SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_H_CVIH301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ALA A 198
LEU A 205
VAL A  72
TYR A  92
PHE A  95
 None
 1.29A 5vlmH-1dlcA:
1.1		 5vlmH-1dlcA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		5 ALA A 250
GLU A 256
LEU A 151
VAL A  25
PHE A 257
 None
 1.37A 5vlmH-1q3kA:
0.0		 5vlmH-1q3kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		5 ALA A 235
SER A 222
LEU A 238
TYR A 167
VAL A 229
 None
 1.26A 5vlmH-1uc8A:
0.1		 5vlmH-1uc8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ALA A 384
GLU A 402
LEU A 405
VAL A 370
PHE A 398
 None
 1.45A 5vlmH-2b9eA:
undetectable		 5vlmH-2b9eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.45A 5vlmH-2de2A:
undetectable		 5vlmH-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 MET A  95
ALA A  44
SER A  48
LEU A 103
TYR A  87
 None
 1.30A 5vlmH-2gzsA:
0.0		 5vlmH-2gzsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzj UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Mus musculus) 		PF16190
(E1_FCCH) 		5 MET A 265
SER A 251
GLU A 252
VAL A 221
CYH A 234
 None
 1.19A 5vlmH-2lzjA:
undetectable		 5vlmH-2lzjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		5 ALA A  56
SER A 107
GLU A 109
VAL A  32
CYH A  29
 None
 1.35A 5vlmH-2p0nA:
1.0		 5vlmH-2p0nA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		5 ALA A  46
GLU A  54
VAL A  43
TYR A  36
PHE A  55
 None
MG  A1001 (-3.2A)
None
None
None
 1.43A 5vlmH-2vzbA:
2.0		 5vlmH-2vzbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		5 ALA A 274
SER A  84
GLU A  85
LEU A 463
TYR A 269
 None
 1.26A 5vlmH-2weuA:
0.5		 5vlmH-2weuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 MET A 600
ALA A 464
GLU A 470
CYH A 437
TYR A 479
 None
 1.42A 5vlmH-2yn9A:
undetectable		 5vlmH-2yn9A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 MET B 527
ALA B 545
SER B 574
VAL B 341
PHE B 465
 None
 1.46A 5vlmH-2z2mB:
undetectable		 5vlmH-2z2mB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ALA A 713
SER A 670
LEU A 633
TYR A1028
VAL A 660
 None
 1.45A 5vlmH-2zxqA:
undetectable		 5vlmH-2zxqA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		5 MET A 235
ALA A 229
GLU A 213
LEU A 211
VAL A 223
 None
 1.49A 5vlmH-3dbyA:
2.4		 5vlmH-3dbyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		5 ALA A 125
SER A 127
LEU A  16
TYR A  89
VAL A  78
 None
 1.37A 5vlmH-3gffA:
undetectable		 5vlmH-3gffA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 ALA A 111
SER A 106
LEU A 102
VAL A 194
CYH A 189
 None
 1.28A 5vlmH-3l8aA:
undetectable		 5vlmH-3l8aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 MET X 357
ALA X 370
GLU X 343
VAL X 382
CYH X 428
 None
 1.37A 5vlmH-3lxuX:
undetectable		 5vlmH-3lxuX:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans) 		PF03328
(HpcH_HpaI) 		5 ALA A  57
SER A  29
GLU A  30
LEU A  32
TYR A 112
 None
 1.48A 5vlmH-3r4iA:
undetectable		 5vlmH-3r4iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		5 ALA A  57
SER A  55
LEU A  88
TYR A 151
TYR A  46
 None
 1.35A 5vlmH-4bi3A:
undetectable		 5vlmH-4bi3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		5 ALA A 160
SER A 123
LEU A  47
TYR A  25
VAL A 133
 None
 1.27A 5vlmH-4bz7A:
undetectable		 5vlmH-4bz7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 MET A 216
ALA A 209
LEU A 248
ARG A 154
TYR A 532
 None
 1.37A 5vlmH-4cj0A:
1.2		 5vlmH-4cj0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		5 ALA A 115
SER A 120
GLU A 123
TYR A 197
PHE A 129
 None
 1.49A 5vlmH-4di3A:
3.2		 5vlmH-4di3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 MET A 225
ALA A 229
