SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_E_CVIE301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 193
GLN A 287
TYR A 289
ASP A 196
 None
 1.05A 5vlmE-1fepA:
undetectable		 5vlmE-1fepA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 GLY A 374
TYR A 294
TRP A 313
ASP A  50
 None
 0.96A 5vlmE-1fp3A:
undetectable		 5vlmE-1fp3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 256
GLY A 252
ASP A 122
ASP A 299
 None
 1.09A 5vlmE-1guzA:
0.0		 5vlmE-1guzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 GLY A 307
GLN A 222
TYR A 224
ASP A 436
 None
CL  A 530 (-3.7A)
None
CA  A   3 ( 4.5A)
 1.13A 5vlmE-1ktwA:
undetectable		 5vlmE-1ktwA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.82A 5vlmE-1mqsA:
2.7		 5vlmE-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 GLN A 332
GLY A 331
GLN A 469
TRP A 320
 None
 1.14A 5vlmE-1ms8A:
undetectable		 5vlmE-1ms8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.01A 5vlmE-1rm8A:
0.3		 5vlmE-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 GLN A  63
GLY A  48
GLN A 321
ASP A  52
 GLC  A 503 ( 3.9A)
None
None
None
 1.09A 5vlmE-1ua7A:
undetectable		 5vlmE-1ua7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 GLY A 382
GLN A 403
ASP A 400
ASP A 415
 None
IFL  A1432 ( 3.6A)
None
None
 1.13A 5vlmE-1uz4A:
undetectable		 5vlmE-1uz4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 GLN A  59
GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.14A 5vlmE-1wzzA:
undetectable		 5vlmE-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 GLN A 465
GLY A 120
TRP A 128
ASP A 115
 None
 1.11A 5vlmE-1z14A:
undetectable		 5vlmE-1z14A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 GLN A 223
GLY A 221
TYR A  52
ASP A 310
 NAD  A1350 (-4.7A)
None
None
NAD  A1350 (-4.6A)
 1.06A 5vlmE-1z9aA:
0.0		 5vlmE-1z9aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLN X 244
GLY X 251
TRP X 246
ASP X 322
 None
 0.97A 5vlmE-2b5dX:
1.6		 5vlmE-2b5dX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 GLN A 280
GLN A 301
TYR A 309
TRP A 260
 None
 1.16A 5vlmE-2d4vA:
2.3		 5vlmE-2d4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.00A 5vlmE-2dlcX:
undetectable		 5vlmE-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLN A 124
GLY A 165
GLN A 287
ASP A  13
 None
None
G  C  70 ( 4.0A)
None
 1.11A 5vlmE-2fmtA:
undetectable		 5vlmE-2fmtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		4 GLY A 364
TYR A 284
TRP A 303
ASP A  47
 None
 0.97A 5vlmE-2gz6A:
1.4		 5vlmE-2gz6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1t HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06475
(Glycolipid_bind) 		4 GLY A  83
GLN A 145
ASP A 101
ASP A  54
 None
 0.74A 5vlmE-2h1tA:
undetectable		 5vlmE-2h1tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		4 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.97A 5vlmE-2hs5A:
1.5		 5vlmE-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		4 GLY A 283
GLN A 312
TYR A   6
ASP A 276
 None
 0.97A 5vlmE-2i7gA:
undetectable		 5vlmE-2i7gA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 0.95A 5vlmE-2j2mA:
undetectable		 5vlmE-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.09A 5vlmE-2jcjA:
undetectable		 5vlmE-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 GLY A  84
TYR A  96
ASP A 118
ASP A 128
 None
 1.01A 5vlmE-2pbgA:
undetectable		 5vlmE-2pbgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107

(Mycobacterium
tuberculosis) 		PF10862
(FcoT) 		4 GLN A  45
GLY A  57
GLN A 114
TYR A 110
 None
 0.99A 5vlmE-2pfcA:
undetectable		 5vlmE-2pfcA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv3 CHAPERONE SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N) 		4 GLN A  85
GLY A  84
GLN A  95
ASP A  77
 None
 1.10A 5vlmE-2pv3A:
2.5		 5vlmE-2pv3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLN A 396
GLY A 258
TYR A 296
ASP A 137
