SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_B_CVIB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cun PROTEIN (ALPHA
SPECTRIN)

(Gallus gallus) 		PF00435
(Spectrin) 		5 ALA A 119
GLU A 113
ILE A 189
VAL A 171
CYH A 172
 None
 1.19A 5vlmB-1cunA:
2.1		 5vlmB-1cunA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 MET A 289
ALA A 346
SER A 350
GLU A 353
LEU A 351
 None
 1.21A 5vlmB-1gk2A:
undetectable		 5vlmB-1gk2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 ALA A  67
GLU A 140
LEU A  72
ILE A  80
VAL A 134
 None
 1.26A 5vlmB-1j1wA:
0.5		 5vlmB-1j1wA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 ALA A 123
LEU A 202
ILE A  57
VAL A 212
PHE A 233
 None
 1.31A 5vlmB-1jxnA:
undetectable		 5vlmB-1jxnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 MET A 281
MET A 280
GLU A  24
VAL A  39
PHE A  52
 None
 1.35A 5vlmB-1nrwA:
undetectable		 5vlmB-1nrwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA B 475
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.39A 5vlmB-1pjmB:
2.0		 5vlmB-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 SER B 488
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.35A 5vlmB-1pjmB:
2.0		 5vlmB-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		5 GLN A  75
ALA A 116
SER A 114
VAL A 121
TYR A 108
 None
 1.37A 5vlmB-1qq0A:
undetectable		 5vlmB-1qq0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 MET A 159
ALA A 153
GLU A 148
VAL A 104
TYR A 130
 None
 1.26A 5vlmB-1rzmA:
undetectable		 5vlmB-1rzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssq SERINE
ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 MET A  54
GLN A 131
LEU A  59
ILE A  62
TYR A 115
 None
 1.34A 5vlmB-1ssqA:
1.7		 5vlmB-1ssqA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG

(Thermotoga
maritima) 		PF01628
(HrcA) 		5 SER A 329
GLU A 330
LEU A 325
ILE A 324
VAL A 119
 None
 1.16A 5vlmB-1stzA:
3.0		 5vlmB-1stzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 MET A 269
MET A 268
ALA A 264
ILE A 277
PHE A 306
 None
 1.22A 5vlmB-1szpA:
undetectable		 5vlmB-1szpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 MET A 269
MET A 268
ALA A 264
LEU A 313
ILE A 277
 None
 1.24A 5vlmB-1szpA:
undetectable		 5vlmB-1szpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS22, YPL002C

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		5 MET A  65
GLU A 120
VAL A  95
CYH A  96
PHE A 124
 None
 1.31A 5vlmB-1w7pA:
undetectable		 5vlmB-1w7pA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A1071
GLU A1059
LEU A1066
ILE A1065
VAL A1104
 None
 1.29A 5vlmB-1wufA:
undetectable		 5vlmB-1wufA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 ALA A  23
SER A  21
GLU A 231
ILE A 233
VAL A 238
 None
 1.21A 5vlmB-1xhlA:
undetectable		 5vlmB-1xhlA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		5 ALA A  19
LEU A  49
ILE A  53
CYH A  34
PHE A  37
 None
 1.38A 5vlmB-2ahdA:
undetectable		 5vlmB-2ahdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ALA A  65
GLU A 138
LEU A  70
ILE A  78
VAL A 132
 None
 1.30A 5vlmB-2b0tA:
undetectable		 5vlmB-2b0tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		5 GLN A 372
ALA A 369
ILE A 384
VAL A 303
PHE A 307
 None
 1.20A 5vlmB-2b9sA:
undetectable		 5vlmB-2b9sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 MET A 125
ALA A 121
GLU A 116
LEU A  48
VAL A 112
 None
 1.26A 5vlmB-2cu2A:
undetectable		 5vlmB-2cu2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.26A 5vlmB-2fzwA:
undetectable		 5vlmB-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		5 ALA A   6
LEU A  81
ILE A 181
VAL A  91
PHE A 111
 None
 1.35A 5vlmB-2gdfA:
undetectable		 5vlmB-2gdfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9i HYPOTHETICAL PROTEIN

(Helicobacter
pylori) 		PF05211
(NLBH) 		5 GLN A 119
LEU A 121
ILE A 137
TYR A 181
PHE A 180
 None
 1.28A 5vlmB-2i9iA:
undetectable		 5vlmB-2i9iA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		5 ALA A 393
LEU A 400
ILE A 422
VAL A 341
PHE A 415
 None
 1.25A 5vlmB-2lf8A:
undetectable		 5vlmB-2lf8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		5 ALA A  63
GLU A  58
LEU A  46
ILE A  29
PHE A  56
 CH7  A  66 ( 4.0A)
None
NFA  A  65 ( 4.4A)
NFA  A  65 ( 3.9A)
None
 0.99A 5vlmB-2ogrA:
undetectable		 5vlmB-2ogrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 MET A 131
GLN A 133
GLU A 136
LEU A 135
ILE A 120
 None
 1.18A 5vlmB-2pfrA:
undetectable		 5vlmB-2pfrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		5 MET A 369
ALA A 513
SER A 509
ILE A 542
CYH A 674
 None
 1.01A 5vlmB-2putA:
undetectable		 5vlmB-2putA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0z PROTEIN PRO2281