GLU A 137
LEU A 142
TYR A 132
 None
 1.34A 5vlmH-4ldnA:
undetectable		 5vlmH-4ldnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		5 ALA A 187
LEU A 227
ARG A 102
VAL A 113
TYR A 210
 None
 1.40A 5vlmH-4n0nA:
undetectable		 5vlmH-4n0nA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 MET A 310
ALA A 305
GLU A 238
VAL A 165
TYR A 234
 None
 1.34A 5vlmH-4p1lA:
undetectable		 5vlmH-4p1lA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		5 MET A 144
ALA A 246
TYR A 175
VAL A 229
PHE A 210
 None
 1.40A 5vlmH-5b6kA:
undetectable		 5vlmH-5b6kA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.33A 5vlmH-5dm6G:
undetectable		 5vlmH-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvh 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1148 ( 3.5A)
G  X1149 ( 3.2A)
None
None
None
 1.35A 5vlmH-5jvhG:
undetectable		 5vlmH-5jvhG:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ALA A 337
GLU A 384
LEU A 382
VAL A 367
CYH A 368
 None
 1.45A 5vlmH-5ks1A:
2.5		 5vlmH-5ks1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		5 ALA B 486
GLU B 495
ARG A 100
VAL A  98
PHE B 494
 None
 1.38A 5vlmH-5m6uB:
undetectable		 5vlmH-5m6uB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
ALA A  86
SER A  89
GLU A  90
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.8A)
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.56A 5vlmH-5vlgA:
29.2		 5vlmH-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.70A 5vlmH-5vlgA:
29.2		 5vlmH-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 None
None
None
None
SAH  A 502 (-4.6A)
 1.45A 5vlmH-5wp5A:
1.1		 5vlmH-5wp5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ALA A 430
SER A 428
GLU A 425
VAL A 449
TYR A 443
 None
None
CA  A 801 ( 3.1A)
None
None
 1.47A 5vlmH-5x7hA:
undetectable		 5vlmH-5x7hA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 5 MET A 465
ALA A 404
GLU A 411
LEU A 409
VAL A 268
 None
 1.13A 5vlmH-5ygfA:
undetectable		 5vlmH-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 5 MET A 117
ALA A 100
SER A 105
LEU A 115
TYR A 227
 None
None
None
None
GOL  A 304 (-4.7A)
 1.24A 5vlmH-5z95A:
undetectable		 5vlmH-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.31A 5vlmH-6co1A:
undetectable		 5vlmH-6co1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 GLN A 167
GLY A 161
ILE A 204
TRP A 175
 None
 0.82A 5vlmH-1fd9A:
undetectable		 5vlmH-1fd9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		4 GLN A 224
GLY A 284
ILE A  99
ASP A 277
 None
 0.93A 5vlmH-1g5gA:
undetectable		 5vlmH-1g5gA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLN A 581
GLY A 623
ILE A 673
ASP A 614
 None
 0.98A 5vlmH-1kb0A:
undetectable		 5vlmH-1kb0A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A 327
GLY A 354
ILE A 348
ASP A 420
 None
 0.90A 5vlmH-1mdfA:
0.0		 5vlmH-1mdfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		4 GLN A 229
GLY A 224
ILE A  23
GLN A  74
 None
None
FAD  A 652 (-4.8A)
FAD  A 652 ( 4.1A)
 0.78A 5vlmH-1o5wA:
0.2		 5vlmH-1o5wA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		4 GLY A 204
TRP A 189
ASP A 202
ASP A 239
 None
 1.01A 5vlmH-1q9hA:
undetectable		 5vlmH-1q9hA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 262
ILE A 259
GLN A 321
ASP A 302
 None
 0.98A 5vlmH-1vcwA:
undetectable		 5vlmH-1vcwA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLN A 467
GLY A 481
ILE A 504
ASP A 549
 None
 0.92A 5vlmH-1wdtA:
0.0		 5vlmH-1wdtA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLN A 872
GLY A 836
ILE A 880
TRP A 794
 None
 0.87A 5vlmH-1yguA:
0.3		 5vlmH-1yguA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2l UNKNOWN

