SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_C_CVIC301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ALA A 816
GLU A 692
LEU A 819
ARG A 881
ASP A 691
 None
 1.40A 5vlmC-1c7tA:
0.0		 5vlmC-1c7tA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		5 ALA A  99
GLU A 146
ARG A 111
CYH A 154
PHE A 145
 None
 1.27A 5vlmC-1ei5A:
0.0		 5vlmC-1ei5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		5 ALA A  53
LEU A  58
TYR A  24
VAL A  83
ASP A  79
 None
 1.36A 5vlmC-1jr6A:
undetectable		 5vlmC-1jr6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 ALA A  47
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.29A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 ALA A  50
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.46A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A 302
LEU A 295
TRP A  81
TYR A   9
PHE A  96
 None
 1.49A 5vlmC-1pcaA:
undetectable		 5vlmC-1pcaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 MET A 678
ALA A  54
VAL A  40
CYH A 608
PHE A  76
 None
 1.48A 5vlmC-1wkbA:
0.0		 5vlmC-1wkbA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		5 ALA A 160
LEU A 461
ARG A 242
VAL A 142
ASP A 137
 None
 1.42A 5vlmC-1wnbA:
0.0		 5vlmC-1wnbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 ALA A  62
GLU A  88
TYR A  44
VAL A  81
CYH A  99
 None
 1.28A 5vlmC-1ydoA:
0.3		 5vlmC-1ydoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088

(Bacillus
anthracis) 		PF12706
(Lactamase_B_2) 		5 ALA A 199
GLU A 175
LEU A 209
VAL A 151
ASP A 155
 None
None
None
None
ZN  A 246 ( 2.4A)
 1.27A 5vlmC-1zkpA:
undetectable		 5vlmC-1zkpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeq FAB HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 ALA H  99
TYR H  62
VAL H  81
ASP H  31
PHE H  29
 None
 1.45A 5vlmC-2aeqH:
undetectable		 5vlmC-2aeqH:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		5 MET A 221
ALA A 232
LEU A 225
TYR A  47
ASP A 255
 None
 1.40A 5vlmC-2cc1A:
0.0		 5vlmC-2cc1A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 ALA A 192
GLU A 268
LEU A 189
TYR A 201
ASP A 265
 None
None
None
HEM  A 600 (-4.2A)
None
 1.45A 5vlmC-2r7aA:
undetectable		 5vlmC-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF00440
(TetR_N) 		5 MET A  98
ALA A 168
GLU A 114
LEU A 109
VAL A 123
 None
 1.36A 5vlmC-2rasA:
4.6		 5vlmC-2rasA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2snv SINDBIS VIRUS COAT
PROTEIN

(Sindbis virus) 		PF00944
(Peptidase_S3) 		5 MET A 137
LEU A 231
TRP A 247
VAL A 227
PHE A 203
 None
 1.47A 5vlmC-2snvA:
undetectable		 5vlmC-2snvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 282
GLU A 226
LEU A 324
VAL A 240
PHE A 250
 None
 1.47A 5vlmC-2wvgA:
undetectable		 5vlmC-2wvgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhm NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		5 MET A 257
ALA A 264
LEU A 325
VAL A 277
ASP A 345
 None
 1.42A 5vlmC-2yhmA:
3.4		 5vlmC-2yhmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 144
TYR A 330
VAL A 119
ASP A 205
PHE A 206
 STU  A   1 (-4.0A)
None
None
STU  A   1 ( 3.8A)
None
 1.40A 5vlmC-2z7rA:
1.5		 5vlmC-2z7rA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 TRP A 148
TYR A  21
VAL A  43
ASP A 127
PHE A 126
 None
SAH  A 308 (-4.6A)
None
None
SAH  A 308 (-4.6A)
 1.36A 5vlmC-3g5tA:
undetectable		 5vlmC-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ALA A  86
LEU A 343
ARG A 340
VAL A  92
ASP A 334
 None
 1.50A 5vlmC-3ju1A:
undetectable		 5vlmC-3ju1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 MET A 148
LEU A  54
ARG A  86
TYR A 122
ASP A  94
 None
 1.47A 5vlmC-3ls2A:
undetectable		 5vlmC-3ls2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 MET A 213
MET A 212
ALA A 208
LEU A 129
CYH A 203
 None
 1.22A 5vlmC-3odgA:
undetectable		 5vlmC-3odgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 ALA B  14
LEU B 136
VAL B 119
CYH B 117
PHE B 121
 None
 1.49A 5vlmC-3p8cB:
undetectable		 5vlmC-3p8cB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 MET B  68
ALA B  72
GLU B 143
LEU B 194
TYR B   9
 None
 1.37A 5vlmC-3qkcB:
2.4		 5vlmC-3qkcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 MET A 146
LEU A  52
ARG A  84
TYR A 120
ASP A  92
 None
 1.47A 5vlmC-4b6gA:
undetectable		 5vlmC-4b6gA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		5 GLU A 260
TYR A 201
VAL A 276
ASP A  28
PHE A 258
 None
None
None
C5P  A1000 (-2.2A)
GOL  A3000 ( 4.3A)
 1.49A 5vlmC-4berA:
1.0		 5vlmC-4berA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 MET A 394
ALA A 392
LEU A  44
TYR A 332
ASP A  47
 None
None
None
GOL  A1431 (-4.5A)
None
 1.43A 5vlmC-4bf5A:
undetectable		 5vlmC-4bf5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.48A 5vlmC-4i70A:
undetectable		 5vlmC-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.28A 5vlmC-4issA:
undetectable		 5vlmC-4issA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k48 LEUCINE--TRNA LIGASE

