SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_G_CVIG301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 119
LEU A 188
ILE A  54
VAL A 198
PHE A 221
 None
 1.25A 5vlmG-1avbA:
undetectable		 5vlmG-1avbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		5 ALA A 125
LEU A 203
ILE A  58
VAL A 213
PHE A 235
 None
 1.21A 5vlmG-1dbnA:
undetectable		 5vlmG-1dbnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		5 ALA A  17
LEU A  36
ILE A  91
VAL A  20
ASP A  97
 None
GOL  A 902 (-4.1A)
GOL  A 902 (-4.3A)
None
None
 1.30A 5vlmG-1fqtA:
undetectable		 5vlmG-1fqtA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.28A 5vlmG-1g8wA:
undetectable		 5vlmG-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.32A 5vlmG-1gy8A:
0.1		 5vlmG-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6q CYTOCHROME C
MATURATION PROTEIN E

(Shewanella
putrefaciens) 		PF03100
(CcmE) 		5 GLN A  81
GLU A 118
LEU A  93
ILE A  92
ASP A 119
 None
 1.27A 5vlmG-1j6qA:
undetectable		 5vlmG-1j6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.24A 5vlmG-1jxnA:
undetectable		 5vlmG-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 MET A 100
GLN A 103
ALA A 104
GLU A 476
ILE A 479
 None
 1.28A 5vlmG-1ogyA:
0.0		 5vlmG-1ogyA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 ALA A 166
LEU A 146
ILE A 142
VAL A 154
ASP A 240
 None
 1.09A 5vlmG-1q1rA:
undetectable		 5vlmG-1q1rA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 GLN A 401
ALA A 398
GLU A 186
LEU A 181
ILE A 179
 None
None
FAD  A 634 (-4.6A)
None
None
 1.00A 5vlmG-1rq1A:
0.4		 5vlmG-1rq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 MET X  74
MET X  75
GLU X 206
LEU X 194
VAL X 172
 None
 1.13A 5vlmG-1ul1X:
undetectable		 5vlmG-1ul1X:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		5 GLN A   9
GLU A 309
LEU A 316
ILE A 317
ASP A 310
 None
 1.08A 5vlmG-1xcoA:
undetectable		 5vlmG-1xcoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.26A 5vlmG-2a81A:
0.4		 5vlmG-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 350
ALA A 351
GLU A 309
LEU A 367
ILE A 371
 None
 1.00A 5vlmG-2cgjA:
undetectable		 5vlmG-2cgjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 GLN A 239
ALA A 236
LEU A 249
ILE A 216
ASP A 252
 None
None
None
None
PLP  A1001 ( 3.0A)
 1.12A 5vlmG-2eo5A:
0.0		 5vlmG-2eo5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.32A 5vlmG-2fzwA:
undetectable		 5vlmG-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A  68
GLU A 169
LEU A 130
ILE A 129
ARG A 266
 None
 1.32A 5vlmG-2hnhA:
undetectable		 5vlmG-2hnhA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 GLU A  60
LEU A  65
ILE A 128
VAL A  18
ASP A  59
 None
 1.24A 5vlmG-2l6gA:
undetectable		 5vlmG-2l6gA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pej ORF134

(Synechococcus
sp. PCC 7002) 		PF02341
(RcbX) 		5 GLN A  37
ALA A  38
GLU A  63
LEU A  67
ILE A  71
 None
 1.28A 5vlmG-2pejA:
undetectable		 5vlmG-2pejA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		5 ALA B 192
LEU B 240
ILE B 244
VAL B 184
ASP B 175
 None
 1.31A 5vlmG-2pffB:
2.2		 5vlmG-2pffB:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 212
LEU A 223
ILE A 194
VAL A 179
ASP A 226
 None
None
None
None
MG  A 901 ( 2.7A)
 1.32A 5vlmG-2pp3A:
undetectable		 5vlmG-2pp3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 MET A 248
ALA A 215
GLU A 238
LEU A 244
ILE A 234
 None
 1.12A 5vlmG-2q6tA:
undetectable		 5vlmG-2q6tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D  68
ILE D   6
VAL D  42
CYH D  55
ASP D  62
 None
 1.31A 5vlmG-2qe7D:
undetectable		 5vlmG-2qe7D:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 MET A 761
GLN A 762
ALA A 758
LEU A 777
ILE A 776
 None
 1.32A 5vlmG-2qzaA:
1.4		 5vlmG-2qzaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 MET A 171
ALA A 128
LEU A 144
ILE A 112
ASP A 148
 None
 1.24A 5vlmG-2ra8A:
undetectable		 5vlmG-2ra8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  32
ILE A 127
VAL A 113
ASP A 131
PHE A  98
 None
 1.15A 5vlmG-2rb9A:
undetectable		 5vlmG-2rb9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.16A 5vlmG-2wghA:
undetectable		 5vlmG-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yug PROTEIN FRG1

