SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_D_CVID301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4m PROTEIN
(COXSACKIEVIRUS A9)

(Enterovirus B) 		PF00073
(Rhv) 		5 MET 1 103
ALA 1  72
TYR 1 192
VAL 1 119
PHE 1 121
 None
None
W71  1 501 ( 3.7A)
None
None
 1.38A 5vlmD-1d4m1:
undetectable		 5vlmD-1d4m1:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 ALA A 180
LEU A 168
VAL A 213
TYR A 210
ASP A 224
 None
 1.28A 5vlmD-1gq1A:
0.0		 5vlmD-1gq1A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 ALA A 162
LEU A 150
VAL A 195
TYR A 192
ASP A 206
 None
 1.26A 5vlmD-1hzvA:
0.0		 5vlmD-1hzvA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 MET A 304
ALA A 130
VAL A 235
ASP A 143
PHE A 145
 None
 1.48A 5vlmD-1iayA:
0.0		 5vlmD-1iayA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 MET A 469
ALA A 423
LEU A 430
VAL A 367
ASP A 444
 None
 1.48A 5vlmD-1ldjA:
2.2		 5vlmD-1ldjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		5 LEU A  29
TYR A 148
VAL A   8
CYH A 197
ASP A  38
 None
 1.43A 5vlmD-1nfpA:
0.0		 5vlmD-1nfpA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		5 ALA A 133
LEU A 159
VAL A 180
TYR A 149
THR A 183
 None
 1.36A 5vlmD-1npyA:
0.0		 5vlmD-1npyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6e CAPSID PROTEIN P40

(Human
gammaherpesvirus
4) 		PF00716
(Peptidase_S21) 		5 ALA A 118
LEU A  42
TYR A 155
VAL A  13
TYR A  61
 ISP  A1236 ( 4.7A)
None
None
None
None
 1.48A 5vlmD-1o6eA:
undetectable		 5vlmD-1o6eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.27A 5vlmD-1vefA:
undetectable		 5vlmD-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 ALA A 211
LEU A 139
VAL A 200
ASP A 162
THR A 191
 None
 1.49A 5vlmD-1xw8A:
0.3		 5vlmD-1xw8A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		5 ALA A  99
LEU A 118
TYR A  78
VAL A  20
THR A  91
 None
None
None
GDP  A 201 (-4.0A)
None
 1.40A 5vlmD-1z2aA:
undetectable		 5vlmD-1z2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		5 ALA A 214
LEU A  81
VAL A 178
ASP A 191
PHE A 111
 None
 1.44A 5vlmD-2d3rA:
undetectable		 5vlmD-2d3rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 ALA A  32
LEU A 293
VAL A  29
CYH A  27
PHE A 309
 None
 1.49A 5vlmD-2de2A:
0.2		 5vlmD-2de2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae) 		PF03280
(Lipase_chap) 		5 ALA D 113
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.46A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae) 		PF03280
(Lipase_chap) 		5 ALA D 114
LEU D 107
TYR D 132
ASP D  90
PHE D  89
 None
CSO  D  92 ( 4.4A)
None
None
None
 1.49A 5vlmD-2es4D:
1.6		 5vlmD-2es4D:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		5 ALA A 215
LEU A  81
VAL A 179
ASP A 192
PHE A 111
 None
 1.41A 5vlmD-2gdfA:
undetectable		 5vlmD-2gdfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 ALA A 179
LEU A 169
VAL A  72
TYR A 222
ASP A 147
 None
None
None
None
SAM  A 300 (-3.9A)
 1.41A 5vlmD-2oxtA:
undetectable		 5vlmD-2oxtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 MET A 156
ALA A 133
LEU A 273
TYR A 199
ASP A 201
 None
 1.47A 5vlmD-2pfyA:
0.6		 5vlmD-2pfyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 ALA A  40
LEU A 154
VAL A  74
ASP A  83
PHE A  85
 LAE  A1001 ( 3.9A)
None
LAE  A1001 ( 4.6A)
None
None
 1.42A 5vlmD-2q0oA:
undetectable		 5vlmD-2q0oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		5 ALA A 133
VAL A  72
TYR A 167
ASP A  83
THR A  85
 None
 1.45A 5vlmD-2w2rA:
undetectable		 5vlmD-2w2rA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 ALA A 248
VAL A 255
TYR A 234
ASP A 238
PHE A 237
 None
 1.37A 5vlmD-2xpiA:
1.4		 5vlmD-2xpiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ALA A 488
ARG A 744
TYR A 742
ASP A 712
THR A 513
 None
 1.28A 5vlmD-2xt6A:
0.4		 5vlmD-2xt6A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ALA A  65
TYR A  38
ASP A  49
PHE A  48
THR A  47
 None
 1.42A 5vlmD-2y4oA:
undetectable		 5vlmD-2y4oA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B
DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C)
PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ALA A 198
LEU A 205
VAL A 166
TYR C 105
ASP A 149
 None
 1.46A 5vlmD-3aizA:
undetectable		 5vlmD-3aizA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 ALA A 400
VAL A 423
CYH A 424
PHE A 337
THR A 341
 None
 1.36A 5vlmD-3b46A:
undetectable		 5vlmD-3b46A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.37A 5vlmD-3ct4A:
1.1		 5vlmD-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 MET A 103
ALA A 298
VAL A 222
ASP A 255
PHE A 267
 None
 1.29A 5vlmD-3d4uA:
undetectable		 5vlmD-3d4uA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 MET A 142
LEU A 102
TYR A 263
ASP A 237
PHE A 258
 None
 1.48A 5vlmD-3f9tA:
undetectable		 5vlmD-3f9tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fu1 GENERAL SECRETION
PATHWAY PROTEIN G

