SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_B_CVIB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  79
ARG A 221
ASP A 252
ASP A  85
 None
FE  A 400 ( 4.7A)
None
None
 0.98A 5vlmB-1dlmA:
undetectable		 5vlmB-1dlmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 289
ARG A 270
TYR A 179
ASP A 282
 None
 0.98A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 289
TRP A 187
ARG A 270
ASP A 282
 None
 1.01A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.84A 5vlmB-1gtkA:
undetectable		 5vlmB-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A 409
TRP A 465
ARG A 470
ASP A 423
 None
 0.89A 5vlmB-1h39A:
1.2		 5vlmB-1h39A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A 214
ARG A 230
GLN A 232
ASP A 228
 None
 0.76A 5vlmB-1h81A:
undetectable		 5vlmB-1h81A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 ARG A 137
GLN A 188
TYR A 192
ASP A 180
 None
 0.97A 5vlmB-1hjuA:
undetectable		 5vlmB-1hjuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  83
ARG A  78
ASP A 160
ASP A 114
 None
 0.99A 5vlmB-1hrdA:
0.9		 5vlmB-1hrdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 197
ARG A 158
ASP A 171
ASP A  84
 None
None
None
CIT  A 501 (-2.8A)
 0.98A 5vlmB-1m0sA:
0.0		 5vlmB-1m0sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk3 APOPTOSIS REGULATOR
BCL-W

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A  33
ARG A  46
GLN A  23
TYR A  19
 None
 0.84A 5vlmB-1mk3A:
0.1		 5vlmB-1mk3A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.92A 5vlmB-1mqsA:
2.3		 5vlmB-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 196
ARG A 157
ASP A 170
ASP A  84
 None
None
None
ABF  A1269 (-2.6A)
 0.96A 5vlmB-1o8bA:
undetectable		 5vlmB-1o8bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT

(Candida
albicans) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY A  42
ARG A 162
ASP A 145
ASP A 236
 None
 0.95A 5vlmB-1p16A:
undetectable		 5vlmB-1p16A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 GLY A  93
ARG A 105
ASP A 102
ASP A  64
 None
 0.88A 5vlmB-1twdA:
undetectable		 5vlmB-1twdA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 GLY A 597
ARG A 534
GLN A 503
TYR A 499
 None
 1.04A 5vlmB-1u1hA:
0.7		 5vlmB-1u1hA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vct HYPOTHETICAL PROTEIN
PH0236

(Pyrococcus
horikoshii) 		PF01895
(PhoU)
PF02080
(TrkA_C) 		4 GLY A 164
ARG A 180
ASP A  30
ASP A  23
 None
 0.83A 5vlmB-1vctA:
2.8		 5vlmB-1vctA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.03A 5vlmB-1wzzA:
undetectable		 5vlmB-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 235
ARG A 189
ASP A 209
ASP A 110
 None
 1.03A 5vlmB-1xtzA:
1.7		 5vlmB-1xtzA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		4 GLY A  66
ARG A  98
ASP A 101
ASP A  70
 None
 0.83A 5vlmB-1ytkA:
undetectable		 5vlmB-1ytkA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.01A 5vlmB-2dlcX:
undetectable		 5vlmB-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		4 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.85A 5vlmB-2hs5A:
undetectable		 5vlmB-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 1.06A 5vlmB-2j2mA:
1.9		 5vlmB-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.03A 5vlmB-2jcjA:
undetectable		 5vlmB-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 199
ARG A 204
GLN A 207
TYR A 235
 None
 1.05A 5vlmB-2lgzA:
undetectable		 5vlmB-2lgzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ARG A 281
TYR A 205
ASP A 258
ASP A 216
 None
 1.00A 5vlmB-2o4vA:
undetectable		 5vlmB-2o4vA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 258
ARG A 269
TYR A 276
ASP A 296
 None
 1.03A 5vlmB-2pa6A:
undetectable		 5vlmB-2pa6A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 GLY A 274
ARG A 344
ASP A 347
ASP A 102
 None
None
None
MG  A1000 (-2.5A)
