SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_E_CVIE301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ALA A 121
LEU A  59
ILE A  53
VAL A 134
TYR A  51
 None
 1.33A 5vlmE-1dysA:
undetectable		 5vlmE-1dysA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ALA A 125
LEU A  97
ILE A  96
VAL A 165
TYR A 105
 None
 1.36A 5vlmE-1efvA:
undetectable		 5vlmE-1efvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.24A 5vlmE-1g8wA:
undetectable		 5vlmE-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.45A 5vlmE-1gy8A:
0.0		 5vlmE-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		5 ALA A 129
LEU A 135
ARG A 113
VAL A 116
PHE A 148
 None
 1.31A 5vlmE-1j3bA:
undetectable		 5vlmE-1j3bA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H

(Thermus
thermophilus;
Escherichia
coli) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 133
 None
 1.31A 5vlmE-1jl2A:
undetectable		 5vlmE-1jl2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  35
GLU A 329
ILE A 331
ARG A  45
VAL A   4
 None
 1.32A 5vlmE-1jvbA:
undetectable		 5vlmE-1jvbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.25A 5vlmE-1jxnA:
undetectable		 5vlmE-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 ALA A 441
LEU A  85
ILE A  89
TRP A 434
VAL A 424
 None
 1.40A 5vlmE-1l1lA:
0.0		 5vlmE-1l1lA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		5 ALA A 225
LEU A 156
ILE A 155
VAL A 258
TYR A 254
 None
 1.46A 5vlmE-1lmlA:
0.0		 5vlmE-1lmlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		5 ALA A 121
LEU A 195
ILE A  58
VAL A 205
PHE A 228
 None
 1.28A 5vlmE-1n47A:
undetectable		 5vlmE-1n47A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 MET A 281
MET A 280
GLU A  24
VAL A  39
PHE A  52
 None
 1.16A 5vlmE-1nrwA:
undetectable		 5vlmE-1nrwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA B 475
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.28A 5vlmE-1pjmB:
2.1		 5vlmE-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		5 ALA A  57
GLU A  37
LEU A  17
ILE A  46
ARG A  21
 None
 1.23A 5vlmE-1t9kA:
undetectable		 5vlmE-1t9kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.35A 5vlmE-1vefA:
undetectable		 5vlmE-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 132
 None
 1.23A 5vlmE-1wsjA:
undetectable		 5vlmE-1wsjA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 MET A 420
ALA A 424
GLU A 356
LEU A 354
VAL A 362
 None
 1.20A 5vlmE-1xjeA:
undetectable		 5vlmE-1xjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.17A 5vlmE-2a81A:
undetectable		 5vlmE-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 ALA A 135
LEU A  73
ILE A  74
VAL A 111
TYR A  18
 None
 1.26A 5vlmE-2d2nA:
undetectable		 5vlmE-2d2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.43A 5vlmE-2de2A:
undetectable		 5vlmE-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		5 ALA A 185
GLU A 136
ILE A 170
VAL A 119
PHE A 133
 None
CD  A1004 (-2.8A)
None
None
None
 1.21A 5vlmE-2dvzA:
undetectable		 5vlmE-2dvzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		5 ALA A  53
LEU A 129
ILE A 128
VAL A  56
PHE A 206
 None
 1.45A 5vlmE-2f96A:
undetectable		 5vlmE-2f96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.28A 5vlmE-2fzwA:
undetectable		 5vlmE-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		5 ALA A 310
LEU A 348
ILE A 349
ARG A 274
PHE A 318
 None
None
SO4  A 382 (-4.0A)
SO4  A 382 (-3.8A)
None
 1.46A 5vlmE-2hkeA:
undetectable		 5vlmE-2hkeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		5 MET A 150
LEU A 111
ILE A 175
VAL A 103
PHE A 119
 None
 1.44A 5vlmE-2lxnA:
undetectable		 5vlmE-2lxnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 735
MET A 736
GLU A 615
LEU A 753
CYH A 606
 None
 1.40A 5vlmE-2psqA:
undetectable		 5vlmE-2psqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 MET A 396
ALA A  59
ILE A 423
VAL A 417
CYH A 416
 None
