMT  A1799 (-3.5A)
PO4  A1794 ( 3.9A)
PLP  A1634 ( 3.8A)
 0.78A 5vncC-2c4mA:
17.1		 5vncC-2c4mA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		7 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
 PLR  A 940 ( 3.8A)
None
None
None
PLR  A 940 (-2.8A)
PLR  A 940 ( 4.5A)
PLR  A 940 (-3.3A)
 0.70A 5vncC-2gj4A:
18.0		 5vncC-2gj4A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 GLY A  41
HIS A 122
LYS A 185
GLU A 262
PRO A 263
 None
 0.80A 5vncC-2iuyA:
19.6		 5vncC-2iuyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		6 GLY A  15
HIS A 120
VAL A 150
ASN A 173
GLU A 282
GLY A 285
 None
 0.64A 5vncC-2jjmA:
25.3		 5vncC-2jjmA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		6 GLY A  15
HIS A 120
VAL A 150
ASN A 173
LYS A 211
GLU A 282
 None
 0.79A 5vncC-2jjmA:
25.3		 5vncC-2jjmA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 GLY A 187
HIS A 172
VAL A 118
PRO A 160
GLY A 170
 None
 1.50A 5vncC-2vidA:
undetectable		 5vncC-2vidA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 GLY A  23
HIS A 133
LYS A 236
GLU A 316
GLY A 319
 UDP  A 600 (-3.2A)
None
UDP  A 600 (-2.7A)
UDP  A 600 (-3.2A)
None
 0.98A 5vncC-3c4qA:
26.5		 5vncC-3c4qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 HIS A 133
ASN A 171
LYS A 236
GLU A 316
GLY A 319
 None
None
UDP  A 600 (-2.7A)
UDP  A 600 (-3.2A)
None
 1.41A 5vncC-3c4qA:
26.5		 5vncC-3c4qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		7 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
 PLP  A 832 (-3.9A)
NBG  A   1 (-3.8A)
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.3A)
PLP  A 832 (-2.8A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
 0.70A 5vncC-3cemA:
17.5		 5vncC-3cemA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 HIS A 161
VAL A 211
ASN A 246
GLU A 377
GLY A 380
 None
 0.99A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 211
ASN A 246
GLU A 377
PRO A 378
GLY A 380
 None
 1.12A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 211
ASN A 246
LYS A 305
GLU A 377
GLY A 380
 None
 0.84A 5vncC-3d1jA:
16.7		 5vncC-3d1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 GLY A 201
VAL A 154
ASN A 206
PRO A 162
GLY A 160
 None
 1.34A 5vncC-3hxkA:
6.6		 5vncC-3hxkA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 HIS A 151
VAL A 193
ASN A 217
GLU A 339
PRO A 340
GLY A 342
 None
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.77A 5vncC-3l01A:
23.7		 5vncC-3l01A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 VAL A 193
ASN A 217
LYS A 263
GLU A 339
PRO A 340
GLY A 342
 None
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.88A 5vncC-3l01A:
23.7		 5vncC-3l01A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 GLY A 268
ARG A 273
VAL A  92
PRO A  90
GLY A 116
 None
 0.98A 5vncC-3n0vA:
3.0		 5vncC-3n0vA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 GLY A 303
HIS A 438
LYS A 585
GLU A 675
GLY A 678
 UDP  A 901 ( 2.9A)
None
UDP  A 901 (-2.8A)
UDP  A 901 (-4.1A)
UDP  A 901 ( 3.7A)
 0.57A 5vncC-3s29A:
15.3		 5vncC-3s29A:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLY A  99
HIS A 264
VAL A 321
LYS A 413
GLU A 485
PRO A 486
GLY A 488
 SO4  A 704 (-3.2A)
None
None
SO4  A 704 ( 4.0A)
None
None
None
 0.92A 5vncC-3vueA:
13.0		 5vncC-3vueA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		8 GLY A 100
HIS A 264
VAL A 321
ASN A 353
LYS A 413
GLU A 485
PRO A 486
GLY A 488
 SO4  A 704 (-4.1A)
None
None
None
SO4  A 704 ( 4.0A)
None
None
None
 0.73A 5vncC-3vueA:
13.0		 5vncC-3vueA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLY A 138
HIS A 379
VAL A 458
ASN A 487
LYS A 578
GLU A 679
 PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 ( 4.7A)
None
 0.88A 5vncC-4bqiA:
16.5		 5vncC-4bqiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLY A 138
HIS A 379
VAL A 458
ASN A 487
LYS A 578
GLY A 682
 PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 ( 4.7A)
PLP  A 901 (-3.5A)
 0.75A 5vncC-4bqiA:
16.5		 5vncC-4bqiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 GLY A 194
ARG A 439
VAL A 105
ASN A 106
PRO A 100
 None
 1.45A 5vncC-4g5eA:
undetectable		 5vncC-4g5eA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 GLY A 105
HIS A 317