 0.98A 5vlmB-2r7dA:
undetectable		 5vlmB-2r7dA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLY A 335
ARG A 316
TYR A 225
ASP A 328
 None
 0.97A 5vlmB-2tohA:
undetectable		 5vlmB-2tohA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLY A 335
TRP A 233
ARG A 316
ASP A 328
 None
 1.05A 5vlmB-2tohA:
undetectable		 5vlmB-2tohA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 GLY A 426
GLN A 321
TRP A 389
ASP A 445
 None
 1.01A 5vlmB-2vobA:
undetectable		 5vlmB-2vobA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLY A 264
ARG A 304
GLN A 306
ASP A 302
 None
 0.87A 5vlmB-2wzfA:
undetectable		 5vlmB-2wzfA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  75
ARG A 216
ASP A 247
ASP A  81
 None
FE  A1307 ( 4.7A)
None
None
 0.91A 5vlmB-2xsrA:
undetectable		 5vlmB-2xsrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxm CAMELID VHH 9

(Vicugna pacos) 		PF07686
(V-set) 		4 GLY B  26
ARG B  71
TYR B  79
ASP B  73
 None
 0.89A 5vlmB-2xxmB:
undetectable		 5vlmB-2xxmB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  84
ARG A  79
ASP A 161
ASP A 115
 None
 1.03A 5vlmB-2yfhA:
undetectable		 5vlmB-2yfhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.02A 5vlmB-2yokA:
undetectable		 5vlmB-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 GLY A 364
TRP A  35
ASP A  15
ASP A 359
 None
None
None
GLC  A 602 ( 3.3A)
 1.05A 5vlmB-2z1kA:
undetectable		 5vlmB-2z1kA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY O 433
ARG O  16
GLN O  55
ASP O   9
ASP O 400
 None
 1.50A 5vlmB-2zf5O:
undetectable		 5vlmB-2zf5O:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 GLY A 188
TRP A 261
ASP A 238
ASP A 129
 None
None
None
TRS  A 841 (-4.0A)
 1.03A 5vlmB-3a5vA:
undetectable		 5vlmB-3a5vA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 GLY A  60
ARG A 240
ASP A  69
ASP A  90
 None
 0.97A 5vlmB-3c3jA:
undetectable		 5vlmB-3c3jA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 196
ARG A 157
ASP A 170
ASP A  84
 None
 0.98A 5vlmB-3enqA:
undetectable		 5vlmB-3enqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmB-3eq1A:
undetectable		 5vlmB-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc7 HTR-LIKE PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		4 GLY A 213
ARG A 192
GLN A 191
ASP A 210
 None
 1.00A 5vlmB-3fc7A:
undetectable		 5vlmB-3fc7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A  62
TYR A 190
ASP A 139
ASP A  65
 None
 1.05A 5vlmB-3h6tA:
undetectable		 5vlmB-3h6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 229
ARG A 186
ASP A 203
ASP A 107
 None
None
None
5RP  A 501 (-2.6A)
 1.03A 5vlmB-3hheA:
undetectable		 5vlmB-3hheA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 GLY A 192
ARG A 296
ASP A 235
ASP A 228
 None
 0.93A 5vlmB-3i6rA:
undetectable		 5vlmB-3i6rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 GLN T 132
TYR T 147
TRP T 218
ASP T 184
 None
 0.90A 5vlmB-3icqT:
2.1		 5vlmB-3icqT:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 201
ARG A 158
ASP A 175
ASP A  85
 None
 0.93A 5vlmB-3l7oA:
undetectable		 5vlmB-3l7oA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 GLY A 194
GLN A 269
TYR A 270
ASP A  45
 None
None
None
GOL  A 493 (-4.9A)
 0.99A 5vlmB-3n71A:
undetectable		 5vlmB-3n71A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLY A 682
GLN A 470
ASP A 671
ASP A 827
 None
 1.04A 5vlmB-3ne5A:
2.5		 5vlmB-3ne5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY B 297
ARG B 242
TRP B 398
ASP B 244
 None
 0.86A 5vlmB-3ojyB:
undetectable		 5vlmB-3ojyB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 209
ARG A 165
ASP A 183
ASP A  92
 None
None
None
EDO  A 237 (-3.4A)
 1.01A 5vlmB-3u7jA:
undetectable		 5vlmB-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		4 GLY A 173
ARG A 335
GLN A 331
ASP A 406
