SIMILAR PATTERNS OF AMINO ACIDS FOR 5VKQ_B_PCFB1806_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ILE A 320
ILE A 622
LEU A 425
PHE A 625
 None
 0.89A 5vkqB-1a2vA:
0.0
5vkqC-1a2vA:
0.0		 5vkqB-1a2vA:
17.08
5vkqC-1a2vA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		4 ILE A 161
ILE A 118
LEU A  14
PHE A  16
 None
 1.04A 5vkqB-1d5cA:
0.0
5vkqC-1d5cA:
undetectable		 5vkqB-1d5cA:
7.05
5vkqC-1d5cA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 113
ILE A  69
LEU A  68
PHE A  11
 None
 1.03A 5vkqB-1escA:
0.0
5vkqC-1escA:
0.0		 5vkqB-1escA:
10.76
5vkqC-1escA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ILE A 170
ILE A 203
HIS A 224
PHE A 281
 None
 0.98A 5vkqB-1ethA:
0.0
5vkqC-1ethA:
0.0		 5vkqB-1ethA:
13.92
5vkqC-1ethA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 ILE A 156
ILE A 386
LEU A 385
PHE A 186
 None
 1.03A 5vkqB-1g55A:
0.0
5vkqC-1g55A:
0.0		 5vkqB-1g55A:
12.21
5vkqC-1g55A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 ILE A1078
ILE A1200
LEU A1198
PHE A1186
 None
 0.86A 5vkqB-1ha5A:
0.0
5vkqC-1ha5A:
0.0		 5vkqB-1ha5A:
8.49
5vkqC-1ha5A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ILE S 267
ILE S 289
PHE S 248
PHE S 332
 None
 1.05A 5vkqB-1i84S:
0.3
5vkqC-1i84S:
1.3		 5vkqB-1i84S:
22.27
5vkqC-1i84S:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		4 ILE A 195
ILE A 122
LEU A  95
PHE A  71
 None
 0.99A 5vkqB-1ipkA:
undetectable
5vkqC-1ipkA:
undetectable		 5vkqB-1ipkA:
13.26
5vkqC-1ipkA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ith HEMOGLOBIN (CYANO
MET)

(Urechis caupo) 		PF00042
(Globin) 		4 ILE A  99
ILE A  69
LEU A  72
PHE A 119
 HEM  A 143 (-3.9A)
None
None
None
 0.92A 5vkqB-1ithA:
2.2
5vkqC-1ithA:
2.2		 5vkqB-1ithA:
6.46
5vkqC-1ithA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 ILE A 443
LEU A 411
PHE A 417
PHE A 456
 None
 1.02A 5vkqB-1j2bA:
0.0
5vkqC-1j2bA:
0.1		 5vkqB-1j2bA:
15.89
5vkqC-1j2bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A 233
ILE A 246
HIS A 204
PHE A 255
 None
None
ADP  A 635 (-4.5A)
None
 0.79A 5vkqB-1jedA:
undetectable
5vkqC-1jedA:
undetectable		 5vkqB-1jedA:
14.70
5vkqC-1jedA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ILE B 169
ILE B 202
HIS B 223
PHE B 280
 None
 1.02A 5vkqB-1lpbB:
undetectable
5vkqC-1lpbB:
undetectable		 5vkqB-1lpbB:
13.48
5vkqC-1lpbB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 ILE A  93
LEU A 130
PHE A 133
HIS A   4
 None
 0.93A 5vkqB-1nr9A:
undetectable
5vkqC-1nr9A:
undetectable		 5vkqB-1nr9A:
8.98
5vkqC-1nr9A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A 256
ILE A 313
LEU A  24
HIS A  23
 None
 1.03A 5vkqB-1pguA:
undetectable
5vkqC-1pguA:
undetectable		 5vkqB-1pguA:
16.69
5vkqC-1pguA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ILE A 181
ILE A 306
LEU A 328
PHE A 332
 None
 0.83A 5vkqB-1q5nA:
undetectable
5vkqC-1q5nA:
undetectable		 5vkqB-1q5nA:
13.62
5vkqC-1q5nA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ILE A 751
ILE A 683
LEU A 680
PHE A 744
 None
 0.96A 5vkqB-1qvrA:
5.8
5vkqC-1qvrA:
5.8		 5vkqB-1qvrA:
19.75
5vkqC-1qvrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 ILE A 197
ILE A 154
PHE A 237
HIS A 236
 None
 0.91A 5vkqB-1r5lA:
undetectable
5vkqC-1r5lA:
undetectable		 5vkqB-1r5lA:
9.57
5vkqC-1r5lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A 233
ILE A 246
HIS A 204
PHE A 255
 None
 0.81A 5vkqB-1r6xA:
undetectable
5vkqC-1r6xA:
undetectable		 5vkqB-1r6xA:
13.24