(Vibrio cholerae) 		PF08334
(T2SSG) 		5 MET A  25
ALA A  31
VAL A  37
ASP A 127
THR A 112
 None
None
None
CA  A 301 (-3.1A)
None
 1.47A 5vlmD-3fu1A:
undetectable		 5vlmD-3fu1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 ALA A 107
LEU A 121
VAL A 132
ASP A 113
THR A 111
 None
 1.34A 5vlmD-3gc2A:
undetectable		 5vlmD-3gc2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 ALA A 156
TYR A  27
ASP A 186
PHE A 185
THR A 184
 None
 1.14A 5vlmD-3gf6A:
undetectable		 5vlmD-3gf6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 ALA A 292
LEU A  80
VAL A  13
ASP A   5
THR A  96
 None
 1.49A 5vlmD-3hdjA:
undetectable		 5vlmD-3hdjA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		5 ALA A  84
LEU A 140
VAL A  41
TYR A  33
THR A  19
 None
 1.14A 5vlmD-3i1jA:
undetectable		 5vlmD-3i1jA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1

(Enterovirus B) 		PF00073
(Rhv) 		5 MET A  41
ALA A  10
TYR A 130
VAL A  57
PHE A  59
 None
 1.39A 5vlmD-3j2jA:
undetectable		 5vlmD-3j2jA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		5 MET A  64
TYR A 317
VAL A  99
ASP A  82
PHE A  81
 None
 1.32A 5vlmD-3opsA:
undetectable		 5vlmD-3opsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 MET A 215
ALA A 413
VAL A 336
ASP A 370
PHE A 382
 None
 1.29A 5vlmD-3oslA:
undetectable		 5vlmD-3oslA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 ALA A 243
LEU A 291
ARG A 218
VAL A 274
ASP A 251
 None
 1.20A 5vlmD-3othA:
undetectable		 5vlmD-3othA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 192
ARG A 208
VAL A 100
ASP A  49
PHE A  46
 None
 1.42A 5vlmD-3r9qA:
undetectable		 5vlmD-3r9qA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  96
LEU A  26
TYR A 226
ASP A 193
PHE A 197
 None
 1.49A 5vlmD-3swdA:
undetectable		 5vlmD-3swdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ALA A4306
LEU A4360
TYR A4317
TYR A1908
THR A1959
 None
 1.21A 5vlmD-3vkgA:
undetectable		 5vlmD-3vkgA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		5 ALA A 127
LEU A 115
VAL A  38
ASP A  91
PHE A  94
 None
 1.29A 5vlmD-3wibA:
undetectable		 5vlmD-3wibA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 ALA M 678
LEU M 673
VAL M   9
ASP M  87
PHE M  16
 None
 1.47A 5vlmD-4gq2M:
0.5		 5vlmD-4gq2M:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 244
LEU A 308
VAL A 262
TYR A 377
PHE A 292
 None
 1.15A 5vlmD-4ha4A:
undetectable		 5vlmD-4ha4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 244
VAL A 262
TYR A 377
ASP A 293
PHE A 292
 None
 1.46A 5vlmD-4ha4A:
undetectable		 5vlmD-4ha4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.34A 5vlmD-4i70A:
undetectable		 5vlmD-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ALA A 184
LEU A 138
VAL A 178
ASP A 222
PHE A 197
 None
 1.47A 5vlmD-4jn6A:
undetectable		 5vlmD-4jn6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ALA A 188
ARG A 204
VAL A  96
ASP A  45
PHE A  42
 None
 1.39A 5vlmD-4z0mA:
undetectable		 5vlmD-4z0mA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2682
VAL A2422
CYH A2419
TYR A2428
ASP A2579
 None
 1.45A 5vlmD-4z37A:
0.6		 5vlmD-4z37A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 MET A 561
ALA A 529
LEU A 675
VAL A 615
ASP A 612
 None
 1.50A 5vlmD-5aeeA:
0.4		 5vlmD-5aeeA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1t SMALL GTPASE EHRABX3

(Entamoeba
histolytica) 		PF00071
(Ras) 		5 ALA A 213
LEU A 184
TYR A 225
ASP A 281
THR A 195
 None
 1.42A 5vlmD-5c1tA:
undetectable		 5vlmD-5c1tA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 MET A 509
ALA A 449
LEU A 420
VAL A 427
ASP A 477
 None
 1.47A 5vlmD-5cdiA:
undetectable		 5vlmD-5cdiA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 MET A  88
ALA A  95
VAL A 179
TYR A 122
THR A 139
 None
 1.46A 5vlmD-5cg0A:
undetectable		 5vlmD-5cg0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 TYR A  32
VAL A 200
ASP A 243
PHE A 185
THR A 181
 None
 1.41A 5vlmD-5gmsA:
undetectable		 5vlmD-5gmsA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 ALA A  43
LEU A  54
VAL B 343
TYR B 362
ASP A  57
 None
 1.29A 5vlmD-5hftA:
undetectable		 5vlmD-5hftA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25

(Mycolicibacterium
smegmatis) 		PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C) 		5 ALA W 135
VAL W 100
TYR W  38
ASP W  96
THR W  80
 None
None
A  B  74 ( 4.2A)
G  B  76 ( 3.4A)
None
 1.21A 5vlmD-5o60W:
undetectable		 5vlmD-5o60W:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 MET A 544
ALA A 512
LEU A 660
VAL A 598
ASP A 595
 None
 1.47A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 5 ALA A 282
VAL A 227
ASP A 196
PHE A 198
THR A 276
 None
 1.45A 5vlmD-5oq3A:
undetectable		 5vlmD-5oq3A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE

(Cyanidioschyzon
merolae) 		no annotation 5 MET A 299
LEU A 295
VAL A 277
ASP A 286
THR A 280
 None
 1.18A 5vlmD-5ud6A:
0.3		 5vlmD-5ud6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 12 MET A  67
MET A  68
ALA A  86
LEU A  94
ARG A 102
TYR A 118
VAL A 159
CYH A 160
TYR A 166
ASP A 175
PHE A 178
THR A 179
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
None
 0.60A 5vlmD-5vlgA:
29.7		 5vlmD-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE

(Cladophialophora
bantiana) 		no annotation 5 ALA A 113
LEU A 204
VAL A 122
TYR A 264
ASP A 210
 None
None
NA  A 301 (-4.8A)
None
None
 0.90A 5vlmD-5xwzA:
undetectable		 5vlmD-5xwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 5 MET A 183
MET A 182
ALA A 176
LEU A 188
PHE A 165
 None
 1.38A 5vlmD-6co1A:
undetectable		 5vlmD-6co1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhq CD11B

(Homo sapiens) 		PF00092
(VWA) 		4 GLN 1 298
GLY 1 270
GLU 1 283
ASP 1 140
 None
None
None
CD  1 901 ( 3.9A)
 1.06A 5vlmD-1bhq1:
undetectable		 5vlmD-1bhq1:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 125
GLU A 127
ILE A 159
GLN A 182
 None
 0.98A 5vlmD-1cs1A:
0.0		 5vlmD-1cs1A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		4 GLN B 156
GLY B  18
ILE B 145
GLN B 219
 None
 1.00A 5vlmD-1ekbB:
undetectable		 5vlmD-1ekbB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1
ECHOVIRUS 1

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 GLY 2 133
ILE 2 146
TRP 2  79
ASP 1 197
 None
 0.92A 5vlmD-1ev12:
undetectable		 5vlmD-1ev12:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 322
GLU A 267
GLN A 385
ASP A 291
 None
 0.97A 5vlmD-1f8wA:
0.0		 5vlmD-1f8wA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i54 CYTOCHROME C

(Thunnus thynnus) 		PF00034
(Cytochrom_C) 		4 GLN A  92
GLY A  89
ILE A  85
GLN A  12
 None
 1.07A 5vlmD-1i54A:
undetectable		 5vlmD-1i54A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 GLN A  46
GLY A  43
ILE A  30
TRP A  22
 None
 1.05A 5vlmD-1kehA:
0.0		 5vlmD-1kehA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  20
GLY A  62
ILE A 344
GLN A 355
 None
ATP  A 450 (-3.5A)
ATP  A 450 (-4.0A)
None
 1.01A 5vlmD-1kyiA:
0.0		 5vlmD-1kyiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLY A 239
GLU A  78
ILE A 242
ASP A 241
 None
 0.96A 5vlmD-1l8kA:
0.0		 5vlmD-1l8kA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		4 GLN A2730
GLY A2735
ILE A2756
GLN A2762
 None
 0.91A 5vlmD-1lm5A:
0.0		 5vlmD-1lm5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT
HIV-2 RT

