SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_C_CVIC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ALA A 816
GLU A 692
LEU A 819
ARG A 881
ASP A 691
 None
 1.40A 5vlmC-1c7tA:
0.0		 5vlmC-1c7tA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		5 ALA A  99
GLU A 146
ARG A 111
CYH A 154
PHE A 145
 None
 1.27A 5vlmC-1ei5A:
0.0		 5vlmC-1ei5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		5 ALA A  53
LEU A  58
TYR A  24
VAL A  83
ASP A  79
 None
 1.36A 5vlmC-1jr6A:
undetectable		 5vlmC-1jr6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 ALA A  47
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.29A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 ALA A  50
LEU A 158
VAL A 276
ASP A 297
PHE A 280
 None
 1.46A 5vlmC-1mtpA:
0.9		 5vlmC-1mtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A 302
LEU A 295
TRP A  81
TYR A   9
PHE A  96
 None
 1.49A 5vlmC-1pcaA:
undetectable		 5vlmC-1pcaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 MET A 678
ALA A  54
VAL A  40
CYH A 608
PHE A  76
 None
 1.48A 5vlmC-1wkbA:
0.0		 5vlmC-1wkbA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		5 ALA A 160
LEU A 461
ARG A 242
VAL A 142
ASP A 137
 None
 1.42A 5vlmC-1wnbA:
0.0		 5vlmC-1wnbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 ALA A  62
GLU A  88
TYR A  44
VAL A  81
CYH A  99
 None
 1.28A 5vlmC-1ydoA:
0.3		 5vlmC-1ydoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088

(Bacillus
anthracis) 		PF12706
(Lactamase_B_2) 		5 ALA A 199
GLU A 175
LEU A 209
VAL A 151
ASP A 155
 None
None
None
None
ZN  A 246 ( 2.4A)
 1.27A 5vlmC-1zkpA:
undetectable		 5vlmC-1zkpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeq FAB HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 ALA H  99
TYR H  62
VAL H  81
ASP H  31
PHE H  29
 None
 1.45A 5vlmC-2aeqH:
undetectable		 5vlmC-2aeqH:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		5 MET A 221
ALA A 232
LEU A 225
TYR A  47
ASP A 255
 None
 1.40A 5vlmC-2cc1A:
0.0		 5vlmC-2cc1A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 ALA A 192
GLU A 268
LEU A 189
TYR A 201
ASP A 265
 None
None
None
HEM  A 600 (-4.2A)
None
 1.45A 5vlmC-2r7aA:
undetectable		 5vlmC-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF00440
(TetR_N) 		5 MET A  98
ALA A 168
GLU A 114
LEU A 109
VAL A 123
 None
 1.36A 5vlmC-2rasA:
4.6		 5vlmC-2rasA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2snv SINDBIS VIRUS COAT
PROTEIN