 1.39A 5vlmE-2q5oA:
undetectable		 5vlmE-2q5oA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ALA A  45
LEU A  40
ILE A  61
VAL A  68
PHE A  69
 None
 1.12A 5vlmE-2r9uA:
undetectable		 5vlmE-2r9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		5 GLU A 286
LEU A 285
ILE A 288
ARG A 291
VAL A 293
 None
 1.29A 5vlmE-2uv7A:
undetectable		 5vlmE-2uv7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.08A 5vlmE-2wghA:
undetectable		 5vlmE-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 ALA B 312
GLU B 322
LEU B 418
ILE B 422
VAL B 327
 None
 0.93A 5vlmE-2xdqB:
undetectable		 5vlmE-2xdqB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 ALA A 687
GLU A 596
ILE A 683
VAL A 647
PHE A 591
 None
 1.45A 5vlmE-3a5iA:
undetectable		 5vlmE-3a5iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		5 MET A  45
ALA A  41
LEU A  78
ILE A  48
VAL A  34
 None
 1.40A 5vlmE-3bdkA:
undetectable		 5vlmE-3bdkA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 ALA A  28
GLU A 108
LEU A  50
ILE A  51
VAL A 105
 None
 1.45A 5vlmE-3cq0A:
undetectable		 5vlmE-3cq0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.43A 5vlmE-3ct4A:
undetectable		 5vlmE-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A  17
LEU A  51
ILE A  54
VAL A 121
PHE A  30
 None
 1.39A 5vlmE-3d3uA:
undetectable		 5vlmE-3d3uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 ALA A  62
LEU A  83
ILE A  82
ARG A 142
PHE A 135
 None
 1.39A 5vlmE-3e9dA:
undetectable		 5vlmE-3e9dA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 ALA A 206
LEU A 185
VAL A 132
TYR A  93
PHE A 191
 None
 1.33A 5vlmE-3etvA:
2.4		 5vlmE-3etvA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 ALA A 269
LEU A  50
ILE A  52
VAL A 229
PHE A 236
 None
 1.44A 5vlmE-3fs2A:
undetectable		 5vlmE-3fs2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ALA A 271
GLU A 254
LEU A  42
ILE A  68
TYR A 124
 None
 1.41A 5vlmE-3holA:
undetectable		 5vlmE-3holA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A  65
LEU A  34
ILE A 148
VAL A  48
CYH A 115
 None
 1.42A 5vlmE-3k5wA:
undetectable		 5vlmE-3k5wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1

(Vibrio cholerae) 		PF01226
(Form_Nir_trans) 		5 MET A 213
ALA A 211
LEU A 127
ILE A  42
VAL A  81
 None
None
None
BOG  A 282 ( 4.1A)
None
 1.43A 5vlmE-3klyA:
undetectable		 5vlmE-3klyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		5 MET A 106
GLU A 282
LEU A 280
TYR A 237
PHE A 240
 None
 1.22A 5vlmE-3lhlA:
undetectable		 5vlmE-3lhlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF04777
(Evr1_Alr) 		5 ALA A 338
GLU A 380
LEU A 308
ILE A 311
PHE A 371
 None
 1.06A 5vlmE-3llkA:
undetectable		 5vlmE-3llkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		5 MET A 222
ALA A 210
LEU A 226
ILE A 228
ARG A 230
 None
 1.33A 5vlmE-3ltwA:
undetectable		 5vlmE-3ltwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 MET A  97
LEU A 134
ILE A 132
VAL A  86
PHE A  77
 None
 1.30A 5vlmE-3o5dA:
undetectable		 5vlmE-3o5dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oev PROTEASOME COMPONENT
C1

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA F 193
GLU F 209
LEU F 229
ILE F 233
PHE F 208
 None
 1.27A 5vlmE-3oevF:
undetectable		 5vlmE-3oevF:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 MET A 185
ALA A 190
LEU A 172
ILE A 173
CYH A 242
 None
 1.24A 5vlmE-3opbA:
2.2		 5vlmE-3opbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 ALA X 166
ILE X 329
ARG X 333
VAL X 338
PHE X 282
 None
 1.43A 5vlmE-3pb9X:
undetectable		 5vlmE-3pb9X:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 MET B 123
ALA B  72
LEU B 144
VAL B  54
CYH B  57
 None
 1.44A 5vlmE-3qkcB:
2.0		 5vlmE-3qkcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 443
LEU A 448
ILE A 451
TYR A 151
PHE A 416
 None
 1.34A 5vlmE-3rimA:
undetectable		 5vlmE-3rimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 341