(Klebsiella
pneumoniae) 		PF03928
(Haem_degrading) 		4 GLN A 100
GLY A  93
ILE A 104
GLN A  76
 None
 0.83A 5vlmH-2a2lA:
0.0		 5vlmH-2a2lA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLN A 265
GLY A 268
ILE A 182
ASP A 309
 None
None
FAD  A 480 (-4.2A)
FAD  A 480 (-2.8A)
 0.93A 5vlmH-2a8xA:
0.0		 5vlmH-2a8xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLN A 256
GLY A  39
ILE A  47
ASP A  73
 None
 1.02A 5vlmH-2ahwA:
0.0		 5vlmH-2ahwA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLN A 560
GLY A 497
ILE A 555
GLN A 569
 None
 1.02A 5vlmH-2e8yA:
undetectable		 5vlmH-2e8yA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A 126
ILE A 104
GLN A 148
ASP A  97
 None
 0.88A 5vlmH-2eryA:
undetectable		 5vlmH-2eryA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		4 GLY A 351
ILE A 277
GLN A 273
ASP A 336
 None
 0.99A 5vlmH-2f28A:
undetectable		 5vlmH-2f28A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1

(Danio rerio) 		PF04564
(U-box) 		4 GLN A 243
GLY A 246
ILE A 238
ASP A 249
 None
 1.03A 5vlmH-2f42A:
undetectable		 5vlmH-2f42A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsn HYPOTHETICAL PROTEIN
TA0583

(Thermoplasma
acidophilum) 		no annotation 4 GLY A  58
ILE A  66
GLN A  70
ASP A 228
 None
 0.95A 5vlmH-2fsnA:
undetectable		 5vlmH-2fsnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 GLN A 696
GLY A 694
ILE A 560
ASP A 731
 None
 0.95A 5vlmH-2fuqA:
1.7		 5vlmH-2fuqA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 GLY A  77
ILE A 124
GLN A 117
ASP A  57
 None
 0.92A 5vlmH-2hmcA:
undetectable		 5vlmH-2hmcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		4 GLY A 197
ILE A  47
ASP A  12
ASP A 180
 None
None
UNL  A 227 ( 4.6A)
None
 1.03A 5vlmH-2hszA:
undetectable		 5vlmH-2hszA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 135
ILE A  77
GLN A 108
ASP A 214
 None
 1.00A 5vlmH-2i6lA:
undetectable		 5vlmH-2i6lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		4 GLY A  75
ILE A  37
ASP A  68
ASP A  72
 None
 0.96A 5vlmH-2o5rA:
undetectable		 5vlmH-2o5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4v DIAMINE
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 GLY A  75
ILE A   6
GLN A 103
ASP A  13
 None
 1.03A 5vlmH-2q4vA:
undetectable		 5vlmH-2q4vA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 GLN A 184
GLY A 179
ILE A 154
GLN A 327
 None
 0.89A 5vlmH-2r3sA:
undetectable		 5vlmH-2r3sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		4 GLY A  80
ILE A 180
ASP A 108
ASP A 105
 None
None
None
GAL  A 368 (-2.9A)
 1.03A 5vlmH-2rjoA:
undetectable		 5vlmH-2rjoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 GLN A  84
GLY A  81
ASP A  77
ASP A  17
 None
 1.00A 5vlmH-2taaA:
undetectable		 5vlmH-2taaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLN A 718
GLY A 720
GLN A 637
TRP A 715
 None
 0.93A 5vlmH-2v9yA:
undetectable		 5vlmH-2v9yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 GLN A  91
GLY A  85
ILE A 128
TRP A  99
 None
 0.83A 5vlmH-2vcdA:
undetectable		 5vlmH-2vcdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 GLY A  93
ILE A  38
TRP A  23
ASP A  56
 None
 0.81A 5vlmH-2w3pA:
undetectable		 5vlmH-2w3pA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		4 GLN A  52
GLY A  50
ILE A  72
ASP A  76
 FAD  A 400 (-3.9A)
FAD  A 400 ( 4.7A)
None
None
 1.01A 5vlmH-2whdA:
undetectable		 5vlmH-2whdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 GLN A 244
GLY A 209
ASP A 175
ASP A 181
 None
 1.00A 5vlmH-2yg1A:
undetectable		 5vlmH-2yg1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 GLY B 173
ILE B 265
TRP B 167
ASP B 170
 None
 1.01A 5vlmH-3a0hB:
undetectable		 5vlmH-3a0hB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLN A 461
GLY A 463
ASP A 469
ASP A 148
 None
 0.92A 5vlmH-3cghA:
0.8		 5vlmH-3cghA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		4 GLN A 179
GLY A 251
TRP A 317
ASP A 311
 None
 1.00A 5vlmH-3gt5A:
1.0		 5vlmH-3gt5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		4 GLN A 120
GLY A 122
ILE A 128
ASP A 242
 None
 1.01A 5vlmH-3i1aA:
2.2		 5vlmH-3i1aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i42 RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY-LIKE)

