SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_G_CVIG301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 119
LEU A 188
ILE A  54
VAL A 198
PHE A 221
 None
 1.25A 5vlmG-1avbA:
undetectable		 5vlmG-1avbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		5 ALA A 125
LEU A 203
ILE A  58
VAL A 213
PHE A 235
 None
 1.21A 5vlmG-1dbnA:
undetectable		 5vlmG-1dbnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		5 ALA A  17
LEU A  36
ILE A  91
VAL A  20
ASP A  97
 None
GOL  A 902 (-4.1A)
GOL  A 902 (-4.3A)
None
None
 1.30A 5vlmG-1fqtA:
undetectable		 5vlmG-1fqtA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.28A 5vlmG-1g8wA:
undetectable		 5vlmG-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.32A 5vlmG-1gy8A:
0.1		 5vlmG-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6q CYTOCHROME C
MATURATION PROTEIN E

(Shewanella
putrefaciens) 		PF03100
(CcmE) 		5 GLN A  81
GLU A 118
LEU A  93
ILE A  92
ASP A 119
 None
 1.27A 5vlmG-1j6qA:
undetectable		 5vlmG-1j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.24A 5vlmG-1jxnA:
undetectable		 5vlmG-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 MET A 100
GLN A 103
ALA A 104
GLU A 476
ILE A 479
 None
 1.28A 5vlmG-1ogyA:
0.0		 5vlmG-1ogyA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ALA A 166
LEU A 146
ILE A 142
VAL A 154
ASP A 240
 None
 1.09A 5vlmG-1q1rA:
undetectable		 5vlmG-1q1rA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 GLN A 401
ALA A 398
GLU A 186
LEU A 181
ILE A 179
 None
None
FAD  A 634 (-4.6A)
None
None
 1.00A 5vlmG-1rq1A:
0.4		 5vlmG-1rq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 MET X  74
MET X  75
GLU X 206
LEU X 194
VAL X 172
 None
 1.13A 5vlmG-1ul1X:
undetectable		 5vlmG-1ul1X:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		5 GLN A   9
GLU A 309
LEU A 316
ILE A 317
ASP A 310
 None
 1.08A 5vlmG-1xcoA:
undetectable		 5vlmG-1xcoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.26A 5vlmG-2a81A:
0.4		 5vlmG-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 350
ALA A 351
GLU A 309
LEU A 367
ILE A 371
 None
 1.00A 5vlmG-2cgjA:
undetectable		 5vlmG-2cgjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 GLN A 239
ALA A 236
LEU A 249
ILE A 216
ASP A 252
 None
None
None
None
PLP  A1001 ( 3.0A)
 1.12A 5vlmG-2eo5A:
0.0		 5vlmG-2eo5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.32A 5vlmG-2fzwA:
undetectable		 5vlmG-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A  68
GLU A 169
LEU A 130
ILE A 129
ARG A 266
 None
 1.32A 5vlmG-2hnhA:
undetectable		 5vlmG-2hnhA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 GLU A  60
LEU A  65
ILE A 128
VAL A  18
ASP A  59
 None
 1.24A 5vlmG-2l6gA:
undetectable		 5vlmG-2l6gA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pej ORF134

(Synechococcus
sp. PCC 7002) 		PF02341
(RcbX) 		5 GLN A  37
ALA A  38
GLU A  63
LEU A  67
ILE A  71
 None
 1.28A 5vlmG-2pejA:
undetectable		 5vlmG-2pejA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 ALA B 192
LEU B 240
ILE B 244
VAL B 184
ASP B 175
 None
 1.31A 5vlmG-2pffB:
2.2		 5vlmG-2pffB:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 212
LEU A 223
ILE A 194
VAL A 179
ASP A 226
 None
None
None
None
MG  A 901 ( 2.7A)
 1.32A 5vlmG-2pp3A:
undetectable		 5vlmG-2pp3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 MET A 248
ALA A 215
GLU A 238
LEU A 244
ILE A 234
 None
 1.12A 5vlmG-2q6tA:
undetectable		 5vlmG-2q6tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D  68
ILE D   6
VAL D  42
CYH D  55
ASP D  62
 None
 1.31A 5vlmG-2qe7D:
undetectable		 5vlmG-2qe7D:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 MET A 761
GLN A 762
ALA A 758
LEU A 777
ILE A 776
 None
 1.32A 5vlmG-2qzaA:
1.4		 5vlmG-2qzaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 MET A 171
ALA A 128
LEU A 144
ILE A 112
ASP A 148
 None
 1.24A 5vlmG-2ra8A:
undetectable		 5vlmG-2ra8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  32
ILE A 127
VAL A 113
ASP A 131
PHE A  98
 None
 1.15A 5vlmG-2rb9A:
undetectable		 5vlmG-2rb9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.16A 5vlmG-2wghA:
undetectable		 5vlmG-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yug PROTEIN FRG1

(Mus musculus) 		PF06229
(FRG1) 		5 ALA A  66
LEU A 116
ILE A 145
VAL A  17
PHE A 109
 None
 1.16A 5vlmG-2yugA:
undetectable		 5vlmG-2yugA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		5 ALA A   8
LEU A  30
ILE A  31
ARG A  69
VAL A  62
 None
 1.18A 5vlmG-2yxgA:
undetectable		 5vlmG-2yxgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  34
ILE A 123
VAL A 109
ASP A 127
PHE A  94
 None
 1.13A 5vlmG-2z1uA:
undetectable		 5vlmG-2z1uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 MET A 221
GLN A 277
GLU A   7
ILE A 282
ASP A   5
 None
 1.27A 5vlmG-3abzA:
undetectable		 5vlmG-3abzA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 ALA A 197
LEU A 153
ILE A 139
VAL A 161
PHE A 127
 None
 1.26A 5vlmG-3b90A:
undetectable		 5vlmG-3b90A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 175
LEU A 188
ILE A 162
VAL A 146
ASP A 191
 None
None
None
None
PLP  A 500 (-3.1A)
 1.22A 5vlmG-3bb8A:
undetectable		 5vlmG-3bb8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 GLN A 275
ALA A 278
GLU A 291
LEU A 295
ILE A 266
 None
 0.94A 5vlmG-3d0kA:
undetectable		 5vlmG-3d0kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3w L-XYLULOSE REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLN B  25
ALA B  26
LEU B  47
ILE B  54
VAL B  10
 None
 1.32A 5vlmG-3d3wB:
undetectable		 5vlmG-3d3wB:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 719
ILE A 659
VAL A 677
ASP A 751
PHE A 714
 None
 1.08A 5vlmG-3ddrA:
undetectable		 5vlmG-3ddrA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 ALA A  10
LEU A  76
ILE A  77
VAL A  85
ASP A  95
 None
 1.29A 5vlmG-3dtoA:
undetectable		 5vlmG-3dtoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLN A 414
ALA A  56
LEU A 400
ILE A 375
ARG A 425
 None
 1.11A 5vlmG-3eyaA:
undetectable		 5vlmG-3eyaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkc TRANSCRIPTIONAL
REGULATOR KAISO

(Homo sapiens) 		PF00651
(BTB) 		5 ALA A  79
GLU A 100
ILE A 113
VAL A  93
ASP A  99
 None
 1.17A 5vlmG-3fkcA:
undetectable		 5vlmG-3fkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A 151
ALA A 149
GLU A  92
VAL A 124
PHE A 117
 None
 1.29A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A 151
GLU A  92
ILE A  89
VAL A 124
PHE A 117
 None
 1.22A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itq PROLYL
4-HYDROXYLASE, ALPHA
SUBUNIT DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13640
(2OG-FeII_Oxy_3) 		5 ALA A  93
GLU A  55
LEU A  59
ILE A 115
ASP A  54
 None
 1.23A 5vlmG-3itqA:
undetectable		 5vlmG-3itqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 GLN A 104
ALA A 101
LEU A 213
ILE A 215
VAL A  32
 None
 1.29A 5vlmG-3lgsA:
undetectable		 5vlmG-3lgsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		5 GLN A 405
ALA A 404
GLU A 160
ILE A 324
ASP A 318
 None
None
GOL  A 491 (-3.3A)
GOL  A 482 (-4.5A)
GOL  A 491 ( 3.3A)
 1.25A 5vlmG-3n6xA:
undetectable		 5vlmG-3n6xA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa) 		PF00112
(Peptidase_C1) 		5 ALA A  85
GLU A 111
LEU A 133
ILE A 181
ASP A 128
 None
 1.26A 5vlmG-3oisA:
undetectable		 5vlmG-3oisA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		5 MET A 231
GLN A 234
ALA A 236
LEU A 342
VAL A 349
 HEM  A 400 ( 3.9A)
HEM  A 400 ( 4.7A)
None
None
None
 1.08A 5vlmG-3oo3A:
undetectable		 5vlmG-3oo3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		5 GLN A  25
ALA A  26
LEU A 375
VAL A 327
PHE A  18
 None
 0.90A 5vlmG-3pmmA:
1.4		 5vlmG-3pmmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 MET A 331
GLN A 334
ALA A 335
VAL A 265
PHE A 145
 None
 1.28A 5vlmG-3s2uA:
undetectable		 5vlmG-3s2uA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sky COPPER-EXPORTING
P-TYPE ATPASE B

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ALA A 624
LEU A 615
ILE A 600
VAL A 386
ASP A 612
 None
 1.30A 5vlmG-3skyA:
undetectable		 5vlmG-3skyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		5 ALA A  43
ILE A  27
