SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_F_CVIF301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzt DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE


(Salmonella
enterica)
PF00908
(dTDP_sugar_isom)
4 ILE A 147
TRP A 158
VAL A  85
ASP A  88
None
1.05A 5vlmF-1dztA:
undetectable
5vlmF-1dztA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG


(Serratia
marcescens;
Serratia
marcescens)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase)
4 ARG A 408
GLN A 378
VAL B  18
ASP A 113
None
1.17A 5vlmF-1i7qA:
undetectable
5vlmF-1i7qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens)
PF00888
(Cullin)
PF10557
(Cullin_Nedd8)
4 ILE A 403
GLN A 368
VAL A 373
ASP A 396
None
1.17A 5vlmF-1ldjA:
0.5
5vlmF-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A


(Haemophilus
influenzae)
PF06026
(Rib_5-P_isom_A)
4 ILE A 169
ARG A 158
VAL A 172
ASP A  84
None
None
None
CIT  A 501 (-2.8A)
0.97A 5vlmF-1m0sA:
0.4
5vlmF-1m0sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF06026
(Rib_5-P_isom_A)
4 ILE A 168
ARG A 157
VAL A 171
ASP A  84
None
None
None
ABF  A1269 (-2.6A)
1.12A 5vlmF-1o8bA:
0.0
5vlmF-1o8bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus)
PF00042
(Globin)
4 ILE B 110
TRP B 131
GLN B 132
VAL B 138
None
0.82A 5vlmF-1spgB:
0.0
5vlmF-1spgB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
4 ILE A 587
ARG A 589
GLN A 557
ASP A 578
None
1.11A 5vlmF-1ulvA:
1.6
5vlmF-1ulvA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ILE A 397
TYR A 369
TRP A 351
VAL A 547
None
1.05A 5vlmF-1v5fA:
0.0
5vlmF-1v5fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B


(Cellulomonas
fimi;
Streptomyces
olivaceoviridis)
PF00331
(Glyco_hydro_10)
4 ILE A 209
GLN A 252
TYR A 256
VAL A 284
None
1.10A 5vlmF-1v6yA:
0.0
5vlmF-1v6yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 ILE A 194
ARG A 190
TRP A 199
ASP A 278
BR  A1645 ( 4.4A)
None
None
None
1.14A 5vlmF-1w99A:
1.4
5vlmF-1w99A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE


(Bacillus
subtilis)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 ILE A 112
TYR A  84
VAL A  95
ASP A 118
None
1.09A 5vlmF-1yx2A:
undetectable
5vlmF-1yx2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9w DIHYDRONEOPTERIN
ALDOLASE


(Mycobacterium
tuberculosis)
PF02152
(FolB)
4 ILE A  37
ARG A  89
GLN A  88
VAL A  84
None
1.14A 5vlmF-1z9wA:
undetectable
5vlmF-1z9wA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE


(Podophyllum
peltatum)
PF13561
(adh_short_C2)
4 ILE A  28
TYR A 167
VAL A 195
ASP A 238
None
1.17A 5vlmF-2bgkA:
undetectable
5vlmF-2bgkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 ILE A 254
TYR A 375
TRP A 302
VAL A 250
None
1.03A 5vlmF-2g3nA:
undetectable
5vlmF-2g3nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE


(Cellulomonas
fimi)
PF00331
(Glyco_hydro_10)
4 ILE A 207
GLN A 250
TYR A 254
VAL A 282
None
1.14A 5vlmF-2hisA:
undetectable
5vlmF-2hisA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis)
PF11721
(Malectin)
4 ILE A 117
GLN A  98
VAL A 112
ASP A 128
None
1.04A 5vlmF-2jwpA:
undetectable
5vlmF-2jwpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyb DIHYDROFOLATE
REDUCTASE


(Haloferax
volcanii)
PF00186
(DHFR_1)
4 ILE A 100
GLN A 110
VAL A 117
ASP A  29
None
0.90A 5vlmF-2jybA:
undetectable
5vlmF-2jybA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgf CAPSID PROTEIN P27