(Sindbis virus) 		PF00944
(Peptidase_S3) 		5 MET A 137
LEU A 231
TRP A 247
VAL A 227
PHE A 203
 None
 1.47A 5vlmC-2snvA:
undetectable		 5vlmC-2snvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 282
GLU A 226
LEU A 324
VAL A 240
PHE A 250
 None
 1.47A 5vlmC-2wvgA:
undetectable		 5vlmC-2wvgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhm NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		5 MET A 257
ALA A 264
LEU A 325
VAL A 277
ASP A 345
 None
 1.42A 5vlmC-2yhmA:
3.4		 5vlmC-2yhmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 144
TYR A 330
VAL A 119
ASP A 205
PHE A 206
 STU  A   1 (-4.0A)
None
None
STU  A   1 ( 3.8A)
None
 1.40A 5vlmC-2z7rA:
1.5		 5vlmC-2z7rA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 TRP A 148
TYR A  21
VAL A  43
ASP A 127
PHE A 126
 None
SAH  A 308 (-4.6A)
None
None
SAH  A 308 (-4.6A)
 1.36A 5vlmC-3g5tA:
undetectable		 5vlmC-3g5tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ALA A  86
LEU A 343
ARG A 340
VAL A  92
ASP A 334
 None
 1.50A 5vlmC-3ju1A:
undetectable		 5vlmC-3ju1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 MET A 148
LEU A  54
ARG A  86
TYR A 122
ASP A  94
 None
 1.47A 5vlmC-3ls2A:
undetectable		 5vlmC-3ls2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 MET A 213
MET A 212
ALA A 208
LEU A 129
CYH A 203
 None
 1.22A 5vlmC-3odgA:
undetectable		 5vlmC-3odgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 ALA B  14
LEU B 136
VAL B 119
CYH B 117
PHE B 121
 None
 1.49A 5vlmC-3p8cB:
undetectable		 5vlmC-3p8cB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkc GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Antirrhinum
majus) 		no annotation 5 MET B  68
ALA B  72
GLU B 143
LEU B 194
TYR B   9
 None
 1.37A 5vlmC-3qkcB:
2.4		 5vlmC-3qkcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 MET A 146
LEU A  52
ARG A  84
TYR A 120
ASP A  92
 None
 1.47A 5vlmC-4b6gA:
undetectable		 5vlmC-4b6gA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		5 GLU A 260
TYR A 201
VAL A 276
ASP A  28
PHE A 258
 None
None
None
C5P  A1000 (-2.2A)
GOL  A3000 ( 4.3A)
 1.49A 5vlmC-4berA:
1.0		 5vlmC-4berA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 MET A 394
ALA A 392
LEU A  44
TYR A 332
ASP A  47
 None
None
None
GOL  A1431 (-4.5A)
None
 1.43A 5vlmC-4bf5A:
undetectable		 5vlmC-4bf5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.48A 5vlmC-4i70A:
undetectable		 5vlmC-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.28A 5vlmC-4issA:
undetectable		 5vlmC-4issA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k48 LEUCINE--TRNA LIGASE

(Streptococcus
pneumoniae) 		PF13603
(tRNA-synt_1_2) 		5 ALA A 309
GLU A 242
LEU A 267
TYR A 327
PHE A 234
 None
 1.46A 5vlmC-4k48A:
undetectable		 5vlmC-4k48A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 371
LEU A 451
VAL A 377
ASP A 404
PHE A 405
 None
None
None
VGG  A 601 ( 4.7A)
None
 1.48A 5vlmC-4lggA:
1.2		 5vlmC-4lggA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		5 ALA A 153
GLU A  89
LEU A 119
ARG A 103
ASP A 128
 None
5GP  A 301 ( 3.9A)
None
ACT  A 303 (-3.5A)
None
 1.42A 5vlmC-4o7zA:
undetectable		 5vlmC-4o7zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 151
LEU A 224
ARG A 158
TYR A  34
ASP A 221
 MPD  A1340 ( 4.3A)
MPD  A1340 ( 4.0A)
None
None
None
 1.34A 5vlmC-4v2pA:
undetectable		 5vlmC-4v2pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yru NEURONAL CALCIUM
SENSOR 1