GLU A 383
LEU A 311
ILE A 314
PHE A 374
 None
 1.11A 5vlmE-3t58A:
1.9		 5vlmE-3t58A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 268
ILE A 191
VAL A 350
CYH A 365
TYR A 352
 None
 1.25A 5vlmE-3to3A:
undetectable		 5vlmE-3to3A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 732
MET A 733
GLU A 612
LEU A 750
CYH A 603
 None
 1.39A 5vlmE-3tt0A:
undetectable		 5vlmE-3tt0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.12A 5vlmE-3twiD:
undetectable		 5vlmE-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF) 		5 MET C 418
ALA C 381
LEU C 400
ILE C 397
VAL C 385
 None
 1.35A 5vlmE-3u88C:
undetectable		 5vlmE-3u88C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA G 195
GLU G 212
LEU G 235
ILE G 239
PHE G 211
 None
 1.24A 5vlmE-3wxrG:
undetectable		 5vlmE-3wxrG:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 ALA A1560
ILE A1645
VAL A1563
TYR A1577
PHE A1600
 None
 1.33A 5vlmE-4a5wA:
2.8		 5vlmE-4a5wA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ALA A  79
GLU A 106
LEU A  82
ILE A  60
VAL A 102
 CMP  A 400 (-3.5A)
None
None
None
None
 1.04A 5vlmE-4avcA:
undetectable		 5vlmE-4avcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 LEU A 134
ILE A 135
ARG A 167
VAL A 171
TYR A 163
 None
 1.24A 5vlmE-4b2oA:
undetectable		 5vlmE-4b2oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA C 363
GLU C  97
LEU C 388
ILE C 390
VAL C  59
 None
 1.40A 5vlmE-4b3iC:
undetectable		 5vlmE-4b3iC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A  39
GLU A  88
LEU A  90
ILE A 117
VAL A  58
 None
 1.43A 5vlmE-4e6eA:
undetectable		 5vlmE-4e6eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 ALA A 121
LEU A  74
VAL A 105
TYR A  67
PHE A  31
 None
 1.33A 5vlmE-4j1sA:
undetectable		 5vlmE-4j1sA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 5 ALA B  26
LEU B  21
ILE B  42
VAL B  49
PHE B  50
 None
 1.24A 5vlmE-4k5uB:
undetectable		 5vlmE-4k5uB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		5 ALA A  52
GLU A   6
LEU A  26
ILE A  25
ARG A 132
 None
 1.28A 5vlmE-4ly7A:
undetectable		 5vlmE-4ly7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11

(Homo sapiens) 		PF06337
(DUSP)
PF14836
(Ubiquitin_3) 		5 ALA A 201
GLU A 155
ARG A 188
VAL A 181
PHE A 172
 None
 1.39A 5vlmE-4melA:
undetectable		 5vlmE-4melA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 MET A 638
GLU A 679
LEU A 677
ILE A 674
TRP A 629
 None
 1.33A 5vlmE-4o1oA:
2.2		 5vlmE-4o1oA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 341
GLU A 383
LEU A 311
ILE A 314
PHE A 374
 None
 1.16A 5vlmE-4p2lA:
undetectable		 5vlmE-4p2lA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.25A 5vlmE-4qi4A:
undetectable		 5vlmE-4qi4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.38A 5vlmE-4qi6A:
undetectable		 5vlmE-4qi6A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ALA A  32
LEU A  27
ILE A  51
ARG A  67
VAL A  42
 None
 1.42A 5vlmE-4r7uA:
undetectable		 5vlmE-4r7uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLU A 567
LEU A 569
ILE A 610
ARG A 615
VAL A 585
 None
 1.43A 5vlmE-4xi2A:
undetectable		 5vlmE-4xi2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 ALA B 634
GLU B 617
LEU B 619
ILE B 622
ARG B 625
 None
 1.40A 5vlmE-4yg8B:
undetectable		 5vlmE-4yg8B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL34
VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		PF04541
(Herpes_U34)
PF02718
(Herpes_UL31) 		5 MET A 169
MET A 151
ILE B 118
VAL B 102
TYR B 228
 None
 1.41A 5vlmE-4zxsA:
undetectable		 5vlmE-4zxsA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.11A 5vlmE-5eb5A:
undetectable		 5vlmE-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 ALA A  18
LEU A 313
ILE A 314
VAL A 327
PHE A 320
 None
 1.12A 5vlmE-5epdA:
undetectable		 5vlmE-5epdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 ALA X 336
