SIMILAR PATTERNS OF AMINO ACIDS FOR 5VLM_A_CVIA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 MET A 357
ALA A 352
LEU A  90
ILE A  92
PHE A  50
 None
 1.45A 5vlmA-1a0dA:
undetectable		 5vlmA-1a0dA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A 240
GLU A 247
LEU A 312
ILE A 308
CYH A 187
 None
None
None
None
NAD  A 380 (-3.3A)
 1.23A 5vlmA-1bxkA:
undetectable		 5vlmA-1bxkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		5 ALA A 524
GLU A 557
LEU A 559
ILE A 565
CYH A 546
 None
 1.15A 5vlmA-1dceA:
2.0		 5vlmA-1dceA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		5 GLN A 112
ALA A 114
GLU A 106
LEU A 108
ILE A  37
 None
 1.31A 5vlmA-1evsA:
0.1		 5vlmA-1evsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.40A 5vlmA-1gy8A:
1.6		 5vlmA-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		5 MET A 179
LEU A 161
ILE A 165
ASP A 290
PHE A 291
 None
 1.49A 5vlmA-1hvyA:
undetectable		 5vlmA-1hvyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 ALA A 377
SER A 380
LEU A 385
ILE A 283
TYR A 302
 None
 1.46A 5vlmA-1i7oA:
undetectable		 5vlmA-1i7oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 MET A  93
ALA A 125
LEU A 106
ILE A 108
PHE A 171
 None
 1.47A 5vlmA-1in8A:
0.6		 5vlmA-1in8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 MET A 298
ALA A 208
LEU A 194
ILE A 321
ASP A 324
 None
 1.41A 5vlmA-1iy1A:
undetectable		 5vlmA-1iy1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 MET A 162
ALA A 148
LEU A 160
ILE A 184
ASP A 117
 None
 1.15A 5vlmA-1ji0A:
0.0		 5vlmA-1ji0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		5 ALA A 182
SER A 186
GLU A 208
LEU A 191
ILE A 213
 ALA  A 182 ( 0.0A)
SER  A 186 ( 0.0A)
GLU  A 208 ( 0.6A)
LEU  A 191 ( 0.6A)
ILE  A 213 ( 0.7A)
 1.50A 5vlmA-1omoA:
0.0		 5vlmA-1omoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 SER A 464
GLU A 466
LEU A 468
ILE A 378
TYR A 434
 None
 1.20A 5vlmA-1ph5A:
undetectable		 5vlmA-1ph5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 GLN A 179
ALA A 178
SER A 167
ILE A 182
PHE A   6
 None
 1.48A 5vlmA-1su1A:
undetectable		 5vlmA-1su1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9v KIAA0561 PROTEIN

(Homo sapiens) 		PF08926
(DUF1908) 		5 GLN A  13
ALA A  12
GLU A  20
ILE A 102
TYR A  65
 None
 1.18A 5vlmA-1v9vA:
undetectable		 5vlmA-1v9vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		5 MET A 288
ALA A 286
ILE A 320
TYR A 281
ASP A 315
 None
 1.47A 5vlmA-1vgqA:
undetectable		 5vlmA-1vgqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 GLN A 421
ALA A 297
SER A 295
LEU A 427
ASP A 293
 None
 1.28A 5vlmA-1wleA:
2.2		 5vlmA-1wleA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		5 GLN A 190
ALA A 194
GLU A  22
LEU A  29
PHE A  19
 None
 1.38A 5vlmA-2btdA:
undetectable		 5vlmA-2btdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ALA A 169
GLU A 299
ILE A 212
TYR A  11
PHE A 300
 None
 1.24A 5vlmA-2fpgA:
undetectable		 5vlmA-2fpgA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		5 ALA A 268
GLU A 281
LEU A 287
ILE A 304
PHE A 280
 None
 1.33A 5vlmA-2gopA:
undetectable		 5vlmA-2gopA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 MET A 247
SER A 261
ILE A 218
TYR A 302
CYH A 273
 ADP  A1556 (-4.1A)
None
None
None
None
 1.22A 5vlmA-2ji9A:
undetectable		 5vlmA-2ji9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9v DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 GLN A  61
SER A  60
GLU A  58
ILE A  27
ASP A  55
 None
 1.50A 5vlmA-2n9vA:
undetectable		 5vlmA-2n9vA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A  82
ILE A 189
CYH A 133
ASP A 200
PHE A 199
 None
 1.15A 5vlmA-2nztA:
undetectable		 5vlmA-2nztA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans) 		no annotation 5 MET A 653
ALA A 667
SER A 670
LEU A 605
ASP A 676
 None
 1.50A 5vlmA-2of3A:
undetectable		 5vlmA-2of3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohw YUEI PROTEIN

