SIMILAR PATTERNS OF AMINO ACIDS FOR 5VM8_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1auz SPOIIAA

(Bacillus
subtilis) 		PF01740
(STAS) 		5 VAL A  62
GLY A  61
LEU A  17
LEU A  21
ALA A  26
 None
 1.00A 5vm8B-1auzA:
undetectable		 5vm8B-1auzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 VAL A  77
GLY A  33
LEU A  58
ILE A  41
ALA A  79
 None
 0.96A 5vm8B-1b25A:
undetectable		 5vm8B-1b25A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 VAL A  77
GLY A  34
LEU A  58
ILE A  41
ALA A  79
 None
 1.07A 5vm8B-1b25A:
undetectable		 5vm8B-1b25A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4o NADP(H)
TRANSHYDROGENASE

(Bos taurus) 		PF02233
(PNTB) 		5 GLY A 105
GLY A  30
LEU A 174
ILE A  27
LEU A 102
 NAP  A 201 (-4.0A)
NAP  A 201 (-3.2A)
None
None
None
 0.99A 5vm8B-1d4oA:
2.4		 5vm8B-1d4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwu RIBOSOMAL PROTEIN L1

(Methanothermococcus
thermolithotrophicus) 		PF00687
(Ribosomal_L1) 		5 VAL A 122
GLY A 120
GLY A 116
LEU A  88
ALA A  95
 None
 0.96A 5vm8B-1dwuA:
3.0		 5vm8B-1dwuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		5 GLY A  80
GLY A 134
LEU A  64
ILE A  71
LEU A  74
 None
 1.03A 5vm8B-1f76A:
undetectable		 5vm8B-1f76A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Agrobacterium
tumefaciens) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 LEU A  21
ILE A  28
LEU A  11
THR A   9
ALA A  12
 None
 1.03A 5vm8B-1l3lA:
undetectable		 5vm8B-1l3lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 VAL A 425
GLY A 414
ILE A 216
LEU A 217
ALA A 222
 None
 1.02A 5vm8B-1mb9A:
undetectable		 5vm8B-1mb9A:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 GLY A 195
GLY A 199
LEU A 218
THR A 225
ALA A 228
 None
 0.87A 5vm8B-1nxzA:
28.6		 5vm8B-1nxzA:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 GLY A 195
LEU A 218
LEU A 223
THR A 225
ALA A 228
 None
 0.72A 5vm8B-1nxzA:
28.6		 5vm8B-1nxzA:
41.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		5 GLY B 187
GLY B 169
TRP B 170
LEU B 190
THR B 147
 None
 1.05A 5vm8B-1poiB:
undetectable		 5vm8B-1poiB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL A 190
GLY A 203
LEU A 174
LEU A 221
ALA A 222
 None
 1.03A 5vm8B-1r6mA:
undetectable		 5vm8B-1r6mA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		5 VAL A  90
GLY A  89
GLY A  32
ILE A 165
ALA A  93
 None
 1.04A 5vm8B-1sg3A:
undetectable		 5vm8B-1sg3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 GLY A 145
GLY A 143
LEU A 129
ILE A 193
ALA A 133
 None
 1.01A 5vm8B-1snyA:
2.1		 5vm8B-1snyA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 VAL A  50
GLY A  49
GLY A  44
LEU A 146
ILE A 112
 None
 1.01A 5vm8B-1tzbA:
undetectable		 5vm8B-1tzbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02233
(PNTB) 		5 GLY A 128
GLY A  53
LEU A 197
ILE A  50
LEU A 125
 NDP  A 300 (-3.6A)
NDP  A 300 ( 3.7A)
None
None
None
 0.95A 5vm8B-1u31A:
undetectable		 5vm8B-1u31A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  13
GLY A  14
LEU A 147
ILE A 116
THR A  77
 NAD  A1310 (-3.6A)
None
NAD  A1310 ( 4.0A)
None
None
 1.04A 5vm8B-1uxiA:
3.5		 5vm8B-1uxiA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		5 VAL A 180
GLY A 181
GLY A 185
LEU A 209
ALA A 214
 None
 0.50A 5vm8B-1v6zA:
18.5		 5vm8B-1v6zA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		6 GLY A 204
GLY A 208
ILE A 231
LEU A 232
THR A 234
ALA A 237
 None
 0.48A 5vm8B-1vhkA:
27.4		 5vm8B-1vhkA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 GLY A 207