(Methylobacillus
flagellatus) 		PF00072
(Response_reg) 		4 GLN A  83
GLY A  51
ILE A  68
ASP A  26
 None
 1.01A 5vlmH-3i42A:
undetectable		 5vlmH-3i42A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 GLN A 196
ILE A 119
GLN A 124
TRP A 222
 None
 1.00A 5vlmH-3j4uA:
undetectable		 5vlmH-3j4uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 GLN A 327
GLY A 371
ILE A 375
ASP A 311
 None
 0.89A 5vlmH-3la4A:
undetectable		 5vlmH-3la4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcy TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 GLN A  30
GLY A  60
ILE A  39
GLN A  50
 None
 0.89A 5vlmH-3lcyA:
undetectable		 5vlmH-3lcyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 GLN A  35
GLY A  38
GLN A 441
ASP A  43
 None
 0.97A 5vlmH-3lvvA:
undetectable		 5vlmH-3lvvA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLN A 269
GLY A 267
ILE A  51
ASP A  85
 None
 1.00A 5vlmH-3m5hA:
undetectable		 5vlmH-3m5hA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmn HISTIDINE KINASE
HOMOLOG

(Arabidopsis
thaliana) 		PF00072
(Response_reg) 		4 GLN A1109
GLY A 936
ILE A1079
ASP A1100
 None
 1.00A 5vlmH-3mmnA:
undetectable		 5vlmH-3mmnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq4 DBF4

(Saccharomyces
cerevisiae) 		PF08630
(Dfp1_Him1_M) 		4 GLY A 154
ILE A 174
TRP A 202
ASP A 149
 None
 1.04A 5vlmH-3oq4A:
undetectable		 5vlmH-3oq4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 GLY A 149
ILE A 151
ASP A 280
ASP A 285
 BAU  A 400 (-3.5A)
None
MG  A 315 (-3.2A)
None
 0.89A 5vlmH-3p0fA:
undetectable		 5vlmH-3p0fA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs2 FIMBRILLIN MATB
HOMOLOG

(Escherichia
coli) 		PF16449
(MatB) 		4 GLN A  34
GLY A  41
ILE A 137
TRP A 159
 None
 1.01A 5vlmH-3qs2A:
undetectable		 5vlmH-3qs2A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		4 GLY A  68
ILE A  63
GLN A  60
ASP A  23
 None
 0.80A 5vlmH-3rnrA:
undetectable		 5vlmH-3rnrA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 GLN A  45
GLY A  48
ILE A  23
ASP A  13
 None
 0.84A 5vlmH-3sd7A:
undetectable		 5vlmH-3sd7A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		4 GLN A 274
GLY A  65
ILE A 241
GLN A 257
 None
 0.74A 5vlmH-3t32A:
undetectable		 5vlmH-3t32A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 GLN A 372
GLY A 301
ILE A 341
GLN A 306
 None
 1.02A 5vlmH-3vssA:
undetectable		 5vlmH-3vssA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpn PHOTOSYSTEM II
REACTION CENTER
PSB28 PROTEIN

(Thermosynechococcus
elongatus) 		PF03912
(Psb28) 		4 GLN A   8
GLY A  53
ILE A  80
ASP A  67
 None
 1.00A 5vlmH-3zpnA:
undetectable		 5vlmH-3zpnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 GLY A 287
ILE A 284
GLN A 295
ASP A 406
 None
 0.98A 5vlmH-3zs6A:
undetectable		 5vlmH-3zs6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 523
ILE A 154
GLN A 272
ASP A 501
 None
ANP  A1564 (-4.2A)
None
None
 0.80A 5vlmH-4d25A:
undetectable		 5vlmH-4d25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		4 GLN A 223
GLY A 227
ILE A  11
GLN A  57
 None
 0.89A 5vlmH-4fs3A:
undetectable		 5vlmH-4fs3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLY A 183
ILE A 254
GLN A 295
ASP A 201
 None
 0.98A 5vlmH-4imiA:
1.7		 5vlmH-4imiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 GLY A 200
GLN A 391
TRP A 197
ASP A 210
 None
 1.01A 5vlmH-4ineA:
undetectable		 5vlmH-4ineA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ize INTERLEUKIN-36 GAMMA