(Mason-Pfizer
monkey virus)
PF00607
(Gag_p24)
4 ILE A  44
TRP A  74
VAL A  65
ASP A  20
None
1.12A 5vlmF-2kgfA:
undetectable
5vlmF-2kgfA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4


(Homo sapiens)
PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF)
4 ILE A 292
GLN A 340
TYR A 299
ASP A 447
None
1.15A 5vlmF-2pz1A:
undetectable
5vlmF-2pz1A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv CARBON CATABOLITE
DEREPRESSING PROTEIN
KINASE
PROTEIN SIP2
NUCLEAR PROTEIN SNF4


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF16579
(AdenylateSensor)
PF04739
(AMPKBI)
PF16561
(AMPK1_CBM)
PF00571
(CBS)
4 ILE C  42
GLN B 406
TYR A 613
VAL C 164
None
1.05A 5vlmF-2qlvC:
undetectable
5vlmF-2qlvC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1


(Halothermothrix
orenii)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
4 ILE A 194
TYR A  38
VAL A 225
ASP A 221
None
1.16A 5vlmF-2r66A:
undetectable
5vlmF-2r66A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN


(Shigella
dysenteriae)
PF01497
(Peripla_BP_2)
4 ILE A 186
TYR A 201
VAL A 251
ASP A 265
None
HEM  A 600 (-4.2A)
None
None
1.14A 5vlmF-2r7aA:
undetectable
5vlmF-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6c PROLIFERATION-ASSOCI
ATED PROTEIN 2G4


(Mus musculus)
PF00557
(Peptidase_M24)
4 GLN A 242
TYR A 309
VAL A  45
ASP A  53
None
1.09A 5vlmF-2v6cA:
undetectable
5vlmF-2v6cA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN


(Shigella
flexneri)
PF00497
(SBP_bac_3)
4 ILE A 107
GLN A  44
TRP A 242
ASP A 227
None
None
None
TRS  A1281 (-3.4A)
1.03A 5vlmF-2vhaA:
undetectable
5vlmF-2vhaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 ILE A 499
TYR A 592
TRP A 508
VAL A 495
None
0.90A 5vlmF-2x40A:
undetectable
5vlmF-2x40A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis)
PF07859
(Abhydrolase_3)
4 ILE A 184
TYR A 180
VAL A 277
ASP A 254
None
1.04A 5vlmF-2yh2A:
undetectable
5vlmF-2yh2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE


(Sulfurisphaera
tokodaii)
PF07859
(Abhydrolase_3)
4 ILE A 176
TYR A 172
VAL A 266
ASP A 243
None
1.03A 5vlmF-3ailA:
undetectable
5vlmF-3ailA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE


(Huperzia
serrata)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 ILE A  93
ARG A 104
GLN A 105
VAL A 203
None
1.15A 5vlmF-3awkA:
undetectable
5vlmF-3awkA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ILE A 369
TYR A 500
TRP A 424
VAL A 365
None
0.91A 5vlmF-3cttA:
undetectable
5vlmF-3cttA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsq PYRROLYSYL-TRNA
SYNTHETASE


(Desulfitobacterium
hafniense)
PF01409
(tRNA-synt_2d)
4 ILE A 263
ARG A 259
VAL A 223
ASP A 227
None
1.03A 5vlmF-3dsqA:
undetectable
5vlmF-3dsqA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A


(Vibrio
vulnificus)
PF06026
(Rib_5-P_isom_A)
4 ILE A 168
ARG A 157
VAL A 171
ASP A  84
None
1.01A 5vlmF-3enqA:
undetectable
5vlmF-3enqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 ILE A 239
ARG A1029
VAL A 280
ASP A 273
None
1.14A 5vlmF-3f2bA:
undetectable
5vlmF-3f2bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF13847
(Methyltransf_31)
4 ILE A 147
TRP A 148
TYR A  21
VAL A  43
None
None
SAH  A 308 (-4.6A)
None
0.96A 5vlmF-3g5tA:
undetectable
5vlmF-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
4 ILE A 196
ARG A 364
VAL A 212
ASP A 201
None
1.03A 5vlmF-3h5cA:
undetectable
5vlmF-3h5cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3


