SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_F_CVIF301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		5 ALA A 165
GLY A 168
SER A 167
LEU A 250
ASP A 222
 None
None
HEM  A 350 ( 3.7A)
None
CA  A 351 (-3.3A)
 1.49A 5vlmF-1atjA:
0.0		 5vlmF-1atjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 MET A 266
ALA A 168
GLY A 170
SER A 171
LEU A 410
 None
 1.40A 5vlmF-1e5mA:
0.0		 5vlmF-1e5mA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 GLN A 361
GLY A 386
GLU A 384
ASP A 389
PHE A 436
 None
 1.39A 5vlmF-1gxnA:
1.9		 5vlmF-1gxnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 MET A 229
ALA A 157
GLY A 153
ASP A  86
PHE A 107
 None
 1.36A 5vlmF-1i36A:
undetectable		 5vlmF-1i36A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		5 ALA A 181
GLY A 185
SER A 186
GLU A 188
LEU A 349
 None
 1.30A 5vlmF-1mg7A:
0.6		 5vlmF-1mg7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 GLY A 228
SER A 227
CYH A 166
ASP A 167
PHE A 184
 None
 1.44A 5vlmF-1o60A:
undetectable		 5vlmF-1o60A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 ALA A 160
GLY A 163
SER A 162
LEU A 245
ASP A 217
 None
None
HEM  A1350 (-3.4A)
None
CA  A2002 (-3.3A)
 1.47A 5vlmF-1qgjA:
0.0		 5vlmF-1qgjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 ALA A 164
GLY A 167
SER A 166
LEU A 249
ASP A 221
 None
None
HEM  A 374 ( 3.9A)
None
CA  A 376 (-3.4A)
 1.45A 5vlmF-1qo4A:
0.0		 5vlmF-1qo4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 GLN A 189
SER A 220
GLU A 222
LEU A 194
CYH A 235
 None
 1.36A 5vlmF-1rzmA:
undetectable		 5vlmF-1rzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 GLN A 242
ALA A  51
GLY A  49
LEU A 388
CYH A  33
 EDO  A1232 (-3.3A)
None
EDO  A1223 (-3.5A)
None
None
 1.42A 5vlmF-1szsA:
0.0		 5vlmF-1szsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 MET A 238
GLY A 261
SER A  66
GLU A  65
PHE A  62
 None
 1.42A 5vlmF-1u60A:
undetectable		 5vlmF-1u60A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ALA M 395
GLY M 426
GLU M 391
LEU M 178
PHE M 390
 None
 1.46A 5vlmF-2bp5M:
undetectable		 5vlmF-2bp5M:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 MET A  45
GLY A 269
SER A 270
GLU A 267
LEU A  63
 None
 1.33A 5vlmF-2cuyA:
undetectable		 5vlmF-2cuyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 MET A  45
GLY A 269
SER A 270
GLU A 267
PHE A   6
 None
 1.41A 5vlmF-2cuyA:
undetectable		 5vlmF-2cuyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 243
GLY A 245
GLU A  73
LEU A  71
ASP A  78
 None
 1.46A 5vlmF-2dvlA:
undetectable		 5vlmF-2dvlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 MET A 247
ALA A 251
GLY A 254
SER A 253
LEU A 205
 None
 1.44A 5vlmF-2ef4A:
undetectable		 5vlmF-2ef4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfv FK506-BINDING
PROTEIN 3

(Homo sapiens) 		no annotation 5 GLN A  33
SER A  36
GLU A  37
LEU A  39
ASP A  76
 None
 1.43A 5vlmF-2kfvA:
undetectable		 5vlmF-2kfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxj COLD SHOCK-LIKE
PROTEIN CSPLA