(Mus musculus) 		PF06229
(FRG1) 		5 ALA A  66
LEU A 116
ILE A 145
VAL A  17
PHE A 109
 None
 1.16A 5vlmG-2yugA:
undetectable		 5vlmG-2yugA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		5 ALA A   8
LEU A  30
ILE A  31
ARG A  69
VAL A  62
 None
 1.18A 5vlmG-2yxgA:
undetectable		 5vlmG-2yxgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  34
ILE A 123
VAL A 109
ASP A 127
PHE A  94
 None
 1.13A 5vlmG-2z1uA:
undetectable		 5vlmG-2z1uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 MET A 221
GLN A 277
GLU A   7
ILE A 282
ASP A   5
 None
 1.27A 5vlmG-3abzA:
undetectable		 5vlmG-3abzA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 ALA A 197
LEU A 153
ILE A 139
VAL A 161
PHE A 127
 None
 1.26A 5vlmG-3b90A:
undetectable		 5vlmG-3b90A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 175
LEU A 188
ILE A 162
VAL A 146
ASP A 191
 None
None
None
None
PLP  A 500 (-3.1A)
 1.22A 5vlmG-3bb8A:
undetectable		 5vlmG-3bb8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 GLN A 275
ALA A 278
GLU A 291
LEU A 295
ILE A 266
 None
 0.94A 5vlmG-3d0kA:
undetectable		 5vlmG-3d0kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3w L-XYLULOSE REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLN B  25
ALA B  26
LEU B  47
ILE B  54
VAL B  10
 None
 1.32A 5vlmG-3d3wB:
undetectable		 5vlmG-3d3wB:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 719
ILE A 659
VAL A 677
ASP A 751
PHE A 714
 None
 1.08A 5vlmG-3ddrA:
undetectable		 5vlmG-3ddrA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 ALA A  10
LEU A  76
ILE A  77
VAL A  85
ASP A  95
 None
 1.29A 5vlmG-3dtoA:
undetectable		 5vlmG-3dtoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLN A 414
ALA A  56
LEU A 400
ILE A 375
ARG A 425
 None
 1.11A 5vlmG-3eyaA:
undetectable		 5vlmG-3eyaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkc TRANSCRIPTIONAL
REGULATOR KAISO

(Homo sapiens) 		PF00651
(BTB) 		5 ALA A  79
GLU A 100
ILE A 113
VAL A  93
ASP A  99
 None
 1.17A 5vlmG-3fkcA:
undetectable		 5vlmG-3fkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A 151
ALA A 149
GLU A  92
VAL A 124
PHE A 117
 None
 1.29A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLN A 151
GLU A  92
ILE A  89
VAL A 124
PHE A 117
 None
 1.22A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itq PROLYL
4-HYDROXYLASE, ALPHA
SUBUNIT DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13640
(2OG-FeII_Oxy_3) 		5 ALA A  93
GLU A  55
LEU A  59
ILE A 115
ASP A  54
 None
 1.23A 5vlmG-3itqA:
undetectable		 5vlmG-3itqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 GLN A 104
ALA A 101
LEU A 213
ILE A 215
VAL A  32
 None
 1.29A 5vlmG-3lgsA:
undetectable		 5vlmG-3lgsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		5 GLN A 405
ALA A 404
GLU A 160
ILE A 324
ASP A 318
 None
None
GOL  A 491 (-3.3A)
GOL  A 482 (-4.5A)
GOL  A 491 ( 3.3A)
 1.25A 5vlmG-3n6xA:
undetectable		 5vlmG-3n6xA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa) 		PF00112
(Peptidase_C1) 		5 ALA A  85
GLU A 111
LEU A 133
ILE A 181
ASP A 128
 None
 1.26A 5vlmG-3oisA:
undetectable		 5vlmG-3oisA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		5 MET A 231
GLN A 234
ALA A 236
LEU A 342
VAL A 349
 HEM  A 400 ( 3.9A)
HEM  A 400 ( 4.7A)
None
None
None
 1.08A 5vlmG-3oo3A:
undetectable		 5vlmG-3oo3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		5 GLN A  25
ALA A  26
LEU A 375
VAL A 327
PHE A  18
 None
 0.90A 5vlmG-3pmmA:
1.4		 5vlmG-3pmmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 MET A 331
GLN A 334
ALA A 335
VAL A 265
PHE A 145
 None
 1.28A 5vlmG-3s2uA:
undetectable		 5vlmG-3s2uA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sky COPPER-EXPORTING
P-TYPE ATPASE B