(Homo sapiens) 		PF02889
(Sec63) 		5 MET X 141
GLN X 140
ILE X 113
VAL X 120
CYH X 119
 None
 1.33A 5vlmB-2q0zX:
undetectable		 5vlmB-2q0zX:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 ALA A  16
SER A  19
ILE A  24
VAL A 234
PHE A 236
 None
 1.25A 5vlmB-2quaA:
undetectable		 5vlmB-2quaA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		5 ALA A 139
GLU A 145
ILE A 187
VAL A 168
TYR A 149
 None
 1.36A 5vlmB-2v7sA:
undetectable		 5vlmB-2v7sA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbx CADHERIN-23

(Mus musculus) 		PF00028
(Cadherin) 		5 GLN A  69
LEU A  67
ILE A  20
VAL A  81
PHE A  83
 None
 1.17A 5vlmB-2wbxA:
undetectable		 5vlmB-2wbxA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 0.96A 5vlmB-2wghA:
undetectable		 5vlmB-2wghA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF01106
(NifU) 		5 GLN A  42
ALA A  28
LEU A  20
ILE A  16
VAL A   9
 None
 1.22A 5vlmB-2z51A:
2.4		 5vlmB-2z51A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		5 GLN A  63
ALA A  62
LEU A  56
VAL A 250
PHE A 271
 None
 1.19A 5vlmB-3a3uA:
undetectable		 5vlmB-3a3uA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn6 LACTADHERIN

(Bos taurus) 		PF00754
(F5_F8_type_C) 		5 LEU A 156
ILE A  73
VAL A 138
TYR A 104
PHE A 133
 None
 1.40A 5vlmB-3bn6A:
undetectable		 5vlmB-3bn6A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 GLN A 327
ALA A 360
LEU A 328
ILE A 297
CYH A 393
 None
 1.35A 5vlmB-3c0kA:
undetectable		 5vlmB-3c0kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  95
LEU A  50
VAL A  75
CYH A  76
PHE A 115
 None
 1.40A 5vlmB-3ct4A:
undetectable		 5vlmB-3ct4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		5 MET A 191
SER A 197
GLU A 198
LEU A 203
ILE A 240
 None
 1.35A 5vlmB-3do6A:
undetectable		 5vlmB-3do6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		5 MET A  55
GLN A  54
LEU A 115
ILE A 118
CYH A  69
 None
 1.33A 5vlmB-3h07A:
undetectable		 5vlmB-3h07A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		5 MET A1870
ALA A1882
SER A1880
ILE A1963
VAL A2097
 None
 1.25A 5vlmB-3ilsA:
undetectable		 5vlmB-3ilsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		5 MET A 186
ALA A 182
SER A 180
LEU A  59
ILE A  56
 None
 1.27A 5vlmB-3ix6A:
undetectable		 5vlmB-3ix6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		5 ALA A  22
GLU A  33
LEU A  59
ILE A  58
VAL A  29
 None
MG  A3001 (-2.5A)
None
GOL  A1003 ( 4.8A)
None
 1.32A 5vlmB-3jr2A:
undetectable		 5vlmB-3jr2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6e CBS DOMAIN PROTEIN