(Listeria
monocytogenes) 		PF00313
(CSD) 		5 GLN A  45
ALA A  46
GLY A   4
LEU A  41
ASP A  25
 None
 1.45A 5vlmF-2lxjA:
undetectable		 5vlmF-2lxjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 211
GLY A 214
GLU A 268
LEU A 311
TYR A 217
 None
 1.49A 5vlmF-2vpqA:
undetectable		 5vlmF-2vpqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		5 MET A  96
ALA A  92
GLY A  89
LEU A  59
ASP A  83
 PG4  A1212 ( 3.9A)
PG4  A1212 (-3.7A)
None
None
None
 1.30A 5vlmF-2xf4A:
undetectable		 5vlmF-2xf4A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 MET A 349
GLY A 160
SER A 161
LEU A 346
PHE A  26
 None
 1.35A 5vlmF-2xutA:
undetectable		 5vlmF-2xutA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		5 ALA A 297
GLY A 284
SER A 283
GLU A 252
CYH A 346
 None
 1.04A 5vlmF-3fgbA:
undetectable		 5vlmF-3fgbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 ALA A 135
GLY A 159
SER A 158
GLU A 157
LEU A  83
 None
 1.15A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 MET A  59
ALA A 135
GLY A 159
SER A 158
GLU A 157
 None
 1.48A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 MET A  59
GLY A 159
SER A 158
GLU A 157
LEU A  83
 None
 1.33A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		5 ALA A 238
GLY A 242
GLU A 146
LEU A 142
ASP A 211
 None
 1.36A 5vlmF-3igfA:
1.5		 5vlmF-3igfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		5 ALA A  58
GLY A 176
SER A 177
GLU A 174
LEU A 180
 None
 1.26A 5vlmF-3kh1A:
undetectable		 5vlmF-3kh1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		5 ALA A  58
SER A 177
GLU A 174
LEU A 180
ASP A 137
 None
 1.36A 5vlmF-3kh1A:
undetectable		 5vlmF-3kh1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ALA A 312
GLY A 316
SER A 315
GLU A 318
TYR A 298
 FAD  A 401 (-3.6A)
None
None
None
None
 1.46A 5vlmF-3kkjA:
undetectable		 5vlmF-3kkjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7h PUTIDACIN L1

(Pseudomonas
putida) 		PF01453
(B_lectin) 		5 ALA A 150
GLY A 152
SER A 153
GLU A 154
ASP A 204
 None
 1.29A 5vlmF-3m7hA:
undetectable		 5vlmF-3m7hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 108
SER A  52
GLU A  51
ASP A 115
PHE A 322
 None
 1.41A 5vlmF-3mwcA:
undetectable		 5vlmF-3mwcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 ALA A 114
GLY A 118
SER A 119
LEU A 138
PHE A  94
 None
 1.50A 5vlmF-3r0oA:
undetectable		 5vlmF-3r0oA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 MET A 260
ALA A 368
SER A 366
LEU A 255
ASP A 446
 None
 1.31A 5vlmF-3s5kA:
undetectable		 5vlmF-3s5kA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		5 ALA A 298
GLY A 285
SER A 284
GLU A 253
CYH A 347
 None
None
None
UNL  A 385 ( 4.9A)
None
 1.06A 5vlmF-3scyA:
undetectable		 5vlmF-3scyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		5 ALA A 283
GLY A  76
SER A  75
LEU A  70
ASP A  58
 None
 1.24A 5vlmF-3ttkA:
undetectable		 5vlmF-3ttkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 GLY A 378
SER A 380
GLU A 382
LEU A 384
ASP A 207
 None
GOL  A1404 ( 4.7A)
None
None
ANP  A1401 ( 4.9A)
 1.44A 5vlmF-3zlbA:
undetectable		 5vlmF-3zlbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 402
GLY A 504
SER A 411
LEU A 406
TYR A 493
 None
 1.32A 5vlmF-3zx1A:
undetectable		 5vlmF-3zx1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		5 ALA A 166
GLY A 169
SER A 168
LEU A 251
ASP A 223
 None
None
HEM  A1307 (-3.6A)
None
CA  A1309 (-3.3A)
 1.42A 5vlmF-4a5gA:
undetectable		 5vlmF-4a5gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 MET A 386
ALA A  74
GLY A 296
SER A  77
LEU A 434
 None
 1.32A 5vlmF-4atqA:
undetectable		 5vlmF-4atqA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		5 ALA A 254
GLY A 193
SER A 194
ASP A 166
TYR A 167
 None
 1.40A 5vlmF-4bs9A:
undetectable		 5vlmF-4bs9A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ALA A 256
GLY A 251
GLU A 155
LEU A 274
ASP A 229
 None
 1.44A 5vlmF-4gp1A:
undetectable		 5vlmF-4gp1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 GLN A 189
SER A 220
GLU A 222
LEU A 194
CYH A 235
 None
 1.36A 5vlmF-4grsA:
undetectable		 5vlmF-4grsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0o PROTEIN ELYS

(Mus musculus) 		PF16687
(ELYS-bb) 		5 GLN A  53
ALA A  22
GLY A  24
GLU A  27
LEU A  34
 None
 1.21A 5vlmF-4i0oA:
undetectable		 5vlmF-4i0oA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixa RESPONSE REGULATOR
SAER

