SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_D_CVID301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4m PROTEIN
(COXSACKIEVIRUS A9)

(Enterovirus B) 		PF00073
(Rhv) 		5 MET 1 103
ALA 1  72
TYR 1 192
VAL 1 119
PHE 1 121
 None
None
W71  1 501 ( 3.7A)
None
None
 1.38A 5vlmD-1d4m1:
undetectable		 5vlmD-1d4m1:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 ALA A 180
LEU A 168
VAL A 213
TYR A 210
ASP A 224
 None
 1.28A 5vlmD-1gq1A:
0.0		 5vlmD-1gq1A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 ALA A 162
LEU A 150
VAL A 195
TYR A 192
ASP A 206
 None
 1.26A 5vlmD-1hzvA:
0.0		 5vlmD-1hzvA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 MET A 304
ALA A 130
VAL A 235
ASP A 143
PHE A 145
 None
 1.48A 5vlmD-1iayA:
0.0		 5vlmD-1iayA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 MET A 469
ALA A 423
LEU A 430
VAL A 367
ASP A 444
 None
 1.48A 5vlmD-1ldjA:
2.2		 5vlmD-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		5 LEU A  29
TYR A 148
VAL A   8
CYH A 197
ASP A  38
 None
 1.43A 5vlmD-1nfpA:
0.0		 5vlmD-1nfpA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		5 ALA A 133
LEU A 159
VAL A 180
TYR A 149
THR A 183
 None
 1.36A 5vlmD-1npyA:
0.0		 5vlmD-1npyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6e CAPSID PROTEIN P40

(Human
gammaherpesvirus
4) 		PF00716
(Peptidase_S21) 		5 ALA A 118
LEU A  42
TYR A 155
VAL A  13
TYR A  61
 ISP  A1236 ( 4.7A)
None
None
None
None
 1.48A 5vlmD-1o6eA:
undetectable		 5vlmD-1o6eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.27A 5vlmD-1vefA:
undetectable		 5vlmD-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 ALA A 211
LEU A 139
VAL A 200
ASP A 162
THR A 191
 None
 1.49A 5vlmD-1xw8A:
0.3		 5vlmD-1xw8A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  99
LEU A 118
TYR A  78
VAL A  20
THR A  91
 None
None
None
GDP  A 201 (-4.0A)
None
 1.40A 5vlmD-1z2aA:
undetectable		 5vlmD-1z2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		5 ALA A 214
LEU A  81
VAL A 178
ASP A 191
PHE A 111
 None
 1.44A 5vlmD-2d3rA:
undetectable		 5vlmD-2d3rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.49A 5vlmD-2de2A:
0.2		 5vlmD-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae) 		PF03280
(Lipase_chap) 		5 ALA D 113
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.46A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae) 		PF03280
(Lipase_chap) 		5 ALA D 114
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.49A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		5 ALA A 215
LEU A  81
VAL A 179
ASP A 192
PHE A 111
 None
 1.41A 5vlmD-2gdfA:
undetectable		 5vlmD-2gdfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 ALA A 179
LEU A 169
VAL A  72
TYR A 222
ASP A 147
 None
None
None
None
SAM  A 300 (-3.9A)
 1.41A 5vlmD-2oxtA:
undetectable		 5vlmD-2oxtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 MET A 156
ALA A 133
LEU A 273
TYR A 199
ASP A 201
 None
 1.47A 5vlmD-2pfyA:
0.6		 5vlmD-2pfyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 ALA A  40
LEU A 154
VAL A  74
ASP A  83
PHE A  85
 LAE  A1001 ( 3.9A)
None
LAE  A1001 ( 4.6A)
None
None
 1.42A 5vlmD-2q0oA:
undetectable		 5vlmD-2q0oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		5 ALA A 133
VAL A  72
TYR A 167
ASP A  83
THR A  85
 None
 1.45A 5vlmD-2w2rA:
undetectable		 5vlmD-2w2rA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 ALA A 248
VAL A 255
TYR A 234
ASP A 238
PHE A 237
 None
 1.37A 5vlmD-2xpiA:
1.4		 5vlmD-2xpiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ALA A 488
ARG A 744
TYR A 742
ASP A 712
THR A 513
 None
 1.28A 5vlmD-2xt6A:
0.4		 5vlmD-2xt6A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ALA A  65
TYR A  38
ASP A  49
PHE A  48
THR A  47
 None
 1.42A 5vlmD-2y4oA:
undetectable		 5vlmD-2y4oA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B
DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C)
PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ALA A 198
LEU A 205
VAL A 166
TYR C 105
ASP A 149
 None
 1.46A 5vlmD-3aizA:
undetectable		 5vlmD-3aizA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 ALA A 400
VAL A 423
CYH A 424
PHE A 337
THR A 341
 None
 1.36A 5vlmD-3b46A:
undetectable		 5vlmD-3b46A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.37A 5vlmD-3ct4A:
1.1		 5vlmD-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 MET A 103
ALA A 298
VAL A 222
ASP A 255
PHE A 267
 None
 1.29A 5vlmD-3d4uA:
undetectable		 5vlmD-3d4uA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 MET A 142
LEU A 102
TYR A 263
ASP A 237
PHE A 258
 None
 1.48A 5vlmD-3f9tA:
undetectable		 5vlmD-3f9tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fu1 GENERAL SECRETION
PATHWAY PROTEIN G

