SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_E_CVIE301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ALA A 121
LEU A  59
ILE A  53
VAL A 134
TYR A  51
 None
 1.33A 5vlmE-1dysA:
undetectable		 5vlmE-1dysA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ALA A 125
LEU A  97
ILE A  96
VAL A 165
TYR A 105
 None
 1.36A 5vlmE-1efvA:
undetectable		 5vlmE-1efvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.24A 5vlmE-1g8wA:
undetectable		 5vlmE-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.45A 5vlmE-1gy8A:
0.0		 5vlmE-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		5 ALA A 129
LEU A 135
ARG A 113
VAL A 116
PHE A 148
 None
 1.31A 5vlmE-1j3bA:
undetectable		 5vlmE-1j3bA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H

(Thermus
thermophilus;
Escherichia
coli) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 133
 None
 1.31A 5vlmE-1jl2A:
undetectable		 5vlmE-1jl2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  35
GLU A 329
ILE A 331
ARG A  45
VAL A   4
 None
 1.32A 5vlmE-1jvbA:
undetectable		 5vlmE-1jvbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.25A 5vlmE-1jxnA:
undetectable		 5vlmE-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 ALA A 441
LEU A  85
ILE A  89
TRP A 434
VAL A 424
 None
 1.40A 5vlmE-1l1lA:
0.0		 5vlmE-1l1lA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		5 ALA A 225
LEU A 156
ILE A 155
VAL A 258
TYR A 254
 None
 1.46A 5vlmE-1lmlA:
0.0		 5vlmE-1lmlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		5 ALA A 121
LEU A 195
ILE A  58
VAL A 205
PHE A 228
 None
 1.28A 5vlmE-1n47A:
undetectable		 5vlmE-1n47A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 MET A 281
MET A 280
GLU A  24
VAL A  39
PHE A  52
 None
 1.16A 5vlmE-1nrwA:
undetectable		 5vlmE-1nrwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA B 475
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.28A 5vlmE-1pjmB:
2.1		 5vlmE-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		5 ALA A  57
GLU A  37
LEU A  17
ILE A  46
ARG A  21
 None
 1.23A 5vlmE-1t9kA:
undetectable		 5vlmE-1t9kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.35A 5vlmE-1vefA:
undetectable		 5vlmE-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 132
 None
 1.23A 5vlmE-1wsjA:
undetectable		 5vlmE-1wsjA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 MET A 420
ALA A 424
GLU A 356
LEU A 354
VAL A 362
 None
 1.20A 5vlmE-1xjeA:
undetectable		 5vlmE-1xjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.17A 5vlmE-2a81A:
undetectable		 5vlmE-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 ALA A 135
LEU A  73
ILE A  74
VAL A 111
TYR A  18
 None
 1.26A 5vlmE-2d2nA:
undetectable		 5vlmE-2d2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.43A 5vlmE-2de2A:
undetectable		 5vlmE-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		5 ALA A 185
GLU A 136
ILE A 170
VAL A 119
PHE A 133
 None
CD  A1004 (-2.8A)
None
None
None
 1.21A 5vlmE-2dvzA:
undetectable		 5vlmE-2dvzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		5 ALA A  53
LEU A 129
ILE A 128
VAL A  56
PHE A 206
 None
 1.45A 5vlmE-2f96A:
undetectable		 5vlmE-2f96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.28A 5vlmE-2fzwA:
undetectable		 5vlmE-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		5 ALA A 310
LEU A 348
ILE A 349
ARG A 274
PHE A 318
 None
None
SO4  A 382 (-4.0A)
SO4  A 382 (-3.8A)
None
 1.46A 5vlmE-2hkeA:
undetectable		 5vlmE-2hkeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		5 MET A 150
LEU A 111
ILE A 175
VAL A 103
PHE A 119
 None
 1.44A 5vlmE-2lxnA:
undetectable		 5vlmE-2lxnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 735
MET A 736
GLU A 615
LEU A 753
CYH A 606
 None
 1.40A 5vlmE-2psqA:
undetectable		 5vlmE-2psqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 MET A 396
ALA A  59
ILE A 423
VAL A 417
CYH A 416