(Streptococcus
pneumoniae) 		PF00571
(CBS) 		5 GLN A 125
LEU A  18
ILE A 127
VAL A  26
TYR A  45
 None
None
None
None
PO4  A 154 (-4.6A)
 1.39A 5vlmB-3k6eA:
undetectable		 5vlmB-3k6eA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 GLN A 168
ALA A 169
LEU A 198
ILE A 202
VAL A 158
 None
 1.30A 5vlmB-3majA:
undetectable		 5vlmB-3majA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 MET A  97
LEU A 134
ILE A 132
VAL A  86
PHE A  77
 None
 1.31A 5vlmB-3o5dA:
undetectable		 5vlmB-3o5dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 MET A 185
ALA A 190
LEU A 172
ILE A 173
CYH A 242
 None
 1.22A 5vlmB-3opbA:
1.3		 5vlmB-3opbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		5 GLN A  75
ALA A 116
SER A 114
VAL A 121
TYR A 108
 None
 1.38A 5vlmB-3otmA:
undetectable		 5vlmB-3otmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8b TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Pyrococcus
furiosus) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		5 ALA B   7
GLU B  49
LEU B  37
ILE B  36
VAL B  56
 None
 1.28A 5vlmB-3p8bB:
undetectable		 5vlmB-3p8bB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 314
SER A 310
LEU A 346
ILE A 344
VAL A 295
 None
 1.24A 5vlmB-3r11A:
undetectable		 5vlmB-3r11A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		5 ALA A 146
LEU A 219
ILE A 220
TYR A  59
PHE A  81
 None
 1.31A 5vlmB-3rnsA:
undetectable		 5vlmB-3rnsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swn U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 ALA A  30
GLU A  62
LEU A  65
ILE A  42
CYH A  14
 None
 1.16A 5vlmB-3swnA:
undetectable		 5vlmB-3swnA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 268
ILE A 191
VAL A 350
CYH A 365
TYR A 352
 None
 1.27A 5vlmB-3to3A:
1.4		 5vlmB-3to3A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.13A 5vlmB-3twiD:
undetectable		 5vlmB-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF) 		5 MET C 418
ALA C 381
LEU C 400
ILE C 397
VAL C 385
 None
 1.32A 5vlmB-3u88C:
undetectable		 5vlmB-3u88C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		5 MET A 190
ALA A 252
ILE A 214
VAL A 225
PHE A 265
 None
 1.31A 5vlmB-3wpwA:
undetectable		 5vlmB-3wpwA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 SER A 309
LEU A 258
ILE A 254
VAL A 287
CYH A 281
 None
 1.25A 5vlmB-3wwhA:
undetectable		 5vlmB-3wwhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 ALA A1560
ILE A1645
VAL A1563
TYR A1577
PHE A1600
 None
 1.20A 5vlmB-4a5wA:
2.5		 5vlmB-4a5wA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 5 ALA A  69
GLU A 102
LEU A 107
ILE A  38
VAL A  50
 None
 1.19A 5vlmB-4csoA:
undetectable		 5vlmB-4csoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16415
(CNOT1_CAF1_bind) 		5 ALA A1219
GLU A1267
LEU A1274
ILE A1278
VAL A1260
 None
 1.04A 5vlmB-4ct4A:
4.6		 5vlmB-4ct4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 GLN A  35
ALA A  32
LEU A  62
ILE A  64
VAL A  46
 None
 1.38A 5vlmB-4e4rA:
undetectable		 5vlmB-4e4rA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 244
LEU A 308
VAL A 262
TYR A 377
PHE A 292
 None
 1.27A 5vlmB-4ha4A:
undetectable		 5vlmB-4ha4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		5 ALA A  42
GLU A  48
LEU A  17
ILE A  22
VAL A  57
 None
 1.04A 5vlmB-4icqA:
undetectable		 5vlmB-4icqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l01 TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 641
MET A 642
GLU A 706
LEU A 710
PHE A 838
 None
 1.36A 5vlmB-4l01A:
undetectable		 5vlmB-4l01A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 MET A 225
ALA A 229
GLU A 137
LEU A 142
TYR A 132
 None
 1.20A 5vlmB-4ldnA:
undetectable		 5vlmB-4ldnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 ALA A  15
GLU A  21
LEU A 110
ILE A 114
VAL A  29
 None
 0.92A 5vlmB-4lzlA:
undetectable		 5vlmB-4lzlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		5 ALA A 470
LEU A 403
ILE A 402
VAL A 449
PHE A 430
 None
 1.28A 5vlmB-4mr0A:
undetectable		 5vlmB-4mr0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLN A 509
GLU A 191
LEU A 508
VAL A 446
CYH A 447
 None
 1.17A 5vlmB-4nbqA:
2.5		 5vlmB-4nbqA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqq CADHERIN-3

(Mus musculus) 		PF00028
(Cadherin) 		5 SER A 116
LEU A 212
ILE A 211
VAL A 174
PHE A 163
 None
 1.33A 5vlmB-4nqqA:
undetectable		 5vlmB-4nqqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.22A 5vlmB-4qi4A:
undetectable		 5vlmB-4qi4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ALA A 263
LEU A 419
ILE A 242
VAL A 434
PHE A 432
 None
 1.34A 5vlmB-4qi6A:
undetectable		 5vlmB-4qi6A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro5 SAT DOMAIN FROM CAZM

(Chaetomium
globosum) 		PF16073
(SAT) 		5 ALA A 253
SER A 255
LEU A 229
ILE A 225
VAL A 267
 None
 1.37A 5vlmB-4ro5A:
undetectable		 5vlmB-4ro5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLN A 374
ALA A 375
SER A 403
ILE A 360
VAL A 420
 None
 1.33A 5vlmB-4x1zA:
undetectable		 5vlmB-4x1zA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5t UNCHARACTERIZED
PROTEIN MJ0489