(Rattus
norvegicus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 MET A 156
MET A 155
GLU A 120
LEU A 164
VAL A 125
 None
None
CA  A 202 (-2.2A)
None
None
 1.41A 5vlmC-4yruA:
undetectable		 5vlmC-4yruA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 MET A 244
ALA A 261
GLU A 277
LEU A 279
VAL A 216
 None
None
None
GOL  A 408 ( 4.6A)
None
 1.42A 5vlmC-5c0pA:
undetectable		 5vlmC-5c0pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.45A 5vlmC-5dm6G:
undetectable		 5vlmC-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 ALA A 462
ARG A 453
TYR A 414
ASP A 442
PHE A 443
 None
 1.44A 5vlmC-5fnoA:
undetectable		 5vlmC-5fnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 MET A 117
ALA A 123
GLU A  73
TRP A 110
VAL A  82
 45D  A 501 ( 2.8A)
None
None
45D  A 501 (-2.8A)
None
 1.41A 5vlmC-5hgrA:
1.0		 5vlmC-5hgrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.26A 5vlmC-5i8iA:
undetectable		 5vlmC-5i8iA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 5 ALA A  62
GLU A 121
TYR A 202
VAL A  59
ASP A 122
 FEG  A 404 (-4.2A)
None
None
None
None
 1.38A 5vlmC-5ok4A:
undetectable		 5vlmC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 ALA A  74
LEU A  83
VAL A 123
ASP A 106
PHE A 100
 None
 1.24A 5vlmC-5uibA:
undetectable		 5vlmC-5uibA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 MET A 312
ALA A 375
LEU A 380
TYR A 300
VAL A 280
 None
 1.46A 5vlmC-5uidA:
undetectable		 5vlmC-5uidA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
TRP A 101
ARG A 102
TYR A 118
VAL A 159
CYH A 160
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
 0.55A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 MET A  67
MET A  68
ALA A  86
GLU A  90
LEU A  94
VAL A 159
CYH A 160
ASP A 175
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
 0.84A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
MET A  68
ALA A  86
LEU A  94
TRP A 101
ARG A 102
TYR A 118
VAL A 159
CYH A 160
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.1A)
 0.42A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 MET A  67
MET A  68
ALA A  86
LEU A  94
VAL A 159
CYH A 160
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 0.73A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 ALA A  46
GLU A  66
LEU A  53
VAL A  69
ASP A  78
 None
 1.26A 5vlmC-5x7sA:
undetectable		 5vlmC-5x7sA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc3 PROBABLE RAB-RELATED
GTPASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ARG A 105
TYR A  76
VAL A  97
ASP A 141
PHE A 138
 None
 1.49A 5vlmC-5xc3A:
undetectable		 5vlmC-5xc3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		5 GLU A 556
LEU A 561
TYR A 625
CYH A 744
PHE A 375
 None
 1.40A 5vlmC-5xmcA:
2.2		 5vlmC-5xmcA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		4 GLN A 182
ILE A  80
GLN A  71
TYR A 274
 None
 0.97A 5vlmC-1eomA:
undetectable		 5vlmC-1eomA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 GLN A 254
GLY A 250
ILE A 362
GLN A 340
 None
 1.16A 5vlmC-1fpsA:
1.8		 5vlmC-1fpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 GLN S 361
GLY S 363
GLN S 418
ASP S 424
 None
 1.05A 5vlmC-1i84S:
0.7		 5vlmC-1i84S:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 GLN A 195
GLY A 193
ILE A 200
GLN A 265
 None
 1.11A 5vlmC-1iqpA:
3.0		 5vlmC-1iqpA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		4 GLN B  94
GLY B 128
GLN B 172
ASP B 131
 None
 1.09A 5vlmC-1jtdB:
undetectable		 5vlmC-1jtdB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		4 ILE A  71
GLN A 185
TRP A 218
TYR A 141
 KCX  A  70 ( 4.3A)
None
None
None
 1.10A 5vlmC-1k38A:
undetectable		 5vlmC-1k38A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		4 GLN A2730
GLY A2735
ILE A2756
GLN A2762
 None
 0.90A 5vlmC-1lm5A:
undetectable		 5vlmC-1lm5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 GLY A 484
ILE A 489
GLN A 530
ASP A 525
 None
 1.17A 5vlmC-1lshA:
1.6		 5vlmC-1lshA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 GLY A 285
GLN A 295
ASP A 119
TYR A 239
 None
 1.12A 5vlmC-1qwyA:
undetectable		 5vlmC-1qwyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.07A 5vlmC-1rm8A:
0.3		 5vlmC-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpu 19 KDA PROTEIN

(Carnation
Italian
ringspot virus) 		PF03220
(Tombus_P19) 		4 GLY A  88
ILE A 138
GLN A 131
TYR A 112
 None
 1.08A 5vlmC-1rpuA:
undetectable		 5vlmC-1rpuA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 GLN A 271
GLY A 272
ILE A 460
GLN A 454
 None
 1.00A 5vlmC-1t8wA:
0.0		 5vlmC-1t8wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 GLN A 175
GLY A 183
ILE A 188
GLN A   5
 None
 1.11A 5vlmC-1tisA:
0.0		 5vlmC-1tisA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 GLN B 155
GLY B 190
ILE B 181
GLN B  80
 None
 1.07A 5vlmC-1tnuB:
0.8		 5vlmC-1tnuB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 GLN A  63
GLY A  48
GLN A 321
ASP A  52
 GLC  A 503 ( 3.9A)
None
None
None
 0.95A 5vlmC-1ua7A:
undetectable		 5vlmC-1ua7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  96
GLY A 154
ILE A 351
GLN A 362
 None
ADP  A 487 (-2.7A)
ADP  A 487 (-3.9A)
None
 1.07A 5vlmC-1um8A:
undetectable		 5vlmC-1um8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 GLN A 146
GLY A 144
ILE A  78
ASP A 255
 None
 1.16A 5vlmC-1upsA:
undetectable		 5vlmC-1upsA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 GLN A  83
GLY A 113
GLN A 170
TRP A 111
 None
None
None
CIT  A4001 (-4.4A)
 1.07A 5vlmC-1vbjA:
undetectable		 5vlmC-1vbjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 GLY A 358
ILE A 474
GLN A 368
TYR A 363
 None
 1.12A 5vlmC-1xfuA:
undetectable		 5vlmC-1xfuA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 GLN A 162
GLY A 183
ILE A 112
GLN A 192
 None
None
ACT  A1501 (-4.5A)
None
 1.12A 5vlmC-2bb0A:
undetectable		 5vlmC-2bb0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 GLN A 100
GLY A 351
GLN A 254
TYR A 385
 None
 1.04A 5vlmC-2d1gA:
undetectable		 5vlmC-2d1gA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm0 TYROSINE-PROTEIN
KINASE TXK