(Human
immunodeficiency
virus 2;
Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 GLY A 383
GLU B  29
ILE A 385
GLN A 372
 None
 0.91A 5vlmD-1mu2A:
0.2		 5vlmD-1mu2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  20
GLY A  62
ILE A 344
GLN A 355
 None
ADP  A 450 (-3.3A)
ADP  A 450 ( 4.0A)
None
 0.94A 5vlmD-1ofhA:
undetectable		 5vlmD-1ofhA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.07A 5vlmD-1rm8A:
undetectable		 5vlmD-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 GLN A 271
GLY A 272
ILE A 460
GLN A 454
 None
 0.88A 5vlmD-1t8wA:
undetectable		 5vlmD-1t8wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 GLN A  63
GLY A  48
GLN A 321
ASP A  52
 GLC  A 503 ( 3.9A)
None
None
None
 1.02A 5vlmD-1ua7A:
undetectable		 5vlmD-1ua7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  96
GLY A 154
ILE A 351
GLN A 362
 None
ADP  A 487 (-2.7A)
ADP  A 487 (-3.9A)
None
 0.98A 5vlmD-1um8A:
undetectable		 5vlmD-1um8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLN A 136
GLY A 106
GLU A 100
ILE A 110
 None
 0.99A 5vlmD-1x1qA:
undetectable		 5vlmD-1x1qA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 GLN A  85
GLY A  31
ILE A  28
GLN A  96
 None
 1.02A 5vlmD-1xw8A:
undetectable		 5vlmD-1xw8A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 479
GLU A 491
ILE A 460
GLN A 379
 None
None
None
SRM  A 569 (-3.9A)
 1.02A 5vlmD-1zj9A:
undetectable		 5vlmD-1zj9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 GLY A 326
GLU A 343
ILE A 312
GLN A  31
 None
 1.07A 5vlmD-2bjrA:
undetectable		 5vlmD-2bjrA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 GLY A 689
GLU A 639
ILE A 683
GLN A 719
 None
 1.05A 5vlmD-2ec5A:
2.2		 5vlmD-2ec5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 GLN A 182
GLY A 180
ILE A 187
GLN A 118
 None
 0.91A 5vlmD-2i0mA:
1.9		 5vlmD-2i0mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		4 GLY A  68
TRP A 121
GLN A 117
ASP A  85
 None
 1.04A 5vlmD-2lghA:
undetectable		 5vlmD-2lghA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 GLN A 121
ILE A 145
GLN A 138
ASP A 104
 None
 1.05A 5vlmD-2vj5A:
3.6		 5vlmD-2vj5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 GLN A 560
GLY A 498
GLU A 584
ILE A 495
 None
 1.02A 5vlmD-2vz9A:
undetectable		 5vlmD-2vz9A:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 GLY A  93
ILE A  38
TRP A  23
ASP A  56
 None
 0.89A 5vlmD-2w3pA:
undetectable		 5vlmD-2w3pA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 GLN A 309
GLY A 305
ILE A 298
TRP A 311
 None
 1.03A 5vlmD-2x3lA:
undetectable		 5vlmD-2x3lA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 GLY A 627
ILE A 644
TRP A 579
ASP A 694
 None
 1.03A 5vlmD-2yk0A:
2.8		 5vlmD-2yk0A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLN A 371
GLY A 374
ILE A 296
GLN A 288
 None
 1.04A 5vlmD-2z1qA:
1.0		 5vlmD-2z1qA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLN A 146
GLY A 143
GLN A 307
ASP A 264
 None
 0.99A 5vlmD-3e82A:
undetectable		 5vlmD-3e82A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)

(Rhodobacter
sphaeroides) 		PF00588
(SpoU_methylase) 		4 GLY A 108
ILE A   3
TRP A 158
GLN A 161
 None
 1.09A 5vlmD-3onpA:
undetectable		 5vlmD-3onpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 GLN B  52
GLY B  51
ILE B  25
GLN B  30
 None
None
ECN  B 411 (-4.5A)
None
 1.00A 5vlmD-3ozvB:
2.1		 5vlmD-3ozvB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqy RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
PROTEIN FUSION