(Methanocaldococcus
jannaschii) 		PF06690
(DUF1188) 		5 ALA A  63
GLU A  49
LEU A 113
ILE A 114
VAL A  76
 None
 1.31A 5vlmB-5d5tA:
undetectable		 5vlmB-5d5tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 SER A 153
GLU A 152
LEU A 149
ILE A 122
VAL A  61
 None
 1.40A 5vlmB-5dm4A:
undetectable		 5vlmB-5dm4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 MET A 318
ALA A 357
LEU A 401
ILE A 397
PHE A 500
 None
 1.37A 5vlmB-5ez3A:
undetectable		 5vlmB-5ez3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 5 ALA A 784
GLU A 741
LEU A 739
ILE A 724
VAL A 746
 None
 1.28A 5vlmB-5f0oA:
3.5		 5vlmB-5f0oA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		5 GLN J 424
ALA J 420
GLU J 399
LEU J 396
ILE J 392
 None
 1.31A 5vlmB-5furJ:
3.4		 5vlmB-5furJ:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0y PERIPLASMIC
PROTEIN-PROBABLY
INVOLVED IN
HIGH-AFFINITY FE2+
TRANSPORT

(Escherichia
coli) 		PF10634
(Iron_transport) 		5 ALA A  47
ILE A 102
VAL A 112
TYR A 149
PHE A 147
 None
 1.24A 5vlmB-5i0yA:
undetectable		 5vlmB-5i0yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 GLU A  65
LEU A  74
ILE A 224
VAL A 379
CYH A 382
 None
 1.19A 5vlmB-5kteA:
undetectable		 5vlmB-5kteA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvz INTERLEUKIN-1 BETA

(Homo sapiens) 		PF00340
(IL1) 		5 SER U 114
GLU U 113
LEU U 134
ILE U 122
VAL U  58
 None
 1.27A 5vlmB-5mvzU:
undetectable		 5vlmB-5mvzU:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 5 SER A 250
GLU A 251
LEU A 246
ILE A 238
VAL A 258
 None
 1.30A 5vlmB-5ot0A:
undetectable		 5vlmB-5ot0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 0.98A 5vlmB-5tusA:
undetectable		 5vlmB-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twa BCL-X HOMOLOGOUS
PROTEIN, BHP2

(Geodia cydonium) 		PF00452
(Bcl-2) 		5 GLU A 118
ILE A 155
VAL A 162
TYR A 149
PHE A 146
 None
 1.37A 5vlmB-5twaA:
undetectable		 5vlmB-5twaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf1 O13

(Petromyzon
marinus) 		no annotation 5 ALA B  45
LEU B  40
ILE B  61
VAL B  68
PHE B  69
 None
 1.14A 5vlmB-5uf1B:
undetectable		 5vlmB-5uf1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 ALA A  28
LEU A  23
ILE A  44
VAL A  51
PHE A  52
 None
 1.14A 5vlmB-5ufbA:
undetectable		 5vlmB-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		5 MET A   1
ALA A  97
GLU A  11
ILE A   9
VAL A 149
 None
 1.31A 5vlmB-5v88A:
undetectable		 5vlmB-5v88A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A

(Homo sapiens) 		PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1) 		5 ALA A 125
SER A 121
LEU A 166
VAL A 142
TYR A 148
 None
 1.39A 5vlmB-5v9pA:
undetectable		 5vlmB-5v9pA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 10 MET A  67
ALA A  86
SER A  89
GLU A  90
LEU A  94
ILE A  98
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.8A)
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.48A 5vlmB-5vlgA:
29.7		 5vlmB-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 9 MET A  67
MET A  68
ALA A  86
LEU A  94
ILE A  98
VAL A 159
CYH A 160
TYR A 166
PHE A 178
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
MGR  A 300 (-3.0A)
MGR  A 300 (-3.1A)
 0.56A 5vlmB-5vlgA:
29.7		 5vlmB-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 5 MET A  67
MET A  68
SER A  85
VAL A 159
CYH A 160
 MGR  A 300 (-4.6A)
None
None
MGR  A 300 (-4.4A)
MGR  A 300 (-2.8A)
 1.24A 5vlmB-5vlgA:
29.7		 5vlmB-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 5 MET A 600
MET A 601
GLU A 665
LEU A 669
ILE A 670
 None
 1.03A 5vlmB-5winA:
undetectable		 5vlmB-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk4 VARIABLE LYMPHOCYTE
RECEPTOR 39