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A  34
GLY A 118
ILE A  42
GLN A 100
 None
 1.16A 5vlmC-2dm0A:
undetectable		 5vlmC-2dm0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fui BROMODOMAIN PHD
FINGER TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF00628
(PHD) 		4 GLN A  42
ILE A  24
GLN A  55
TYR A  17
 None
 1.17A 5vlmC-2fuiA:
undetectable		 5vlmC-2fuiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 GLY A  93
ILE A  75
GLN A 114
TYR A 138
 None
 1.05A 5vlmC-2i00A:
undetectable		 5vlmC-2i00A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 GLN A 176
ILE A 283
GLN A 271
TYR A 258
 None
 0.87A 5vlmC-2lnlA:
undetectable		 5vlmC-2lnlA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 GLN A 124
ILE A 117
GLN A 144
TRP A 126
 None
 1.10A 5vlmC-2qr4A:
3.2		 5vlmC-2qr4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 415
GLY A 413
ILE A 396
ASP A  57
 GLN  A 415 ( 0.6A)
GLY  A 413 ( 0.0A)
ILE  A 396 ( 0.7A)
ASP  A  57 ( 0.5A)
 1.16A 5vlmC-2vbfA:
undetectable		 5vlmC-2vbfA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLN A 370
GLY A 412
ILE A 428
TYR A 445
 None
 1.09A 5vlmC-2vcaA:
1.8		 5vlmC-2vcaA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 GLN A 577
GLY A 280
ILE A 282
TYR A 655
 None
 1.12A 5vlmC-2vycA:
undetectable		 5vlmC-2vycA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 GLN A  89
GLY A 119
GLN A 178
TRP A 117
 None
 1.10A 5vlmC-2wzmA:
undetectable		 5vlmC-2wzmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 GLN A 309
GLY A 305
ILE A 298
TRP A 311
 None
 1.05A 5vlmC-2x3lA:
undetectable		 5vlmC-2x3lA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 GLN A  85
GLY A 115
GLN A 172
TRP A 113
 None
None
None
NDP  A   1 ( 4.2A)
 1.06A 5vlmC-3d3fA:
undetectable		 5vlmC-3d3fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY H 226
ILE H 158
GLN H  30
ASP H 194
 0G6  H   1 ( 3.9A)
None
None
None
 0.98A 5vlmC-3f6uH:
undetectable		 5vlmC-3f6uH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 ILE C  76
GLN C 190
TRP C 223
TYR C 146
 KCX  C  75 ( 4.4A)
None
None
None
 1.01A 5vlmC-3if6C:
undetectable		 5vlmC-3if6C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 542
ILE A 620
GLN A 376
ASP A 586
 None
 1.17A 5vlmC-3n23A:
undetectable		 5vlmC-3n23A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 GLY A 353
ILE A 362
ASP A 190
TYR A 189
 GDP  A 663 (-3.6A)
None
None
None
 0.97A 5vlmC-3p27A:
undetectable		 5vlmC-3p27A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  66
ILE L  29
GLN L  89
TYR L  50
 None
 1.05A 5vlmC-3r08L:
undetectable		 5vlmC-3r08L:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0m LLAMA VHH A12