 None
 0.89A 5vlmB-3uyjA:
undetectable		 5vlmB-3uyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A  99
GLN A 140
TRP A  73
ASP A 401
 None
 1.03A 5vlmB-3vb9A:
undetectable		 5vlmB-3vb9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 136
GLN A 357
TYR A 365
ASP A 139
 None
HEM  A3000 (-3.7A)
None
None
 0.99A 5vlmB-4b7gA:
undetectable		 5vlmB-4b7gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 1.06A 5vlmB-4cabA:
undetectable		 5vlmB-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 GLY B 342
TRP B 191
ARG B 246
ASP B 267
 None
XYP  B 802 (-4.2A)
XYP  B 801 ( 3.0A)
None
 0.96A 5vlmB-4g68B:
undetectable		 5vlmB-4g68B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 204
ARG A 160
ASP A 178
ASP A  87
 None
None
None
PO4  A 301 (-2.6A)
 0.99A 5vlmB-4gmkA:
undetectable		 5vlmB-4gmkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 211
ARG A 143
GLN A 146
ASP A 117
 None
ACT  A 402 ( 2.6A)
None
None
 0.84A 5vlmB-4htgA:
undetectable		 5vlmB-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 202
ARG A 163
ASP A 176
ASP A  90
 None
None
None
PO4  A 306 ( 4.8A)
 0.97A 5vlmB-4io1A:
undetectable		 5vlmB-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 GLY A 387
ARG A 476
ASP A 169
ASP A 175
 None
 0.98A 5vlmB-4k70A:
undetectable		 5vlmB-4k70A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 GLY A  85
ARG A  68
TRP A  81
ASP A  91
 None
 1.00A 5vlmB-4kvoA:
1.5		 5vlmB-4kvoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 GLY A 119
ARG A 299
TRP A 233
ASP A 123
 None
 1.01A 5vlmB-4llfA:
undetectable		 5vlmB-4llfA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 GLY A  39
ARG A   8
ASP A  36
ASP A  75
 None
 0.66A 5vlmB-4lw8A:
undetectable		 5vlmB-4lw8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 GLY A 300
TRP A 374
ASP A 340
ASP A 243
 None
 1.04A 5vlmB-4ogzA:
undetectable		 5vlmB-4ogzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwo DSBA

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 GLY A 110
ARG A 184
ASP A 181
ASP A 105
 None
 1.05A 5vlmB-4pwoA:
undetectable		 5vlmB-4pwoA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY A  43
ARG A 162
ASP A 145
ASP A 235
 None
 1.00A 5vlmB-4pz7A:
undetectable		 5vlmB-4pz7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc8 VP2

(Ungulate
bocaparvovirus
1) 		PF00740
(Parvo_coat) 		4 GLY A  50
ARG A  64
GLN A 475
TYR A 134
 None
 0.93A 5vlmB-4qc8A:
undetectable		 5vlmB-4qc8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 123
GLN A 344
TYR A 352
ASP A 126
 None
HEM  A 502 ( 3.7A)
None
None
 0.96A 5vlmB-4qorA:
undetectable		 5vlmB-4qorA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A3064
ARG A3011
TRP A3070
ASP A3059
 None
 1.02A 5vlmB-4qyrA:
undetectable		 5vlmB-4qyrA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 GLY A 332
GLN A 392
ASP A 209
ASP A 213
 None
MG  A 506 (-3.7A)
None
None
 0.75A 5vlmB-4r7fA:
undetectable		 5vlmB-4r7fA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ARG A 283
TYR A 206
ASP A 260
ASP A 217
 None
 1.04A 5vlmB-4rjwA:
undetectable		 5vlmB-4rjwA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.24A 5vlmB-4rkuA:
undetectable		 5vlmB-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 GLY A 651
GLN A 149
TYR A 151
ASP A 548
 None
 1.06A 5vlmB-4s3pA:
undetectable		 5vlmB-4s3pA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u83 ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 100
ARG A 107
TRP A  57
ASP A 103
 None
 0.82A 5vlmB-4u83A:
undetectable		 5vlmB-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY S 246
ARG L 254
TYR L 448
ASP L 248
 None
None
None
MPD  S2006 ( 4.0A)
 0.87A 5vlmB-4u9iS:
undetectable		 5vlmB-4u9iS:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.06A 5vlmB-4uomL:
undetectable		 5vlmB-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 200