 None
 1.39A 5vlmE-2q5oA:
undetectable		 5vlmE-2q5oA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ALA A  45
LEU A  40
ILE A  61
VAL A  68
PHE A  69
 None
 1.12A 5vlmE-2r9uA:
undetectable		 5vlmE-2r9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		5 GLU A 286
LEU A 285
ILE A 288
ARG A 291
VAL A 293
 None
 1.29A 5vlmE-2uv7A:
undetectable		 5vlmE-2uv7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.08A 5vlmE-2wghA:
undetectable		 5vlmE-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 ALA B 312
GLU B 322
LEU B 418
ILE B 422
VAL B 327
 None
 0.93A 5vlmE-2xdqB:
undetectable		 5vlmE-2xdqB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 ALA A 687
GLU A 596
ILE A 683
VAL A 647
PHE A 591
 None
 1.45A 5vlmE-3a5iA:
undetectable		 5vlmE-3a5iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		5 MET A  45
ALA A  41
LEU A  78
ILE A  48
VAL A  34
 None
 1.40A 5vlmE-3bdkA:
undetectable		 5vlmE-3bdkA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 ALA A  28
GLU A 108
LEU A  50
ILE A  51
VAL A 105
 None
 1.45A 5vlmE-3cq0A:
undetectable		 5vlmE-3cq0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.43A 5vlmE-3ct4A:
undetectable		 5vlmE-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A  17
LEU A  51
ILE A  54
VAL A 121
PHE A  30
 None
 1.39A 5vlmE-3d3uA:
undetectable		 5vlmE-3d3uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 ALA A  62
LEU A  83
ILE A  82
ARG A 142
PHE A 135
 None
 1.39A 5vlmE-3e9dA:
undetectable		 5vlmE-3e9dA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 ALA A 206
LEU A 185
VAL A 132
TYR A  93
PHE A 191
 None
 1.33A 5vlmE-3etvA:
2.4		 5vlmE-3etvA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 ALA A 269
LEU A  50
ILE A  52
VAL A 229
PHE A 236
 None
 1.44A 5vlmE-3fs2A:
undetectable		 5vlmE-3fs2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ALA A 271
GLU A 254
LEU A  42
ILE A  68
TYR A 124
 None
 1.41A 5vlmE-3holA:
undetectable		 5vlmE-3holA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A  65
LEU A  34
ILE A 148
VAL A  48
CYH A 115
 None
 1.42A 5vlmE-3k5wA:
undetectable		 5vlmE-3k5wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1

(Vibrio cholerae) 		PF01226
(Form_Nir_trans) 		5 MET A 213
ALA A 211
LEU A 127
ILE A  42
VAL A  81
 None
None
None
BOG  A 282 ( 4.1A)
None
 1.43A 5vlmE-3klyA:
undetectable		 5vlmE-3klyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		5 MET A 106
GLU A 282
LEU A 280
TYR A 237
PHE A 240
 None
 1.22A 5vlmE-3lhlA:
undetectable		 5vlmE-3lhlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF04777
(Evr1_Alr) 		5 ALA A 338
GLU A 380
LEU A 308
ILE A 311
PHE A 371
 None
 1.06A 5vlmE-3llkA:
undetectable		 5vlmE-3llkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		5 MET A 222
ALA A 210
LEU A 226
ILE A 228
ARG A 230
 None
 1.33A 5vlmE-3ltwA:
undetectable		 5vlmE-3ltwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 MET A  97
LEU A 134
ILE A 132
VAL A  86
PHE A  77
 None
 1.30A 5vlmE-3o5dA:
undetectable		 5vlmE-3o5dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oev PROTEASOME COMPONENT
C1

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA F 193
GLU F 209
LEU F 229
ILE F 233
PHE F 208
 None
 1.27A 5vlmE-3oevF:
undetectable		 5vlmE-3oevF:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 MET A 185
ALA A 190
LEU A 172
ILE A 173
CYH A 242
 None
 1.24A 5vlmE-3opbA:
2.2		 5vlmE-3opbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 ALA X 166
ILE X 329
ARG X 333
VAL X 338
PHE X 282
 None
 1.43A 5vlmE-3pb9X:
undetectable		 5vlmE-3pb9X:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 MET B 123
ALA B  72
LEU B 144
VAL B  54
CYH B  57
 None
 1.44A 5vlmE-3qkcB:
2.0		 5vlmE-3qkcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 443
LEU A 448
ILE A 451
TYR A 151
PHE A 416
 None
 1.34A 5vlmE-3rimA:
undetectable		 5vlmE-3rimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 341
GLU A 383
LEU A 311
ILE A 314
PHE A 374
 None
 1.11A 5vlmE-3t58A:
1.9		 5vlmE-3t58A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 268
ILE A 191
VAL A 350
CYH A 365
TYR A 352
 None
 1.25A 5vlmE-3to3A:
undetectable		 5vlmE-3to3A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 732
MET A 733
GLU A 612
LEU A 750
CYH A 603
 None
 1.39A 5vlmE-3tt0A:
undetectable		 5vlmE-3tt0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.12A 5vlmE-3twiD:
undetectable		 5vlmE-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF) 		5 MET C 418
ALA C 381
LEU C 400
ILE C 397
VAL C 385
 None
 1.35A 5vlmE-3u88C:
undetectable		 5vlmE-3u88C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA G 195
GLU G 212
LEU G 235
ILE G 239
PHE G 211
 None
 1.24A 5vlmE-3wxrG:
undetectable		 5vlmE-3wxrG:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 ALA A1560
ILE A1645
VAL A1563
TYR A1577
PHE A1600
 None
 1.33A 5vlmE-4a5wA:
2.8		 5vlmE-4a5wA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ALA A  79
GLU A 106
LEU A  82
ILE A  60
VAL A 102
 CMP  A 400 (-3.5A)
None
None
None
None
 1.04A 5vlmE-4avcA:
undetectable		 5vlmE-4avcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 LEU A 134
ILE A 135
ARG A 167
VAL A 171
TYR A 163
 None
 1.24A 5vlmE-4b2oA:
undetectable		 5vlmE-4b2oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA C 363
GLU C  97
LEU C 388
ILE C 390
VAL C  59
 None
 1.40A 5vlmE-4b3iC:
undetectable		 5vlmE-4b3iC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A  39
GLU A  88
LEU A  90
ILE A 117
VAL A  58
 None
 1.43A 5vlmE-4e6eA:
undetectable		 5vlmE-4e6eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 ALA A 121
LEU A  74
VAL A 105
TYR A  67
PHE A  31
 None
 1.33A 5vlmE-4j1sA:
undetectable		 5vlmE-4j1sA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 ALA B  26
LEU B  21
ILE B  42
VAL B  49
PHE B  50
 None
 1.24A 5vlmE-4k5uB:
undetectable		 5vlmE-4k5uB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 132
 None
 1.28A 5vlmE-4ly7A:
undetectable		 5vlmE-4ly7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11

(Homo sapiens) 		PF06337
(DUSP)
PF14836
(Ubiquitin_3) 		5 ALA A 201
GLU A 155
ARG A 188
VAL A 181
PHE A 172
 None
 1.39A 5vlmE-4melA:
undetectable		 5vlmE-4melA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 MET A 638
GLU A 679
LEU A 677
ILE A 674
TRP A 629
 None
 1.33A 5vlmE-4o1oA:
2.2		 5vlmE-4o1oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 341
GLU A 383
LEU A 311
ILE A 314
PHE A 374
 None
 1.16A 5vlmE-4p2lA:
undetectable		 5vlmE-4p2lA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.25A 5vlmE-4qi4A:
undetectable		 5vlmE-4qi4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.38A 5vlmE-4qi6A:
undetectable		 5vlmE-4qi6A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ALA A  32
LEU A  27
ILE A  51
ARG A  67
VAL A  42
 None
 1.42A 5vlmE-4r7uA:
undetectable		 5vlmE-4r7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLU A 567
LEU A 569
ILE A 610
ARG A 615
VAL A 585
 None
 1.43A 5vlmE-4xi2A:
undetectable		 5vlmE-4xi2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 ALA B 634
GLU B 617
LEU B 619
ILE B 622
ARG B 625
 None
 1.40A 5vlmE-4yg8B:
undetectable		 5vlmE-4yg8B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL34
VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		PF04541
(Herpes_U34)
PF02718
(Herpes_UL31) 		5 MET A 169
MET A 151
ILE B 118
VAL B 102
TYR B 228
 None
 1.41A 5vlmE-4zxsA:
undetectable		 5vlmE-4zxsA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.11A 5vlmE-5eb5A:
undetectable		 5vlmE-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 ALA A  18
LEU A 313
ILE A 314
VAL A 327
PHE A 320
 None
 1.12A 5vlmE-5epdA:
undetectable		 5vlmE-5epdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 ALA X 336
GLU X 345
ILE X 349