(Saccharomyces
cerevisiae)
PF11496
(HDA2-3)
4 ILE A 235
ARG A 237
VAL A 136
ASP A 210
None
1.17A 5vlmF-3hgqA:
undetectable
5vlmF-3hgqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN


(Streptococcus
thermophilus)
PF00497
(SBP_bac_3)
4 ILE A  46
TRP A  87
TRP A 108
VAL A  77
None
1.11A 5vlmF-3hv1A:
undetectable
5vlmF-3hv1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN


(Oleispira
antarctica)
PF13419
(HAD_2)
4 ARG A 107
GLN A 100
TYR A 134
ASP A 223
None
1.16A 5vlmF-3iruA:
undetectable
5vlmF-3iruA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4


(Homo sapiens)
PF00557
(Peptidase_M24)
4 GLN A 242
TYR A 309
VAL A  45
ASP A  53
None
1.16A 5vlmF-3j2iA:
undetectable
5vlmF-3j2iA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5


(Plasmodium
falciparum)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
4 ILE G  75
GLN G  80
TRP G  41
VAL G  51
None
1.14A 5vlmF-3j7aG:
undetectable
5vlmF-3j7aG:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA


(Escherichia
coli;
Homo sapiens)
no annotation 4 ILE D 574
ARG D 604
VAL D 564
ASP D 542
None
1.13A 5vlmF-3j9pD:
undetectable
5vlmF-3j9pD:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae)
PF02223
(Thymidylate_kin)
4 ILE A 157
ARG A 156
VAL A  72
ASP A  65
TMP  A 214 (-3.3A)
None
TYD  A 215 (-4.1A)
CL  A 222 ( 4.7A)
1.10A 5vlmF-3lv8A:
1.4
5vlmF-3lv8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyb PUTATIVE
ENDORIBONUCLEASE


(Klebsiella
pneumoniae)
PF01042
(Ribonuc_L-PSP)
4 ILE A  29
GLN A  99
TYR A 110
VAL A  94
None
1.08A 5vlmF-3lybA:
undetectable
5vlmF-3lybA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE


(Salmonella
enterica)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
4 ILE A 243
ARG A 281
GLN A 280
ASP A 236
None
None
PG4  A 607 ( 4.4A)
None
0.94A 5vlmF-3m07A:
undetectable
5vlmF-3m07A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1


(Necator
americanus)
PF00188
(CAP)
4 ILE A 356
TRP A 349
ARG A 351
ASP A 259
None
1.16A 5vlmF-3nt8A:
undetectable
5vlmF-3nt8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
4 ILE A 237
GLN A 276
VAL A 230
ASP A  83
None
1.06A 5vlmF-3pv4A:
undetectable
5vlmF-3pv4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN


(Thermanaerovibrio
acidaminovorans)
PF07228
(SpoIIE)
4 ILE A  63
GLN A  60
VAL A  54
ASP A  23
None
1.03A 5vlmF-3rnrA:
undetectable
5vlmF-3rnrA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5q PUTATIVE
GLYCOSYLHYDROLASE


(Parabacteroides
distasonis)
PF06439
(DUF1080)
4 TRP A 121
ARG A 122
GLN A 105
TYR A 127
None
1.14A 5vlmF-3s5qA:
undetectable
5vlmF-3s5qA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A


(Burkholderia
thailandensis)
PF06026
(Rib_5-P_isom_A)
4 ILE A 181
ARG A 165
VAL A 184
ASP A  92
None
None
None
EDO  A 237 (-3.4A)
1.05A 5vlmF-3u7jA:
undetectable
5vlmF-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE


(Homo sapiens)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 GLN A 141
TYR A 142
VAL A 109
ASP A  22
None
1.12A 5vlmF-3v98A:
undetectable
5vlmF-3v98A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpc PUTATIVE
ACETYLORNITHINE
DEACETYLASE