ARG A 161
ASP A 174
ASP A  88
 None
None
None
FLC  A 300 (-2.8A)
 0.96A 5vlmB-4x84A:
undetectable		 5vlmB-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 GLY A 182
ARG A 131
ASP A 179
ASP A 174
 None
 0.81A 5vlmB-4yaiA:
undetectable		 5vlmB-4yaiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		4 GLY A 411
ARG A 376
GLN A 360
ASP A 414
 None
 1.04A 5vlmB-4ye9A:
undetectable		 5vlmB-4ye9A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 GLY A 103
ARG A  50
ASP A 145
ASP A 106
 SO4  A 505 ( 4.6A)
None
None
None
 0.92A 5vlmB-4zxwA:
undetectable		 5vlmB-4zxwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 GLY A 383
TRP A 335
GLN A  74
ASP A  71
ASP A 409
 None
None
None
None
CA  A 903 (-3.0A)
 1.42A 5vlmB-5c2vA:
undetectable		 5vlmB-5c2vA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 GLY A1266
ARG A1318
ASP A1084
ASP A1269
 None
 1.06A 5vlmB-5cslA:
1.5		 5vlmB-5cslA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 GLY A  34
TRP A 120
ASP A 122
ASP A 407
 None
 0.96A 5vlmB-5du9A:
undetectable		 5vlmB-5du9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  76
TYR A 512
TRP A  69
ASP A  93
 None
PEG  A6002 ( 4.1A)
None
PEG  A6002 (-3.3A)
 1.03A 5vlmB-5fjjA:
undetectable		 5vlmB-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 4 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.77A 5vlmB-5h6oA:
undetectable		 5vlmB-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 GLY A  84
ARG A 118
ASP A 123
ASP A 152
 None
 1.00A 5vlmB-5i7nA:
undetectable		 5vlmB-5i7nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.85A 5vlmB-5ixmA:
undetectable		 5vlmB-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 GLY B 419
ARG B 642
GLN B 607
TYR B 193
ASP B 426
 None
 1.49A 5vlmB-5iz5B:
undetectable		 5vlmB-5iz5B:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLY A 673
ARG A 485
GLN A 484
ASP A 682
 None
None
EDO  A1007 (-4.4A)
EDO  A1007 (-2.5A)
 1.06A 5vlmB-5kdxA:
undetectable		 5vlmB-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 276
TRP A 174
ARG A 257
ASP A 269
 None
None
6Z4  A 502 (-2.8A)
None
 1.05A 5vlmB-5l01A:
undetectable		 5vlmB-5l01A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		4 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.02A 5vlmB-5mdxC:
2.1		 5vlmB-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 245
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.04A 5vlmB-5o5dA:
undetectable		 5vlmB-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 198
ARG A 130
GLN A 133
ASP A 104
 None
AWQ  A 401 (-3.8A)
None
None
 0.80A 5vlmB-5ov6A:
undetectable		 5vlmB-5ov6A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  90
ARG A 232
ASP A 263
ASP A  96
 None
ZN  A 401 ( 4.7A)
None
None
 0.97A 5vlmB-5td3A:
undetectable		 5vlmB-5td3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 197
ARG A 158
ASP A 171
ASP A  85
 None
None
None
EDO  A 306 (-3.5A)
 0.96A 5vlmB-5uf2A:
undetectable		 5vlmB-5uf2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 GLY A  88
TRP A 101
ARG A 102
GLN A 105
TYR A 118
TRP A 125
ASP A 163
ASP A 175
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 ( 4.3A)
 0.39A 5vlmB-5vlgA:
29.7		 5vlmB-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL) 		4 GLY B 161
ARG B 166
TYR B 169
ASP B 163
 None
 1.01A 5vlmB-5vocB:
undetectable		 5vlmB-5vocB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 GLY A 322
ARG A 345
GLN A 297
ASP A 343
 None
 1.01A 5vlmB-5xevA:
undetectable		 5vlmB-5xevA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 GLY A  87
ARG A  70
TRP A  83
ASP A  93
 None
 0.96A 5vlmB-6c9mA:
3.6		 5vlmB-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 4 GLY B 235
TRP B 288
ASP B 265
ASP B 181
 None
 1.06A 5vlmB-6f4cB:
undetectable		 5vlmB-6f4cB:
undetectable