(Homo sapiens) 		PF00340
(IL1) 		4 GLY A  25
ILE A  27
GLN A  32
ASP A 169
 None
 0.90A 5vlmH-4izeA:
undetectable		 5vlmH-4izeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 GLN A  89
ILE A 112
GLN A 119
ASP A  48
 None
 1.04A 5vlmH-4j05A:
undetectable		 5vlmH-4j05A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		4 GLN A 295
GLY A 271
ILE A 226
ASP A 248
 None
None
PLP  A 403 (-4.7A)
None
 0.94A 5vlmH-4lmaA:
undetectable		 5vlmH-4lmaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		4 GLN A 295
GLY A 271
ILE A 226
ASP A 248
 None
None
PLP  A 403 ( 4.7A)
None
 0.94A 5vlmH-4lmbA:
undetectable		 5vlmH-4lmbA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		4 GLN A 250
GLY A 195
ILE A 225
GLN A 237
 None
GDP  A 401 ( 4.7A)
None
None
 1.02A 5vlmH-4n9wA:
undetectable		 5vlmH-4n9wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvr PUTATIVE
ACYLTRANSFERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 GLN A 247
GLY A 114
ILE A 141
GLN A 191
ASP A 116
 None
None
None
None
CL  A 402 (-3.3A)
 1.10A 5vlmH-4nvrA:
undetectable		 5vlmH-4nvrA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 GLN A  69
GLY A  71
ILE A  85
GLN A 238
 None
None
MES  A 403 (-4.6A)
None
 0.92A 5vlmH-4pbqA:
undetectable		 5vlmH-4pbqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 GLY A 332
GLN A 392
ASP A 209
ASP A 213
 None
MG  A 506 (-3.7A)
None
None
 0.83A 5vlmH-4r7fA:
undetectable		 5vlmH-4r7fA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF00223
(PsaA_PsaB) 		4 GLY A 698
ILE A 704
GLN A 721
ASP B 540
 None
CLA  A1139 ( 4.5A)
None
None
 1.01A 5vlmH-4rkuA:
undetectable		 5vlmH-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.01A 5vlmH-4rs3A:
undetectable		 5vlmH-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 0.97A 5vlmH-4uomL:
undetectable		 5vlmH-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 GLN A 109
ILE A 124
GLN A 118
ASP A  67
 UCA  A 301 (-3.5A)
None
None
None
 1.04A 5vlmH-4w97A:
6.7		 5vlmH-4w97A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		4 GLN A  61
GLY A  47
ILE A  42
ASP A 198
 None
 0.80A 5vlmH-4wedA:
undetectable		 5vlmH-4wedA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		4 GLY A  65
ILE A 270
ASP A 342
ASP A 112
 None
None
MPD  A 502 (-2.7A)
None
 0.88A 5vlmH-4wgxA:
undetectable		 5vlmH-4wgxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 GLN B 288
GLY B 310
ILE B 318
TRP B  67
 None
 0.99A 5vlmH-4yjfB:
undetectable		 5vlmH-4yjfB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 GLY A  84
ILE A  76
GLN A  69
ASP A 829
 None
 0.95A 5vlmH-4zgvA:
undetectable		 5vlmH-4zgvA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ILE A 334
GLN A  50
ASP A  62
ASP A  71
 None
 1.02A 5vlmH-4ztxA:
undetectable		 5vlmH-4ztxA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyw INTERFERON
ANTAGONIST C7

(Vaccinia virus) 		PF03287
(Pox_C7_F8A) 		4 GLN B   4
GLY B  25
ILE B  55
ASP B 102
 None
 1.00A 5vlmH-5cywB:
undetectable		 5vlmH-5cywB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2
RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Mus musculus;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00595
(PDZ) 		4 GLN B  45
GLY B 121
ILE A1810
GLN A1803
 None
 1.01A 5vlmH-5e6pB:
undetectable		 5vlmH-5e6pB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 GLN A 310
GLY A 276
ILE A 212
GLN A 286
 None
 0.94A 5vlmH-5ev7A:
undetectable		 5vlmH-5ev7A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffl CD300 ANTIGEN-LIKE
FAMILY MEMBER F