ILE A 231
LEU A 232
THR A 234
ALA A 237
 None
 0.96A 5vm8B-1vhkA:
27.4		 5vm8B-1vhkA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 GLY A 207
LEU A 227
ILE A 231
LEU A 232
THR A 234
 None
 1.04A 5vm8B-1vhkA:
27.4		 5vm8B-1vhkA:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 401
GLY A 406
LEU A 445
LEU A 449
ALA A 394
 VAL  A 401 ( 0.6A)
GLY  A 406 ( 0.0A)
LEU  A 445 ( 0.6A)
LEU  A 449 ( 0.6A)
ALA  A 394 ( 0.0A)
 1.07A 5vm8B-1wqaA:
undetectable		 5vm8B-1wqaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 VAL A 318
GLY A 319
GLY A 323
ILE A 245
ALA A 269
 None
 1.04A 5vm8B-1z6rA:
undetectable		 5vm8B-1z6rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		5 VAL A 104
GLY A  95
LEU A  61
ILE A  27
ALA A 107
 None
 1.04A 5vm8B-2aifA:
undetectable		 5vm8B-2aifA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 VAL A 100
GLY A 101
GLY A 106
ILE A 218
LEU A 217
 None
 1.02A 5vm8B-2d0dA:
undetectable		 5vm8B-2d0dA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 VAL A 201
GLY A 202
GLY A 204
THR A 209
ALA A 213
 None
 1.00A 5vm8B-2dsjA:
undetectable		 5vm8B-2dsjA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		6 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
THR A 215
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
 0.76A 5vm8B-2egwA:
25.5		 5vm8B-2egwA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		6 VAL A 184
GLY A 185
GLY A 189
LEU A 213
THR A 215
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
 0.51A 5vm8B-2egwA:
25.5		 5vm8B-2egwA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 GLY A 206
GLY A 209
ILE A 158
THR A 204
ALA A 167
 None
ASP  A 502 (-4.2A)
None
None
None
 0.95A 5vm8B-2hmfA:
undetectable		 5vm8B-2hmfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		5 VAL A  39
GLY A  40
GLY A  42
THR A  70
ALA A  74
 None
SO4  A 301 (-3.4A)
None
None
None
 1.04A 5vm8B-2ij9A:
2.8		 5vm8B-2ij9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  30
GLY A  31
LEU A 164
ILE A 133
THR A  94
 None
 0.90A 5vm8B-2ldxA:
2.7		 5vm8B-2ldxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 375
GLY A 374
GLY A 372
ILE A 295
ALA A 325
 None
 0.93A 5vm8B-2nqlA:
undetectable		 5vm8B-2nqlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 VAL A 241
ILE A 292
LEU A 300
THR A 298
ALA A 301
 None
 1.04A 5vm8B-2olsA:
undetectable		 5vm8B-2olsA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		5 VAL B 365
ILE B 427
LEU B 389
THR B 391
ALA B 388
 None
 1.04A 5vm8B-2p1nB:
undetectable		 5vm8B-2p1nB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 VAL A 123
GLY A 124
GLY A 126
ILE A 176
ALA A 179
 None
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
S4M  A 501 (-3.5A)
 0.94A 5vm8B-2pt6A:
2.4		 5vm8B-2pt6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		5 VAL A 146
GLY A 147
GLY A 152
ILE A 327
LEU A 326
 None
 0.95A 5vm8B-2vatA:
undetectable		 5vm8B-2vatA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 VAL B 249
GLY B 248
ILE B 422
THR B 415
ALA B 286
 None
 0.99A 5vm8B-2xdqB:
undetectable		 5vm8B-2xdqB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		5 VAL A  59
GLY A  57
LEU A  21
THR A  19
ALA A  22
 None
 0.91A 5vm8B-3au7A:
undetectable		 5vm8B-3au7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 370
GLY A 369
GLY A 367
LEU A  42
ILE A 122
 None
 0.99A 5vm8B-3ddmA:
undetectable		 5vm8B-3ddmA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 163
GLY A 164
GLY A 166