(Staphylococcus
epidermidis) 		PF00486
(Trans_reg_C) 		5 ALA A 191
GLU A 180
LEU A 178
ASP A 186
TYR A 185
 None
 1.30A 5vlmF-4ixaA:
2.2		 5vlmF-4ixaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 ALA A 347
GLY A 360
SER A 359
ASP A 307
TYR A 306
 None
 1.46A 5vlmF-4j5uA:
2.3		 5vlmF-4j5uA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgf GAMMA-CRYSTALLIN D

(Homo sapiens) 		PF00030
(Crystall) 		5 GLN A 142
GLY A  70
LEU A  53
CYH A  32
ASP A  73
 None
 1.37A 5vlmF-4jgfA:
undetectable		 5vlmF-4jgfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 ALA A 131
GLY A 153
GLU A 154
LEU A 156
ASP A 162
 None
 1.34A 5vlmF-4kmrA:
undetectable		 5vlmF-4kmrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 MET A 225
ALA A 229
GLU A 137
LEU A 142
TYR A 132
 None
 1.32A 5vlmF-4ldnA:
undetectable		 5vlmF-4ldnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 GLY A 127
SER A 184
LEU A 327
CYH A 180
ASP A 208
 None
None
None
None
PLP  A 701 (-2.7A)
 1.46A 5vlmF-4o6zA:
2.0		 5vlmF-4o6zA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		5 MET A  95
ALA A 147
GLY A 149
SER A 150
TYR A  36
 None
 1.20A 5vlmF-4ozvA:
1.4		 5vlmF-4ozvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 GLN A 558
GLU A 376
LEU A 290
ASP A 506
PHE A 563
 None
 1.50A 5vlmF-4pf1A:
undetectable		 5vlmF-4pf1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 ALA A 504
GLY A 510
SER A 506
GLU A 507
LEU A 636
 None
 1.43A 5vlmF-4qi4A:
undetectable		 5vlmF-4qi4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ALA A 504
GLY A 510
SER A 506
GLU A 507
LEU A 636
 None
 1.30A 5vlmF-4qi6A:
undetectable		 5vlmF-4qi6A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 665
GLY A 798
GLU A 800
ASP A 870
PHE A 936
 P30  A1001 ( 3.7A)
None
None
None
None
 1.50A 5vlmF-4rt7A:
undetectable		 5vlmF-4rt7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 5 GLY C 522
SER C 525
GLU C 524
LEU C 529
PHE C 523
 None
 1.36A 5vlmF-4u3jC:
1.8		 5vlmF-4u3jC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u83 ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 248
GLY A 250
GLU A  73
LEU A  71
ASP A  78
 None
 1.39A 5vlmF-4u83A:
undetectable		 5vlmF-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLY A 413
SER A 414
LEU A 418
TYR A 168
PHE A 313
 None
 1.50A 5vlmF-4u8hA:
1.5		 5vlmF-4u8hA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 ALA A 247
GLY A 187
SER A 188
ASP A 160
TYR A 161
 None
 1.34A 5vlmF-4v1uA:
undetectable		 5vlmF-4v1uA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 573
GLU A 575
LEU A 580
ASP A 647
PHE A 712
 None
 1.23A 5vlmF-4yffA:
undetectable		 5vlmF-4yffA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		5 ALA A 206
GLY A 209
SER A 208
LEU A 285
ASP A 257
 None
None
None
None
CA  A1342 (-3.2A)
 1.50A 5vlmF-5aogA:
undetectable		 5vlmF-5aogA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		5 ALA A 337
GLY A 330
LEU A  45
CYH A 251
PHE A 314
 None
None
None
None
BMA  A 401 (-3.9A)
 1.41A 5vlmF-5b0sA:
undetectable		 5vlmF-5b0sA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		5 ALA A 407
GLY A 410
SER A 411
LEU A 414
ASP A 424
 None
 1.30A 5vlmF-5dm3A:
undetectable		 5vlmF-5dm3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 MET A 339
ALA A 324
GLY A 368
GLU A 370
LEU A 329
 None
 1.48A 5vlmF-5gtkA:
undetectable		 5vlmF-5gtkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hf4 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLN A 374
ALA A 370
GLY A 330
GLU A 331
PHE A 400
 None
 1.27A 5vlmF-5hf4A:
undetectable		 5vlmF-5hf4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 110
GLY A 107
SER A 108
LEU A 124
ASP A 177
 None
 1.50A 5vlmF-5jscA:
undetectable		 5vlmF-5jscA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 5 GLN A 141
GLY A 120
SER A 119
GLU A 118
LEU A  74
 None
 1.26A 5vlmF-5mu5A:
4.1		 5vlmF-5mu5A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 5 ALA A  25
GLY A  21
GLU A  20
TYR A 227
PHE A  17
 None
 1.49A 5vlmF-5o3zA:
undetectable		 5vlmF-5o3zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		5 ALA A 162
GLY A 165
SER A 164
LEU A 239
ASP A 211
 None
None
HEM  A 301 (-3.0A)
None
CA  A 302 (-3.3A)
 1.47A 5vlmF-5twtA:
undetectable		 5vlmF-5twtA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 9 MET A  67
GLY A  88
SER A  89
GLU A  90
LEU A  94
CYH A 160
ASP A 163
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
MGR  A 300 ( 2.9A)
MGR  A 300 ( 4.8A)
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.86A 5vlmF-5vlgA:
29.2		 5vlmF-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
GLY A  88
GLU A  90
LEU A  94
CYH A 160
ASP A 163
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 2.9A)
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.75A 5vlmF-5vlgA:
29.2		 5vlmF-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  86
GLY A 148
GLU A 147
LEU A 131
ASP A 125
 None
 1.40A 5vlmF-5wrpA:
undetectable		 5vlmF-5wrpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 1
NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13