(Lama glama) 		PF07686
(V-set) 		4 GLY A  35
GLN A   3
ASP A 102
TYR A 101
 None
 1.11A 5vlmC-3r0mA:
undetectable		 5vlmC-3r0mA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 GLN A 220
GLY A 221
ILE A 240
TYR A 313
 None
 0.80A 5vlmC-3r7tA:
undetectable		 5vlmC-3r7tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5q PUTATIVE
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 GLN A  60
ILE A  98
TRP A  63
TYR A 127
 None
 1.09A 5vlmC-3s5qA:
undetectable		 5vlmC-3s5qA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 GLN A  12
GLY A  13
ILE A 195
GLN A 167
 GLY  A 314 (-4.0A)
None
None
None
 1.15A 5vlmC-3tqeA:
undetectable		 5vlmC-3tqeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLN A 254
GLY A 226
ILE A 221
TRP A 330
 None
 1.16A 5vlmC-3tqiA:
undetectable		 5vlmC-3tqiA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLN A1000
GLY A 994
ILE A 335
ASP A 633
 None
 1.11A 5vlmC-3w9hA:
undetectable		 5vlmC-3w9hA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.83A 5vlmC-3zcwA:
undetectable		 5vlmC-3zcwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLY A 492
ILE A 487
GLN A 602
TYR A 484
 None
None
PEG  A1667 ( 4.6A)
None
 1.14A 5vlmC-3zukA:
2.1		 5vlmC-3zukA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 GLY A 407
ILE A 435
TRP A 203
TYR A 257
 None
 1.14A 5vlmC-4aefA:
undetectable		 5vlmC-4aefA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 GLN A 213
GLY A 150
ILE A 219
TRP A  11
 None
 1.16A 5vlmC-4am3A:
2.9		 5vlmC-4am3A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLN A 342
GLY A 346
ILE A 307
TRP A 328
 None
 1.11A 5vlmC-4b0nA:
undetectable		 5vlmC-4b0nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLN A1128
GLY A1123
ILE A 509
ASP A 430
 None
 1.13A 5vlmC-4bedA:
undetectable		 5vlmC-4bedA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 GLN A 345
GLY A 102
ILE A 305
TYR A  30
 None
 1.14A 5vlmC-4djiA:
1.6		 5vlmC-4djiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		4 GLN A 355
GLY A 285
ILE A 348
TYR A 265
 None
 1.17A 5vlmC-4ekuA:
undetectable		 5vlmC-4ekuA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esq SERINE/THREONINE
PROTEIN KINASE

(Mycobacterium
tuberculosis) 		PF14032
(PknH_C) 		4 GLN A 520
GLY A 504
GLN A 483
ASP A 471
 None
None
None
TB  A 703 (-3.1A)
 1.17A 5vlmC-4esqA:
undetectable		 5vlmC-4esqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 GLN A  84
GLY A 114
GLN A 171
TRP A 112
 None
None
None
GLU  A 301 (-4.1A)
 1.11A 5vlmC-4fziA:
undetectable		 5vlmC-4fziA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		PF16440
(DUF5037) 		4 GLY A 240
ILE A 256
GLN A 262
TYR A 183
 None
 0.97A 5vlmC-4gl6A:
undetectable		 5vlmC-4gl6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1l ANI2.3 TCR A CHAIN
ANI2.3 TCR B CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLN G   5
GLY H  40
ILE G 102
ASP H  57
 None
 1.01A 5vlmC-4h1lG:
undetectable		 5vlmC-4h1lG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 GLN A 697
GLY A 816
GLN A 852
ASP A 818
 None
 1.10A 5vlmC-4k0eA:
1.1		 5vlmC-4k0eA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLY A 661
ILE A 667
GLN A 684
ASP A 780
 None
 1.05A 5vlmC-4k3cA:
undetectable		 5vlmC-4k3cA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu6 KINECTIN 1 (KINESIN
RECEPTOR)