(Bacillus
subtilis) 		PF07997
(DUF1694) 		5 GLN A  44
GLU A  57
LEU A  40
ILE A 105
TYR A  74
 None
 1.36A 5vlmA-2ohwA:
undetectable		 5vlmA-2ohwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ALA A 120
SER A  54
LEU A  99
TYR A 132
PHE A  32
 FAD  A 400 (-3.6A)
FAD  A 400 (-3.7A)
None
None
None
 1.43A 5vlmA-2qdxA:
undetectable		 5vlmA-2qdxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 MET A 761
GLN A 762
ALA A 758
LEU A 773
ILE A 776
 None
 1.50A 5vlmA-2qzaA:
undetectable		 5vlmA-2qzaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 MET A 761
GLN A 762
ALA A 758
LEU A 777
ILE A 776
 None
 1.41A 5vlmA-2qzaA:
undetectable		 5vlmA-2qzaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 ALA A 192
GLU A 268
LEU A 189
TYR A 201
ASP A 265
 None
None
None
HEM  A 600 (-4.2A)
None
 1.50A 5vlmA-2r7aA:
undetectable		 5vlmA-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 MET A  21
ALA A 217
SER A 111
LEU A  73
ILE A 225
 None
 1.50A 5vlmA-2xecA:
undetectable		 5vlmA-2xecA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		5 MET A 112
ALA A 114
SER A 118
LEU A 119
ILE A  57
 None
 1.42A 5vlmA-2ygkA:
undetectable		 5vlmA-2ygkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 GLN A 739
SER A 524
GLU A 723
LEU A 743
PHE A 678
 None
None
GLU  A 301 ( 2.8A)
None
None
 1.50A 5vlmA-2znsA:
undetectable		 5vlmA-2znsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 MET A 133
ALA A 387
LEU A 129
ILE A 111
TYR A 105
 None
 1.37A 5vlmA-3ez6A:
undetectable		 5vlmA-3ez6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ALA A 216
SER A 269
GLU A 257
LEU A 254
ILE A 271
 None
 1.45A 5vlmA-3jsaA:
undetectable		 5vlmA-3jsaA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLN A  85
SER A  83
ILE A  90
TYR A  58
ASP A 118
 None
 1.49A 5vlmA-3kzwA:
1.4		 5vlmA-3kzwA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 ALA A  36
GLU A 275
LEU A  33
ILE A   8
TYR A 441
 FAD  A 500 (-3.6A)
None
None
None
None
 1.49A 5vlmA-3lovA:
undetectable		 5vlmA-3lovA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		5 ALA X  70
GLU X 163
LEU X 165
ILE X 179
TYR X 128
 None
 1.46A 5vlmA-3lwtX:
undetectable		 5vlmA-3lwtX:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		5 ALA A 318
GLU A 309
LEU A 301
ILE A 307
TYR A 331
 None
 1.34A 5vlmA-3m7dA:
undetectable		 5vlmA-3m7dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 5 ALA G 337
LEU G 138
ILE G 139
TYR G 327
CYH G 287
 None
 1.25A 5vlmA-3mmpG:
undetectable		 5vlmA-3mmpG:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 MET A 535
SER A 337
GLU A 339
LEU A 341
ILE A 348
 None
 1.12A 5vlmA-3nvlA:
1.7		 5vlmA-3nvlA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otd TRNA(HIS)
GUANYLYLTRANSFERASE

(Homo sapiens) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 MET A  97
ALA A 101
LEU A  65
ILE A  68
TYR A 143
 None
 1.28A 5vlmA-3otdA:
undetectable		 5vlmA-3otdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 MET A 256
ALA A 236
SER A 239
LEU A 252
ASP A 179
 None
 1.49A 5vlmA-3oukA:
undetectable		 5vlmA-3oukA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 ALA A 330
SER A 238
GLU A 239
LEU A 253
ILE A 273
 None
 1.41A 5vlmA-3pquA:
undetectable		 5vlmA-3pquA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		5 GLN A  57
ALA A  55
LEU A  60
ILE A  63
ASP A 250
 None
 1.17A 5vlmA-3qxlA:
undetectable		 5vlmA-3qxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh3 UNCHARACTERIZED
DUF3829-LIKE PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLN A 162
SER A 201
LEU A 205
ILE A 217
PHE A 257
 None
 1.43A 5vlmA-3rh3A:
1.8		 5vlmA-3rh3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 ALA A 341
GLU A 383
LEU A 311
ILE A 314
PHE A 374
 None
 1.29A 5vlmA-3t58A:
undetectable		 5vlmA-3t58A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLN A 461
SER A 420
LEU A 475
ILE A 300
PHE A 424
 None
 1.50A 5vlmA-3ue3A:
undetectable		 5vlmA-3ue3A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 GLN A  50
GLU A  44
LEU A  46
ILE A 114
TYR A   3
 None
 1.45A 5vlmA-3w6qA:
undetectable		 5vlmA-3w6qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alb PHENOLIC ACID
DECARBOXYLASE PADC