(Homo sapiens;
Homo sapiens) 		PF15879
(MWFE)
PF06212
(GRIM-19) 		5 SER S  46
GLU S  49
LEU S  47
TYR W 143
PHE W 140
 None
None
None
None
PEE  W 201 (-3.5A)
 1.29A 5vlmF-5xtcS:
undetectable		 5vlmF-5xtcS:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 5 MET A 289
ALA A 292
GLY A 295
SER A 294
LEU A 298
 None
 1.46A 5vlmF-6bkaA:
undetectable		 5vlmF-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzt DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Salmonella
enterica) 		PF00908
(dTDP_sugar_isom) 		4 ILE A 147
TRP A 158
VAL A  85
ASP A  88
 None
 1.05A 5vlmF-1dztA:
undetectable		 5vlmF-1dztA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens;
Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		4 ARG A 408
GLN A 378
VAL B  18
ASP A 113
 None
 1.17A 5vlmF-1i7qA:
undetectable		 5vlmF-1i7qA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE A 403
GLN A 368
VAL A 373
ASP A 396
 None
 1.17A 5vlmF-1ldjA:
0.5		 5vlmF-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 169
ARG A 158
VAL A 172
ASP A  84
 None
None
None
CIT  A 501 (-2.8A)
 0.97A 5vlmF-1m0sA:
0.4		 5vlmF-1m0sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 168
ARG A 157
VAL A 171
ASP A  84
 None
None
None
ABF  A1269 (-2.6A)
 1.12A 5vlmF-1o8bA:
0.0		 5vlmF-1o8bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		4 ILE B 110
TRP B 131
GLN B 132
VAL B 138
 None
 0.82A 5vlmF-1spgB:
0.0		 5vlmF-1spgB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 ILE A 587
ARG A 589
GLN A 557
ASP A 578
 None
 1.11A 5vlmF-1ulvA:
1.6		 5vlmF-1ulvA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 397
TYR A 369
TRP A 351
VAL A 547
 None
 1.05A 5vlmF-1v5fA:
0.0		 5vlmF-1v5fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		4 ILE A 209
GLN A 252
TYR A 256
VAL A 284
 None
 1.10A 5vlmF-1v6yA:
0.0		 5vlmF-1v6yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 194
ARG A 190
TRP A 199
ASP A 278
 BR  A1645 ( 4.4A)
None
None
None
 1.14A 5vlmF-1w99A:
1.4		 5vlmF-1w99A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ILE A 112
TYR A  84
VAL A  95
ASP A 118
 None
 1.09A 5vlmF-1yx2A:
undetectable		 5vlmF-1yx2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9w DIHYDRONEOPTERIN
ALDOLASE