 None
FAD  A1594 (-3.3A)
None
FAD  A1594 (-4.1A)
 1.12A 5vlmE-2v6oA:
undetectable		 5vlmE-2v6oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 GLN B 356
GLY B 355
GLN B 228
ASP B 431
 None
 1.16A 5vlmE-2wfxB:
undetectable		 5vlmE-2wfxB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 260
GLY A 258
TYR A 215
ASP A 232
 None
 1.08A 5vlmE-2y6cA:
undetectable		 5vlmE-2y6cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.13A 5vlmE-2yokA:
undetectable		 5vlmE-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 868
TYR A1006
ASP A 910
ASP A 839
 None
 1.07A 5vlmE-2zxqA:
2.8		 5vlmE-2zxqA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 GLY A 153
GLN A  54
TYR A  56
ASP A 192
 None
GOL  A 441 ( 3.7A)
None
None
 1.16A 5vlmE-3cc1A:
undetectable		 5vlmE-3cc1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		4 GLN A 118
GLY A 120
TYR A  83
ASP A 174
 None
None
None
ADP  A1211 (-2.7A)
 0.90A 5vlmE-3cr3A:
undetectable		 5vlmE-3cr3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 GLN A  17
GLY A 319
GLN A 364
TRP A 460
ASP A  12
 None
None
None
None
ZN  A 602 (-2.2A)
 1.47A 5vlmE-3e2dA:
3.4		 5vlmE-3e2dA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 842
TYR A 963
ASP A 884
ASP A 813
 None
None
None
GOL  A2003 (-3.6A)
 1.11A 5vlmE-3ecqA:
undetectable		 5vlmE-3ecqA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 GLY A  81
TRP A 441
ASP A 150
ASP A 186
 None
 1.09A 5vlmE-3eqaA:
1.4		 5vlmE-3eqaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A  62
TYR A 190
ASP A 139
ASP A  65
 None
 1.10A 5vlmE-3h6tA:
undetectable		 5vlmE-3h6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		4 GLN A1371
GLY A1366
GLN A1456
ASP A1360
 None
 1.11A 5vlmE-3hrrA:
undetectable		 5vlmE-3hrrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 GLN A 303
TYR A 291
TRP A 371
ASP A  42
 None
None
EDO  A  11 (-4.5A)
EDO  A   8 (-4.4A)
 1.01A 5vlmE-3i09A:
undetectable		 5vlmE-3i09A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 GLN T 132
TYR T 147
TRP T 218
ASP T 184
 None
 0.95A 5vlmE-3icqT:
2.2		 5vlmE-3icqT:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis) 		PF00383
(dCMP_cyt_deam_1) 		4 GLN X  15
GLY X  30
ASP X  80
ASP X 107
 None
 1.11A 5vlmE-3ijfX:
undetectable		 5vlmE-3ijfX:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Yersinia pestis) 		PF02348
(CTP_transf_3) 		4 GLN A  98
GLY A  99
GLN A 237
ASP A  50
 None
 1.14A 5vlmE-3jtjA:
undetectable		 5vlmE-3jtjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		4 GLN K 409
GLY K  83
GLN K 207
ASP K 188
 None
 1.15A 5vlmE-3mvdK:
undetectable		 5vlmE-3mvdK:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY A 318
TYR A 126
ASP A 428
ASP B 219
 None
 1.15A 5vlmE-3ojyA:
undetectable		 5vlmE-3ojyA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 210
GLN A 245
ASP A 207
ASP A 167
 None
None
None
MG  A 326 (-2.4A)
 1.13A 5vlmE-3p4gA:
undetectable		 5vlmE-3p4gA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M) 		PF04744
(Monooxygenase_B) 		4 GLY A  65
TYR A 341
TRP A  50
ASP A 117
 None
 1.10A 5vlmE-3rfrA:
undetectable		 5vlmE-3rfrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 4 GLY B  98
GLN B  20
TYR B 113
ASP B  25
 None
 1.00A 5vlmE-3s5cB:
undetectable		 5vlmE-3s5cB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt6 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Bacillus
subtilis) 		PF00574
(CLP_protease) 		4 GLN A 159
GLY A 183
GLN A  81
TYR A  77
 None
 1.09A 5vlmE-3tt6A:
undetectable		 5vlmE-3tt6A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 GLN A  17
GLY A 315
GLN A 360
TRP A 456
ASP A  12
 None
None
None
None
ZN  A 505 ( 2.1A)
 1.49A 5vlmE-3wbhA:
3.3		 5vlmE-3wbhA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 GLN A 193
GLY A 237
TYR A  67
ASP A 228
 None
 1.14A 5vlmE-3wrcA:
undetectable		 5vlmE-3wrcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2