(Bacillus
subtilis) 		PF05870
(PA_decarbox) 		5 MET A  75
SER A   7
GLU A 136
LEU A 133
TYR A  13
 None
 1.18A 5vlmA-4albA:
undetectable		 5vlmA-4albA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 MET A 177
GLU A 137
LEU A 141
ILE A 127
PHE A 131
 None
 1.04A 5vlmA-4c2fA:
undetectable		 5vlmA-4c2fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		5 ALA B 316
SER B 320
LEU B 324
ILE B 268
TYR B 177
 None
 1.42A 5vlmA-4ci6B:
3.5		 5vlmA-4ci6B:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		5 ALA A  66
GLU A 140
LEU A 114
ILE A 133
TYR A  12
 None
 1.46A 5vlmA-4dyxA:
undetectable		 5vlmA-4dyxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ALA A1031
LEU A 832
ILE A 833
TYR A1021
CYH A 981
 None
 1.28A 5vlmA-4fwtA:
2.5		 5vlmA-4fwtA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6z GLUTAMATE-TRNA
LIGASE

(Burkholderia
thailandensis) 		PF00749
(tRNA-synt_1c) 		5 ALA A  25
LEU A  41
ILE A  43
TYR A 187
ASP A  57
 None
 1.46A 5vlmA-4g6zA:
undetectable		 5vlmA-4g6zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k48 LEUCINE--TRNA LIGASE

(Streptococcus
pneumoniae) 		PF13603
(tRNA-synt_1_2) 		5 ALA A 309
GLU A 242
LEU A 267
TYR A 327
PHE A 234
 None
 1.49A 5vlmA-4k48A:
undetectable		 5vlmA-4k48A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		5 MET A  49
ALA A  21
LEU A  47
ILE A  60
PHE A  96
 None
CA  A 402 (-4.9A)
None
None
None
 1.26A 5vlmA-4lq0A:
2.2		 5vlmA-4lq0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP

(Shewanella
oneidensis) 		PF03480
(DctP) 		5 ALA A  55
SER A 273
GLU A 272
LEU A 270
ILE A 266
 None
 1.23A 5vlmA-4mx6A:
undetectable		 5vlmA-4mx6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 ALA A  39
SER A  58
LEU A  61
ILE A  64
CYH A  10
 None
 1.34A 5vlmA-4n18A:
undetectable		 5vlmA-4n18A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  95
ILE A  99
TYR A 190
ASP A  42
PHE A  34
 None
 1.44A 5vlmA-4n5cA:
1.9		 5vlmA-4n5cA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxi UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01323
(DSBA) 		5 ALA A  68
SER A  46
LEU A 136
ILE A  76
PHE A  15
 None
 1.26A 5vlmA-4nxiA:
undetectable		 5vlmA-4nxiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 5 MET A 238
ALA A 242
SER A 244
LEU A 485
ILE A 484
 None
 1.12A 5vlmA-4ofzA:
undetectable		 5vlmA-4ofzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oir DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
thermophilus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 MET A 140
ALA A 130
GLU A  84
LEU A  82
ILE A  79
 None
 1.26A 5vlmA-4oirA:
undetectable		 5vlmA-4oirA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 MET A 145
GLN A  57
ALA A  60
LEU A  53
ILE A  52
 None
 1.48A 5vlmA-4p58A:
undetectable		 5vlmA-4p58A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 GLN A 108
ALA A 112
ILE A 133
ASP A 201
PHE A 170
 None
 1.33A 5vlmA-4raeA:
undetectable		 5vlmA-4raeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 SRX DOMAIN