(Mycobacterium
tuberculosis) 		PF02152
(FolB) 		4 ILE A  37
ARG A  89
GLN A  88
VAL A  84
 None
 1.14A 5vlmF-1z9wA:
undetectable		 5vlmF-1z9wA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		4 ILE A  28
TYR A 167
VAL A 195
ASP A 238
 None
 1.17A 5vlmF-2bgkA:
undetectable		 5vlmF-2bgkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ILE A 254
TYR A 375
TRP A 302
VAL A 250
 None
 1.03A 5vlmF-2g3nA:
undetectable		 5vlmF-2g3nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		4 ILE A 207
GLN A 250
TYR A 254
VAL A 282
 None
 1.14A 5vlmF-2hisA:
undetectable		 5vlmF-2hisA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis) 		PF11721
(Malectin) 		4 ILE A 117
GLN A  98
VAL A 112
ASP A 128
 None
 1.04A 5vlmF-2jwpA:
undetectable		 5vlmF-2jwpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyb DIHYDROFOLATE
REDUCTASE

(Haloferax
volcanii) 		PF00186
(DHFR_1) 		4 ILE A 100
GLN A 110
VAL A 117
ASP A  29
 None
 0.90A 5vlmF-2jybA:
undetectable		 5vlmF-2jybA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgf CAPSID PROTEIN P27

(Mason-Pfizer
monkey virus) 		PF00607
(Gag_p24) 		4 ILE A  44
TRP A  74
VAL A  65
ASP A  20
 None
 1.12A 5vlmF-2kgfA:
undetectable		 5vlmF-2kgfA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 292
GLN A 340
TYR A 299
ASP A 447
 None
 1.15A 5vlmF-2pz1A:
undetectable		 5vlmF-2pz1A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv CARBON CATABOLITE
DEREPRESSING PROTEIN
KINASE
PROTEIN SIP2
NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF16579
(AdenylateSensor)
PF04739
(AMPKBI)
PF16561
(AMPK1_CBM)
PF00571
(CBS) 		4 ILE C  42
GLN B 406
TYR A 613
VAL C 164
 None
 1.05A 5vlmF-2qlvC:
undetectable		 5vlmF-2qlvC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ILE A 194
TYR A  38
VAL A 225
ASP A 221
 None
 1.16A 5vlmF-2r66A:
undetectable		 5vlmF-2r66A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		4 ILE A 186
TYR A 201
VAL A 251
ASP A 265
 None
HEM  A 600 (-4.2A)
None
None
 1.14A 5vlmF-2r7aA:
undetectable		 5vlmF-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6c PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Mus musculus) 		PF00557
(Peptidase_M24) 		4 GLN A 242
TYR A 309
VAL A  45
ASP A  53
 None
 1.09A 5vlmF-2v6cA:
undetectable		 5vlmF-2v6cA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		4 ILE A 107
GLN A  44
TRP A 242
ASP A 227
 None
None
None
TRS  A1281 (-3.4A)
 1.03A 5vlmF-2vhaA:
undetectable		 5vlmF-2vhaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 499
TYR A 592
TRP A 508
VAL A 495
 None
 0.90A 5vlmF-2x40A:
undetectable		 5vlmF-2x40A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 ILE A 184
TYR A 180
VAL A 277
ASP A 254
 None
 1.04A 5vlmF-2yh2A:
undetectable		 5vlmF-2yh2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ILE A 176
TYR A 172
VAL A 266
ASP A 243
 None
 1.03A 5vlmF-3ailA:
undetectable		 5vlmF-3ailA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A  93
ARG A 104
GLN A 105
VAL A 203
 None
 1.15A 5vlmF-3awkA:
undetectable		 5vlmF-3awkA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ILE A 369
TYR A 500
TRP A 424
VAL A 365
 None
 0.91A 5vlmF-3cttA:
undetectable		 5vlmF-3cttA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsq PYRROLYSYL-TRNA
SYNTHETASE

(Desulfitobacterium
hafniense) 		PF01409
(tRNA-synt_2d) 		4 ILE A 263
ARG A 259
VAL A 223
ASP A 227
 None
 1.03A 5vlmF-3dsqA:
undetectable		 5vlmF-3dsqA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 168
ARG A 157
VAL A 171
ASP A  84
 None
 1.01A 5vlmF-3enqA:
undetectable		 5vlmF-3enqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ILE A 239
ARG A1029
VAL A 280
ASP A 273
 None
 1.14A 5vlmF-3f2bA:
undetectable		 5vlmF-3f2bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		4 ILE A 147
TRP A 148
TYR A  21
VAL A  43
 None
None
SAH  A 308 (-4.6A)
None
 0.96A 5vlmF-3g5tA:
undetectable		 5vlmF-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 196
ARG A 364
VAL A 212
ASP A 201
 None
 1.03A 5vlmF-3h5cA:
undetectable		 5vlmF-3h5cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 ILE A 235
ARG A 237
VAL A 136
ASP A 210
 None
 1.17A 5vlmF-3hgqA:
undetectable		 5vlmF-3hgqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		4 ILE A  46
TRP A  87
TRP A 108
VAL A  77
 None
 1.11A 5vlmF-3hv1A:
undetectable		 5vlmF-3hv1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN

(Oleispira
antarctica) 		PF13419
(HAD_2) 		4 ARG A 107
GLN A 100
TYR A 134
ASP A 223
 None
 1.16A 5vlmF-3iruA:
undetectable		 5vlmF-3iruA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLN A 242
TYR A 309
VAL A  45
ASP A  53
 None
 1.16A 5vlmF-3j2iA:
undetectable		 5vlmF-3j2iA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5

(Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 ILE G  75
GLN G  80
TRP G  41
VAL G  51
 None
 1.14A 5vlmF-3j7aG:
undetectable		 5vlmF-3j7aG:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ILE D 574
ARG D 604
VAL D 564
ASP D 542
 None
 1.13A 5vlmF-3j9pD:
undetectable		 5vlmF-3j9pD:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		4 ILE A 157
ARG A 156
VAL A  72
ASP A  65
 TMP  A 214 (-3.3A)
None
TYD  A 215 (-4.1A)
CL  A 222 ( 4.7A)
 1.10A 5vlmF-3lv8A:
1.4		 5vlmF-3lv8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyb PUTATIVE
ENDORIBONUCLEASE

(Klebsiella
pneumoniae) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A  29
GLN A  99
TYR A 110
VAL A  94
 None
 1.08A 5vlmF-3lybA:
undetectable		 5vlmF-3lybA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ILE A 243
ARG A 281
GLN A 280
ASP A 236
 None
None
PG4  A 607 ( 4.4A)
None
 0.94A 5vlmF-3m07A:
undetectable		 5vlmF-3m07A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1

(Necator
americanus) 		PF00188
(CAP) 		4 ILE A 356
TRP A 349
ARG A 351
ASP A 259
 None
 1.16A 5vlmF-3nt8A:
undetectable		 5vlmF-3nt8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A 237
GLN A 276
VAL A 230
ASP A  83
 None
 1.06A 5vlmF-3pv4A:
undetectable		 5vlmF-3pv4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		4 ILE A  63
GLN A  60
VAL A  54
ASP A  23
 None
 1.03A 5vlmF-3rnrA:
undetectable		 5vlmF-3rnrA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5q PUTATIVE
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 TRP A 121
ARG A 122
GLN A 105
TYR A 127
 None
 1.14A 5vlmF-3s5qA:
undetectable		 5vlmF-3s5qA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 181
ARG A 165
VAL A 184
ASP A  92
 None
None
None
EDO  A 237 (-3.4A)
 1.05A 5vlmF-3u7jA:
undetectable		 5vlmF-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLN A 141
TYR A 142
VAL A 109
ASP A  22
 None
 1.12A 5vlmF-3v98A:
undetectable		 5vlmF-3v98A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpc PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Sulfurisphaera
tokodaii) 		PF08443
(RimK) 		4 ILE A 180
TYR A 275
VAL A 226
ASP A 237
 None
 1.11A 5vlmF-3vpcA:
undetectable		 5vlmF-3vpcA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 ILE A 243
TRP A 218
VAL A 195
ASP A 199
 None
 1.11A 5vlmF-3vx6A:
undetectable		 5vlmF-3vx6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A) 		PF00947
(Pico_P2A) 		4 ILE A  53
GLN A   5
VAL A  17
ASP A 136
 None
 1.09A 5vlmF-3w95A:
undetectable		 5vlmF-3w95A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		4 ILE A 442
GLN A 479
VAL A 417
ASP A 445
 None
 1.02A 5vlmF-3wsyA:
undetectable		 5vlmF-3wsyA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		4 ILE A 245
GLN A 288
TYR A 292
VAL A 320
 None
 1.08A 5vlmF-3wufA:
undetectable		 5vlmF-3wufA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		4 ILE A  84
ARG A  76
VAL A  71
ASP A  49
 None
 1.13A 5vlmF-4cbvA:
undetectable		 5vlmF-4cbvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 ILE A  76
TYR A 261
VAL A  81
ASP A 120
 None
 1.15A 5vlmF-4d8uA:
undetectable		 5vlmF-4d8uA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		4 ILE B 289
TRP B 292
ARG B 293
ASP B 107
 None
 0.98A 5vlmF-4di4B:
undetectable		 5vlmF-4di4B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		4 ILE A  16
TYR A 159
VAL A 187
ASP A 226
 None
 1.14A 5vlmF-4e3zA:
undetectable		 5vlmF-4e3zA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2l 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		no annotation 4 ILE A 328
ARG A 331
VAL A 296
ASP A 290
 None
 1.17A 5vlmF-4f2lA:
undetectable		 5vlmF-4f2lA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE

(Penicillium
canescens) 		PF00331
(Glyco_hydro_10) 		4 ILE A 242
GLN A 289
TYR A 293
VAL A 322
 None
 1.10A 5vlmF-4f8xA:
undetectable		 5vlmF-4f8xA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzl BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 ILE A 213
TRP A 221
ARG A 176
VAL A 168
 None
 1.16A 5vlmF-4fzlA:
1.9		 5vlmF-4fzlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 ILE A 213
TRP A 221
ARG A 176
VAL A 168
 None
 0.98A 5vlmF-4fznA:
1.6		 5vlmF-4fznA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 174
ARG A 163
VAL A 177
ASP A  90
 None
None
None
PO4  A 306 ( 4.8A)
 1.04A 5vlmF-4io1A:
undetectable		 5vlmF-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 116
ARG A  92
GLN A  91
VAL A 165
 None
 1.15A 5vlmF-4j8lA:
undetectable		 5vlmF-4j8lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 TRP A 471
TYR A 472
TRP A 521
VAL A 563
 None
1KV  A 701 (-3.8A)
None
None
 0.98A 5vlmF-4jhzA:
undetectable		 5vlmF-4jhzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 ILE A 467
TRP A 464
TYR A 455
VAL A 390
 None
 1.05A 5vlmF-4jw1A:
2.3		 5vlmF-4jw1A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 895
TRP A 868
GLN A 904
VAL A 928
 None
 1.17A 5vlmF-4kxbA:
undetectable		 5vlmF-4kxbA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A) 		PF00947
(Pico_P2A) 		4 ILE A  53
GLN A   5
VAL A  17
ASP A 136
 None
 1.10A 5vlmF-4mg3A:
undetectable		 5vlmF-4mg3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 TRP A 114
GLN A  65
TRP A 158
VAL A 122
 VIB  A 401 (-3.7A)
None
VIB  A 401 (-4.0A)
None
 0.97A 5vlmF-4nmyA:
undetectable		 5vlmF-4nmyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofn GLUTATHIONE
S-TRANSFERASE-1

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  11
TYR A 107
VAL A  51
ASP A  31
 None
None
GSH  A 301 (-4.5A)
None
 1.16A 5vlmF-4ofnA:
undetectable		 5vlmF-4ofnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		4 ILE A 329
TYR A 295
VAL A 358
ASP A  39
 None
 1.04A 5vlmF-4ojzA:
2.4		 5vlmF-4ojzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		4 ILE C 422
ARG C 426
TYR C 387
ASP C 364
 None
None
U  D  21 ( 4.8A)
None
 1.07A 5vlmF-4oogC:
undetectable		 5vlmF-4oogC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 ILE A 241
GLN A  84
VAL A 102
ASP A 109
 None
 1.02A 5vlmF-4p47A:
undetectable		 5vlmF-4p47A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		4 ILE A  33
ARG A  36
GLN A  39
TYR A  74
 None
 0.88A 5vlmF-4q88A:
undetectable		 5vlmF-4q88A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2