(Sulfurisphaera
tokodaii)
PF08443
(RimK)
4 ILE A 180
TYR A 275
VAL A 226
ASP A 237
None
1.11A 5vlmF-3vpcA:
undetectable
5vlmF-3vpcA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus)
PF16420
(ATG7_N)
4 ILE A 243
TRP A 218
VAL A 195
ASP A 199
None
1.11A 5vlmF-3vx6A:
undetectable
5vlmF-3vx6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A)
PF00947
(Pico_P2A)
4 ILE A  53
GLN A   5
VAL A  17
ASP A 136
None
1.09A 5vlmF-3w95A:
undetectable
5vlmF-3w95A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR


(Homo sapiens)
PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10)
4 ILE A 442
GLN A 479
VAL A 417
ASP A 445
None
1.02A 5vlmF-3wsyA:
undetectable
5vlmF-3wsyA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A


(Streptomyces
sp.)
PF00331
(Glyco_hydro_10)
4 ILE A 245
GLN A 288
TYR A 292
VAL A 320
None
1.08A 5vlmF-3wufA:
undetectable
5vlmF-3wufA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae)
PF00072
(Response_reg)
PF04397
(LytTR)
4 ILE A  84
ARG A  76
VAL A  71
ASP A  49
None
1.13A 5vlmF-4cbvA:
undetectable
5vlmF-4cbvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE


(Salmonella
enterica)
PF00291
(PALP)
4 ILE A  76
TYR A 261
VAL A  81
ASP A 120
None
1.15A 5vlmF-4d8uA:
undetectable
5vlmF-4d8uA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum)
PF03480
(DctP)
4 ILE B 289
TRP B 292
ARG B 293
ASP B 107
None
0.98A 5vlmF-4di4B:
undetectable
5vlmF-4di4B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
4 ILE A  16
TYR A 159
VAL A 187
ASP A 226
None
1.14A 5vlmF-4e3zA:
undetectable
5vlmF-4e3zA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2l 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Rattus
norvegicus)
no annotation 4 ILE A 328
ARG A 331
VAL A 296
ASP A 290
None
1.17A 5vlmF-4f2lA:
undetectable
5vlmF-4f2lA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE


(Penicillium
canescens)
PF00331
(Glyco_hydro_10)
4 ILE A 242
GLN A 289
TYR A 293
VAL A 322
None
1.10A 5vlmF-4f8xA:
undetectable
5vlmF-4f8xA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzl BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3)
PF14859
(Colicin_M)
4 ILE A 213
TRP A 221
ARG A 176
VAL A 168
None
1.16A 5vlmF-4fzlA:
1.9
5vlmF-4fzlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3)
PF14859
(Colicin_M)
4 ILE A 213
TRP A 221
ARG A 176
VAL A 168
None
0.98A 5vlmF-4fznA:
1.6
5vlmF-4fznA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A


(Francisella
tularensis)
PF06026
(Rib_5-P_isom_A)
4 ILE A 174
ARG A 163
VAL A 177
ASP A  90
None
None
None
PO4  A 306 ( 4.8A)
1.04A 5vlmF-4io1A:
undetectable
5vlmF-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS


(Escherichia
coli)
PF00155
(Aminotran_1_2)
4 ILE A 116
ARG A  92
GLN A  91
VAL A 165
None
1.15A 5vlmF-4j8lA:
undetectable
5vlmF-4j8lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 TRP A 471
TYR A 472
TRP A 521
VAL A 563
None
1KV  A 701 (-3.8A)
None
None
0.98A 5vlmF-4jhzA:
undetectable
5vlmF-4jhzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila)
no annotation 4 ILE A 467
TRP A 464
TYR A 455
VAL A 390
None
1.05A 5vlmF-4jw1A:
2.3
5vlmF-4jw1A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 ILE A 895
TRP A 868
GLN A 904
VAL A 928
None
1.17A 5vlmF-4kxbA:
undetectable
5vlmF-4kxbA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A)
PF00947
(Pico_P2A)
4 ILE A  53
GLN A   5
VAL A  17
ASP A 136
None
1.10A 5vlmF-4mg3A:
undetectable
5vlmF-4mg3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Clostridioides
difficile)
PF09084
(NMT1)
4 TRP A 114
GLN A  65
TRP A 158
VAL A 122
VIB  A 401 (-3.7A)
None
VIB  A 401 (-4.0A)
None
0.97A 5vlmF-4nmyA:
undetectable
5vlmF-4nmyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofn GLUTATHIONE
S-TRANSFERASE-1