(Petromyzon
marinus) 		no annotation 5 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
 1.23A 5vlmB-5wk4D:
undetectable		 5vlmB-5wk4D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 PC  A 704 (-4.3A)
None
None
None
SAH  A 701 (-4.6A)
 1.36A 5vlmB-5wp4A:
undetectable		 5vlmB-5wp4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 None
None
None
None
SAH  A 502 (-4.6A)
 1.40A 5vlmB-5wp5A:
undetectable		 5vlmB-5wp5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 5 MET A 465
ALA A 404
GLU A 411
LEU A 409
VAL A 268
 None
 1.24A 5vlmB-5ygfA:
undetectable		 5vlmB-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		5 MET A 194
ALA A 190
SER A 188
LEU A  67
ILE A  64
 None
 1.22A 5vlmB-6aujA:
undetectable		 5vlmB-6aujA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 MET A 662
LEU A 667
ILE A 670
VAL A 637
PHE A 654
 None
EDO  A 803 ( 3.8A)
EDO  A 803 ( 4.3A)
None
None
 1.34A 5vlmB-6cgmA:
undetectable		 5vlmB-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 GLN A 508
GLU A 193
LEU A 507
VAL A 445
CYH A 446
 None
 1.23A 5vlmB-6d6kA:
undetectable		 5vlmB-6d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25

(Homo sapiens) 		no annotation 5 MET A 600
GLU A 566
LEU A 569
ILE A 558
CYH A 524
 None
 1.38A 5vlmB-6flnA:
undetectable		 5vlmB-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 5 ALA A  68
GLU A 141
LEU A  73
ILE A  81
VAL A 135
 None
 1.27A 5vlmB-6g3uA:
undetectable		 5vlmB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  79
ARG A 221
ASP A 252
ASP A  85
 None
FE  A 400 ( 4.7A)
None
None
 0.98A 5vlmB-1dlmA:
undetectable		 5vlmB-1dlmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 289
ARG A 270
TYR A 179
ASP A 282
 None
 0.98A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 289
TRP A 187
ARG A 270
ASP A 282
 None
 1.01A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.84A 5vlmB-1gtkA:
undetectable		 5vlmB-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A 409
TRP A 465
ARG A 470
ASP A 423
 None
 0.89A 5vlmB-1h39A:
1.2		 5vlmB-1h39A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A 214
ARG A 230
GLN A 232
ASP A 228
 None
 0.76A 5vlmB-1h81A:
undetectable		 5vlmB-1h81A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 ARG A 137
GLN A 188
TYR A 192
ASP A 180
 None
 0.97A 5vlmB-1hjuA:
undetectable		 5vlmB-1hjuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  83
ARG A  78
ASP A 160
ASP A 114
 None
 0.99A 5vlmB-1hrdA:
0.9		 5vlmB-1hrdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 197
ARG A 158
ASP A 171
ASP A  84
 None
None
None
CIT  A 501 (-2.8A)
 0.98A 5vlmB-1m0sA:
0.0		 5vlmB-1m0sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk3 APOPTOSIS REGULATOR
BCL-W

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A  33
ARG A  46
GLN A  23
TYR A  19
 None
 0.84A 5vlmB-1mk3A:
0.1		 5vlmB-1mk3A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 GLY A 232
GLN A 601
TYR A 603
ASP A 586
 None
 0.92A 5vlmB-1mqsA:
2.3		 5vlmB-1mqsA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 196
ARG A 157
ASP A 170
ASP A  84
 None
None
None
ABF  A1269 (-2.6A)
 0.96A 5vlmB-1o8bA:
undetectable		 5vlmB-1o8bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT

(Candida
albicans) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY A  42
ARG A 162
ASP A 145
ASP A 236
 None
 0.95A 5vlmB-1p16A:
undetectable		 5vlmB-1p16A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 GLY A  93
ARG A 105
ASP A 102
ASP A  64
 None
 0.88A 5vlmB-1twdA:
undetectable		 5vlmB-1twdA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 GLY A 597
ARG A 534
GLN A 503
TYR A 499
 None
 1.04A 5vlmB-1u1hA:
0.7		 5vlmB-1u1hA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vct HYPOTHETICAL PROTEIN
PH0236