(Pseudomonas
aeruginosa) 		no annotation 4 ILE B 588
TRP B 612
VAL B 615
ASP B 594
 None
 1.16A 5vlmF-4qkoB:
undetectable		 5vlmF-4qkoB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  91
GLN A 122
VAL A 100
ASP A 227
 None
38Z  A 418 (-3.7A)
None
None
 1.14A 5vlmF-4qtbA:
undetectable		 5vlmF-4qtbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 ARG Q 388
TRP Q 442
VAL Q 435
ASP Q 114
 None
GOL  Q1561 ( 4.4A)
None
CSX  Q  75 ( 4.5A)
 1.10A 5vlmF-4upeQ:
1.8		 5vlmF-4upeQ:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 172
ARG A 161
VAL A 175
ASP A  88
 None
None
None
FLC  A 300 (-2.8A)
 1.00A 5vlmF-4x84A:
undetectable		 5vlmF-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 ILE A 649
ARG A 647
GLN A 563
VAL A 555
 None
 1.03A 5vlmF-4yj1A:
undetectable		 5vlmF-4yj1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		4 ILE A 336
ARG A 335
VAL A 329
ASP A 406
 None
 1.04A 5vlmF-5bukA:
undetectable		 5vlmF-5bukA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 ILE A 375
TYR A 275
VAL A 249
ASP A 370
 EDO  A 408 ( 4.4A)
None
None
None
 1.09A 5vlmF-5ex8A:
undetectable		 5vlmF-5ex8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 ILE A  84
GLN A  91
TYR A 123
VAL A 107
 LMT  A 602 (-3.9A)
LMT  A 602 (-2.8A)
None
LMT  A 602 ( 4.8A)
 1.08A 5vlmF-5fgnA:
undetectable		 5vlmF-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmv RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF00041
(fn3)
PF12567
(CD45) 		4 ILE A 233
TYR A 237
VAL A 279
ASP A 227
 None
 1.00A 5vlmF-5fmvA:
undetectable		 5vlmF-5fmvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF00041
(fn3)
PF12567
(CD45) 		4 ILE A  18
TYR A  22
VAL A  64
ASP A  12
 None
 0.96A 5vlmF-5fn6A:
undetectable		 5vlmF-5fn6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF12567
(CD45) 		4 ILE A  18
TYR A  22
VAL A  64
ASP A  12
 None
 0.99A 5vlmF-5fn7A:
undetectable		 5vlmF-5fn7A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 TRP A 223
ARG A 224
GLN A 228
TRP A 244
 None
 1.12A 5vlmF-5l9sA:
undetectable		 5vlmF-5l9sA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 ILE A 446
TYR A 575
TRP A 499
VAL A 442
 None
 0.98A 5vlmF-5nn8A:
undetectable		 5vlmF-5nn8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ARG A 316
GLN A 287
VAL A 392
ASP A 467
 EDO  A 904 ( 4.6A)
None
None
None
 1.14A 5vlmF-5t98A:
undetectable		 5vlmF-5t98A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 169
ARG A 158
VAL A 172
ASP A  85
 None
None
None
EDO  A 306 (-3.5A)
 1.07A 5vlmF-5uf2A:
undetectable		 5vlmF-5uf2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
14

(Homo sapiens) 		PF00004
(AAA) 		4 ILE c 203
ARG c 161
TYR c 200
VAL c 143
 None
 1.16A 5vlmF-5vhic:
2.1		 5vlmF-5vhic:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 ILE A  98
TRP A 101
ARG A 102
GLN A 105
TYR A 118
TRP A 125
VAL A 159
ASP A 175
 MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-4.4A)
MGR  A 300 ( 4.3A)
 0.48A 5vlmF-5vlgA:
29.2		 5vlmF-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE

(Cryptococcus
neoformans) 		no annotation 4 ILE A 143
GLN A 305
VAL A 289
ASP A 118
 None
 1.15A 5vlmF-5w4cA:
undetectable		 5vlmF-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 4 ILE A 221
GLN A 266
TYR A 270
VAL A 298
 None
 1.17A 5vlmF-5xzuA:
1.0		 5vlmF-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 ILE B 555
ARG B 533
GLN B 534
TYR A 335
 None
 1.15A 5vlmF-5y58B:
undetectable		 5vlmF-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 4 ILE B 120
TRP B 154
VAL B 140
ASP B 164
 None
 0.84A 5vlmF-5yllB:
undetectable		 5vlmF-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca) 		no annotation 4 ILE M  36
TYR M 137
VAL M  45
ASP M  52
 None
U  J   2 ( 3.1A)
None
None
 1.13A 5vlmF-6c66M:
undetectable		 5vlmF-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 TRP X 569
ARG X 171
VAL X 535
ASP X 548
 None
 1.08A 5vlmF-6elqX:
undetectable		 5vlmF-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A1023
TYR A1157
VAL A1116
ASP A1058
 None
 1.02A 5vlmF-6eojA:
undetectable		 5vlmF-6eojA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 ILE E  31
GLN E  43
VAL E  69
ASP E  22
 None
 1.12A 5vlmF-6g72E:
undetectable		 5vlmF-6g72E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 4 ILE A  27
ARG A 123
TYR A  40
ASP A  21
 None
 0.91A 5vlmF-6ghcA:
undetectable		 5vlmF-6ghcA:
undetectable