SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_H_CVIH301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ALA A 198
LEU A 205
VAL A  72
TYR A  92
PHE A  95
 None
 1.29A 5vlmH-1dlcA:
1.1		 5vlmH-1dlcA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		5 ALA A 250
GLU A 256
LEU A 151
VAL A  25
PHE A 257
 None
 1.37A 5vlmH-1q3kA:
0.0		 5vlmH-1q3kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		5 ALA A 235
SER A 222
LEU A 238
TYR A 167
VAL A 229
 None
 1.26A 5vlmH-1uc8A:
0.1		 5vlmH-1uc8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ALA A 384
GLU A 402
LEU A 405
VAL A 370
PHE A 398
 None
 1.45A 5vlmH-2b9eA:
undetectable		 5vlmH-2b9eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.45A 5vlmH-2de2A:
undetectable		 5vlmH-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 MET A  95
ALA A  44
SER A  48
LEU A 103
TYR A  87
 None
 1.30A 5vlmH-2gzsA:
0.0		 5vlmH-2gzsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzj UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Mus musculus) 		PF16190
(E1_FCCH) 		5 MET A 265
SER A 251
GLU A 252
VAL A 221
CYH A 234
 None
 1.19A 5vlmH-2lzjA:
undetectable		 5vlmH-2lzjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		5 ALA A  56
SER A 107
GLU A 109
VAL A  32
CYH A  29
 None
 1.35A 5vlmH-2p0nA:
1.0		 5vlmH-2p0nA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		5 ALA A  46
GLU A  54
VAL A  43
TYR A  36
PHE A  55
 None
MG  A1001 (-3.2A)
None
None
None
 1.43A 5vlmH-2vzbA:
2.0		 5vlmH-2vzbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		5 ALA A 274
SER A  84
GLU A  85
LEU A 463
TYR A 269
 None
 1.26A 5vlmH-2weuA:
0.5		 5vlmH-2weuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 MET A 600
ALA A 464
GLU A 470
CYH A 437
TYR A 479
 None
 1.42A 5vlmH-2yn9A:
undetectable		 5vlmH-2yn9A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 MET B 527
ALA B 545
SER B 574
VAL B 341
PHE B 465
 None
 1.46A 5vlmH-2z2mB:
undetectable		 5vlmH-2z2mB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ALA A 713
SER A 670
LEU A 633
TYR A1028
VAL A 660
 None
 1.45A 5vlmH-2zxqA:
undetectable		 5vlmH-2zxqA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		5 MET A 235
ALA A 229
GLU A 213
LEU A 211
VAL A 223
 None
 1.49A 5vlmH-3dbyA:
2.4		 5vlmH-3dbyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		5 ALA A 125
SER A 127
LEU A  16
TYR A  89
VAL A  78
 None
 1.37A 5vlmH-3gffA:
undetectable		 5vlmH-3gffA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 ALA A 111
SER A 106
LEU A 102
VAL A 194
CYH A 189
 None
 1.28A 5vlmH-3l8aA:
undetectable		 5vlmH-3l8aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 MET X 357
ALA X 370
GLU X 343
VAL X 382
CYH X 428
 None
 1.37A 5vlmH-3lxuX:
undetectable		 5vlmH-3lxuX:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans) 		PF03328
(HpcH_HpaI) 		5 ALA A  57
SER A  29
GLU A  30
LEU A  32
TYR A 112
 None
 1.48A 5vlmH-3r4iA:
undetectable		 5vlmH-3r4iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		5 ALA A  57
SER A  55
LEU A  88
TYR A 151
TYR A  46
 None
 1.35A 5vlmH-4bi3A:
undetectable		 5vlmH-4bi3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		5 ALA A 160
SER A 123
LEU A  47
TYR A  25
VAL A 133
 None
 1.27A 5vlmH-4bz7A:
undetectable		 5vlmH-4bz7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 MET A 216
ALA A 209
LEU A 248
ARG A 154
TYR A 532
 None
 1.37A 5vlmH-4cj0A:
1.2		 5vlmH-4cj0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		5 ALA A 115
SER A 120
GLU A 123
TYR A 197
PHE A 129
 None
 1.49A 5vlmH-4di3A:
3.2		 5vlmH-4di3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 MET A 225
ALA A 229
GLU A 137
LEU A 142
TYR A 132
 None
 1.34A 5vlmH-4ldnA:
undetectable		 5vlmH-4ldnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		5 ALA A 187
LEU A 227
ARG A 102
VAL A 113
TYR A 210
 None
 1.40A 5vlmH-4n0nA:
undetectable		 5vlmH-4n0nA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 MET A 310
ALA A 305
GLU A 238
VAL A 165
TYR A 234
 None
 1.34A 5vlmH-4p1lA:
undetectable		 5vlmH-4p1lA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		5 MET A 144
ALA A 246
TYR A 175
VAL A 229
PHE A 210
 None
 1.40A 5vlmH-5b6kA:
undetectable		 5vlmH-5b6kA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.33A 5vlmH-5dm6G:
undetectable		 5vlmH-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvh 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1148 ( 3.5A)
G  X1149 ( 3.2A)
None
None
None
 1.35A 5vlmH-5jvhG:
undetectable		 5vlmH-5jvhG:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ALA A 337
GLU A 384
LEU A 382
VAL A 367
CYH A 368
 None
 1.45A 5vlmH-5ks1A:
2.5		 5vlmH-5ks1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		5 ALA B 486
GLU B 495
ARG A 100
VAL A  98
PHE B 494
 None
 1.38A 5vlmH-5m6uB:
undetectable		 5vlmH-5m6uB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
ALA A  86
SER A  89
GLU A  90
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.8A)
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.56A 5vlmH-5vlgA:
29.2		 5vlmH-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.70A 5vlmH-5vlgA:
29.2		 5vlmH-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 None
None
None
None
SAH  A 502 (-4.6A)
 1.45A 5vlmH-5wp5A:
1.1		 5vlmH-5wp5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ALA A 430
SER A 428
GLU A 425
VAL A 449
TYR A 443
 None
None
CA  A 801 ( 3.1A)
None
None
 1.47A 5vlmH-5x7hA:
undetectable		 5vlmH-5x7hA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 5 MET A 465
ALA A 404
GLU A 411
LEU A 409
VAL A 268
 None
 1.13A 5vlmH-5ygfA:
undetectable		 5vlmH-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 5 MET A 117
ALA A 100
SER A 105
LEU A 115
TYR A 227
 None
None
None
None
GOL  A 304 (-4.7A)
 1.24A 5vlmH-5z95A:
undetectable		 5vlmH-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.31A 5vlmH-6co1A:
undetectable		 5vlmH-6co1A:
undetectable