(Pyrococcus
horikoshii) 		PF01895
(PhoU)
PF02080
(TrkA_C) 		4 GLY A 164
ARG A 180
ASP A  30
ASP A  23
 None
 0.83A 5vlmB-1vctA:
2.8		 5vlmB-1vctA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.03A 5vlmB-1wzzA:
undetectable		 5vlmB-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 235
ARG A 189
ASP A 209
ASP A 110
 None
 1.03A 5vlmB-1xtzA:
1.7		 5vlmB-1xtzA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		4 GLY A  66
ARG A  98
ASP A 101
ASP A  70
 None
 0.83A 5vlmB-1ytkA:
undetectable		 5vlmB-1ytkA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.01A 5vlmB-2dlcX:
undetectable		 5vlmB-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		4 GLY A 190
TYR A 101
ASP A 148
ASP A 133
 None
ACT  A 238 (-4.4A)
ACT  A 238 (-2.7A)
None
 0.85A 5vlmB-2hs5A:
undetectable		 5vlmB-2hs5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 1.06A 5vlmB-2j2mA:
1.9		 5vlmB-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.03A 5vlmB-2jcjA:
undetectable		 5vlmB-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 199
ARG A 204
GLN A 207
TYR A 235
 None
 1.05A 5vlmB-2lgzA:
undetectable		 5vlmB-2lgzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ARG A 281
TYR A 205
ASP A 258
ASP A 216
 None
 1.00A 5vlmB-2o4vA:
undetectable		 5vlmB-2o4vA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 258
ARG A 269
TYR A 276
ASP A 296
 None
 1.03A 5vlmB-2pa6A:
undetectable		 5vlmB-2pa6A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 GLY A 274
ARG A 344
ASP A 347
ASP A 102
 None
None
None
MG  A1000 (-2.5A)
 0.98A 5vlmB-2r7dA:
undetectable		 5vlmB-2r7dA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLY A 335
ARG A 316
TYR A 225
ASP A 328
 None
 0.97A 5vlmB-2tohA:
undetectable		 5vlmB-2tohA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLY A 335
TRP A 233
ARG A 316
ASP A 328
 None
 1.05A 5vlmB-2tohA:
undetectable		 5vlmB-2tohA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 GLY A 426
GLN A 321
TRP A 389
ASP A 445
 None
 1.01A 5vlmB-2vobA:
undetectable		 5vlmB-2vobA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLY A 264
ARG A 304
GLN A 306
ASP A 302
 None
 0.87A 5vlmB-2wzfA:
undetectable		 5vlmB-2wzfA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  75
ARG A 216
ASP A 247
ASP A  81
 None
FE  A1307 ( 4.7A)
None
None
 0.91A 5vlmB-2xsrA:
undetectable		 5vlmB-2xsrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxm CAMELID VHH 9

(Vicugna pacos) 		PF07686
(V-set) 		4 GLY B  26
ARG B  71
TYR B  79
ASP B  73
 None
 0.89A 5vlmB-2xxmB:
undetectable		 5vlmB-2xxmB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  84
ARG A  79
ASP A 161
ASP A 115
 None
 1.03A 5vlmB-2yfhA:
undetectable		 5vlmB-2yfhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.02A 5vlmB-2yokA:
undetectable		 5vlmB-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 GLY A 364
TRP A  35
ASP A  15
ASP A 359
 None
None
None
GLC  A 602 ( 3.3A)
 1.05A 5vlmB-2z1kA:
undetectable		 5vlmB-2z1kA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY O 433
ARG O  16
GLN O  55
ASP O   9
ASP O 400
 None
 1.50A 5vlmB-2zf5O:
undetectable		 5vlmB-2zf5O:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 GLY A 188
TRP A 261
ASP A 238
ASP A 129
 None
None
None
TRS  A 841 (-4.0A)
 1.03A 5vlmB-3a5vA:
undetectable		 5vlmB-3a5vA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 GLY A  60
ARG A 240
ASP A  69
ASP A  90
 None
 0.97A 5vlmB-3c3jA:
undetectable		 5vlmB-3c3jA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 196
ARG A 157
ASP A 170
ASP A  84
 None
 0.98A 5vlmB-3enqA:
undetectable		 5vlmB-3enqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmB-3eq1A:
undetectable		 5vlmB-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc7 HTR-LIKE PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		4 GLY A 213
ARG A 192
GLN A 191
ASP A 210
 None
 1.00A 5vlmB-3fc7A:
undetectable		 5vlmB-3fc7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A  62
TYR A 190
ASP A 139
ASP A  65
 None
 1.05A 5vlmB-3h6tA:
undetectable		 5vlmB-3h6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 229
ARG A 186
ASP A 203
ASP A 107
 None
None
None
5RP  A 501 (-2.6A)
 1.03A 5vlmB-3hheA:
undetectable		 5vlmB-3hheA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 GLY A 192
ARG A 296
ASP A 235
ASP A 228
 None
 0.93A 5vlmB-3i6rA:
undetectable		 5vlmB-3i6rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 GLN T 132
TYR T 147
TRP T 218
ASP T 184
 None
 0.90A 5vlmB-3icqT:
2.1		 5vlmB-3icqT:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 201
ARG A 158
ASP A 175
ASP A  85
 None
 0.93A 5vlmB-3l7oA:
undetectable		 5vlmB-3l7oA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 GLY A 194
GLN A 269
TYR A 270
ASP A  45
 None
None
None
GOL  A 493 (-4.9A)
 0.99A 5vlmB-3n71A:
undetectable		 5vlmB-3n71A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLY A 682
GLN A 470
ASP A 671
ASP A 827
 None
 1.04A 5vlmB-3ne5A:
2.5		 5vlmB-3ne5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY B 297
ARG B 242
TRP B 398
ASP B 244
 None
 0.86A 5vlmB-3ojyB:
undetectable		 5vlmB-3ojyB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 209
ARG A 165
ASP A 183
ASP A  92
 None
None
None
EDO  A 237 (-3.4A)
 1.01A 5vlmB-3u7jA:
undetectable		 5vlmB-3u7jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		4 GLY A 173
ARG A 335
GLN A 331
ASP A 406
 None
 0.89A 5vlmB-3uyjA:
undetectable		 5vlmB-3uyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A  99
GLN A 140
TRP A  73
ASP A 401
 None
 1.03A 5vlmB-3vb9A:
undetectable		 5vlmB-3vb9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 136
GLN A 357
TYR A 365
ASP A 139
 None
HEM  A3000 (-3.7A)
None
None
 0.99A 5vlmB-4b7gA:
undetectable		 5vlmB-4b7gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 1.06A 5vlmB-4cabA:
undetectable		 5vlmB-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 GLY B 342
TRP B 191
ARG B 246
ASP B 267
 None
XYP  B 802 (-4.2A)
XYP  B 801 ( 3.0A)
None
 0.96A 5vlmB-4g68B:
undetectable		 5vlmB-4g68B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 204
ARG A 160
ASP A 178
ASP A  87
 None
None
None
PO4  A 301 (-2.6A)
 0.99A 5vlmB-4gmkA:
undetectable		 5vlmB-4gmkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 211
ARG A 143
GLN A 146
ASP A 117
 None
ACT  A 402 ( 2.6A)
None
None
 0.84A 5vlmB-4htgA:
undetectable		 5vlmB-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 202
ARG A 163
ASP A 176
ASP A  90
 None
None
None
PO4  A 306 ( 4.8A)
 0.97A 5vlmB-4io1A:
undetectable		 5vlmB-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 GLY A 387
ARG A 476
ASP A 169
ASP A 175
 None
 0.98A 5vlmB-4k70A:
undetectable		 5vlmB-4k70A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 GLY A  85
ARG A  68
TRP A  81
ASP A  91
 None
 1.00A 5vlmB-4kvoA:
1.5		 5vlmB-4kvoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 GLY A 119
ARG A 299
TRP A 233
ASP A 123
 None
 1.01A 5vlmB-4llfA:
undetectable		 5vlmB-4llfA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 GLY A  39
ARG A   8
ASP A  36
ASP A  75
 None
 0.66A 5vlmB-4lw8A:
undetectable		 5vlmB-4lw8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 GLY A 300
TRP A 374
ASP A 340
ASP A 243
 None
 1.04A 5vlmB-4ogzA:
undetectable		 5vlmB-4ogzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwo DSBA