(Legionella
pneumophila) 		no annotation 4 GLN A  76
GLY A 227
ILE A 232
GLN A 238
 None
 0.96A 5vlmC-4mu6A:
undetectable		 5vlmC-4mu6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 GLN A 175
GLY A 173
ILE A 183
TRP A 176
 None
 1.02A 5vlmC-4n03A:
undetectable		 5vlmC-4n03A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 GLY A  23
GLN A 163
ASP A 237
TYR A  32
 None
 1.12A 5vlmC-4p48A:
undetectable		 5vlmC-4p48A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 247
GLY A 422
ILE A 398
GLN A 487
 None
 1.00A 5vlmC-4rjkA:
undetectable		 5vlmC-4rjkA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwr STAGE II SPORULATION
PROTEIN D

(Bacillus
anthracis) 		PF08486
(SpoIID) 		4 GLY A 301
ILE A 315
TRP A 205
TYR A 320
 None
 1.10A 5vlmC-4rwrA:
undetectable		 5vlmC-4rwrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 GLN A  40
GLY A  70
ILE A  54
GLN A 107
 None
 1.11A 5vlmC-4tn5A:
undetectable		 5vlmC-4tn5A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 GLN B  21
GLY B 300
GLN B 364
ASP B 146
 None
 1.16A 5vlmC-4tx2B:
undetectable		 5vlmC-4tx2B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 GLN A  44
GLY A 231
ASP A 150
TYR A 151
 None
 1.03A 5vlmC-4xaeA:
undetectable		 5vlmC-4xaeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 313
GLY A 315
ILE A 318
GLN A 320
 None
 0.92A 5vlmC-4yljA:
undetectable		 5vlmC-4yljA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 315
ILE A 284
GLN A 469
ASP A 339
 None
None
SO4  A 504 (-3.7A)
None
 1.14A 5vlmC-4yljA:
undetectable		 5vlmC-4yljA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		4 GLN A 197
GLY A 188
ILE A  19
GLN A 211
 None
None
BR  A 304 (-4.5A)
None
 0.77A 5vlmC-4z0tA:
undetectable		 5vlmC-4z0tA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		4 GLN A 190
GLY A 205
ILE A 183
TRP A 192
 NAG  A 702 (-3.7A)
NAG  A 701 ( 3.7A)
None
None
 1.16A 5vlmC-5ampA:
undetectable		 5vlmC-5ampA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d68 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M)
PF13857
(Ank_5) 		4 GLN A 689
GLY A 691
ILE A 709
GLN A 643
 None
 1.06A 5vlmC-5d68A:
undetectable		 5vlmC-5d68A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLY A 125
ILE A 120
GLN A  40
ASP A  36
 None
None
GSH  A 301 (-3.8A)
None
 1.13A 5vlmC-5f07A:
undetectable		 5vlmC-5f07A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLN A  97
GLY A 147
GLN A 388
TYR A  85
 FRU  A3001 ( 3.5A)
None
None
None
 1.15A 5vlmC-5fkcA:
undetectable		 5vlmC-5fkcA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 GLN A 465
GLY A 489
ILE A 485
GLN A 474
 None
 1.12A 5vlmC-5fqlA:
undetectable		 5vlmC-5fqlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 GLN A 227
GLY A 228
ILE A 271
GLN A 199
 None
 1.11A 5vlmC-5g5nA:
undetectable		 5vlmC-5g5nA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtx BUCKWHEAT
GLUTAREDOXIN

(Polygonaceae) 		PF00462
(Glutaredoxin) 		4 GLN A  71
GLY A  67
ILE A  59
GLN A  24
 None
 1.06A 5vlmC-5gtxA:
undetectable		 5vlmC-5gtxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLN A 448
GLY A 216
ILE A 223
GLN A 194
 None
 1.16A 5vlmC-5h53A:
2.6		 5vlmC-5h53A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		4 GLY A 325
ILE A 235
ASP A 332
TYR A 367
 None
None
None
EDO  A 710 (-4.6A)
 1.06A 5vlmC-5ikkA:
undetectable		 5vlmC-5ikkA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8n EXODEOXYRIBONUCLEASE
III

(Methanosarcina
mazei) 		PF03372
(Exo_endo_phos) 		4 GLN A  38
GLY A  73
ILE A  34
TYR A  57
 None
 1.12A 5vlmC-5j8nA:
undetectable		 5vlmC-5j8nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9p PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
tumefaciens) 		PF13416
(SBP_bac_8) 		4 GLN A 240
GLY A 236
ILE A 224
GLN A 219
 None
 0.99A 5vlmC-5l9pA:
undetectable		 5vlmC-5l9pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 GLN A 214
GLY A 187
ILE A 217
TYR A 128
 None
 1.04A 5vlmC-5mifA:
undetectable		 5vlmC-5mifA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 4 GLN A  60
GLY A 104
ILE A  98
TRP A  42
 None
 1.10A 5vlmC-5nfqA:
undetectable		 5vlmC-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlt CVAA9A