(Necator
americanus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 ILE A  11
TYR A 107
VAL A  51
ASP A  31
None
None
GSH  A 301 (-4.5A)
None
1.16A 5vlmF-4ofnA:
undetectable
5vlmF-4ofnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE


(Saccharophagus
degradans)
PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III)
4 ILE A 329
TYR A 295
VAL A 358
ASP A  39
None
1.04A 5vlmF-4ojzA:
2.4
5vlmF-4ojzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae)
PF00035
(dsrm)
PF00636
(Ribonuclease_3)
4 ILE C 422
ARG C 426
TYR C 387
ASP C 364
None
None
U  D  21 ( 4.8A)
None
1.07A 5vlmF-4oogC:
undetectable
5vlmF-4oogC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
4 ILE A 241
GLN A  84
VAL A 102
ASP A 109
None
1.02A 5vlmF-4p47A:
undetectable
5vlmF-4p47A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN


(Bacteroides
vulgatus)
PF07470
(Glyco_hydro_88)
4 ILE A  33
ARG A  36
GLN A  39
TYR A  74
None
0.88A 5vlmF-4q88A:
undetectable
5vlmF-4q88A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2

(Pseudomonas
aeruginosa)
no annotation 4 ILE B 588
TRP B 612
VAL B 615
ASP B 594
None
1.16A 5vlmF-4qkoB:
undetectable
5vlmF-4qkoB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  91
GLN A 122
VAL A 100
ASP A 227
None
38Z  A 418 (-3.7A)
None
None
1.14A 5vlmF-4qtbA:
undetectable
5vlmF-4qtbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Desulfovibrio
fructosivorans)
PF00374
(NiFeSe_Hases)
4 ARG Q 388
TRP Q 442
VAL Q 435
ASP Q 114
None
GOL  Q1561 ( 4.4A)
None
CSX  Q  75 ( 4.5A)
1.10A 5vlmF-4upeQ:
1.8
5vlmF-4upeQ:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A


(Pseudomonas
aeruginosa)
PF06026
(Rib_5-P_isom_A)
4 ILE A 172
ARG A 161
VAL A 175
ASP A  88
None
None
None
FLC  A 300 (-2.8A)
1.00A 5vlmF-4x84A:
undetectable
5vlmF-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN


(Trypanosoma
brucei)
PF09818
(ABC_ATPase)
4 ILE A 649
ARG A 647
GLN A 563
VAL A 555
None
1.03A 5vlmF-4yj1A:
undetectable
5vlmF-4yj1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE


(Streptomyces
sp. CNQ-418)
PF04820
(Trp_halogenase)
4 ILE A 336
ARG A 335
VAL A 329
ASP A 406
None
1.04A 5vlmF-5bukA:
undetectable
5vlmF-5bukA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis)
PF00067
(p450)
4 ILE A 375
TYR A 275
VAL A 249
ASP A 370
EDO  A 408 ( 4.4A)
None
None
None
1.09A 5vlmF-5ex8A:
undetectable
5vlmF-5ex8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A


(Neisseria
meningitidis)
PF00884
(Sulfatase)
PF08019
(DUF1705)
4 ILE A  84
GLN A  91
TYR A 123
VAL A 107
LMT  A 602 (-3.9A)
LMT  A 602 (-2.8A)
None
LMT  A 602 ( 4.8A)
1.08A 5vlmF-5fgnA:
undetectable
5vlmF-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmv RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C