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 GLY A 110
ARG A 184
ASP A 181
ASP A 105
 None
 1.05A 5vlmB-4pwoA:
undetectable		 5vlmB-4pwoA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY A  43
ARG A 162
ASP A 145
ASP A 235
 None
 1.00A 5vlmB-4pz7A:
undetectable		 5vlmB-4pz7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc8 VP2

(Ungulate
bocaparvovirus
1) 		PF00740
(Parvo_coat) 		4 GLY A  50
ARG A  64
GLN A 475
TYR A 134
 None
 0.93A 5vlmB-4qc8A:
undetectable		 5vlmB-4qc8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLY A 123
GLN A 344
TYR A 352
ASP A 126
 None
HEM  A 502 ( 3.7A)
None
None
 0.96A 5vlmB-4qorA:
undetectable		 5vlmB-4qorA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A3064
ARG A3011
TRP A3070
ASP A3059
 None
 1.02A 5vlmB-4qyrA:
undetectable		 5vlmB-4qyrA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 GLY A 332
GLN A 392
ASP A 209
ASP A 213
 None
MG  A 506 (-3.7A)
None
None
 0.75A 5vlmB-4r7fA:
undetectable		 5vlmB-4r7fA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjw PORIN O

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ARG A 283
TYR A 206
ASP A 260
ASP A 217
 None
 1.04A 5vlmB-4rjwA:
undetectable		 5vlmB-4rjwA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.24A 5vlmB-4rkuA:
undetectable		 5vlmB-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 GLY A 651
GLN A 149
TYR A 151
ASP A 548
 None
 1.06A 5vlmB-4s3pA:
undetectable		 5vlmB-4s3pA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u83 ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 100
ARG A 107
TRP A  57
ASP A 103
 None
 0.82A 5vlmB-4u83A:
undetectable		 5vlmB-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY S 246
ARG L 254
TYR L 448
ASP L 248
 None
None
None
MPD  S2006 ( 4.0A)
 0.87A 5vlmB-4u9iS:
undetectable		 5vlmB-4u9iS:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  12
GLN L  38
ASP L  83
ASP L  15
 None
 1.06A 5vlmB-4uomL:
undetectable		 5vlmB-4uomL:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 200
ARG A 161
ASP A 174
ASP A  88
 None
None
None
FLC  A 300 (-2.8A)
 0.96A 5vlmB-4x84A:
undetectable		 5vlmB-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 GLY A 182
ARG A 131
ASP A 179
ASP A 174
 None
 0.81A 5vlmB-4yaiA:
undetectable		 5vlmB-4yaiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		4 GLY A 411
ARG A 376
GLN A 360
ASP A 414
 None
 1.04A 5vlmB-4ye9A:
undetectable		 5vlmB-4ye9A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 GLY A 103
ARG A  50
ASP A 145
ASP A 106
 SO4  A 505 ( 4.6A)
None
None
None
 0.92A 5vlmB-4zxwA:
undetectable		 5vlmB-4zxwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 GLY A 383
TRP A 335
GLN A  74
ASP A  71
ASP A 409
 None
None
None
None
CA  A 903 (-3.0A)
 1.42A 5vlmB-5c2vA:
undetectable		 5vlmB-5c2vA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 GLY A1266
ARG A1318
ASP A1084
ASP A1269
 None
 1.06A 5vlmB-5cslA:
1.5		 5vlmB-5cslA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 GLY A  34
TRP A 120
ASP A 122
ASP A 407
 None
 0.96A 5vlmB-5du9A:
undetectable		 5vlmB-5du9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  76
TYR A 512
TRP A  69
ASP A  93
 None
PEG  A6002 ( 4.1A)
None
PEG  A6002 (-3.3A)
 1.03A 5vlmB-5fjjA:
undetectable		 5vlmB-5fjjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 4 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.77A 5vlmB-5h6oA:
undetectable		 5vlmB-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 GLY A  84
ARG A 118
ASP A 123
ASP A 152
 None
 1.00A 5vlmB-5i7nA:
undetectable		 5vlmB-5i7nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.85A 5vlmB-5ixmA:
undetectable		 5vlmB-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 GLY B 419
ARG B 642
GLN B 607
TYR B 193
ASP B 426
 None
 1.49A 5vlmB-5iz5B:
undetectable		 5vlmB-5iz5B:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLY A 673
ARG A 485
GLN A 484
ASP A 682
 None
None
EDO  A1007 (-4.4A)
EDO  A1007 (-2.5A)
 1.06A 5vlmB-5kdxA:
undetectable		 5vlmB-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLY A 276
TRP A 174
ARG A 257
ASP A 269
 None
None
6Z4  A 502 (-2.8A)
None
 1.05A 5vlmB-5l01A:
undetectable		 5vlmB-5l01A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00421
(PSII)
PF01716
(MSP) 		4 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.02A 5vlmB-5mdxC:
2.1		 5vlmB-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLY A 245
GLN A 335
ASP A 257
ASP A 173
 None
None
None
BTB  A 604 (-3.7A)
 1.04A 5vlmB-5o5dA:
undetectable		 5vlmB-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 198
ARG A 130
GLN A 133
ASP A 104
 None
AWQ  A 401 (-3.8A)
None
None
 0.80A 5vlmB-5ov6A:
undetectable		 5vlmB-5ov6A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A  90
ARG A 232
ASP A 263
ASP A  96
 None
ZN  A 401 ( 4.7A)
None
None
 0.97A 5vlmB-5td3A:
undetectable		 5vlmB-5td3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A 197
ARG A 158
ASP A 171
ASP A  85
 None
None
None
EDO  A 306 (-3.5A)
 0.96A 5vlmB-5uf2A:
undetectable		 5vlmB-5uf2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 GLY A  88
TRP A 101
ARG A 102
GLN A 105
TYR A 118
TRP A 125
ASP A 163
ASP A 175
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 ( 3.0A)
None
MGR  A 300 (-3.5A)
MGR  A 300 (-3.5A)
MGR  A 300 ( 4.3A)
 0.39A 5vlmB-5vlgA:
29.7		 5vlmB-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL) 		4 GLY B 161
ARG B 166
TYR B 169
ASP B 163
 None
 1.01A 5vlmB-5vocB:
undetectable		 5vlmB-5vocB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 GLY A 322
ARG A 345
GLN A 297
ASP A 343
 None
 1.01A 5vlmB-5xevA:
undetectable		 5vlmB-5xevA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 GLY A  87
ARG A  70
TRP A  83
ASP A  93
 None
 0.96A 5vlmB-6c9mA:
3.6		 5vlmB-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 4 GLY B 235
TRP B 288
ASP B 265
ASP B 181
 None
 1.06A 5vlmB-6f4cB:
undetectable		 5vlmB-6f4cB:
undetectable