VAL A 195
ASP A  70
PHE A 168
 None
 1.27A 5vlmG-3sl1A:
undetectable		 5vlmG-3sl1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.26A 5vlmG-3twiD:
undetectable		 5vlmG-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 217
LEU A 184
ILE A  11
VAL A  24
ASP A  16
 None
 1.21A 5vlmG-3vnsA:
undetectable		 5vlmG-3vnsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ALA A 173
LEU A 107
ILE A 101
VAL A 192
PHE A 125
 None
 1.23A 5vlmG-3wbkA:
undetectable		 5vlmG-3wbkA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 440
ILE A 439
ARG A 427
VAL A 398
ASP A 408
 None
 1.27A 5vlmG-3wdjA:
undetectable		 5vlmG-3wdjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 ALA A  53
LEU A  84
ILE A  88
VAL A  60
ASP A  74
 None
 1.30A 5vlmG-4a2qA:
2.3		 5vlmG-4a2qA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 MET A  88
ILE A  24
VAL A 109
CYH A 110
ASP A  12
 None
 1.14A 5vlmG-4czeA:
undetectable		 5vlmG-4czeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 ALA P 567
GLU P 659
LEU P 663
ILE P 664
ASP P 658
 None
 1.25A 5vlmG-4dvyP:
undetectable		 5vlmG-4dvyP:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el1 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 GLN A  93
ALA A  91
VAL A  46
ASP A 109
PHE A 105
 None
 1.31A 5vlmG-4el1A:
undetectable		 5vlmG-4el1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLN B  42
ALA B  40
ILE B  60
VAL B  94
PHE B  87
 None
 1.25A 5vlmG-4g7eB:
undetectable		 5vlmG-4g7eB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 ALA A 301
LEU A 307
ILE A 257
VAL A 270
ASP A 310
 None
 1.16A 5vlmG-4hxyA:
undetectable		 5vlmG-4hxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		5 LEU A 352
ILE A 341
VAL A 418
ASP A 390
PHE A 379
 None
 1.22A 5vlmG-4ifsA:
undetectable		 5vlmG-4ifsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c SEED LECTIN BETA
CHAIN

(Spatholobus
parviflorus) 		PF00139
(Lectin_legB) 		5 ALA F 124
LEU F 200
ILE F  59
VAL F 210
PHE F 233
 None
 1.32A 5vlmG-4m3cF:
undetectable		 5vlmG-4m3cF:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 ALA A 294
LEU A 272
ILE A 271
VAL A 199
ASP A 277
 None
 1.24A 5vlmG-4p5wA:
undetectable		 5vlmG-4p5wA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw1 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		no annotation 5 GLN A 148
ALA A 120
ARG A 277
VAL A  87
PHE A 143
 None
 1.21A 5vlmG-4pw1A:
undetectable		 5vlmG-4pw1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 MET N  60
ALA D 124
GLU D  49
ILE D  59
VAL D  99
 None
 1.29A 5vlmG-4qiwN:
undetectable		 5vlmG-4qiwN:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 GLN A 108
ALA A 112
ILE A 133
ASP A 201
PHE A 170
 None
 1.22A 5vlmG-4raeA:
undetectable		 5vlmG-4raeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 ALA A  27
GLU A  35
LEU A  33
ILE A 141
VAL A  46
 None
 1.27A 5vlmG-4rqoA:
1.7		 5vlmG-4rqoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 143
LEU A 245
ILE A 255
VAL A 276
ASP A 258
 None
 1.18A 5vlmG-4wojA:
undetectable		 5vlmG-4wojA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 5 GLN A 633
ALA A 632
ILE A 547
VAL A 537
ASP A 541
 None
 1.23A 5vlmG-4yomA:
undetectable		 5vlmG-4yomA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLN A  51
ALA A  48
ILE A 196
ARG A  95
VAL A  88
 None
 1.28A 5vlmG-4zemA:
2.4		 5vlmG-4zemA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLN A  51
LEU A 197
ILE A 196
ARG A  95
VAL A  88
 None
 1.20A 5vlmG-4zemA:
2.4		 5vlmG-4zemA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 GLN O 639
ALA O 640
LEU A1768
ILE A1767
ARG A1798
 None
 1.25A 5vlmG-5a31O:
undetectable		 5vlmG-5a31O:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLN A 274
ALA A 272
LEU A 278
ILE A 309
ARG A 312
 None
 1.14A 5vlmG-5boeA:
undetectable		 5vlmG-5boeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 GLU A  93
LEU A  96
ILE A  58
VAL A  42
ASP A  89
 None
 1.31A 5vlmG-5e0cA:
undetectable		 5vlmG-5e0cA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.29A 5vlmG-5eb5A:
undetectable		 5vlmG-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ALA A  86