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ALA A 624
LEU A 615
ILE A 600
VAL A 386
ASP A 612
 None
 1.30A 5vlmG-3skyA:
undetectable		 5vlmG-3skyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		5 ALA A  43
ILE A  27
VAL A 195
ASP A  70
PHE A 168
 None
 1.27A 5vlmG-3sl1A:
undetectable		 5vlmG-3sl1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.26A 5vlmG-3twiD:
undetectable		 5vlmG-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 217
LEU A 184
ILE A  11
VAL A  24
ASP A  16
 None
 1.21A 5vlmG-3vnsA:
undetectable		 5vlmG-3vnsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ALA A 173
LEU A 107
ILE A 101
VAL A 192
PHE A 125
 None
 1.23A 5vlmG-3wbkA:
undetectable		 5vlmG-3wbkA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 440
ILE A 439
ARG A 427
VAL A 398
ASP A 408
 None
 1.27A 5vlmG-3wdjA:
undetectable		 5vlmG-3wdjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 ALA A  53
LEU A  84
ILE A  88
VAL A  60
ASP A  74
 None
 1.30A 5vlmG-4a2qA:
2.3		 5vlmG-4a2qA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 MET A  88
ILE A  24
VAL A 109
CYH A 110
ASP A  12
 None
 1.14A 5vlmG-4czeA:
undetectable		 5vlmG-4czeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 ALA P 567
GLU P 659
LEU P 663
ILE P 664
ASP P 658
 None
 1.25A 5vlmG-4dvyP:
undetectable		 5vlmG-4dvyP:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el1 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 GLN A  93
ALA A  91
VAL A  46
ASP A 109
PHE A 105
 None
 1.31A 5vlmG-4el1A:
undetectable		 5vlmG-4el1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLN B  42
ALA B  40
ILE B  60
VAL B  94
PHE B  87
 None
 1.25A 5vlmG-4g7eB:
undetectable		 5vlmG-4g7eB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 ALA A 301
LEU A 307
ILE A 257
VAL A 270
ASP A 310
 None
 1.16A 5vlmG-4hxyA:
undetectable		 5vlmG-4hxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		5 LEU A 352
ILE A 341
VAL A 418
ASP A 390
PHE A 379
 None
 1.22A 5vlmG-4ifsA:
undetectable		 5vlmG-4ifsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c SEED LECTIN BETA
CHAIN