GLU X 345
ILE X 349
ARG X 306
VAL X   8
 None
 1.00A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLU X 345
LEU X 352
ILE X 349
ARG X 306
VAL X   8
 None
 1.05A 5vlmE-5evyX:
1.8		 5vlmE-5evyX:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 MET A 167
MET A 168
LEU A 156
ILE A 157
TYR A 210
 None
 1.00A 5vlmE-5h7jA:
undetectable		 5vlmE-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 MET A 117
ALA A 123
GLU A  73
TRP A 110
VAL A  82
 45D  A 501 ( 2.8A)
None
None
45D  A 501 (-2.8A)
None
 1.37A 5vlmE-5hgrA:
2.3		 5vlmE-5hgrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0y PERIPLASMIC
PROTEIN-PROBABLY
INVOLVED IN
HIGH-AFFINITY FE2+
TRANSPORT

(Escherichia
coli) 		PF10634
(Iron_transport) 		5 ALA A  47
ILE A 102
VAL A 112
TYR A 149
PHE A 147
 None
 1.29A 5vlmE-5i0yA:
undetectable		 5vlmE-5i0yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		5 MET G 288
ALA G  72
LEU G 293
ILE G 296
ARG G 308
 None
 1.40A 5vlmE-5l75G:
undetectable		 5vlmE-5l75G:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE BETA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF08882
(Acetone_carb_G) 		5 ALA A 378
LEU C 104
ILE C 101
TRP C  20
ARG C  33
 None
 1.09A 5vlmE-5l9wA:
undetectable		 5vlmE-5l9wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 214
GLU A 192
LEU A 197
ILE A 194
VAL A 180
 None
 1.40A 5vlmE-5lxdA:
undetectable		 5vlmE-5lxdA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		5 ALA N 518
LEU N 535
ILE N 536
ARG N 570
TYR N 559
 None
 1.28A 5vlmE-5mpdN:
1.9		 5vlmE-5mpdN:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ILE A 597
ARG A 617
VAL A 557
CYH A 558
PHE A 787
 None
 1.18A 5vlmE-5n2gA:
undetectable		 5vlmE-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o99 SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		no annotation 5 ALA B 521
GLU B 495
ILE B 489
TRP B 518
VAL B 499
 None
 1.41A 5vlmE-5o99B:
undetectable		 5vlmE-5o99B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		5 LEU A  22
ILE A  28
VAL A  36
CYH A  35
PHE A  62
 None
 1.26A 5vlmE-5t13A:
undetectable		 5vlmE-5t13A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.09A 5vlmE-5tusA:
undetectable		 5vlmE-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 ALA B  45
LEU B  40
ILE B  61
VAL B  68
PHE B  69
 None
 1.15A 5vlmE-5uf1B:
undetectable		 5vlmE-5uf1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 ALA A  28
LEU A  23
ILE A  44
VAL A  51
PHE A  52
 None
 1.13A 5vlmE-5ufbA:
undetectable		 5vlmE-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
ILE A  98
TRP A 101
ARG A 102
CYH A 160
TYR A 166
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
 1.04A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
MET A  68
ALA A  86
LEU A  94
ILE A  98
TRP A 101
ARG A 102
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.39A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Aquifex
aeolicus) 		no annotation 5 MET A  93
ALA A  87
LEU A 172
ILE A 173
VAL A 112
 None
 1.24A 5vlmE-5xj6A:
2.3		 5vlmE-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 MET A 274
GLU A 252
LEU A 257
ILE A 254
VAL A 240
 None
 1.45A 5vlmE-5y86A:
undetectable		 5vlmE-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.42A 5vlmE-6co1A:
undetectable		 5vlmE-6co1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 MET A 298
LEU A 134
ILE A 131
TRP A 164
VAL A 170
 None
 1.41A 5vlmE-6cy1A:
undetectable		 5vlmE-6cy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emp -

(-) 		no annotation 5 MET A 418
ALA A 381
LEU A 400
ILE A 397
VAL A 385
 None
 1.45A 5vlmE-6empA:
1.8		 5vlmE-6empA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ALA A 534
LEU A 590
ILE B  49
ARG A 494
VAL A 502
 None
 1.30A 5vlmE-6faeA:
undetectable		 5vlmE-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 5 ALA A  53
LEU A  70
TRP A  40
VAL A  34
PHE A  63
 None
 1.23A 5vlmE-6guoA:
undetectable		 5vlmE-6guoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 193
GLN A 287
TYR A 289
ASP A 196
 None
 1.05A 5vlmE-1fepA:
undetectable		 5vlmE-1fepA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 GLY A 374
TYR A 294
TRP A 313
ASP A  50
 None
 0.96A 5vlmE-1fp3A:
undetectable		 5vlmE-1fp3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 256
GLY A 252
ASP A 122
ASP A 299
 None
 1.09A 5vlmE-1guzA:
0.0		 5vlmE-1guzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 GLY A 307
GLN A 222
TYR A 224
ASP A 436
 None
CL  A 530 (-3.7A)
None
CA  A   3 ( 4.5A)
 1.13A 5vlmE-1ktwA:
undetectable		 5vlmE-1ktwA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.82A 5vlmE-1mqsA:
2.7		 5vlmE-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 GLN A 332
GLY A 331
GLN A 469
TRP A 320
 None
 1.14A 5vlmE-1ms8A:
undetectable		 5vlmE-1ms8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.01A 5vlmE-1rm8A:
0.3		 5vlmE-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 GLN A  63
GLY A  48
GLN A 321
ASP A  52
 GLC  A 503 ( 3.9A)
None
None
None
 1.09A 5vlmE-1ua7A:
undetectable		 5vlmE-1ua7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 GLY A 382
GLN A 403
ASP A 400
ASP A 415
 None
IFL  A1432 ( 3.6A)
None
None
 1.13A 5vlmE-1uz4A:
undetectable		 5vlmE-1uz4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 GLN A  59
GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.14A 5vlmE-1wzzA:
undetectable		 5vlmE-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 GLN A 465
GLY A 120
TRP A 128
ASP A 115
 None
 1.11A 5vlmE-1z14A:
undetectable		 5vlmE-1z14A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 GLN A 223
GLY A 221
TYR A  52
ASP A 310
 NAD  A1350 (-4.7A)
None
None
NAD  A1350 (-4.6A)
 1.06A 5vlmE-1z9aA:
0.0		 5vlmE-1z9aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLN X 244
GLY X 251
TRP X 246
ASP X 322
 None
 0.97A 5vlmE-2b5dX:
1.6		 5vlmE-2b5dX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 GLN A 280
GLN A 301
TYR A 309
TRP A 260
 None
 1.16A 5vlmE-2d4vA:
2.3		 5vlmE-2d4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.00A 5vlmE-2dlcX:
undetectable		 5vlmE-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLN A 124
GLY A 165
GLN A 287
ASP A  13
 None
None
G  C  70 ( 4.0A)
None
 1.11A 5vlmE-2fmtA:
undetectable		 5vlmE-2fmtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		4 GLY A 364
TYR A 284
TRP A 303
ASP A  47
 None
 0.97A 5vlmE-2gz6A:
1.4		 5vlmE-2gz6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1t HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06475
(Glycolipid_bind) 		4 GLY A  83
GLN A 145
ASP A 101
ASP A  54
 None
 0.74A 5vlmE-2h1tA:
undetectable		 5vlmE-2h1tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		4 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.97A 5vlmE-2hs5A:
1.5		 5vlmE-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		4 GLY A 283
GLN A 312
TYR A   6
ASP A 276
 None
 0.97A 5vlmE-2i7gA:
undetectable		 5vlmE-2i7gA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 0.95A 5vlmE-2j2mA:
undetectable		 5vlmE-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.09A 5vlmE-2jcjA:
undetectable		 5vlmE-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 GLY A  84
TYR A  96
ASP A 118
ASP A 128
 None
 1.01A 5vlmE-2pbgA:
undetectable		 5vlmE-2pbgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107

(Mycobacterium
tuberculosis) 		PF10862
(FcoT) 		4 GLN A  45
GLY A  57
GLN A 114
TYR A 110
 None
 0.99A 5vlmE-2pfcA:
undetectable		 5vlmE-2pfcA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv3 CHAPERONE SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N) 		4 GLN A  85
GLY A  84
GLN A  95
ASP A  77
 None
 1.10A 5vlmE-2pv3A:
2.5		 5vlmE-2pv3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLN A 396
GLY A 258
TYR A 296
ASP A 137
 None
FAD  A1594 (-3.3A)
None