(Chaetomium
thermophilum) 		PF04086
(SRP-alpha_N) 		5 ALA A 100
SER A 104
GLU A 108
LEU A 105
PHE A 110
 None
 1.39A 5vlmA-5ck3A:
undetectable		 5vlmA-5ck3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxd HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Staphylococcus
aureus) 		PF01648
(ACPS) 		5 GLN A  22
ALA A  17
LEU A  25
ILE A  29
PHE A  38
 None
 1.50A 5vlmA-5cxdA:
undetectable		 5vlmA-5cxdA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 MET A 224
ALA A  72
LEU A 188
ILE A 189
ASP A 163
 None
 1.36A 5vlmA-5e7qA:
undetectable		 5vlmA-5e7qA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 MET A 411
ALA A 481
SER A 477
LEU A 420
ILE A 433
 None
 1.34A 5vlmA-5e9uA:
undetectable		 5vlmA-5e9uA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE 2,
PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 GLN B 148
SER B 133
ILE B 114
ASP B  82
PHE B  83
 None
 1.43A 5vlmA-5fmgB:
undetectable		 5vlmA-5fmgB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 MET A 189
GLN A 192
ALA A 313
SER A 316
LEU A 320
 None
 1.19A 5vlmA-5fsaA:
undetectable		 5vlmA-5fsaA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 MET A 384
MET A 383
LEU A 151
ILE A 152
ASP A 169
 None
 1.28A 5vlmA-5mrwA:
1.3		 5vlmA-5mrwA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 MET A 165
ALA A 180
LEU A 191
ILE A 216
TYR A 199
 None
 1.49A 5vlmA-5olcA:
undetectable		 5vlmA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 GLN A   8
ALA A  28
LEU A  23
ILE A  44
PHE A  52
 None
 1.44A 5vlmA-5ufbA:
undetectable		 5vlmA-5ufbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 MET A  67
GLN A  71
SER A  89
LEU A  94
ILE A  98
TYR A 118
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
MGR  A 300 ( 4.1A)
MGR  A 300 ( 4.8A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
None
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 1.11A 5vlmA-5vlgA:
30.0		 5vlmA-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 11 MET A  67
MET A  68
GLN A  71
ALA A  86
GLU A  90
LEU A  94
ILE A  98
TYR A 118
CYH A 160
ASP A 175
PHE A 178
 MGR  A 300 (-4.6A)
None
MGR  A 300 ( 4.1A)
None
MGR  A 300 (-4.1A)
MGR  A 300 ( 4.7A)
MGR  A 300 (-3.1A)
None
MGR  A 300 (-2.8A)
MGR  A 300 ( 4.3A)
MGR  A 300 (-3.1A)
 0.81A 5vlmA-5vlgA:
30.0		 5vlmA-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 MET A1192
SER A1320
GLU A1323
ILE A1184
PHE A1322
 None
A  B  25 ( 4.9A)
A  B  26 ( 3.4A)
None
None
 1.45A 5vlmA-5wtkA:
0.9		 5vlmA-5wtkA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 5 ALA A  81
GLU A  49
LEU A  46
ILE A  62
CYH A  73
 None
 1.34A 5vlmA-5yguA:
undetectable		 5vlmA-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 GLU A 652
LEU A 682
ILE A 677
TYR A 452
CYH A 670
 None
 1.39A 5vlmA-6at7A:
undetectable		 5vlmA-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		5 MET A 194
ALA A 190
SER A 188
LEU A  67
ILE A  64
 None
 1.47A 5vlmA-6aujA:
undetectable		 5vlmA-6aujA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		5 MET A 195
ALA A 190
SER A 188
LEU A  67
ILE A  64
 None
 1.48A 5vlmA-6aujA:
undetectable		 5vlmA-6aujA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 5 MET A 417
GLU A 396
LEU A 394
ILE A 458
TYR A 450
 None
 1.45A 5vlmA-6ax8A:
undetectable		 5vlmA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 5 MET A 603
SER A 291
GLU A 282
LEU A 293
ILE A 296
 FZ4  A 801 ( 3.5A)
None
None
None
None
 1.27A 5vlmA-6d7tA:
undetectable		 5vlmA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 5 ALA A 193
SER A 186
GLU A 184
LEU A 182
ILE A 167
 None
 1.47A 5vlmA-6dzsA:
undetectable		 5vlmA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu9 RETINOIC ACID
RECEPTOR

(Platynereis
dumerilii) 		no annotation 5 ALA A 363
LEU A 394
ILE A 398
TYR A 454
PHE A 430
 None
 1.37A 5vlmA-6eu9A:
2.9		 5vlmA-6eu9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 448
GLU A 440
LEU A 401
ILE A 396
ASP A 437
 None
 1.19A 5vlmA-6fbtA:
undetectable		 5vlmA-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		4 GLY A 234
ARG A 255
GLN A 289
TYR A 218
 None
ASN  A 331 (-3.2A)
None
ASN  A 331 (-4.3A)
 1.01A 5vlmA-12asA:
undetectable		 5vlmA-12asA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7o IGG1-KAPPA D1.3 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 GLY L  64
GLN L  89
VAL L  48
TYR L  50
 None
 0.88A 5vlmA-1a7oL:
undetectable		 5vlmA-1a7oL:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnd BRAIN DERIVED
NEUROTROPHIC FACTOR

(Homo sapiens) 		PF00243
(NGF) 		4 GLY A  34
ARG A  97
VAL A  36
ASP A  93
 None
 0.92A 5vlmA-1bndA:
undetectable		 5vlmA-1bndA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 GLY A  59
GLN A 415
VAL A 107
ASP A 106
 None
 1.00A 5vlmA-1ck7A:
undetectable		 5vlmA-1ck7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B2384
VAL B2350
ASP B2346
TYR B2347
 None
 1.04A 5vlmA-1e6yB:
1.1		 5vlmA-1e6yB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 GLY A 387
TRP A 259
GLN A 255
VAL A 249
 None
 0.88A 5vlmA-1em2A:
0.1		 5vlmA-1em2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo9 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN


(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY B 435
ARG B 522
VAL B 384
ASP B 524
 None
 1.06A 5vlmA-1eo9B:
undetectable		 5vlmA-1eo9B:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A  15
TRP A  32
VAL A 487
ASP A 200
 None
GLC  A2003 (-4.1A)
None
None
 1.03A 5vlmA-1eu1A:
undetectable		 5vlmA-1eu1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 GLY A 213
ARG A 119
VAL A 175
ASP A  86
 None
 0.92A 5vlmA-1f0iA:
undetectable		 5vlmA-1f0iA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 GLY A 532
ARG A 130
VAL A 123
ASP A 126
 None
 1.04A 5vlmA-1f7uA:
1.2		 5vlmA-1f7uA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 178
ARG A 136
VAL A 142
ASP A 134
 None
 1.00A 5vlmA-1fehA:
0.0		 5vlmA-1fehA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.87A 5vlmA-1gtkA:
undetectable		 5vlmA-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A 110
ARG A  54
VAL A 106
TYR A  48
 None
 0.94A 5vlmA-1jaeA:
undetectable		 5vlmA-1jaeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A  86
ARG A 124
VAL A 121
ASP A 122
 None
 0.95A 5vlmA-1lk5A:
undetectable		 5vlmA-1lk5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nya CALERYTHRIN

(Saccharopolyspora
erythraea) 		PF13499
(EF-hand_7) 		4 GLY A 176
GLN A 144
VAL A 172
ASP A 171
 None
 0.79A 5vlmA-1nyaA:
undetectable		 5vlmA-1nyaA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		4 GLY D 101
ARG D 182
GLN D 180
ASP D  73
 None
 1.05A 5vlmA-1o94D:
undetectable		 5vlmA-1o94D:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 GLY A 150
GLN A  31
VAL A  39
TYR A  76
 None
 0.96A 5vlmA-1s2jA:
undetectable		 5vlmA-1s2jA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		4 ARG A  97
GLN A 100
VAL A 168
ASP A 167
 None
 1.00A 5vlmA-1s5pA:
undetectable		 5vlmA-1s5pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 GLY A 150
GLN A  31
VAL A  39
TYR A  76
 None
None
None
EDO  A 404 (-4.4A)
 0.91A 5vlmA-1sxrA:
undetectable		 5vlmA-1sxrA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 GLY A 163
TRP A 167
VAL A 191
TYR A 229
 None
 1.07A 5vlmA-1yx1A:
undetectable		 5vlmA-1yx1A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 GLY A 572
ARG A 144
VAL A 565
ASP A 142
 None
 1.05A 5vlmA-2b0tA:
undetectable		 5vlmA-2b0tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cye PUTATIVE
THIOESTERASE

(Thermus
thermophilus) 		PF03061
(4HBT) 		4 GLY A  69
ARG A   9
VAL A  12
ASP A  11
 None
 1.04A 5vlmA-2cyeA:
undetectable		 5vlmA-2cyeA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		4 GLY A 112
ARG A 125
VAL A  84
ASP A  83
 None
 1.08A 5vlmA-2h9fA:
undetectable		 5vlmA-2h9fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR
COLICIN-IA

(Escherichia
coli;
Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug)
PF11504
(Colicin_Ia) 		4 GLY B 361
ARG B 313
GLN A 425
ASP B 311
 None
 0.87A 5vlmA-2hdiB:
undetectable		 5vlmA-2hdiB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		4 GLY A  68
TRP A 121
GLN A 117
ASP A  85
 None
 0.81A 5vlmA-2lghA:
undetectable		 5vlmA-2lghA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 GLY A 274
GLN A 136
VAL A 292
TYR A 259
 None
 1.04A 5vlmA-2oodA:
undetectable		 5vlmA-2oodA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		4 GLY A  76
ARG A 226
VAL A 143
ASP A 180
 None
 0.99A 5vlmA-2oxtA:
undetectable		 5vlmA-2oxtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 GLY B 215
ARG B 246
VAL B 213
ASP B 202
 None
GOL  B 902 (-2.9A)
None
None
 1.04A 5vlmA-2pbiB:
undetectable		 5vlmA-2pbiB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLN A 278
VAL A 204
ASP A 205
TYR A 159
 None
 1.03A 5vlmA-2pozA:
undetectable		 5vlmA-2pozA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 GLY A  52
ARG A  85
VAL A  79
ASP A  82
 None
 0.92A 5vlmA-2q7sA:
undetectable		 5vlmA-2q7sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLY A 335
TRP A 233
ARG A 316
ASP A 328
 None
 1.08A 5vlmA-2tohA:
undetectable		 5vlmA-2tohA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 ARG A 120
VAL A   6
ASP A  92
TYR A 118
 None
 0.81A 5vlmA-2wteA:
2.6		 5vlmA-2wteA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 GLY A 213
ARG A 323
GLN A 324
VAL A 316
 None
 0.98A 5vlmA-2x3kA:
1.7		 5vlmA-2x3kA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 GLY A 213
ARG A 323
VAL A 316
ASP A 319
 None
 0.99A 5vlmA-2x3kA:
1.7		 5vlmA-2x3kA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xha TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		no annotation 4 GLY A  90
ARG A  87
VAL A 163
ASP A 171
 None
ACT  A1238 (-4.0A)
None
ACT  A1235 ( 4.2A)
 1.00A 5vlmA-2xhaA:
undetectable		 5vlmA-2xhaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ARG A 213
TRP A 165
VAL A 173
TYR A 210
 None
 1.06A 5vlmA-3aflA:
undetectable		 5vlmA-3aflA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN

(Streptomyces
coelicolor) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY A 109
ARG A 126
VAL A 119
ASP A 123
 None
 1.02A 5vlmA-3akaA:
undetectable		 5vlmA-3akaA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A1000
ARG A 788
GLN A 925
ASP A 794
 None
 1.08A 5vlmA-3bgaA:
undetectable		 5vlmA-3bgaA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 GLY A 185
ARG A 164
VAL A 152
ASP A 156
 None
 1.00A 5vlmA-3dddA:
undetectable		 5vlmA-3dddA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A 976
ARG A 764
GLN A 901
ASP A 770
 None
 1.07A 5vlmA-3decA:
undetectable		 5vlmA-3decA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmA-3eq1A:
undetectable		 5vlmA-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		4 ARG A 127
TRP A  39
VAL A 122
ASP A 125
 None
 1.00A 5vlmA-3fljA:
undetectable		 5vlmA-3fljA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmg UNCHARACTERIZED
PROTEIN
RV1825/MT1873

(Mycobacterium
tuberculosis) 		PF05949
(DUF881) 		4 GLY A 162
ARG A 273
VAL A 276
ASP A 275
 None
 1.02A 5vlmA-3gmgA:
undetectable		 5vlmA-3gmgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 GLY A 127
TRP A 185
VAL A 223
ASP A 222
 None
 0.85A 5vlmA-3h04A:
undetectable		 5vlmA-3h04A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 310
ARG A 120
VAL A 112
ASP A 116
 GLY  A 310 ( 0.0A)
ARG  A 120 ( 0.6A)
VAL  A 112 ( 0.6A)
ASP  A 116 ( 0.6A)
 1.05A 5vlmA-3i4kA:
undetectable		 5vlmA-3i4kA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLY F 215
TRP F 225
VAL F 240
ASP F 239
 None
 0.98A 5vlmA-3jbrF:
undetectable		 5vlmA-3jbrF:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF02940
(mRNA_triPase) 		4 ARG A 321
VAL A 426
ASP A 425
TYR A 418
 None
 1.02A 5vlmA-3kyhA:
undetectable		 5vlmA-3kyhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 GLY A 428
ARG A 452
VAL A 425
ASP A 465
 None
 1.00A 5vlmA-3mcaA:
undetectable		 5vlmA-3mcaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n08 PUTATIVE
PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
(PEBP)

(Chlamydia
trachomatis) 		PF01161
(PBP) 		4 GLY A  58
ARG A 106
VAL A  50
ASP A  49
 None
 0.67A 5vlmA-3n08A:
undetectable		 5vlmA-3n08A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		4 GLN A 104
VAL A 118
ASP A 122
TYR A 125
 None
None
MN  A 199 (-2.8A)
None
 0.92A 5vlmA-3nr1A:
undetectable		 5vlmA-3nr1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLY D 447
ARG D 425
VAL D 418
ASP D 422
 None
 1.06A 5vlmA-3oaaD:
undetectable		 5vlmA-3oaaD:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY B 297
ARG B 242
TRP B 398
ASP B 244
 None
 0.59A 5vlmA-3ojyB:
undetectable		 5vlmA-3ojyB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe5 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		PF03816
(LytR_cpsA_psr) 		4 GLY A 339
ARG A 150
VAL A 341
ASP A 151
 None
 0.97A 5vlmA-3pe5A:
undetectable		 5vlmA-3pe5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 4 GLY A 173
ARG A 188
VAL A 114
ASP A 118
 None
 1.04A 5vlmA-3pf7A:
1.0		 5vlmA-3pf7A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 388
GLN A 439
TRP A 392
VAL A 428
 None
 1.04A 5vlmA-3r18A:
undetectable		 5vlmA-3r18A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdz BWI-1=PROTEASE
INHIBITOR/TRYPSIN
INHIBITOR