(Spatholobus
parviflorus) 		PF00139
(Lectin_legB) 		5 ALA F 124
LEU F 200
ILE F  59
VAL F 210
PHE F 233
 None
 1.32A 5vlmG-4m3cF:
undetectable		 5vlmG-4m3cF:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 ALA A 294
LEU A 272
ILE A 271
VAL A 199
ASP A 277
 None
 1.24A 5vlmG-4p5wA:
undetectable		 5vlmG-4p5wA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw1 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		no annotation 5 GLN A 148
ALA A 120
ARG A 277
VAL A  87
PHE A 143
 None
 1.21A 5vlmG-4pw1A:
undetectable		 5vlmG-4pw1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 MET N  60
ALA D 124
GLU D  49
ILE D  59
VAL D  99
 None
 1.29A 5vlmG-4qiwN:
undetectable		 5vlmG-4qiwN:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 GLN A 108
ALA A 112
ILE A 133
ASP A 201
PHE A 170
 None
 1.22A 5vlmG-4raeA:
undetectable		 5vlmG-4raeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 ALA A  27
GLU A  35
LEU A  33
ILE A 141
VAL A  46
 None
 1.27A 5vlmG-4rqoA:
1.7		 5vlmG-4rqoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 143
LEU A 245
ILE A 255
VAL A 276
ASP A 258
 None
 1.18A 5vlmG-4wojA:
undetectable		 5vlmG-4wojA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 5 GLN A 633
ALA A 632
ILE A 547
VAL A 537
ASP A 541
 None
 1.23A 5vlmG-4yomA:
undetectable		 5vlmG-4yomA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLN A  51
ALA A  48
ILE A 196
ARG A  95
VAL A  88
 None
 1.28A 5vlmG-4zemA:
2.4		 5vlmG-4zemA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLN A  51
LEU A 197
ILE A 196
ARG A  95
VAL A  88
 None
 1.20A 5vlmG-4zemA:
2.4		 5vlmG-4zemA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 GLN O 639
ALA O 640
LEU A1768
ILE A1767
ARG A1798
 None
 1.25A 5vlmG-5a31O:
undetectable		 5vlmG-5a31O:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLN A 274
ALA A 272
LEU A 278
ILE A 309
ARG A 312
 None
 1.14A 5vlmG-5boeA:
undetectable		 5vlmG-5boeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 GLU A  93
LEU A  96
ILE A  58
VAL A  42
ASP A  89
 None
 1.31A 5vlmG-5e0cA:
undetectable		 5vlmG-5e0cA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.29A 5vlmG-5eb5A:
undetectable		 5vlmG-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ALA A  86
GLU A  97
LEU A 103
ARG A 122
VAL A 110
 None
 1.28A 5vlmG-5ehkA:
undetectable		 5vlmG-5ehkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 794
ILE A 743
VAL A 791
ASP A 732
PHE A 804
 None
 1.30A 5vlmG-5enoA:
undetectable		 5vlmG-5enoA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 GLN A 965
ALA A 962
GLU A 110
ILE A 674
VAL A 178
 ASP  A1001 (-3.7A)
None
None
None
None
 1.22A 5vlmG-5fdnA:
2.2		 5vlmG-5fdnA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.28A 5vlmG-5hrmA:
undetectable		 5vlmG-5hrmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		5 ALA C 315
GLU C 349
LEU C 353
ILE C 338
ASP C 348
 None
 1.31A 5vlmG-5i9gC:
1.2		 5vlmG-5i9gC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.31A 5vlmG-5iojA:
undetectable		 5vlmG-5iojA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		5 MET A  42
ALA A  55
LEU A 248
ILE A 188
CYH A 159
 None
None
None
None
PDG  A 501 (-3.7A)
 1.29A 5vlmG-5k8bA:
undetectable		 5vlmG-5k8bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 GLN A 193
LEU A 190
ILE A 198
VAL A 164
ASP A 149
 None
 1.21A 5vlmG-5khaA:
2.6		 5vlmG-5khaA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 5 ALA A  99
LEU A  34
ILE A  41
ARG A  88
ASP A  30
 None
 1.29A 5vlmG-5lf9A:
undetectable		 5vlmG-5lf9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLN A1949
ALA A1950
LEU A1899
VAL A1967
PHE A1908
 None
 1.27A 5vlmG-5m59A:
undetectable		 5vlmG-5m59A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus) 		no annotation 5 GLN E 172
ALA E 170
ILE E 177
VAL E 134
PHE E 148
 None
 1.32A 5vlmG-5mdmE:
undetectable		 5vlmG-5mdmE:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0d PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		6 ALA A  34
GLU A  30
LEU A  64
VAL A  86
ASP A  29
PHE A  28
 None
 1.47A 5vlmG-5o0dA:
undetectable		 5vlmG-5o0dA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.20A 5vlmG-5tusA:
undetectable		 5vlmG-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 ALA B  45
LEU B  40
ILE B  61
VAL B  68
PHE B  69
 None
 1.31A 5vlmG-5uf1B:
undetectable		 5vlmG-5uf1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 6 GLN A   8
ALA A  28
LEU A  23
ILE A  44
VAL A  51
PHE A  52
 None
 1.43A 5vlmG-5ufbA:
undetectable		 5vlmG-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
GLN A  71
ALA A  86
LEU A  94
ILE A  98
ARG A 102
VAL A 159
CYH A 160
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.3A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.1A)
 0.71A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 9 MET A  67
MET A  68
GLN A  71
ALA A  86
LEU A  94
VAL A 159
CYH A 160
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 0.91A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 6 MET A  67
MET A  68
GLN A  71
GLU A  90
ILE A  98
ARG A 102
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
MGR  A 300 (-4.1A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.3A)
 1.08A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 MET A 254
ALA A 204
LEU A  55
ILE A  59
ASP A  66
 None
None
None
None
IPA  A 501 ( 4.7A)
 1.28A 5vlmG-5wt4A:
undetectable		 5vlmG-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 MET U 410
GLN U 263
ALA U 262
LEU U 406
ASP U 301
 None
 1.25A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 MET U 410
GLN U 263
LEU U 406
ILE U 267
ASP U 301
 None
 1.30A 5vlmG-5zvtU:
undetectable		 5vlmG-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		5 MET A 195
MET A 194
ALA A 190
LEU A  67
ILE A  64
 None
 1.22A 5vlmG-6aujA:
undetectable		 5vlmG-6aujA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ALA A 154
GLU A  60
ILE A 172
VAL A 124
PHE A  88
 LLP  A 181 ( 3.3A)
None
None
None
None
 1.26A 5vlmG-6blgA:
undetectable		 5vlmG-6blgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 GLU A 541
LEU A 610
ILE A 612
VAL A 548
ASP A 542
 None
 1.09A 5vlmG-6et7A:
undetectable		 5vlmG-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 GLN A  55
ALA A  53
GLU A 105
LEU A 107
ILE A  63
 None
 1.14A 5vlmG-6gneA:
undetectable		 5vlmG-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 411
TRP A 462
ASP A 385
TYR A 382
 None
 1.22A 5vlmG-1cb8A:
2.7		 5vlmG-1cb8A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 109
GLN A  88
ASP A  13
TYR A  15
 None
 1.16A 5vlmG-1escA:
undetectable		 5vlmG-1escA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 GLY A 159
TRP A 170
GLN A 149
TYR A 276
 UPG  A 352 (-3.8A)
UPG  A 352 ( 4.9A)
None
None
 1.27A 5vlmG-1guqA:
undetectable		 5vlmG-1guqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		4 GLY A  89
GLN A 174
TYR A 130
ASP A 144
 None
 1.18A 5vlmG-1hg2A:
3.1		 5vlmG-1hg2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		4 GLY A  91
GLN A 188
TYR A 143
ASP A 157
 None
 1.17A 5vlmG-1hx8A:
1.2		 5vlmG-1hx8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 GLN A  64
TYR A 149
ASP A 130
TYR A  38
 None
 1.29A 5vlmG-1k8qA:
undetectable		 5vlmG-1k8qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 GLY A 185
TYR A 257
ASP A 210
TYR A 211
 None
 1.19A 5vlmG-1m2pA:
0.2		 5vlmG-1m2pA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 GLY A 144
TRP A 246
ASP A 169
TYR A 171
 None
 1.20A 5vlmG-1mo2A:
0.4		 5vlmG-1mo2A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.86A 5vlmG-1mqsA:
2.4		 5vlmG-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 619
TRP A 670
ASP A 591
TYR A 588
 None
 1.26A 5vlmG-1n7rA:
3.2		 5vlmG-1n7rA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 GLY A 285
GLN A 295
ASP A 119
TYR A 239
 None
 1.04A 5vlmG-1qwyA:
undetectable		 5vlmG-1qwyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 GLY A 404
GLN A 308
TYR A 316
ASP A 409
 None
 1.29A 5vlmG-1s4fA:
undetectable		 5vlmG-1s4fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 GLY A 169
TRP A 454
GLN A 400
TYR A 333
 None
 1.17A 5vlmG-1wd3A:
undetectable		 5vlmG-1wd3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 GLY A 174
TRP A 465
GLN A 464
TYR A 469
 None
 1.22A 5vlmG-1wz2A:
2.3		 5vlmG-1wz2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 GLY A 191
TRP A 183
TYR A  73
ASP A 198
 None
RET  A 301 (-3.8A)
None
None
 1.20A 5vlmG-1xioA:
undetectable		 5vlmG-1xioA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 1.05A 5vlmG-2j2mA:
undetectable		 5vlmG-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 GLY A 145
TRP A 123
GLN A  88
TYR A 119
 None
None
2HP  A1261 ( 3.9A)
None
 1.18A 5vlmG-2jc4A:
undetectable		 5vlmG-2jc4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.13A 5vlmG-2jcjA:
undetectable		 5vlmG-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 351
TYR A 565
TRP A 551
ASP A 155
 None
 1.24A 5vlmG-2jirA:
undetectable		 5vlmG-2jirA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		4 GLY A  68
TRP A 121
GLN A 117
ASP A  85
 None
 0.98A 5vlmG-2lghA:
undetectable		 5vlmG-2lghA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		4 GLN A 117
TYR A  93
ASP A  30
TYR A  27
 None
 1.26A 5vlmG-2o57A:
undetectable		 5vlmG-2o57A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		4 GLY A 178
GLN A 147
TYR A 206
TYR A 170
 None
 0.78A 5vlmG-2v40A:
undetectable		 5vlmG-2v40A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 GLY A  25
TRP A  63
ASP A  22
TYR A  21
 None
 1.16A 5vlmG-2w38A:
undetectable		 5vlmG-2w38A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 GLY A 470
GLN A 413
ASP A 454
TYR A 467
 None
 1.28A 5vlmG-2yiaA:
1.4		 5vlmG-2yiaA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 GLY D 470
GLN D 413
ASP D 454
TYR D 467
 None
 1.28A 5vlmG-2yibD:
1.6		 5vlmG-2yibD:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		4 GLY A  72
TRP A  24
ASP A  76
TYR A 292
 None
 1.06A 5vlmG-2zymA:
undetectable		 5vlmG-2zymA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		4 GLY A 174
TYR A 164
TRP A 177
TYR A 356
 None
 1.23A 5vlmG-3b1eA:
undetectable		 5vlmG-3b1eA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 GLY A 538
TYR A  21
ASP A 451
TYR A 448
 None
 0.89A 5vlmG-3cskA:
undetectable		 5vlmG-3cskA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 GLY A 602
TRP A 406
ASP A 329
TYR A 301
 None
 1.17A 5vlmG-3cttA:
undetectable		 5vlmG-3cttA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 GLY A 251
TRP A 210
TYR A 154
ASP A 208
 None
 1.15A 5vlmG-3cyvA:
undetectable		 5vlmG-3cyvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 TRP A  45
TYR A 141
ASP A 179
TYR A 182
 FAD  A 500 (-4.1A)
FAD  A 500 (-4.7A)
None
None
 1.10A 5vlmG-3d1cA:
undetectable		 5vlmG-3d1cA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		4 GLY A  33
TYR A 216
ASP A  40
TYR A  37
 SO4  A 278 (-3.1A)
None
None
None
 1.14A 5vlmG-3go4A:
undetectable		 5vlmG-3go4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 GLN A 303
TYR A 291
TRP A 371
ASP A  42
 None
None
EDO  A  11 (-4.5A)
EDO  A   8 (-4.4A)
 1.13A 5vlmG-3i09A:
undetectable		 5vlmG-3i09A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 GLN T 132
TYR T 147
TRP T 218
ASP T 184
 None
 1.03A 5vlmG-3icqT:
3.0		 5vlmG-3icqT:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690