ILE A 215
LEU A 216
 None
 0.94A 5vm8B-3gd5A:
2.7		 5vm8B-3gd5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Salmonella
enterica) 		PF00926
(DHBP_synthase) 		5 VAL A  29
GLY A  28
GLY A  26
LEU A  20
ALA A  19
 None
 1.06A 5vm8B-3lquA:
undetectable		 5vm8B-3lquA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL X  32
GLY X  33
LEU X 167
ILE X 136
THR X  97
 None
 0.88A 5vm8B-3nepX:
4.8		 5vm8B-3nepX:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		5 VAL A  58
GLY A  57
GLY A  55
LEU A  27
ALA A  31
 None
 1.08A 5vm8B-3ngjA:
undetectable		 5vm8B-3ngjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 VAL A 181
GLY A  27
ILE A 123
LEU A 120
ALA A 116
 None
 1.08A 5vm8B-3on7A:
undetectable		 5vm8B-3on7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		6 VAL A 121
GLY A 162
GLY A 159
LEU A 150
ILE A 125
LEU A 124
 None
 1.15A 5vm8B-3ooiA:
undetectable		 5vm8B-3ooiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 189
GLY A 190
LEU A 348
ILE A  11
LEU A   9
 None
 1.00A 5vm8B-3oytA:
undetectable		 5vm8B-3oytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 VAL A 119
GLY A 118
GLY A 116
LEU A  35
THR A  31
 None
 0.95A 5vm8B-3pxgA:
undetectable		 5vm8B-3pxgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 119
GLY A 118
GLY A 116
LEU A  35
THR A  31
 None
 0.95A 5vm8B-3pxiA:
undetectable		 5vm8B-3pxiA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 157
GLY A 160
GLY A 355
LEU A 205
ALA A 203
 None
 1.01A 5vm8B-3rcyA:
undetectable		 5vm8B-3rcyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 VAL A 495
GLY A 496
GLY A 336
ILE A 342
ALA A 363
 None
None
NDP  A 801 (-3.7A)
None
None
 0.91A 5vm8B-3slkA:
2.5		 5vm8B-3slkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 VAL A 454
GLY A 405
ILE A 368
LEU A 413
ALA A 414
 None
 0.94A 5vm8B-3tlmA:
2.6		 5vm8B-3tlmA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		5 MET A 172
GLY A 178
GLY A 183
LEU A 191
THR A 185
 None
 0.99A 5vm8B-3wh7A:
undetectable		 5vm8B-3wh7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 704
ILE A 726
LEU A 725
THR A 723
ALA A 722
 None
 0.94A 5vm8B-3wpeA:
undetectable		 5vm8B-3wpeA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 VAL A 154
GLY A 129
GLY A 253
LEU A 126
ALA A 125
 None
 0.94A 5vm8B-3zbmA:
undetectable		 5vm8B-3zbmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 264
GLY A 262
ILE A  11
LEU A  15
ALA A 269
 None
 0.89A 5vm8B-4a5oA:
2.8		 5vm8B-4a5oA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 VAL A 133
GLY A 134
ILE A  86
THR A  73
ALA A  70
 None
 1.02A 5vm8B-4b52A:
undetectable		 5vm8B-4b52A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 MET A 624
VAL A 586
GLY A 585
ILE A 359
LEU A 360
 None
 1.05A 5vm8B-4c30A:
undetectable		 5vm8B-4c30A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 VAL A 206
GLY A 205
GLY A 203
LEU A 167
ALA A 165
 None
 1.05A 5vm8B-4dioA:
3.3		 5vm8B-4dioA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		5 GLY A  68
GLY A  67
LEU A  89
LEU A  74
THR A  72
 None
 0.96A 5vm8B-4ecfA:
undetectable		 5vm8B-4ecfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 GLY A  24
LEU A 136
ILE A 106
LEU A 124
ALA A  22
 None
 0.97A 5vm8B-4es7A:
undetectable		 5vm8B-4es7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 GLY B 170
GLY B 304
LEU B 251
THR B 253
ALA B 252
 None
 1.08A 5vm8B-4hdsB:
undetectable		 5vm8B-4hdsB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 VAL A  44
GLY A  45
GLY A  49