(Fagopyrum
esculentum) 		PF00280
(potato_inhibit) 		4 GLY C  18
ARG C  59
VAL C  56
ASP C  57
 None
 0.86A 5vlmA-3rdzC:
undetectable		 5vlmA-3rdzC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 GLY A1014
ARG A1039
VAL A1042
ASP A1041
 None
 0.89A 5vlmA-3topA:
undetectable		 5vlmA-3topA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		4 GLY A 173
ARG A 335
GLN A 331
ASP A 406
 None
 0.82A 5vlmA-3uyjA:
undetectable		 5vlmA-3uyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 GLY A  73
ARG A  55
VAL A  71
ASP A  57
 None
 0.96A 5vlmA-3w9rA:
undetectable		 5vlmA-3w9rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ARG A 245
GLN A 246
VAL A 284
ASP A 283
 None
 1.02A 5vlmA-3zzuA:
undetectable		 5vlmA-3zzuA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 GLY A  24
ARG A  17
VAL A  84
ASP A  83
 None
 0.86A 5vlmA-4bucA:
undetectable		 5vlmA-4bucA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 408
ARG A 357
VAL A 364
ASP A 361
 None
 1.07A 5vlmA-4d5gA:
undetectable		 5vlmA-4d5gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 389
ARG A 364
VAL A 385
ASP A 407
 None
 1.07A 5vlmA-4f7kA:
undetectable		 5vlmA-4f7kA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		4 GLY B 342
TRP B 191
ARG B 246
ASP B 267
 None
XYP  B 802 (-4.2A)
XYP  B 801 ( 3.0A)
None
 0.94A 5vlmA-4g68B:
undetectable		 5vlmA-4g68B:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 211
ARG A 143
GLN A 146
ASP A 117
 None
ACT  A 402 ( 2.6A)
None
None
 0.87A 5vlmA-4htgA:
undetectable		 5vlmA-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 211
ARG A 143
GLN A 146
VAL A 115
 None
ACT  A 402 ( 2.6A)
None
None
 1.00A 5vlmA-4htgA:
undetectable		 5vlmA-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 GLY A 520
GLN A 626
VAL A 506
ASP A 513
 None
 1.08A 5vlmA-4jc8A:
3.0		 5vlmA-4jc8A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  41
ARG A  20
VAL A  49
ASP A  48
 None
 0.95A 5vlmA-4nd4A:
undetectable		 5vlmA-4nd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 TRP A 114
GLN A  65
TRP A 158
VAL A 122
 VIB  A 401 (-3.7A)
None
VIB  A 401 (-4.0A)
None
 1.06A 5vlmA-4nmyA:
undetectable		 5vlmA-4nmyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p62 METALLO-BETA-LACTAMA
SE AIM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLY A 121
ARG A  93
VAL A  97
ASP A  96
 None
 1.07A 5vlmA-4p62A:
undetectable		 5vlmA-4p62A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 336
ARG A 436
VAL A 455
ASP A 456
 GOL  A 702 (-3.9A)
None
None
None
 0.91A 5vlmA-4pf1A:
undetectable		 5vlmA-4pf1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 GLY A1366
ARG A1325
ASP A1341
TYR A1345
 None
 1.07A 5vlmA-4pk1A:
undetectable		 5vlmA-4pk1A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLY A  63
ARG A 162
GLN A 161
ASP A  58
 None
 1.08A 5vlmA-4rnwA:
undetectable		 5vlmA-4rnwA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx7 CLASS I CHITINASE

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 GLY A 159
GLN A 153
VAL A 187
ASP A 185
 None
 1.03A 5vlmA-4tx7A:
undetectable		 5vlmA-4tx7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 GLY A 561
TRP A 567
ARG A 557
GLN A 556
 None
 1.05A 5vlmA-4txgA:
undetectable		 5vlmA-4txgA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u83 ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 100
ARG A 107
TRP A  57
ASP A 103
 None
 0.97A 5vlmA-4u83A:
2.2		 5vlmA-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1

(Homo sapiens) 		PF00753
(Lactamase_B) 		4 GLY A 115
GLN A 175
VAL A 178
ASP A 177
 None
 0.89A 5vlmA-4v0hA:
undetectable		 5vlmA-4v0hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 GLY A 599
ARG A 137
VAL A 129
ASP A 133
 None
 0.92A 5vlmA-4yj1A:
undetectable		 5vlmA-4yj1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLY A 363
ARG A  63
GLN A  62
ASP A 358
 None
 1.08A 5vlmA-4yncA:
undetectable		 5vlmA-4yncA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		4 GLY A 237
ARG A 220
VAL A 213
ASP A 217
 None
 1.06A 5vlmA-4zrmA:
1.0		 5vlmA-4zrmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 GLY A 437
TRP A 510
ASP A 391
TYR A 394
 None
 1.08A 5vlmA-5axhA:
undetectable		 5vlmA-5axhA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-GAMMA