ARG X 306
VAL X   8
 None
 1.00A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLU X 345
LEU X 352
ILE X 349
ARG X 306
VAL X   8
 None
 1.05A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 MET A 167
MET A 168
LEU A 156
ILE A 157
TYR A 210
 None
 1.00A 5vlmE-5h7jA:
undetectable		 5vlmE-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 MET A 117
ALA A 123
GLU A  73
TRP A 110
VAL A  82
 45D  A 501 ( 2.8A)
None
None
45D  A 501 (-2.8A)
None
 1.37A 5vlmE-5hgrA:
2.3		 5vlmE-5hgrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0y PERIPLASMIC
PROTEIN-PROBABLY
INVOLVED IN
HIGH-AFFINITY FE2+
TRANSPORT

(Escherichia
coli) 		PF10634
(Iron_transport) 		5 ALA A  47
ILE A 102
VAL A 112
TYR A 149
PHE A 147
 None
 1.29A 5vlmE-5i0yA:
undetectable		 5vlmE-5i0yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		5 MET G 288
ALA G  72
LEU G 293
ILE G 296
ARG G 308
 None
 1.40A 5vlmE-5l75G:
undetectable		 5vlmE-5l75G:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE BETA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF08882
(Acetone_carb_G) 		5 ALA A 378
LEU C 104
ILE C 101
TRP C  20
ARG C  33
 None
 1.09A 5vlmE-5l9wA:
undetectable		 5vlmE-5l9wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 214
GLU A 192
LEU A 197
ILE A 194
VAL A 180
 None
 1.40A 5vlmE-5lxdA:
undetectable		 5vlmE-5lxdA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		5 ALA N 518
LEU N 535
ILE N 536
ARG N 570
TYR N 559
 None
 1.28A 5vlmE-5mpdN:
1.9		 5vlmE-5mpdN:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ILE A 597
ARG A 617
VAL A 557
CYH A 558
PHE A 787
 None
 1.18A 5vlmE-5n2gA:
undetectable		 5vlmE-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o99 SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		no annotation 5 ALA B 521
GLU B 495
ILE B 489
TRP B 518
VAL B 499
 None
 1.41A 5vlmE-5o99B:
undetectable		 5vlmE-5o99B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		5 LEU A  22
ILE A  28
VAL A  36
CYH A  35
PHE A  62
 None
 1.26A 5vlmE-5t13A:
undetectable		 5vlmE-5t13A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.09A 5vlmE-5tusA:
undetectable		 5vlmE-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 ALA B  45
LEU B  40
ILE B  61
VAL B  68
PHE B  69
 None
 1.15A 5vlmE-5uf1B:
undetectable		 5vlmE-5uf1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 ALA A  28
LEU A  23
ILE A  44
VAL A  51
PHE A  52
 None
 1.13A 5vlmE-5ufbA:
undetectable		 5vlmE-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
ILE A  98
TRP A 101
ARG A 102
CYH A 160
TYR A 166
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
 1.04A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
MET A  68
ALA A  86
LEU A  94
ILE A  98
TRP A 101
ARG A 102
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.39A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Aquifex
aeolicus) 		no annotation 5 MET A  93
ALA A  87
LEU A 172
ILE A 173
VAL A 112
 None
 1.24A 5vlmE-5xj6A:
2.3		 5vlmE-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 MET A 274
GLU A 252
LEU A 257
ILE A 254
VAL A 240
 None
 1.45A 5vlmE-5y86A:
undetectable		 5vlmE-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.42A 5vlmE-6co1A:
undetectable		 5vlmE-6co1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 MET A 298
LEU A 134
ILE A 131
TRP A 164
VAL A 170
 None
 1.41A 5vlmE-6cy1A:
undetectable		 5vlmE-6cy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emp -

(-) 		no annotation 5 MET A 418
ALA A 381
LEU A 400
ILE A 397
VAL A 385
 None
 1.45A 5vlmE-6empA:
1.8		 5vlmE-6empA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ALA A 534
LEU A 590
ILE B  49
ARG A 494
VAL A 502
 None
 1.30A 5vlmE-6faeA:
undetectable		 5vlmE-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 5 ALA A  53
LEU A  70
TRP A  40
VAL A  34
PHE A  63
 None
 1.23A 5vlmE-6guoA:
undetectable		 5vlmE-6guoA:
undetectable