FAD  A1594 (-4.1A)
 1.12A 5vlmE-2v6oA:
undetectable		 5vlmE-2v6oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 GLN B 356
GLY B 355
GLN B 228
ASP B 431
 None
 1.16A 5vlmE-2wfxB:
undetectable		 5vlmE-2wfxB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 260
GLY A 258
TYR A 215
ASP A 232
 None
 1.08A 5vlmE-2y6cA:
undetectable		 5vlmE-2y6cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.13A 5vlmE-2yokA:
undetectable		 5vlmE-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 868
TYR A1006
ASP A 910
ASP A 839
 None
 1.07A 5vlmE-2zxqA:
2.8		 5vlmE-2zxqA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 GLY A 153
GLN A  54
TYR A  56
ASP A 192
 None
GOL  A 441 ( 3.7A)
None
None
 1.16A 5vlmE-3cc1A:
undetectable		 5vlmE-3cc1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		4 GLN A 118
GLY A 120
TYR A  83
ASP A 174
 None
None
None
ADP  A1211 (-2.7A)
 0.90A 5vlmE-3cr3A:
undetectable		 5vlmE-3cr3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 GLN A  17
GLY A 319
GLN A 364
TRP A 460
ASP A  12
 None
None
None
None
ZN  A 602 (-2.2A)
 1.47A 5vlmE-3e2dA:
3.4		 5vlmE-3e2dA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 842
TYR A 963
ASP A 884
ASP A 813
 None
None
None
GOL  A2003 (-3.6A)
 1.11A 5vlmE-3ecqA:
undetectable		 5vlmE-3ecqA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 GLY A  81
TRP A 441
ASP A 150
ASP A 186
 None
 1.09A 5vlmE-3eqaA:
1.4		 5vlmE-3eqaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A  62
TYR A 190
ASP A 139
ASP A  65
 None
 1.10A 5vlmE-3h6tA:
undetectable		 5vlmE-3h6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		4 GLN A1371
GLY A1366
GLN A1456
ASP A1360
 None
 1.11A 5vlmE-3hrrA:
undetectable		 5vlmE-3hrrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 GLN A 303
TYR A 291
TRP A 371
ASP A  42
 None
None
EDO  A  11 (-4.5A)
EDO  A   8 (-4.4A)
 1.01A 5vlmE-3i09A:
undetectable		 5vlmE-3i09A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 GLN T 132
TYR T 147
TRP T 218
ASP T 184
 None
 0.95A 5vlmE-3icqT:
2.2		 5vlmE-3icqT:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis) 		PF00383
(dCMP_cyt_deam_1) 		4 GLN X  15
GLY X  30
ASP X  80
ASP X 107
 None
 1.11A 5vlmE-3ijfX:
undetectable		 5vlmE-3ijfX:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Yersinia pestis) 		PF02348
(CTP_transf_3) 		4 GLN A  98
GLY A  99
GLN A 237
ASP A  50
 None
 1.14A 5vlmE-3jtjA:
undetectable		 5vlmE-3jtjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		4 GLN K 409
GLY K  83
GLN K 207
ASP K 188
 None
 1.15A 5vlmE-3mvdK:
undetectable		 5vlmE-3mvdK:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY A 318
TYR A 126
ASP A 428
ASP B 219
 None
 1.15A 5vlmE-3ojyA:
undetectable		 5vlmE-3ojyA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 210
GLN A 245
ASP A 207
ASP A 167
 None
None
None
MG  A 326 (-2.4A)
 1.13A 5vlmE-3p4gA:
undetectable		 5vlmE-3p4gA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M) 		PF04744
(Monooxygenase_B) 		4 GLY A  65
TYR A 341
TRP A  50
ASP A 117
 None
 1.10A 5vlmE-3rfrA:
undetectable		 5vlmE-3rfrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 4 GLY B  98
GLN B  20
TYR B 113
ASP B  25
 None
 1.00A 5vlmE-3s5cB:
undetectable		 5vlmE-3s5cB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt6 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Bacillus
subtilis) 		PF00574
(CLP_protease) 		4 GLN A 159
GLY A 183
GLN A  81
TYR A  77
 None
 1.09A 5vlmE-3tt6A:
undetectable		 5vlmE-3tt6A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 GLN A  17
GLY A 315
GLN A 360
TRP A 456
ASP A  12
 None
None
None
None
ZN  A 505 ( 2.1A)
 1.49A 5vlmE-3wbhA:
3.3		 5vlmE-3wbhA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 GLN A 193
GLY A 237
TYR A  67
ASP A 228
 None
 1.14A 5vlmE-3wrcA:
undetectable		 5vlmE-3wrcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2

(Homo sapiens) 		PF10250
