SIMILAR PATTERNS OF AMINO ACIDS FOR 5VKQ_D_PCFD1802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ASN A 575
LEU A 469
TRP A 404
THR A 573
 None
 1.43A 5vkqA-1mpxA:
0.1
5vkqD-1mpxA:
0.2		 5vkqA-1mpxA:
16.87
5vkqD-1mpxA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASN A 288
LEU A 280
TRP A 295
THR A 292
 None
 1.47A 5vkqA-2vbiA:
0.7
5vkqD-2vbiA:
0.0		 5vkqA-2vbiA:
15.61
5vkqD-2vbiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		4 ASN A 255
LEU A 237
TRP A 207
THR A 230
 None
 1.45A 5vkqA-5a5cA:
0.0
5vkqD-5a5cA:
0.0		 5vkqA-5a5cA:
12.51
5vkqD-5a5cA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		4 ASN A 146
LEU A 219
TRP A 182
THR A 180
 None
 1.46A 5vkqA-5lh9A:
0.0
5vkqD-5lh9A:
0.2		 5vkqA-5lh9A:
14.54
5vkqD-5lh9A:
14.54