GLU A  97
LEU A 103
ARG A 122
VAL A 110
 None
 1.28A 5vlmG-5ehkA:
undetectable		 5vlmG-5ehkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 794
ILE A 743
VAL A 791
ASP A 732
PHE A 804
 None
 1.30A 5vlmG-5enoA:
undetectable		 5vlmG-5enoA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 GLN A 965
ALA A 962
GLU A 110
ILE A 674
VAL A 178
 ASP  A1001 (-3.7A)
None
None
None
None
 1.22A 5vlmG-5fdnA:
2.2		 5vlmG-5fdnA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.28A 5vlmG-5hrmA:
undetectable		 5vlmG-5hrmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		5 ALA C 315
GLU C 349
LEU C 353
ILE C 338
ASP C 348
 None
 1.31A 5vlmG-5i9gC:
1.2		 5vlmG-5i9gC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.31A 5vlmG-5iojA:
undetectable		 5vlmG-5iojA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		5 MET A  42
ALA A  55
LEU A 248
ILE A 188
CYH A 159
 None
None
None
None
PDG  A 501 (-3.7A)
 1.29A 5vlmG-5k8bA:
undetectable		 5vlmG-5k8bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 GLN A 193
LEU A 190
ILE A 198
VAL A 164
ASP A 149
 None
 1.21A 5vlmG-5khaA:
2.6		 5vlmG-5khaA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 5 ALA A  99
LEU A  34
ILE A  41
ARG A  88
ASP A  30
 None
 1.29A 5vlmG-5lf9A:
undetectable		 5vlmG-5lf9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLN A1949
ALA A1950
LEU A1899
VAL A1967
PHE A1908
 None
 1.27A 5vlmG-5m59A:
undetectable		 5vlmG-5m59A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus) 		no annotation 5 GLN E 172
ALA E 170
ILE E 177
VAL E 134
PHE E 148
 None
 1.32A 5vlmG-5mdmE:
undetectable		 5vlmG-5mdmE:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0d PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		6 ALA A  34
GLU A  30
LEU A  64
VAL A  86
ASP A  29
PHE A  28
 None
 1.47A 5vlmG-5o0dA:
undetectable		 5vlmG-5o0dA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.20A 5vlmG-5tusA:
undetectable		 5vlmG-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 ALA B  45
LEU B  40
ILE B  61
VAL B  68
PHE B  69
 None
 1.31A 5vlmG-5uf1B:
undetectable		 5vlmG-5uf1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 6 GLN A   8
ALA A  28
LEU A  23
ILE A  44
VAL A  51
PHE A  52
 None
 1.43A 5vlmG-5ufbA:
undetectable		 5vlmG-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
GLN A  71
ALA A  86
LEU A  94
ILE A  98
ARG A 102
VAL A 159
CYH A 160
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.3A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.1A)
 0.71A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 9 MET A  67
MET A  68
GLN A  71
ALA A  86
LEU A  94
VAL A 159
CYH A 160
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 0.91A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 6 MET A  67
MET A  68
GLN A  71
GLU A  90
ILE A  98
ARG A 102
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
MGR  A 300 (-4.1A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.3A)
 1.08A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 MET A 254
ALA A 204
LEU A  55
ILE A  59
ASP A  66
 None
None
None
None
IPA  A 501 ( 4.7A)
 1.28A 5vlmG-5wt4A:
undetectable		 5vlmG-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 MET U 410
GLN U 263
ALA U 262
LEU U 406
ASP U 301
 None
 1.25A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 MET U 410
GLN U 263
LEU U 406
ILE U 267
ASP U 301
 None
 1.30A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		5 MET A 195
MET A 194
ALA A 190
LEU A  67
ILE A  64
 None
 1.22A 5vlmG-6aujA:
undetectable		 5vlmG-6aujA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ALA A 154
GLU A  60
ILE A 172
VAL A 124
PHE A  88
 LLP  A 181 ( 3.3A)
None
None
None
None
 1.26A 5vlmG-6blgA:
undetectable		 5vlmG-6blgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 GLU A 541
LEU A 610
ILE A 612
VAL A 548
ASP A 542
 None
 1.09A 5vlmG-6et7A:
undetectable		 5vlmG-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 GLN A  55
ALA A  53
GLU A 105
LEU A 107
ILE A  63
 None
 1.14A 5vlmG-6gneA:
undetectable		 5vlmG-6gneA:
undetectable