VAL A 384
ASN A 413
GLY A 603
 None
 0.67A 5vncC-4l22A:
16.9		 5vncC-4l22A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		6 GLY A 105
HIS A 317
VAL A 384
ASN A 413
LYS A 503
GLU A 600
 None
 0.87A 5vncC-4l22A:
16.9		 5vncC-4l22A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		5 GLY A  16
HIS A 118
VAL A 147
ASN A 168
GLY A 277
 GDP  A 401 (-3.7A)
None
None
None
None
 0.63A 5vncC-4n9wA:
20.8		 5vncC-4n9wA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		5 GLY A  16
HIS A 242
LYS A 333
GLU A 404
GLY A 407
 UDP  A 601 ( 3.0A)
NAG  A 602 (-3.9A)
UDP  A 601 (-2.8A)
NAG  A 602 (-3.6A)
UDP  A 601 ( 3.4A)
 0.67A 5vncC-4pqgA:
18.2		 5vncC-4pqgA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		6 GLY A  59
HIS A 223
VAL A 276
ASN A 298
PRO A 532
TRP A 533
 None
 0.52A 5vncC-4qlbA:
41.7		 5vncC-4qlbA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		7 HIS A 223
VAL A 276
ASN A 298
LYS A 355
PRO A 532
TRP A 533
GLY A 534
 None
 0.84A 5vncC-4qlbA:
41.7		 5vncC-4qlbA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		7 VAL A 276
ASN A 298
LYS A 355
GLU A 531
PRO A 532
TRP A 533
GLY A 534
 None
 0.89A 5vncC-4qlbA:
41.7		 5vncC-4qlbA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 7 GLY B  14
HIS B 121
ASN B 174
LYS B 213
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.9A)
UPG  B 403 (-3.2A)
UPG  B 403 (-2.7A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.70A 5vncC-4xsrB:
25.4		 5vncC-4xsrB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		7 GLY A  16
HIS A 121
VAL A 151
ASN A 174
LYS A 212
GLU A 283
GLY A 286
 GMT  A 401 (-3.4A)
GMT  A 401 (-3.8A)
GMT  A 401 (-4.3A)
GMT  A 401 (-3.4A)
GMT  A 401 ( 4.4A)
GMT  A 401 (-3.6A)
GMT  A 401 (-3.7A)
 0.41A 5vncC-5d01A:
12.0		 5vncC-5d01A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 GLY A  16
HIS A 242
LYS A 333
GLU A 404
GLY A 407
 UDP  A 601 (-3.1A)
NAG  A 602 (-3.6A)
UDP  A 601 ( 4.6A)
None
NAG  A 602 (-3.3A)
 1.14A 5vncC-5e9uA:
17.5		 5vncC-5e9uA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		7 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
 PLP  A 901 ( 3.8A)
None
None
None
PLP  A 901 (-3.3A)
None
PLP  A 901 (-3.3A)
 0.86A 5vncC-5ikpA:
16.2		 5vncC-5ikpA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		7 GLY A 182
HIS A 421
VAL A 584
ASN A 613
LYS A 704
GLU A 806
GLY A 809
 GLC  A1001 ( 3.7A)
GLC  A1001 (-3.7A)
None
GLC  A1001 (-3.8A)
GLC  A1001 (-3.1A)
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.81A 5vncC-5lrbA:
16.4		 5vncC-5lrbA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1

(Sacbrood virus) 		no annotation 5 GLY A 192
VAL A 127
ASN A 125
PRO A  59
GLY A 197
 None
 1.37A 5vncC-6egxA:
undetectable		 5vncC-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 5 GLY A  16
HIS A 118
ASN A 166
LYS A 196
GLU A 267
 UDP  A 401 (-3.0A)
CL  A 404 ( 4.5A)
None
UDP  A 401 (-2.9A)
NA  A 403 (-3.6A)
 0.83A 5vncC-6ejjA:
24.4		 5vncC-6ejjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 8 GLY A  42
HIS A 190
VAL A 244
ASN A 277
LYS A 337
GLU A 412
PRO A 413
GLY A 415
 ADP  A 601 ( 3.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
ACR  A 602 (-3.3A)
ADP  A 601 (-2.8A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.49A 5vncC-6gneA:
24.0		 5vncC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 8 GLY A  19
HIS A 181
VAL A 251
ASN A 283
LYS A 343
GLU A 414
PRO A 415
GLY A 417
 ADP  A 601 ( 3.3A)
QPS  A 602 (-4.1A)
QPS  A 602 ( 4.6A)
QPS  A 602 (-3.4A)
ADP  A 601 (-2.8A)
QPS  A 602 (-3.6A)
QPS  A 602 (-3.6A)
QPS  A 602 (-3.7A)
 0.48A 5vncC-6gnfA:
21.5		 5vncC-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 ARG A 356
ASN A 301
LYS A 361
GLU A 434
GLY A 437
 ADP  A 602 ( 3.6A)
QPS  A 601 (-3.2A)
ADP  A 602 (-2.8A)
QPS  A 601 ( 3.7A)
ADP  A 602 ( 3.6A)
 1.36A 5vncC-6gngA:
21.8		 5vncC-6gngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 8 GLY A  37
HIS A 199
VAL A 269
ASN A 301
LYS A 361
GLU A 434
PRO A 435
GLY A 437
 ADP  A 602 ( 3.4A)
QPS  A 601 (-4.4A)
QPS  A 601 ( 4.7A)
QPS  A 601 (-3.2A)
ADP  A 602 (-2.8A)
QPS  A 601 ( 3.7A)
QPS  A 601 (-3.9A)
ADP  A 602 ( 3.6A)
 0.72A 5vncC-6gngA:
21.8		 5vncC-6gngA:
undetectable