(Ophiostoma
novo-ulmi) 		PF00961
(LAGLIDADG_1) 		4 GLN A  46
GLY A  44
TRP A  64
ASP A  86
 None
 1.06A 5vlmD-3qqyA:
undetectable		 5vlmD-3qqyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 181
GLU A  56
ILE A 141
ASP A 185
 None
 1.00A 5vlmD-3r7kA:
2.5		 5vlmD-3r7kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 GLN A 545
GLU A 525
ILE A 510
GLN A 583
 None
 0.98A 5vlmD-3sfzA:
undetectable		 5vlmD-3sfzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 709
GLU A 768
ILE A 685
GLN A 727
 None
 0.94A 5vlmD-3v9fA:
undetectable		 5vlmD-3v9fA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 833
GLY A 846
GLU A 881
ILE A 950
 None
 1.04A 5vlmD-3va7A:
undetectable		 5vlmD-3va7A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		4 GLN A 178
GLY A 179
ILE A 155
ASP A 186
 None
 0.83A 5vlmD-3vaxA:
undetectable		 5vlmD-3vaxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.89A 5vlmD-3zcwA:
undetectable		 5vlmD-3zcwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY A 361
GLU A 364
GLN A 319
ASP A 309
 None
 1.09A 5vlmD-4ak9A:
2.8		 5vlmD-4ak9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLN A1934
GLY A1853
TRP A1844
ASP A1843
 None
 1.00A 5vlmD-4bpcA:
undetectable		 5vlmD-4bpcA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A 454
GLU A 459
ILE A 419
GLN A 426
 None
 1.06A 5vlmD-4ciuA:
2.3		 5vlmD-4ciuA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 GLN A 357
GLY A  45
GLU A  40
ILE A 382
 None
 1.03A 5vlmD-4fwgA:
undetectable		 5vlmD-4fwgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 GLN A 175
GLY A 165
GLU A 170
ASP A  43
 None
 1.07A 5vlmD-4ghkA:
undetectable		 5vlmD-4ghkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLN A 283
GLY A  83
TRP A 265
GLN A 266
 None
CL  A 403 ( 3.9A)
None
None
 1.00A 5vlmD-4hnlA:
undetectable		 5vlmD-4hnlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		4 GLU A 191
ILE A 188
TRP A 198
GLN A 199
 None
EDO  A 510 (-3.9A)
None
None
 1.08A 5vlmD-4irtA:
undetectable		 5vlmD-4irtA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLY A 661
ILE A 667
GLN A 684
ASP A 780
 None
 1.07A 5vlmD-4k3cA:
undetectable		 5vlmD-4k3cA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		4 GLN A  30
GLY A  27
GLU A  22
ILE A  50
 None
 1.08A 5vlmD-4mtnA:
undetectable		 5vlmD-4mtnA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 GLY A 139
GLU A 136
ILE A 188
GLN A 170
 UNX  A 506 ( 3.9A)
None
None
None
 0.87A 5vlmD-4mvtA:
undetectable		 5vlmD-4mvtA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLN A 178
GLY A  93
GLU A 112
TRP A 223
 None
 1.05A 5vlmD-4nf8A:
undetectable		 5vlmD-4nf8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2l GTP-BINDING PROTEIN
RHEB

(Mus musculus) 		PF00071
(Ras) 		4 GLN A  52
GLY A  51
ILE A  47
GLN A 154
 None
 1.06A 5vlmD-4o2lA:
undetectable		 5vlmD-4o2lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		4 GLY A 201
GLU A 272
ILE A 198
ASP A 276
 None
ACT  A 402 (-3.4A)
None
None
 0.99A 5vlmD-4okoA:
undetectable		 5vlmD-4okoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 GLY A  47
GLU A  45
ILE A 244
GLN A 221
 None
 0.85A 5vlmD-4otkA:
undetectable		 5vlmD-4otkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		4 GLN A  41
GLY A  64
GLU A   8
ILE A  73
 None
 0.94A 5vlmD-4p0fA:
undetectable		 5vlmD-4p0fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 GLY A 236
GLU A 234
GLN A  59
TRP A 182
 None
 1.05A 5vlmD-4pspA:
undetectable		 5vlmD-4pspA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 GLN A 142
GLU A 689
ILE A 473
GLN A 487
 None
 1.05A 5vlmD-4rbnA:
undetectable		 5vlmD-4rbnA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1982
GLU A2095
ILE A2424
GLN A2285
 ATP  A4403 (-3.3A)
MG  A4404 ( 2.9A)
None
None
 1.03A 5vlmD-4rh7A:
undetectable		 5vlmD-4rh7A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 247
GLY A 422
ILE A 398
GLN A 487
 None
 0.93A 5vlmD-4rjkA:
undetectable		 5vlmD-4rjkA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlc OUTER MEMBRANE PORIN
F

(Pseudomonas
aeruginosa) 		PF05736
(OprF) 		4 GLY A  34
GLU A   9
ILE A  74
ASP A  72
 C8E  A 207 ( 4.3A)
None
None
None
 1.05A 5vlmD-4rlcA:
undetectable		 5vlmD-4rlcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLN A 451
GLY A 449
GLU A 494
ILE A 426
 None
 0.92A 5vlmD-4wjlA:
undetectable		 5vlmD-4wjlA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		4 GLY D  38
GLU D  41
ILE C 178
ASP C 177
 None
 1.04A 5vlmD-4xb6D:
undetectable		 5vlmD-4xb6D:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Grosmannia
penicillata) 		PF00961
(LAGLIDADG_1) 		4 GLN A  43
GLY A  41
TRP A  61
ASP A  83
 None
 1.01A 5vlmD-4yhxA:
undetectable		 5vlmD-4yhxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN

(Schizosaccharomyces
pombe) 		PF07855
(ATG101) 		4 GLN A 135
ILE A   7
TRP A 106
GLN A 105
 None
 1.08A 5vlmD-4yk8A:
undetectable		 5vlmD-4yk8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 313
GLY A 315
ILE A 318
GLN A 320
 None
 0.93A 5vlmD-4yljA:
undetectable		 5vlmD-4yljA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		4 GLN A 197
GLY A 188
ILE A  19
GLN A 211
 None
None
BR  A 304 (-4.5A)
None
 0.75A 5vlmD-4z0tA:
undetectable		 5vlmD-4z0tA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 239
GLY A 238
GLN A 201
TRP A 233
 None
 1.04A 5vlmD-4zoxA:
undetectable		 5vlmD-4zoxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 4 GLY A 627
GLU A 713
ILE A 634
GLN A 135
 None
 1.06A 5vlmD-4zuzA:
undetectable		 5vlmD-4zuzA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 GLY O 661
GLU O 696
ILE O 648
GLN O 617
 None
 0.88A 5vlmD-5a31O:
2.2		 5vlmD-5a31O:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 GLY A 383
TRP A 335
GLN A  74
ASP A  71
 None
 1.02A 5vlmD-5c2vA:
undetectable		 5vlmD-5c2vA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d68 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M)
PF13857
(Ank_5) 		4 GLN A 689
GLY A 691
ILE A 709
GLN A 643
 None
 0.95A 5vlmD-5d68A:
2.7		 5vlmD-5d68A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 302
GLU A 481
ILE A 306
ASP A 329
 None
 1.04A 5vlmD-5e7jA:
undetectable		 5vlmD-5e7jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 GLN A 223
GLY A 315
GLU A 317
GLN A 216
 None
 1.06A 5vlmD-5fgnA:
undetectable		 5vlmD-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 602
GLU A 606
ILE A 525
TRP A 601
 None
 1.05A 5vlmD-5fjjA:
undetectable		 5vlmD-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 GLN A 465
GLY A 489
ILE A 485
GLN A 474
 None
 1.03A 5vlmD-5fqlA:
undetectable		 5vlmD-5fqlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 GLN A 227
GLY A 228
ILE A 271
GLN A 199
 None
 0.97A 5vlmD-5g5nA:
undetectable		 5vlmD-5g5nA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 833
GLY A 846
GLU A 881
ILE A 950
 None
 1.04A 5vlmD-5i8iA:
undetectable		 5vlmD-5i8iA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		4 GLY A 285
GLU A 514
ILE A 319
TRP A 301
 None
 1.06A 5vlmD-5ikjA:
undetectable		 5vlmD-5ikjA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC

(Homo sapiens) 		PF00180
(Iso_dh) 		4 GLN A  14
GLY A  15
ILE A  21
GLN A 320
 None
 1.07A 5vlmD-5k10A:
undetectable		 5vlmD-5k10A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1
C13C6 VARIABLE FAB
DOMAIN HEAVY CHAIN

(Zaire
ebolavirus;
Homo sapiens) 		PF01611
(Filo_glycop)
PF07686
(V-set) 		4 GLN A 221
GLY A 143
GLU A 112
TRP C  53
 None
 0.96A 5vlmD-5kelA:
undetectable		 5vlmD-5kelA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 GLY A 483
GLU A 440
ILE A 395
GLN A 400
 None
 1.00A 5vlmD-5l2rA:
undetectable		 5vlmD-5l2rA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY B 344
GLU B 347
GLN B 302
ASP B 292
 GCP  B 401 (-3.5A)
GCP  B 401 (-3.5A)
None
None
 1.05A 5vlmD-5l3rB:
3.0		 5vlmD-5l3rB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 GLN A 231
GLY A 232
GLU A 166
ASP A 236
 None
 1.04A 5vlmD-5mz9A:
undetectable		 5vlmD-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.97A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 GLN A 359
GLY A 381
ILE A 230
GLN A 187
 None
 1.06A 5vlmD-5ti8A:
undetectable		 5vlmD-5ti8A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  20
GLY A  62
ILE A 343
GLN A 354
 None
ADP  A 501 (-3.2A)
ADP  A 501 ( 4.5A)
None
 0.89A 5vlmD-5txvA:
undetectable		 5vlmD-5txvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1b EGL NINE HOMOLOG 2