ILE A  29
ALA A  66
 None
 1.08A 5vm8B-4imdA:
2.6		 5vm8B-4imdA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuk NREA PROTEIN

(Staphylococcus
carnosus) 		PF13185
(GAF_2) 		6 VAL A  71
GLY A  69
GLY A  66
LEU A 121
ILE A  97
ALA A 108
 None
None
NO3  A 200 ( 3.7A)
None
NO3  A 200 (-3.9A)
None
 1.43A 5vm8B-4iukA:
undetectable		 5vm8B-4iukA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		5 VAL A 134
GLY A  90
LEU A 315
ILE A  39
ALA A 332
 None
 1.08A 5vm8B-4kdsA:
undetectable		 5vm8B-4kdsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		5 GLY A 383
GLY A 200
LEU A 377
THR A 381
ALA A 379
 None
 1.08A 5vm8B-4kjzA:
5.3		 5vm8B-4kjzA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		6 VAL A 198
GLY A 199
GLY A 203
LEU A 222
THR A 229
ALA A 232
 None
 0.66A 5vm8B-4l69A:
28.0		 5vm8B-4l69A:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1054
ILE A1127
LEU A1075
THR A1073
ALA A1076
 None
 1.07A 5vm8B-4ldeA:
undetectable		 5vm8B-4ldeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		5 GLY A 365
GLY A 370
LEU A 381
LEU A 378
ALA A 310
 None
 1.07A 5vm8B-4ofwA:
2.8		 5vm8B-4ofwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		5 VAL A 101
GLY A  97
LEU A 110
ILE A 120
ALA A 129
 None
 1.07A 5vm8B-4pu6A:
undetectable		 5vm8B-4pu6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 GLY P 532
LEU P 359
ILE P 381
LEU P 412
THR P 428
 None
 0.95A 5vm8B-4s2tP:
undetectable		 5vm8B-4s2tP:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN
SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans;
Streptococcus
mutans) 		no annotation
PF16364
(Antigen_C) 		5 VAL A  52
GLY A  53
GLY A  57
ILE B1157
ALA B1323
 None
 1.05A 5vm8B-4tshA:
undetectable		 5vm8B-4tshA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 VAL A 502
GLY A 114
LEU A 401
LEU A 453
THR A 393
 None
 0.97A 5vm8B-4uirA:
undetectable		 5vm8B-4uirA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 VAL A 123
GLY A 124
GLY A 126
ILE A 176
ALA A 179
 None
MTA  A 401 (-3.5A)
MTA  A 401 ( 4.5A)
None
MTA  A 401 (-3.6A)
 0.87A 5vm8B-4uoeA:
undetectable		 5vm8B-4uoeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		6 VAL A  39
GLY A  40
GLY A  43
LEU A 503
ILE A 556
THR A 562
 None
 1.39A 5vm8B-4y23A:
undetectable		 5vm8B-4y23A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a24 DIONAIN-1

(Dionaea
muscipula) 		PF00112
(Peptidase_C1) 		5 VAL A  55
GLY A  65
GLY A  68
TRP A  27
ALA A  94
 None
None
E64  A1224 (-3.4A)
E64  A1224 (-4.9A)
None
 1.03A 5vm8B-5a24A:
undetectable		 5vm8B-5a24A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 GLY A 308
ILE A 312
LEU A 266
THR A 264
ALA A 267
 None
 1.03A 5vm8B-5aexA:
undetectable		 5vm8B-5aexA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 248
GLY A 249
ILE A  70
LEU A  66
ALA A 307
 None
 0.93A 5vm8B-5af7A:
undetectable		 5vm8B-5af7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE

(Colwellia
psychrerythraea) 		PF13580
(SIS_2) 		5 GLY A 157
GLY A 155
LEU A 114
ILE A 129
LEU A 113
 None
 1.06A 5vm8B-5by2A:
undetectable		 5vm8B-5by2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 VAL A 102
GLY A 133
GLY A 135
ILE A  95
THR A 109
 None
None
EDO  A 303 ( 3.7A)
None
None
 1.02A 5vm8B-5hx9A:
undetectable		 5vm8B-5hx9A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 VAL A 160
GLY A 203
GLY A 172
ILE A 235
ALA A 246
 None
None
UPG  A 301 (-3.3A)
None
None
 0.86A 5vm8B-5i1fA:
undetectable		 5vm8B-5i1fA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		5 VAL A 239