(Homo sapiens) 		PF10250
(O-FucT) 		4 GLN A  99
GLY A 365
TYR A  48
TRP A  86
 CL  A1432 (-4.0A)
CL  A1432 (-4.2A)
None
None
 1.14A 5vlmE-4ap5A:
undetectable		 5vlmE-4ap5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 136
GLN A 357
TYR A 365
ASP A 139
 None
HEM  A3000 (-3.7A)
None
None
 0.85A 5vlmE-4b7gA:
2.8		 5vlmE-4b7gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLN A  81
GLY A  88
ASP A 276
ASP A 214
 None
 1.12A 5vlmE-4bedA:
2.5		 5vlmE-4bedA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		4 GLY A 374
GLN A 190
TYR A 194
ASP A 327
 None
 1.15A 5vlmE-4bokA:
1.4		 5vlmE-4bokA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 0.92A 5vlmE-4cabA:
undetectable		 5vlmE-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crw PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00271
(Helicase_C) 		4 GLN B 300
GLY B 412
GLN B 325
ASP B 381
 None
 1.12A 5vlmE-4crwB:
undetectable		 5vlmE-4crwB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		4 GLN A 269
GLY A 327
GLN A 292
ASP A 333
 None
 1.16A 5vlmE-4csiA:
undetectable		 5vlmE-4csiA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 GLY A 810
GLN A 892
ASP A 861
ASP A 434
 None
 1.16A 5vlmE-4ecnA:
undetectable		 5vlmE-4ecnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 GLN A 169
GLY A 195
ASP A 241
ASP A 260
 None
None
CA  A 601 (-2.0A)
None
 1.10A 5vlmE-4hwvA:
undetectable		 5vlmE-4hwvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A  45
GLY A  36
GLN A 180
ASP A 332
 None
 1.03A 5vlmE-4iigA:
undetectable		 5vlmE-4iigA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 GLN A 697
GLY A 816
GLN A 852
ASP A 818
 None
 1.15A 5vlmE-4k0eA:
undetectable		 5vlmE-4k0eA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 GLN A 430
GLY A 431
GLN A 580
ASP A 434
 None
 1.05A 5vlmE-4krfA:
undetectable		 5vlmE-4krfA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 GLN A 104
TYR A 372
ASP A  63
ASP A 112
 None
 1.08A 5vlmE-4l9mA:
2.3		 5vlmE-4l9mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 GLN A 281
GLY A 300
GLN A 414
ASP A 309
 None
 1.00A 5vlmE-4nzjA:
undetectable		 5vlmE-4nzjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 GLY A 216
GLN A 224
ASP A 132
ASP A 475
 None
 1.03A 5vlmE-4ofzA:
undetectable		 5vlmE-4ofzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		4 GLY A 251
GLN A 412
TYR A 416
ASP A 204
 None
 1.03A 5vlmE-4ovjA:
undetectable		 5vlmE-4ovjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLN A 144
GLY A 143
ASP A 267
ASP A 130
 None
 1.13A 5vlmE-4qhbA:
undetectable		 5vlmE-4qhbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 123
GLN A 344
TYR A 352
ASP A 126
 None
HEM  A 502 ( 3.7A)
None
None
 0.83A 5vlmE-4qorA:
undetectable		 5vlmE-4qorA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.33A 5vlmE-4rkuA:
undetectable		 5vlmE-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.09A 5vlmE-4rs3A:
undetectable		 5vlmE-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 GLN B  21
GLY B 300
GLN B 364
ASP B 146
 None
 1.01A 5vlmE-4tx2B:
undetectable		 5vlmE-4tx2B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.09A 5vlmE-4uomL:
undetectable		 5vlmE-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLN A 224
GLY A 220
GLN A 150
ASP A 248
 None
 1.09A 5vlmE-4wwhA:
undetectable		 5vlmE-4wwhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 GLN A 318
GLY A 266
GLN A 421
ASP A 262
 None
 1.04A 5vlmE-4xhbA:
undetectable		 5vlmE-4xhbA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY A  24
GLN B  87
ASP A  91
ASP A  29
 None
 1.09A 5vlmE-4z0xA:
undetectable		 5vlmE-4z0xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLN A 180
GLN A  63
TYR A  59
ASP A 102
 ZN  A 304 ( 2.5A)
EDO  A 307 ( 3.5A)
None
None
 1.14A 5vlmE-4zfzA:
undetectable		 5vlmE-4zfzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 842
TYR A 963