(Methanocaldococcus
jannaschii) 		no annotation 4 GLY A 105
GLN A 190
ASP A 165
TYR A 166
 None
 1.24A 5vlmG-3k32A:
undetectable		 5vlmG-3k32A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 426
TYR A 152
ASP A 421
TYR A 405
 None
None
EDO  A  22 (-3.7A)
None
 1.24A 5vlmG-3l22A:
undetectable		 5vlmG-3l22A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7v PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1377C

(Streptococcus
mutans) 		PF01300
(Sua5_yciO_yrdC) 		4 GLY A  59
TRP A  99
TYR A 104
ASP A 120
 None
 1.25A 5vlmG-3l7vA:
undetectable		 5vlmG-3l7vA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luz EXTRAGENIC
SUPPRESSOR PROTEIN
SUHB

(Bartonella
henselae) 		PF00459
(Inositol_P) 		4 GLY A  90
TYR A 170
ASP A 193
TYR A 196
 None
 1.08A 5vlmG-3luzA:
undetectable		 5vlmG-3luzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		4 GLY A 279
GLN A  27
ASP A 286
TYR A 283
 None
 1.28A 5vlmG-3menA:
undetectable		 5vlmG-3menA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 GLY A 148
TRP A 456
TYR A 455
ASP A 202
 None
 1.29A 5vlmG-3oqqA:
undetectable		 5vlmG-3oqqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0m LLAMA VHH A12