(Streptococcus
pneumoniae) 		PF13603
(tRNA-synt_1_2) 		5 ALA A 309
GLU A 242
LEU A 267
TYR A 327
PHE A 234
 None
 1.46A 5vlmC-4k48A:
undetectable		 5vlmC-4k48A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 371
LEU A 451
VAL A 377
ASP A 404
PHE A 405
 None
None
None
VGG  A 601 ( 4.7A)
None
 1.48A 5vlmC-4lggA:
1.2		 5vlmC-4lggA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		5 ALA A 153
GLU A  89
LEU A 119
ARG A 103
ASP A 128
 None
5GP  A 301 ( 3.9A)
None
ACT  A 303 (-3.5A)
None
 1.42A 5vlmC-4o7zA:
undetectable		 5vlmC-4o7zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 151
LEU A 224
ARG A 158
TYR A  34
ASP A 221
 MPD  A1340 ( 4.3A)
MPD  A1340 ( 4.0A)
None
None
None
 1.34A 5vlmC-4v2pA:
undetectable		 5vlmC-4v2pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yru NEURONAL CALCIUM
SENSOR 1

(Rattus
norvegicus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 MET A 156
MET A 155
GLU A 120
LEU A 164
VAL A 125
 None
None
CA  A 202 (-2.2A)
None
None
 1.41A 5vlmC-4yruA:
undetectable		 5vlmC-4yruA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 MET A 244
ALA A 261
GLU A 277
LEU A 279
VAL A 216
 None
None
None
GOL  A 408 ( 4.6A)
None
 1.42A 5vlmC-5c0pA:
undetectable		 5vlmC-5c0pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.45A 5vlmC-5dm6G:
undetectable		 5vlmC-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 ALA A 462
ARG A 453
TYR A 414
ASP A 442
PHE A 443
 None
 1.44A 5vlmC-5fnoA:
undetectable		 5vlmC-5fnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 MET A 117
ALA A 123
GLU A  73
TRP A 110
VAL A  82
 45D  A 501 ( 2.8A)
None
None
45D  A 501 (-2.8A)
None
 1.41A 5vlmC-5hgrA:
1.0		 5vlmC-5hgrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.26A 5vlmC-5i8iA:
undetectable		 5vlmC-5i8iA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 5 ALA A  62
GLU A 121
TYR A 202
VAL A  59
ASP A 122
 FEG  A 404 (-4.2A)
None
None
None
None
 1.38A 5vlmC-5ok4A:
undetectable		 5vlmC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 ALA A  74
LEU A  83
VAL A 123
ASP A 106
PHE A 100
 None
 1.24A 5vlmC-5uibA:
undetectable		 5vlmC-5uibA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 MET A 312
ALA A 375
LEU A 380
TYR A 300
VAL A 280
 None
 1.46A 5vlmC-5uidA:
undetectable		 5vlmC-5uidA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
TRP A 101
ARG A 102
TYR A 118
VAL A 159
CYH A 160
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
 0.55A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
VAL A 159
CYH A 160
ASP A 175
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
 0.84A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
LEU A  94
TRP A 101
ARG A 102
TYR A 118
VAL A 159
CYH A 160
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.1A)
 0.42A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 MET A  67
MET A  68
ALA A  86
LEU A  94
VAL A 159
CYH A 160
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 0.73A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 ALA A  46
GLU A  66
LEU A  53
VAL A  69
ASP A  78
 None
 1.26A 5vlmC-5x7sA:
undetectable		 5vlmC-5x7sA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc3 PROBABLE RAB-RELATED
GTPASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ARG A 105
TYR A  76
VAL A  97
ASP A 141
PHE A 138
 None
 1.49A 5vlmC-5xc3A:
undetectable		 5vlmC-5xc3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		5 GLU A 556
LEU A 561
TYR A 625
CYH A 744
PHE A 375
 None
 1.40A 5vlmC-5xmcA:
2.2		 5vlmC-5xmcA:
14.47