(O-FucT) 		4 GLN A  99
GLY A 365
TYR A  48
TRP A  86
 CL  A1432 (-4.0A)
CL  A1432 (-4.2A)
None
None
 1.14A 5vlmE-4ap5A:
undetectable		 5vlmE-4ap5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 136
GLN A 357
TYR A 365
ASP A 139
 None
HEM  A3000 (-3.7A)
None
None
 0.85A 5vlmE-4b7gA:
2.8		 5vlmE-4b7gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLN A  81
GLY A  88
ASP A 276
ASP A 214
 None
 1.12A 5vlmE-4bedA:
2.5		 5vlmE-4bedA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		4 GLY A 374
GLN A 190
TYR A 194
ASP A 327
 None
 1.15A 5vlmE-4bokA:
1.4		 5vlmE-4bokA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 0.92A 5vlmE-4cabA:
undetectable		 5vlmE-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crw PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00271
(Helicase_C) 		4 GLN B 300
GLY B 412
GLN B 325
ASP B 381
 None
 1.12A 5vlmE-4crwB:
undetectable		 5vlmE-4crwB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		4 GLN A 269
GLY A 327
GLN A 292
ASP A 333
 None
 1.16A 5vlmE-4csiA:
undetectable		 5vlmE-4csiA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 GLY A 810
GLN A 892
ASP A 861
ASP A 434
 None
 1.16A 5vlmE-4ecnA:
undetectable		 5vlmE-4ecnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 GLN A 169
GLY A 195
ASP A 241
ASP A 260
 None
None
CA  A 601 (-2.0A)
None
 1.10A 5vlmE-4hwvA:
undetectable		 5vlmE-4hwvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A  45
GLY A  36
GLN A 180
ASP A 332
 None
 1.03A 5vlmE-4iigA:
undetectable		 5vlmE-4iigA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 GLN A 697
GLY A 816
GLN A 852
ASP A 818
 None
 1.15A 5vlmE-4k0eA:
undetectable		 5vlmE-4k0eA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 GLN A 430
GLY A 431
GLN A 580
ASP A 434
 None
 1.05A 5vlmE-4krfA:
undetectable		 5vlmE-4krfA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 GLN A 104
TYR A 372
ASP A  63
ASP A 112
 None
 1.08A 5vlmE-4l9mA:
2.3		 5vlmE-4l9mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 GLN A 281
GLY A 300
GLN A 414
ASP A 309
 None
 1.00A 5vlmE-4nzjA:
undetectable		 5vlmE-4nzjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 GLY A 216
GLN A 224
ASP A 132
ASP A 475
 None
 1.03A 5vlmE-4ofzA:
undetectable		 5vlmE-4ofzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		4 GLY A 251
GLN A 412
TYR A 416
ASP A 204
 None
 1.03A 5vlmE-4ovjA:
undetectable		 5vlmE-4ovjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLN A 144
GLY A 143
ASP A 267
ASP A 130
 None
 1.13A 5vlmE-4qhbA:
undetectable		 5vlmE-4qhbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 123
GLN A 344
TYR A 352
ASP A 126
 None
HEM  A 502 ( 3.7A)
None
None
 0.83A 5vlmE-4qorA:
undetectable		 5vlmE-4qorA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.33A 5vlmE-4rkuA:
undetectable		 5vlmE-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.09A 5vlmE-4rs3A:
undetectable		 5vlmE-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 GLN B  21
GLY B 300
GLN B 364
ASP B 146
 None
 1.01A 5vlmE-4tx2B:
undetectable		 5vlmE-4tx2B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.09A 5vlmE-4uomL:
undetectable		 5vlmE-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLN A 224
GLY A 220
GLN A 150
ASP A 248
 None
 1.09A 5vlmE-4wwhA:
undetectable		 5vlmE-4wwhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 GLN A 318
GLY A 266
GLN A 421
ASP A 262
 None
 1.04A 5vlmE-4xhbA:
undetectable		 5vlmE-4xhbA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY A  24
GLN B  87
ASP A  91
ASP A  29
 None
 1.09A 5vlmE-4z0xA:
undetectable		 5vlmE-4z0xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLN A 180
GLN A  63
TYR A  59
ASP A 102
 ZN  A 304 ( 2.5A)
EDO  A 307 ( 3.5A)
None
None
 1.14A 5vlmE-4zfzA:
undetectable		 5vlmE-4zfzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 842
TYR A 963
ASP A 884
ASP A 813
 None