(Lama glama) 		PF07686
(V-set) 		4 GLY A  35
GLN A   3
ASP A 102
TYR A 101
 None
 1.00A 5vlmG-3r0mA:
undetectable		 5vlmG-3r0mA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 TRP A 204
GLN A 207
TYR A 160
TRP A 174
 None
 1.17A 5vlmG-3rbtA:
undetectable		 5vlmG-3rbtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 TRP A 204
TYR A 160
TRP A 174
ASP A 206
 None
 1.10A 5vlmG-3rbtA:
undetectable		 5vlmG-3rbtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 GLY L 284
GLN L 148
ASP L 279
TYR L 276
 None
 1.20A 5vlmG-3rgwL:
1.2		 5vlmG-3rgwL:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 4 GLY B  98
GLN B  20
TYR B 113
ASP B  25
 None
 1.13A 5vlmG-3s5cB:
undetectable		 5vlmG-3s5cB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 GLY A 119
TRP A  77
GLN A  79
ASP A 159
 None
 1.27A 5vlmG-4a5qA:
undetectable		 5vlmG-4a5qA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 TRP A 525
TRP A 653
ASP A 561
TYR A 560
 None
 1.29A 5vlmG-4b2nA:
undetectable		 5vlmG-4b2nA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 136
GLN A 357
TYR A 365
ASP A 139
 None
HEM  A3000 (-3.7A)
None
None
 0.94A 5vlmG-4b7gA:
undetectable		 5vlmG-4b7gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 1.02A 5vlmG-4cabA:
undetectable		 5vlmG-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 217
GLN A 318
TYR A 252
TYR A 186
 None
NI  A1470 ( 2.6A)
None
None
 1.05A 5vlmG-4cotA:
undetectable		 5vlmG-4cotA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 GLY A 220
GLN A 309
ASP A 197
TYR A 303
 None
 1.29A 5vlmG-4hooA:
undetectable		 5vlmG-4hooA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		4 GLY A 240
GLN A 247
TRP A 178
ASP A 245
 None
 1.20A 5vlmG-4l4xA:
undetectable		 5vlmG-4l4xA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY E 185
TYR E 257
ASP E 210
TYR E 211
 None
 1.20A 5vlmG-4md8E:
undetectable		 5vlmG-4md8E:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		4 GLY A 251
GLN A 412
TYR A 416
ASP A 204
 None
 1.15A 5vlmG-4ovjA:
undetectable		 5vlmG-4ovjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 GLY A  23
GLN A 163
ASP A 237
TYR A  32
 None
 1.24A 5vlmG-4p48A:
undetectable		 5vlmG-4p48A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 123
GLN A 344
TYR A 352
ASP A 126
 None
HEM  A 502 ( 3.7A)
None
None
 0.92A 5vlmG-4qorA:
undetectable		 5vlmG-4qorA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		4 GLY A 591
GLN A 460
TYR A 528
ASP A 524
 None
 0.99A 5vlmG-4rhbA:
undetectable		 5vlmG-4rhbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 GLY A 285
GLN A 231
TYR A 259
ASP A 288
 CLA  A1116 (-3.4A)
None
None
None
 1.12A 5vlmG-4rkuA:
undetectable		 5vlmG-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 GLY A 286
GLN A 231
TYR A 259
ASP A 288
 None
 1.11A 5vlmG-4rkuA:
undetectable		 5vlmG-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 GLY A 651
GLN A 149
TYR A 151
ASP A 548
 None
 1.00A 5vlmG-4s3pA:
undetectable		 5vlmG-4s3pA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		4 GLY A 252
TRP A 211
TYR A 155
ASP A 209
 None
 1.26A 5vlmG-4wshA:
undetectable		 5vlmG-4wshA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		4 GLY A 251
TRP A 210
TYR A 154
ASP A 208
 None
 1.29A 5vlmG-4zr8A:
undetectable		 5vlmG-4zr8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 GLY A 318
TRP A 465
GLN A 416
TYR A 427
 None
LOG  A 702 (-3.8A)
None
LOG  A 702 (-4.5A)
 1.21A 5vlmG-5bxpA:
undetectable		 5vlmG-5bxpA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 GLY A 383
TRP A 335
GLN A  74
ASP A  71
 None
 1.15A 5vlmG-5c2vA:
undetectable		 5vlmG-5c2vA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cax GLUTAREDOXIN

(Methanosarcina
acetivorans) 		PF00462
(Glutaredoxin) 		4 GLY A  20
GLN A  66
TYR A  25
ASP A  83
 None
 1.27A 5vlmG-5caxA:
undetectable		 5vlmG-5caxA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 GLY H 214
TYR H 602
TRP H 798
TYR H 328
 None
 1.17A 5vlmG-5dfwH:
undetectable		 5vlmG-5dfwH:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		4 GLY A  54
TRP A 163
GLN A 168
TYR A  98
 None
CL  A 409 (-4.6A)
None
None
 1.22A 5vlmG-5esrA:
undetectable		 5vlmG-5esrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffl CD300 ANTIGEN-LIKE
FAMILY MEMBER F

(Mus musculus) 		PF07686
(V-set) 		4 GLY A  12
TRP A  35
GLN A  37
ASP A  84
 None
 1.15A 5vlmG-5fflA:
undetectable		 5vlmG-5fflA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  76
TYR A 512
TRP A  69
ASP A  93
 None
PEG  A6002 ( 4.1A)
None
PEG  A6002 (-3.3A)
 1.01A 5vlmG-5fjjA:
undetectable		 5vlmG-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY B 796
GLN B 825
TYR B 802
ASP B 901
 None
 1.20A 5vlmG-5fq6B:
undetectable		 5vlmG-5fq6B:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 4 GLY A   5
TRP A 224
TRP A   3
TYR A  33
 None
 1.17A 5vlmG-5fsbA:
undetectable		 5vlmG-5fsbA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP41 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 GLY B 594
TRP B 596
ASP B 589
TYR B 586
 None
None
CIT  B1666 (-3.2A)
None
 1.23A 5vlmG-5fyjB:
undetectable		 5vlmG-5fyjB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		4 GLY A 474
GLN A 604
TYR A 605
TYR A 110
 None
 1.27A 5vlmG-5haxA:
2.9		 5vlmG-5haxA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 GLY A 497
TRP A 513
GLN A 509
TYR A 557
 None
 1.23A 5vlmG-5icqA:
undetectable		 5vlmG-5icqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.83A 5vlmG-5ixmA:
undetectable		 5vlmG-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5js9 GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 GLY D 581
TRP D 583
ASP D 576
TYR D 573
 None
 1.29A 5vlmG-5js9D:
undetectable		 5vlmG-5js9D:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  75
TYR A 507
TRP A  68
ASP A  92
 None
None
None
BGC  A 946 (-3.0A)
 1.08A 5vlmG-5ju6A:
undetectable		 5vlmG-5ju6A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd CCZ1