(Mus musculus) 		PF07686
(V-set) 		4 GLY A  12
TRP A  35
GLN A  37
ASP A  84
 None
 1.02A 5vlmH-5fflA:
undetectable		 5vlmH-5fflA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A 165
ILE A 427
ASP A 151
ASP A 148
 FAD  A 600 (-3.1A)
None
FAD  A 600 ( 3.5A)
None
 0.87A 5vlmH-5fxeA:
undetectable		 5vlmH-5fxeA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 GLN A 142
GLY A 144
ILE A 165
ASP A 205
 None
 1.00A 5vlmH-5hvmA:
undetectable		 5vlmH-5hvmA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7m DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		4 GLN A 446
GLY A 438
ILE A 454
ASP A 435
 None
 0.98A 5vlmH-5i7mA:
undetectable		 5vlmH-5i7mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLN A 411
GLY A 396
ILE A 434
ASP A 438
 None
 0.93A 5vlmH-5ic7A:
undetectable		 5vlmH-5ic7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 GLY A 131
ILE A 111
GLN A 117
ASP A 138
 None
 0.85A 5vlmH-5jjoA:
undetectable		 5vlmH-5jjoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 GLY A 131
ILE A 111
GLN A 117
ASP A 138
 None
 0.92A 5vlmH-5jkpA:
undetectable		 5vlmH-5jkpA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 GLN A 522
GLY A 539
ILE A 500
TRP A 531
 None
 0.91A 5vlmH-5jseA:
undetectable		 5vlmH-5jseA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 GLN A 108
GLY A 106
ILE A  63
TRP A  30
 None
XBU  A 501 (-3.5A)
None
None
 0.91A 5vlmH-5kd0A:
undetectable		 5vlmH-5kd0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19

(Kluyveromyces
lactis) 		no annotation 4 GLN E 259
GLY E 257
ILE E 240
ASP E 250
 None
 0.98A 5vlmH-5mu3E:
undetectable		 5vlmH-5mu3E:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLN B 787
ILE B 689
GLN B 518
ASP B 272
 None
 0.98A 5vlmH-5nd1B:
undetectable		 5vlmH-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLY B 691
GLN B 518
ASP B 585
ASP B 688
 None
 0.96A 5vlmH-5nd1B:
undetectable		 5vlmH-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 GLN A1056
GLY A1049
ILE A 997
ASP A1042
 None
 1.01A 5vlmH-5ng6A:
undetectable		 5vlmH-5ng6A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.95A 5vlmH-5ohsA:
undetectable		 5vlmH-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2s DDK KINASE
REGULATORY SUBUNIT
DBF4,SERINE/THREONIN
E-PROTEIN KINASE
RAD53

(Saccharomyces
cerevisiae) 		PF00498
(FHA)
PF08630
(Dfp1_Him1_M) 		4 GLY A 154
ILE A 174
TRP A 202
ASP A 149
 None
 1.03A 5vlmH-5t2sA:
undetectable		 5vlmH-5t2sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		4 GLY A  77
ILE A  39
ASP A  70
ASP A  74
 None
 1.00A 5vlmH-5tgtA:
undetectable		 5vlmH-5tgtA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 7 GLY A  88
ILE A  98
TRP A 101
GLN A 105
TRP A 125
ASP A 163
ASP A 175
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 ( 3.0A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 ( 4.3A)
 0.41A 5vlmH-5vlgA:
29.2		 5vlmH-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		4 GLN A 180
GLY A 174
ILE A 217
TRP A 188
 None
 0.93A 5vlmH-5xb0A:
undetectable		 5vlmH-5xb0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 4 GLY A 211
ILE A 279
TRP A 326
GLN A 325
 None
 0.98A 5vlmH-5xepA:
undetectable		 5vlmH-5xepA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 GLN A 340
GLY A 323
ILE A 337
ASP A 292
 None
 0.94A 5vlmH-5xmgA:
undetectable		 5vlmH-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 GLY A 206
ILE A 151
GLN A 113
TRP A 157
 None
 0.98A 5vlmH-5z9sA:
1.4		 5vlmH-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 GLN A 433
GLY A 474
TRP A 432
ASP A 536
 None
 1.03A 5vlmH-6byiA:
undetectable		 5vlmH-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 4 GLN A 313
GLY A 339
ILE A 285
ASP A 279
 None
None
None
CA  A 601 (-3.4A)
 1.02A 5vlmH-6c0mA:
undetectable		 5vlmH-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT
PROBABLE
COA-TRANSFERASE BETA
SUBUNIT

(Rhodococcus
jostii;
Rhodococcus
jostii) 		no annotation
no annotation 		4 GLY A  67
ILE A  98
GLN B 117
ASP A  49
 None
 0.98A 5vlmH-6co9A:
undetectable		 5vlmH-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 GLY A1073
ILE A1098
TRP A1207
ASP A1070
 None
 1.04A 5vlmH-6fb3A:
undetectable		 5vlmH-6fb3A:
undetectable