ASP A 884
ASP A 813
 None
 1.09A 5vlmE-5a55A:
undetectable		 5vlmE-5a55A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A 368
GLY A 192
TYR A 147
ASP A 195
 None
 0.97A 5vlmE-5a7mA:
undetectable		 5vlmE-5a7mA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Staphylococcus
aureus) 		PF00574
(CLP_protease) 		4 GLN A 160
GLY A 184
GLN A  82
TYR A  78
 None
 1.14A 5vlmE-5c90A:
undetectable		 5vlmE-5c90A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLN A 162
GLY A 142
GLN A 191
ASP A  95
 None
CL  A 602 ( 4.1A)
None
None
 1.16A 5vlmE-5cniA:
undetectable		 5vlmE-5cniA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 4 GLN B 123
GLY B  54
GLN B  13
TYR B   8
 None
 1.07A 5vlmE-5e9uB:
undetectable		 5vlmE-5e9uB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 406
GLN A 388
TYR A 500
ASP A 395
 None
 1.17A 5vlmE-5f7sA:
undetectable		 5vlmE-5f7sA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 GLN A 509
GLY A 450
GLN A 485
TYR A 598
 None
 0.97A 5vlmE-5f7uA:
undetectable		 5vlmE-5f7uA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  76
TYR A 512
TRP A  69
ASP A  93
 None
PEG  A6002 ( 4.1A)
None
PEG  A6002 (-3.3A)
 0.97A 5vlmE-5fjjA:
undetectable		 5vlmE-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 GLY A 298
GLN A  99
TYR A  97
ASP A 144
 None
 1.12A 5vlmE-5i39A:
undetectable		 5vlmE-5i39A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.98A 5vlmE-5ixmA:
undetectable		 5vlmE-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  75
TYR A 507
TRP A  68
ASP A  92
 None
None
None
BGC  A 946 (-3.0A)
 1.03A 5vlmE-5ju6A:
undetectable		 5vlmE-5ju6A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 GLN A  26
GLY A  22
GLN A 395
ASP A 207
 None
 1.09A 5vlmE-5jy9A:
undetectable		 5vlmE-5jy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLN A 720
GLY A 699
GLN A 814
ASP A 621
 TNR  A1002 (-3.1A)
None
None
EDO  A1008 (-3.6A)
 1.09A 5vlmE-5kdxA:
1.8		 5vlmE-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLN A 210
GLY A 206
ASP A 234
ASP A 277
 None
 1.16A 5vlmE-5kufA:
undetectable		 5vlmE-5kufA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 GLN A 205
GLY A 220
ASP A 226
ASP A 240
 None
 0.91A 5vlmE-5m89A:
undetectable		 5vlmE-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		4 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.03A 5vlmE-5mdxC:
undetectable		 5vlmE-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 244
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.10A 5vlmE-5o5dA:
undetectable		 5vlmE-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 245
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.16A 5vlmE-5o5dA:
undetectable		 5vlmE-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 GLY A 127
GLN A  42
TYR A  38
ASP A 109
 None
 1.07A 5vlmE-5oe5A:
undetectable		 5vlmE-5oe5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLY A 149
GLN A 124
TYR A 129
ASP A 187
 None
 1.07A 5vlmE-5thhA:
undetectable		 5vlmE-5thhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 7 GLN A  71
GLY A  88
GLN A 105
TYR A 118
TRP A 125
ASP A 163
ASP A 175
 MGR  A 300 ( 4.1A)
MGR  A 300 ( 2.9A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 ( 4.3A)
 0.54A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 GLY A 115
GLN A  88
ASP A  85
ASP A 119
 None
None
None
GNP  A 203 (-2.0A)
 1.12A 5vlmE-5wdrA:
undetectable		 5vlmE-5wdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 4 GLN A 141
GLY A 107
GLN A 153
ASP A 102
 None
 1.14A 5vlmE-5ws4A:
undetectable		 5vlmE-5ws4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAD

(Cyanidioschyzon
merolae) 		no annotation 4 GLN D  75
GLN D 105
TYR D 104
ASP D  35
 None
 0.97A 5vlmE-5zgbD:
undetectable		 5vlmE-5zgbD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 GLY A  81
TRP A 441
ASP A 150
ASP A 186
 None
 1.06A 5vlmE-6frvA:
0.6		 5vlmE-6frvA:
undetectable