(Vibrio cholerae) 		PF08334
(T2SSG) 		5 MET A  25
ALA A  31
VAL A  37
ASP A 127
THR A 112
 None
None
None
CA  A 301 (-3.1A)
None
 1.47A 5vlmD-3fu1A:
undetectable		 5vlmD-3fu1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 ALA A 107
LEU A 121
VAL A 132
ASP A 113
THR A 111
 None
 1.34A 5vlmD-3gc2A:
undetectable		 5vlmD-3gc2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 ALA A 156
TYR A  27
ASP A 186
PHE A 185
THR A 184
 None
 1.14A 5vlmD-3gf6A:
undetectable		 5vlmD-3gf6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 ALA A 292
LEU A  80
VAL A  13
ASP A   5
THR A  96
 None
 1.49A 5vlmD-3hdjA:
undetectable		 5vlmD-3hdjA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		5 ALA A  84
LEU A 140
VAL A  41
TYR A  33
THR A  19
 None
 1.14A 5vlmD-3i1jA:
undetectable		 5vlmD-3i1jA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1

(Enterovirus B) 		PF00073
(Rhv) 		5 MET A  41
ALA A  10
TYR A 130
VAL A  57
PHE A  59
 None
 1.39A 5vlmD-3j2jA:
undetectable		 5vlmD-3j2jA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		5 MET A  64
TYR A 317
VAL A  99
ASP A  82
PHE A  81
 None
 1.32A 5vlmD-3opsA:
undetectable		 5vlmD-3opsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 MET A 215
ALA A 413
VAL A 336
ASP A 370
PHE A 382
 None
 1.29A 5vlmD-3oslA:
undetectable		 5vlmD-3oslA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 ALA A 243
LEU A 291
ARG A 218
VAL A 274
ASP A 251
 None
 1.20A 5vlmD-3othA:
undetectable		 5vlmD-3othA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 192
ARG A 208
VAL A 100
ASP A  49
PHE A  46
 None
 1.42A 5vlmD-3r9qA:
undetectable		 5vlmD-3r9qA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  96
LEU A  26
TYR A 226
ASP A 193
PHE A 197
 None
 1.49A 5vlmD-3swdA:
undetectable		 5vlmD-3swdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ALA A4306
LEU A4360
TYR A4317
TYR A1908
THR A1959
 None
 1.21A 5vlmD-3vkgA:
undetectable		 5vlmD-3vkgA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		5 ALA A 127
LEU A 115
VAL A  38
ASP A  91
PHE A  94
 None
 1.29A 5vlmD-3wibA:
undetectable		 5vlmD-3wibA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 ALA M 678
LEU M 673
VAL M   9
ASP M  87
PHE M  16
 None
 1.47A 5vlmD-4gq2M:
0.5		 5vlmD-4gq2M:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 244
LEU A 308
VAL A 262
TYR A 377
PHE A 292
 None
 1.15A 5vlmD-4ha4A:
undetectable		 5vlmD-4ha4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 244
VAL A 262
TYR A 377
ASP A 293
PHE A 292
 None
 1.46A 5vlmD-4ha4A:
undetectable		 5vlmD-4ha4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.34A 5vlmD-4i70A:
undetectable		 5vlmD-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ALA A 184
LEU A 138
VAL A 178
ASP A 222
PHE A 197