(Homo sapiens)
PF00041
(fn3)
PF12567
(CD45)
4 ILE A 233
TYR A 237
VAL A 279
ASP A 227
None
1.00A 5vlmF-5fmvA:
undetectable
5vlmF-5fmvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C


(Homo sapiens)
PF00041
(fn3)
PF12567
(CD45)
4 ILE A  18
TYR A  22
VAL A  64
ASP A  12
None
0.96A 5vlmF-5fn6A:
undetectable
5vlmF-5fn6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C


(Homo sapiens)
PF12567
(CD45)
4 ILE A  18
TYR A  22
VAL A  64
ASP A  12
None
0.99A 5vlmF-5fn7A:
undetectable
5vlmF-5fn7A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)


(Agrobacterium
fabrum)
PF13416
(SBP_bac_8)
4 TRP A 223
ARG A 224
GLN A 228
TRP A 244
None
1.12A 5vlmF-5l9sA:
undetectable
5vlmF-5l9sA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE


(Homo sapiens)
no annotation 4 ILE A 446
TYR A 575
TRP A 499
VAL A 442
None
0.98A 5vlmF-5nn8A:
undetectable
5vlmF-5nn8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 ARG A 316
GLN A 287
VAL A 392
ASP A 467
EDO  A 904 ( 4.6A)
None
None
None
1.14A 5vlmF-5t98A:
undetectable
5vlmF-5t98A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A


(Neisseria
gonorrhoeae)
PF06026
(Rib_5-P_isom_A)
4 ILE A 169
ARG A 158
VAL A 172
ASP A  85
None
None
None
EDO  A 306 (-3.5A)
1.07A 5vlmF-5uf2A:
undetectable
5vlmF-5uf2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
14


(Homo sapiens)
PF00004
(AAA)
4 ILE c 203
ARG c 161
TYR c 200
VAL c 143
None
1.16A 5vlmF-5vhic:
2.1
5vlmF-5vhic:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR


([Enterobacter]
lignolyticus)
no annotation 8 ILE A  98
TRP A 101
ARG A 102
GLN A 105
TYR A 118
TRP A 125
VAL A 159
ASP A 175
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-4.4A)
MGR  A 300 ( 4.3A)
0.48A 5vlmF-5vlgA:
29.2
5vlmF-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE


(Cryptococcus
neoformans)
no annotation 4 ILE A 143
GLN A 305
VAL A 289
ASP A 118
None
1.15A 5vlmF-5w4cA:
undetectable
5vlmF-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1)
no annotation 4 ILE A 221
GLN A 266
TYR A 270
VAL A 298
None
1.17A 5vlmF-5xzuA:
1.0
5vlmF-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
no annotation
no annotation
4 ILE B 555
ARG B 533
GLN B 534
TYR A 335
None
1.15A 5vlmF-5y58B:
undetectable
5vlmF-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus)
no annotation 4 ILE B 120
TRP B 154
VAL B 140
ASP B 164
None
0.84A 5vlmF-5yllB:
undetectable
5vlmF-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY


(Thermobifida
fusca)
no annotation 4 ILE M  36
TYR M 137
VAL M  45
ASP M  52
None
U  J   2 ( 3.1A)
None
None
1.13A 5vlmF-6c66M:
undetectable
5vlmF-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE


(Carboxydothermus
hydrogenoformans)
no annotation 4 TRP X 569
ARG X 171
VAL X 535
ASP X 548
None
1.08A 5vlmF-6elqX:
undetectable
5vlmF-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 4 ILE A1023
TYR A1157
VAL A1116
ASP A1058
None
1.02A 5vlmF-6eojA:
undetectable
5vlmF-6eojA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL


(Mus musculus)
no annotation 4 ILE E  31
GLN E  43
VAL E  69
ASP E  22
None
1.12A 5vlmF-6g72E:
undetectable
5vlmF-6g72E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-)
no annotation 4 ILE A  27
ARG A 123
TYR A  40
ASP A  21
None
0.91A 5vlmF-6ghcA:
undetectable
5vlmF-6ghcA:
undetectable