(Chaetomium
thermophilum) 		PF08217
(DUF1712) 		4 GLY B 121
TRP B 144
GLN B 109
TYR B  23
 None
 1.20A 5vlmG-5lddB:
undetectable		 5vlmG-5lddB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  85
GLN A  64
ASP A   9
TYR A  11
 None
 1.19A 5vlmG-5malA:
undetectable		 5vlmG-5malA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		4 GLY A 113
TYR A 165
ASP A 531
TYR A 532
 FAD  A 600 (-3.4A)
FAD  A 600 ( 4.5A)
FAD  A 600 (-3.7A)
None
 1.29A 5vlmG-5mogA:
undetectable		 5vlmG-5mogA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 185
TYR A 257
ASP A 210
TYR A 211
 None
 1.14A 5vlmG-5movA:
undetectable		 5vlmG-5movA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 425
TRP A 395
ASP A 430
TYR A  18
 None
 1.25A 5vlmG-5neuA:
undetectable		 5vlmG-5neuA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 GLY A 228
GLN A 181
TYR A 535
TYR A 307
 None
 1.11A 5vlmG-5opqA:
undetectable		 5vlmG-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 GLY A  16
TYR A 267
ASP A 289
TYR A 292
 None
FAD  A 402 (-3.7A)
FAD  A 402 (-3.0A)
None
 1.21A 5vlmG-5tukA:
undetectable		 5vlmG-5tukA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 GLY A  16
TYR A  44
ASP A 289
TYR A 292
 None
None
PO4  A 401 (-4.2A)
None
 1.18A 5vlmG-5tulA:
undetectable		 5vlmG-5tulA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		4 GLY A  16
TYR A 267
ASP A 289
TYR A 292
 None
FAD  A 401 (-3.5A)
FAD  A 401 (-2.4A)
None
 1.19A 5vlmG-5tumA:
undetectable		 5vlmG-5tumA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 GLY B 594
TRP B 596
ASP B 589
TYR B 586
 None
 1.25A 5vlmG-5um8B:
undetectable		 5vlmG-5um8B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 GLY A 249
TRP A 329
TYR A 340
TYR A 194
 None
 1.25A 5vlmG-5vanA:
undetectable		 5vlmG-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 GLY A 546
GLN A 512
ASP A 488
TYR A 563
 None
 1.23A 5vlmG-5vatA:
2.0		 5vlmG-5vatA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 7 GLY A  88
TRP A 101
GLN A 105
TYR A 118
TRP A 125
ASP A 163
TYR A 166
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.6A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
 0.32A 5vlmG-5vlgA:
29.4		 5vlmG-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 GLY A 247
TRP A 326
TYR A 337
TYR A 192
 None
 1.21A 5vlmG-5w21A:
undetectable		 5vlmG-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 GLY A 249
TRP A 329
TYR A 340
TYR A 194
 None
 1.22A 5vlmG-5wi9A:
undetectable		 5vlmG-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 GLY A 189
TYR A 261
ASP A 214
TYR A 215
 None
 1.20A 5vlmG-5xvuA:
undetectable		 5vlmG-5xvuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 GLY A 404
GLN A 308
TYR A 316
ASP A 409
 None
 1.25A 5vlmG-5y6rA:
undetectable		 5vlmG-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 GLY A 406
GLN A 308
TYR A 316
ASP A 409
 None
 1.28A 5vlmG-5y6rA:
undetectable		 5vlmG-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 41

(Human
immunodeficiency
virus 1) 		no annotation 4 GLY A 594
TRP A 596
ASP A 589
TYR A 586
 None
 1.21A 5vlmG-6ccbA:
undetectable		 5vlmG-6ccbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 GLY A 592
TRP A 620
TYR A 358
ASP A 615
 None
 1.29A 5vlmG-6eksA:
undetectable		 5vlmG-6eksA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 TYR A 231
TRP A 469
ASP A 451
TYR A 342
 FAD  A 601 (-4.7A)
None
None
None
 1.26A 5vlmG-6f72A:
undetectable		 5vlmG-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A  92
GLN A 395
TRP A 390
ASP A  95
 None
 1.27A 5vlmG-6f8zA:
undetectable		 5vlmG-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe ATPASE YJEE,
PREDICTED TO HAVE
ESSENTIAL ROLE IN
CELL WALL
BIOSYNTHESIS

(Thermotoga
maritima) 		no annotation 4 GLY E 110
TYR E  70
ASP E  80
TYR E  82
 None
None
APC  E 201 ( 4.7A)
None
 1.20A 5vlmG-6fpeE:
undetectable		 5vlmG-6fpeE:
undetectable