GLY A 240
GLY A 242
ILE A  80
ALA A  95
 None
None
None
None
6DB  A 304 (-3.9A)
 1.06A 5vm8B-5itoA:
undetectable		 5vm8B-5itoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		5 VAL A 160
GLY A 203
GLY A 172
ILE A 235
ALA A 246
 None
 0.88A 5vm8B-5j49A:
undetectable		 5vm8B-5j49A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 VAL A 297
GLY A 311
LEU A 294
ILE A 258
ALA A 273
 None
 1.04A 5vm8B-5jozA:
undetectable		 5vm8B-5jozA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 GLY A 686
LEU A 518
ILE A 540
LEU A 569
THR A 585
 None
 0.98A 5vm8B-5jqkA:
undetectable		 5vm8B-5jqkA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 MET A 364
VAL A 368
LEU A 318
THR A 324
ALA A 327
 None
 1.06A 5vm8B-5jtaA:
undetectable		 5vm8B-5jtaA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 5 VAL B 166
GLY B 167
ILE B 146
LEU B 232
ALA B 233
 None
 1.01A 5vm8B-5k59B:
undetectable		 5vm8B-5k59B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY A 255
GLY A 223
LEU A  47
ILE A  35
LEU A  34
 None
 0.91A 5vm8B-5l3sA:
2.2		 5vm8B-5l3sA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 6 GLY A 196
GLY A 200
LEU A 219
LEU A 224
THR A 226
ALA A 229
 SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.71A 5vm8B-5o96A:
30.4		 5vm8B-5o96A:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 GLY A 199
LEU A 219
LEU A 224
THR A 226
ALA A 229
 None
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.83A 5vm8B-5o96A:
30.4		 5vm8B-5o96A:
36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 397
TRP A 403
LEU A 391
ILE A 455
ALA A 393
 None
 1.05A 5vm8B-5vm1A:
undetectable		 5vm8B-5vm1A:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		5 GLY A 192
GLY A 196
TRP A 197
LEU A 215
ALA A 225
 None
 0.96A 5vm8B-5vm8A:
34.1		 5vm8B-5vm8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		6 MET A 169
VAL A 191
GLY A 192
GLY A 196
TRP A 197
LEU A 215
 None
 1.01A 5vm8B-5vm8A:
34.1		 5vm8B-5vm8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		5 GLY A 202
GLY A  58
LEU A 218
LEU A  52
ALA A  51
 None
 1.08A 5vm8B-5x5tA:
undetectable		 5vm8B-5x5tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		5 GLY A 184
GLY A 179
LEU A 214
ILE A  11
THR A 201
 None
 0.99A 5vm8B-5xaoA:
undetectable		 5vm8B-5xaoA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 5 VAL A 427
GLY A 425
LEU A 310
ILE A 616
LEU A 613
 None
 1.05A 5vm8B-5zicA:
2.4		 5vm8B-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 5 GLY A 118
GLY A 357
LEU A 393
ILE A 363
LEU A 364
 None
 1.08A 5vm8B-6arrA:
undetectable		 5vm8B-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bii GLYOXYLATE REDUCTASE

(Pyrococcus
yayanosii) 		no annotation 5 VAL A 156
GLY A 157
GLY A 162
ILE A 176
LEU A 177
 None
NAP  A 401 (-3.4A)
None
None
None
 1.02A 5vm8B-6biiA:
2.0		 5vm8B-6biiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Enterococcus
faecium) 		no annotation 5 MET A  99
GLY A  34
ILE A  44
THR A  37
ALA A  73
 MPD  A 401 (-4.2A)
None
None
None
None
 0.94A 5vm8B-6cfdA:
undetectable		 5vm8B-6cfdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 6 GLY H 264
LEU H 258
ILE H 385
LEU H 259
THR H 268
ALA H 362
 AGS  H 901 (-3.2A)
None
None
None
MG  H 903 ( 3.5A)
None
 1.40A 5vm8B-6chsH:
undetectable		 5vm8B-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 185
GLY A 179
LEU A 134
ILE A 149
ALA A 136
 None
 1.06A 5vm8B-6fc3A:
undetectable		 5vm8B-6fc3A:
undetectable