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 GLN A 393
GLY A 392
TRP A 373
ASP A 304
 None
SO4  A 501 ( 3.8A)
None
None
 1.05A 5vlmD-5v1bA:
undetectable		 5vlmD-5v1bA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 GLY A 390
GLU A 546
GLN A  58
TRP A 426
 None
EDO  A 819 (-3.2A)
None
None
 0.96A 5vlmD-5v1wA:
1.6		 5vlmD-5v1wA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLY B 161
ILE B 135
GLN A  85
ASP A  79
 None
 1.06A 5vlmD-5vgzB:
undetectable		 5vlmD-5vgzB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 6 GLN A  71
GLU A  90
ILE A  98
TRP A 101
GLN A 105
ASP A 163
 MGR  A 300 ( 4.1A)
MGR  A 300 (-4.1A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 ( 3.0A)
MGR  A 300 (-3.5A)
 1.24A 5vlmD-5vlgA:
29.7		 5vlmD-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 7 GLN A  71
GLY A  88
ILE A  98
TRP A 101
GLN A 105
TRP A 125
ASP A 163
 MGR  A 300 ( 4.1A)
MGR  A 300 ( 2.9A)
MGR  A 300 (-3.1A)
MGR  A 300 (-3.6A)
MGR  A 300 ( 3.0A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
 0.66A 5vlmD-5vlgA:
29.7		 5vlmD-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 GLN A 295
GLY A 312
ILE A 302
GLN A 325
ASP A 307
 None
 1.09A 5vlmD-5vmbA:
undetectable		 5vlmD-5vmbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wf2 UNCHARACTERIZED
PROTEIN

(Equus caballus) 		no annotation 4 GLN A 379
GLY A 372
GLU A 410
ILE A 368
 None
 0.99A 5vlmD-5wf2A:
3.4		 5vlmD-5wf2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L27

(Spinacia
oleracea) 		PF01016
(Ribosomal_L27) 		4 GLN X  85
GLY X  83
ILE X  93
GLN X  96
 A  A 932 ( 2.6A)
G  A 866 ( 3.3A)
None
None
 0.99A 5vlmD-5x8tX:
undetectable		 5vlmD-5x8tX:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 GLN A 459
GLY A 397
ILE A 401
GLN A 443
 OLC  A 501 ( 4.5A)
None
None
None
 1.05A 5vlmD-5xjjA:
undetectable		 5vlmD-5xjjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 4 GLY A 102
GLU A 106
ILE A 138
ASP A 135
 None
 0.99A 5vlmD-5xvsA:
undetectable		 5vlmD-5xvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 GLN A1008
GLY A1006
ILE A1003
TRP A 998
 None
 0.91A 5vlmD-6bhuA:
undetectable		 5vlmD-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 4 GLY A 954
GLU A 896
ILE A 903
ASP A 951
 None
 0.79A 5vlmD-6bogA:
3.0		 5vlmD-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PROTEIN FAM126A

(Homo sapiens) 		no annotation 4 GLN C 218
GLY C 214
ILE C 226
TRP C  84
 None
 1.06A 5vlmD-6bq1C:
1.9		 5vlmD-6bq1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY M 397
GLU M 378
ILE L 183
ASP L 179
 None
 1.05A 5vlmD-6g2jM:
undetectable		 5vlmD-6g2jM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 4 GLU A  40
ILE A 198
TRP A 167
TRP A 316
 None
 1.07A 5vlmD-6gqdA:
undetectable		 5vlmD-6gqdA:
undetectable