 None
 1.47A 5vlmD-4jn6A:
undetectable		 5vlmD-4jn6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ALA A 188
ARG A 204
VAL A  96
ASP A  45
PHE A  42
 None
 1.39A 5vlmD-4z0mA:
undetectable		 5vlmD-4z0mA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2682
VAL A2422
CYH A2419
TYR A2428
ASP A2579
 None
 1.45A 5vlmD-4z37A:
0.6		 5vlmD-4z37A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 MET A 561
ALA A 529
LEU A 675
VAL A 615
ASP A 612
 None
 1.50A 5vlmD-5aeeA:
0.4		 5vlmD-5aeeA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1t SMALL GTPASE EHRABX3

(Entamoeba
histolytica) 		PF00071
(Ras) 		5 ALA A 213
LEU A 184
TYR A 225
ASP A 281
THR A 195
 None
 1.42A 5vlmD-5c1tA:
undetectable		 5vlmD-5c1tA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 MET A 509
ALA A 449
LEU A 420
VAL A 427
ASP A 477
 None
 1.47A 5vlmD-5cdiA:
undetectable		 5vlmD-5cdiA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 MET A  88
ALA A  95
VAL A 179
TYR A 122
THR A 139
 None
 1.46A 5vlmD-5cg0A:
undetectable		 5vlmD-5cg0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 TYR A  32
VAL A 200
ASP A 243
PHE A 185
THR A 181
 None
 1.41A 5vlmD-5gmsA:
undetectable		 5vlmD-5gmsA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 ALA A  43
LEU A  54
VAL B 343
TYR B 362
ASP A  57
 None
 1.29A 5vlmD-5hftA:
undetectable		 5vlmD-5hftA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25

(Mycolicibacterium
smegmatis) 		PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C) 		5 ALA W 135
VAL W 100
TYR W  38
ASP W  96
THR W  80
 None
None
A  B  74 ( 4.2A)
G  B  76 ( 3.4A)
None
 1.21A 5vlmD-5o60W:
undetectable		 5vlmD-5o60W:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 MET A 544
ALA A 512
LEU A 660
VAL A 598
ASP A 595
 None
 1.47A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 5 ALA A 282
VAL A 227
ASP A 196
PHE A 198
THR A 276
 None
 1.45A 5vlmD-5oq3A:
undetectable		 5vlmD-5oq3A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE

(Cyanidioschyzon
merolae) 		no annotation 5 MET A 299
LEU A 295
VAL A 277
ASP A 286
THR A 280
 None
 1.18A 5vlmD-5ud6A:
0.3		 5vlmD-5ud6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 12 MET A  67
MET A  68
ALA A  86
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
ASP A 175
PHE A 178
THR A 179
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
None
 0.60A 5vlmD-5vlgA:
29.7		 5vlmD-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE

(Cladophialophora
bantiana) 		no annotation 5 ALA A 113
LEU A 204
VAL A 122
TYR A 264
ASP A 210
 None
None
NA  A 301 (-4.8A)
None
None
 0.90A 5vlmD-5xwzA:
undetectable		 5vlmD-5xwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.38A 5vlmD-6co1A:
undetectable		 5vlmD-6co1A:
undetectable