 1.09A 5vlmE-5a55A:
undetectable		 5vlmE-5a55A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A 368
GLY A 192
TYR A 147
ASP A 195
 None
 0.97A 5vlmE-5a7mA:
undetectable		 5vlmE-5a7mA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Staphylococcus
aureus) 		PF00574
(CLP_protease) 		4 GLN A 160
GLY A 184
GLN A  82
TYR A  78
 None
 1.14A 5vlmE-5c90A:
undetectable		 5vlmE-5c90A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLN A 162
GLY A 142
GLN A 191
ASP A  95
 None
CL  A 602 ( 4.1A)
None
None
 1.16A 5vlmE-5cniA:
undetectable		 5vlmE-5cniA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 4 GLN B 123
GLY B  54
GLN B  13
TYR B   8
 None
 1.07A 5vlmE-5e9uB:
undetectable		 5vlmE-5e9uB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 406
GLN A 388
TYR A 500
ASP A 395
 None
 1.17A 5vlmE-5f7sA:
undetectable		 5vlmE-5f7sA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 GLN A 509
GLY A 450
GLN A 485
TYR A 598
 None
 0.97A 5vlmE-5f7uA:
undetectable		 5vlmE-5f7uA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  76
TYR A 512
TRP A  69
ASP A  93
 None
PEG  A6002 ( 4.1A)
None
PEG  A6002 (-3.3A)
 0.97A 5vlmE-5fjjA:
undetectable		 5vlmE-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 GLY A 298
GLN A  99
TYR A  97
ASP A 144
 None
 1.12A 5vlmE-5i39A:
undetectable		 5vlmE-5i39A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.98A 5vlmE-5ixmA:
undetectable		 5vlmE-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  75
TYR A 507
TRP A  68
ASP A  92
 None
None
None
BGC  A 946 (-3.0A)
 1.03A 5vlmE-5ju6A:
undetectable		 5vlmE-5ju6A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 GLN A  26
GLY A  22
GLN A 395
ASP A 207
 None
 1.09A 5vlmE-5jy9A:
undetectable		 5vlmE-5jy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLN A 720
GLY A 699
GLN A 814
ASP A 621
 TNR  A1002 (-3.1A)
None
None
EDO  A1008 (-3.6A)
 1.09A 5vlmE-5kdxA:
1.8		 5vlmE-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLN A 210
GLY A 206
ASP A 234
ASP A 277
 None
 1.16A 5vlmE-5kufA:
undetectable		 5vlmE-5kufA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 GLN A 205
GLY A 220
ASP A 226
ASP A 240
 None
 0.91A 5vlmE-5m89A:
undetectable		 5vlmE-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		4 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.03A 5vlmE-5mdxC:
undetectable		 5vlmE-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 244
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.10A 5vlmE-5o5dA:
undetectable		 5vlmE-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 245
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.16A 5vlmE-5o5dA:
undetectable		 5vlmE-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 GLY A 127
GLN A  42
TYR A  38
ASP A 109
 None
 1.07A 5vlmE-5oe5A:
undetectable		 5vlmE-5oe5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLY A 149
GLN A 124
TYR A 129
ASP A 187
 None
 1.07A 5vlmE-5thhA:
undetectable		 5vlmE-5thhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 7 GLN A  71
GLY A  88
GLN A 105
TYR A 118
TRP A 125
ASP A 163
ASP A 175
 MGR  A 300 ( 4.1A)
MGR  A 300 ( 2.9A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 ( 4.3A)
 0.54A 5vlmE-5vlgA:
30.3		 5vlmE-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 GLY A 115
GLN A  88
ASP A  85
ASP A 119
 None
None
None
GNP  A 203 (-2.0A)
 1.12A 5vlmE-5wdrA:
undetectable		 5vlmE-5wdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 4 GLN A 141
GLY A 107
GLN A 153
ASP A 102
 None
 1.14A 5vlmE-5ws4A:
undetectable		 5vlmE-5ws4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAD

(Cyanidioschyzon
merolae) 		no annotation 4 GLN D  75
GLN D 105
TYR D 104
ASP D  35
 None
 0.97A 5vlmE-5zgbD:
undetectable		 5vlmE-5zgbD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 GLY A  81
TRP A 441
ASP A 150
ASP A 186
 None
 1.06A 5vlmE-6frvA:
0.6		 5vlmE-6frvA:
undetectable