(Collariella
virescens) 		no annotation 4 GLY A  15
ILE A  22
GLN A 146
TYR A  66
 None
 0.93A 5vlmC-5nltA:
undetectable		 5vlmC-5nltA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLN A  17
ILE A 202
GLN A  28
TRP A  20
 None
 1.13A 5vlmC-5ov6A:
undetectable		 5vlmC-5ov6A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 GLN A 359
GLY A 381
ILE A 230
GLN A 187
 None
 1.02A 5vlmC-5ti8A:
undetectable		 5vlmC-5ti8A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLN A 244
GLY A 216
ILE A 211
TRP A 321
 None
 1.12A 5vlmC-5tw7A:
undetectable		 5vlmC-5tw7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 GLN A  20
GLY A  62
ILE A 343
GLN A 354
 None
ADP  A 501 (-3.2A)
ADP  A 501 ( 4.5A)
None
 1.04A 5vlmC-5txvA:
undetectable		 5vlmC-5txvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLY B 161
ILE B 135
GLN A  85
ASP A  79
 None
 1.00A 5vlmC-5vgzB:
undetectable		 5vlmC-5vgzB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 5 GLN A  71
GLY A  88
TRP A 125
ASP A 163
TYR A 166
 MGR  A 300 ( 4.1A)
MGR  A 300 ( 2.9A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
 0.72A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 6 GLY A  88
ILE A  98
GLN A 105
TRP A 125
ASP A 163
TYR A 166
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.1A)
MGR  A 300 ( 3.0A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
 0.31A 5vlmC-5vlgA:
29.4		 5vlmC-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 GLN A 295
GLY A 312
ILE A 302
GLN A 325
ASP A 307
 None
 1.07A 5vlmC-5vmbA:
undetectable		 5vlmC-5vmbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 173
ILE A 128
TRP A 170
TYR A 145
 None
 1.08A 5vlmC-5vncA:
undetectable		 5vlmC-5vncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzt F-BOX ONLY PROTEIN
31

(Homo sapiens) 		no annotation 4 GLN B 535
GLY B 340
ILE B 337
TYR B 309
 None
None
DTT  B 602 (-4.3A)
DTT  B 602 ( 4.9A)
 1.15A 5vlmC-5vztB:
undetectable		 5vlmC-5vztB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 GLY A  35
ILE A  68
GLN A  80
TYR A 115
 None
 1.05A 5vlmC-5x1tA:
undetectable		 5vlmC-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 GLN A 459
GLY A 397
ILE A 401
GLN A 443
 OLC  A 501 ( 4.5A)
None
None
None
 1.06A 5vlmC-5xjjA:
undetectable		 5vlmC-5xjjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VL CHAIN OF 059-152
VH CHAIN OF 059-152

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLY H  46
ILE H  39
GLN H 112
TYR D  36
 None
 0.94A 5vlmC-5xwdH:
undetectable		 5vlmC-5xwdH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 GLN A1922
GLY A1925
ILE A1943
TYR A1902
 None
 1.06A 5vlmC-5y29A:
undetectable		 5vlmC-5y29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 4 GLN A 861
GLY A 859
ILE A 854
GLN A 849
 None
 1.11A 5vlmC-6brsA:
undetectable		 5vlmC-6brsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB HEAVY
CHAIN

(Mus musculus) 		no annotation 4 GLN A 111
GLY A   8
ILE A  20
ASP A  18
 None
 1.13A 5vlmC-6c08A:
undetectable		 5vlmC-6c08A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens) 		no annotation 4 GLN A 630
ILE A 382
GLN A 456
TYR A 386
 None
 0.96A 5vlmC-6d1wA:
undetectable		 5vlmC-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 GLY A1058
ILE A1052
GLN A1084
TYR A1099
 None
 1.14A 5vlmC-6egtA:
undetectable		 5vlmC-6egtA:
13.87