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLY A  66
ARG A  30
GLN A  28
ASP A  64
 None
 1.02A 5vlmA-5dqsA:
undetectable		 5vlmA-5dqsA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 GLY E 151
VAL E 121
ASP E 119
TYR E 415
 EDO  E 610 (-4.8A)
None
None
None
 0.93A 5vlmA-5e24E:
undetectable		 5vlmA-5e24E:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		4 GLY A  73
ARG A 203
VAL A 199
ASP A 201
 None
 1.07A 5vlmA-5exeA:
undetectable		 5vlmA-5exeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLY A 111
TRP A 121
ARG A 641
ASP A 123
 None
 0.94A 5vlmA-5fkcA:
undetectable		 5vlmA-5fkcA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		4 TRP C 188
ARG C 184
VAL C 177
ASP C 180
 None
 0.85A 5vlmA-5fn4C:
1.2		 5vlmA-5fn4C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 ARG A  95
VAL A  50
ASP A  51
TYR A 379
 None
None
None
GCS  A 801 (-4.2A)
 0.94A 5vlmA-5gsmA:
undetectable		 5vlmA-5gsmA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 4 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.83A 5vlmA-5h6oA:
undetectable		 5vlmA-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 379
ARG A 274
VAL A 270
ASP A 272
 None
 0.98A 5vlmA-5htvA:
undetectable		 5vlmA-5htvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 785
GLN A 352
VAL A 415
TYR A 411
 None
 1.05A 5vlmA-5i2gA:
2.2		 5vlmA-5i2gA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 GLY A  68
ARG A 423
VAL A  25
ASP A  26
 None
 0.87A 5vlmA-5i33A:
undetectable		 5vlmA-5i33A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE U3 SNORNP
PROTEIN
PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF04192
(Utp21)
PF04003
(Utp12) 		4 GLY C1017
TRP C1019
VAL D 841
ASP D 842
 None
 1.05A 5vlmA-5icaC:
2.9		 5vlmA-5icaC:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01016
(Ribosomal_L27) 		4 GLY X  83
ARG X 140
GLN X 143
TYR X 138
 G  A 866 ( 3.1A)
None
None
None
 1.02A 5vlmA-5mlcX:
undetectable		 5vlmA-5mlcX:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 GLY A 147
ARG A 168
VAL A 171
ASP A 170
 None
None
None
EDO  A1029 (-3.5A)
 0.91A 5vlmA-5nn8A:
undetectable		 5vlmA-5nn8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 GLY A 198
ARG A 130
GLN A 133
ASP A 104
 None
AWQ  A 401 (-3.8A)
None
None
 0.90A 5vlmA-5ov6A:
undetectable		 5vlmA-5ov6A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tt1 PUTATIVE SHORT-CHAIN
ALCOHOL
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00106
(adh_short) 		4 GLY A 144
ARG A 233
ASP A 229
TYR A 230
 None
 0.90A 5vlmA-5tt1A:
0.0		 5vlmA-5tt1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 8 GLY A  88
TRP A 101
ARG A 102
GLN A 105
TRP A 125
VAL A 159
ASP A 163
TYR A 166
 MGR  A 300 ( 2.9A)
MGR  A 300 (-3.6A)
MGR  A 300 (-4.3A)
MGR  A 300 ( 3.0A)
MGR  A 300 (-3.5A)
MGR  A 300 (-4.4A)
MGR  A 300 (-3.5A)
MGR  A 300 (-3.0A)
 0.37A 5vlmA-5vlgA:
30.0		 5vlmA-5vlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpj THIOESTERASE

(Actinomadura
verrucosospora) 		PF13279
(4HBT_2) 		5 ARG A  97
TRP A  30
VAL A  11
ASP A  73
TYR A  70
 None
 1.37A 5vlmA-5vpjA:
undetectable		 5vlmA-5vpjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvj PHD FINGER PROTEIN
ALFIN-LIKE 7

(Arabidopsis
thaliana) 		no annotation 4 GLY A 110
ARG A  22
VAL A  15
ASP A  18
 None
 0.98A 5vlmA-5xvjA:
2.0		 5vlmA-5xvjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Burkholderia
cenocepacia) 		no annotation 4 GLY A 214
TRP A 166
GLN A 167
VAL A 173
 None
 1.01A 5vlmA-5y89A:
undetectable		 5vlmA-5y89A:
23.83