5vkqC-1r6xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ILE A   5
ILE A  60
LEU A  58
HIS A  56
 None
 1.04A 5vkqB-1snyA:
undetectable
5vkqC-1snyA:
undetectable		 5vkqB-1snyA:
9.83
5vkqC-1snyA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 ILE A  50
ILE A  23
LEU A  92
HIS A  90
 None
 0.94A 5vkqB-1tt4A:
undetectable
5vkqC-1tt4A:
undetectable		 5vkqB-1tt4A:
11.99
5vkqC-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		4 ILE A 264
ILE A 225
LEU A 226
PHE A 213
 None
 0.79A 5vkqB-1uh9A:
undetectable
5vkqC-1uh9A:
undetectable		 5vkqB-1uh9A:
12.14
5vkqC-1uh9A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 ILE A 104
ILE A  79
LEU A  78
PHE A 138
 None
 0.97A 5vkqB-1vbmA:
undetectable
5vkqC-1vbmA:
undetectable		 5vkqB-1vbmA:
10.93
5vkqC-1vbmA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		4 ILE A  12
ILE A 147
PHE A  93
HIS A  50
 None
 0.93A 5vkqB-1vmkA:
undetectable
5vkqC-1vmkA:
undetectable		 5vkqB-1vmkA:
9.70
5vkqC-1vmkA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A 212
ILE A  21
LEU A 249
PHE A  60
 None
 0.97A 5vkqB-1ys9A:
undetectable
5vkqC-1ys9A:
undetectable		 5vkqB-1ys9A:
10.28
5vkqC-1ys9A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A 214
ILE A  23
LEU A 251
PHE A  62
 None
 0.98A 5vkqB-1yv9A:
undetectable
5vkqC-1yv9A:
undetectable		 5vkqB-1yv9A:
9.70
5vkqC-1yv9A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4r GENERAL CONTROL OF
AMINO ACID SYNTHESIS
PROTEIN 5-LIKE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 ILE A 504
LEU A 598
HIS A 597
PHE A 573
 None
 0.95A 5vkqB-1z4rA:
undetectable
5vkqC-1z4rA:
undetectable		 5vkqB-1z4rA:
6.49
5vkqC-1z4rA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 ILE A  81
LEU A 298
PHE A 301
HIS A 131
 None
SAM  A 417 (-4.8A)
None
SAM  A 417 (-4.6A)
 1.04A 5vkqB-2a5hA:
undetectable
5vkqC-2a5hA:
undetectable		 5vkqB-2a5hA:
12.83
5vkqC-2a5hA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 ILE A  20
ILE A  89
PHE A 184
PHE A 125
 None
 0.97A 5vkqB-2ah5A:
undetectable
5vkqC-2ah5A:
undetectable		 5vkqB-2ah5A:
7.74
5vkqC-2ah5A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ILE A 335
ILE A 264
LEU A 292
PHE A 329
 None
 1.04A 5vkqB-2awaA:
undetectable
5vkqC-2awaA:
undetectable		 5vkqB-2awaA:
13.10
5vkqC-2awaA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE C 460
ILE B 233
LEU C 310
HIS C 313
 None
 1.03A 5vkqB-2bg9C:
3.9
5vkqC-2bg9C:
3.8		 5vkqB-2bg9C:
11.88
5vkqC-2bg9C:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		4 ILE A 211
ILE A 133
LEU A 106
PHE A  82
 None
 0.97A 5vkqB-2eaaA:
undetectable
5vkqC-2eaaA:
undetectable		 5vkqB-2eaaA:
13.14
5vkqC-2eaaA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ILE A 105
ILE A 209
LEU A 212
HIS A 214
 None
 0.95A 5vkqB-2foiA:
undetectable
5vkqC-2foiA:
undetectable		 5vkqB-2foiA:
10.96
5vkqC-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ILE A 130
ILE A 209
LEU A 212
HIS A 214
 None
 1.03A 5vkqB-2foiA:
undetectable
5vkqC-2foiA:
undetectable		 5vkqB-2foiA:
10.96
5vkqC-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		4 ILE A  11
ILE A  45
LEU A 213
HIS A 211
 ILE  A  11 ( 0.7A)
ILE  A  45 ( 0.7A)
LEU  A 213 ( 0.6A)
HIS  A 211 ( 1.0A)
 0.99A 5vkqB-2j5bA:
undetectable
5vkqC-2j5bA:
undetectable		 5vkqB-2j5bA:
12.28
5vkqC-2j5bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		4 ILE A  91
ILE A  30
LEU A  47
PHE A  17
 None
 1.00A 5vkqB-2j8kA:
undetectable
5vkqC-2j8kA:
undetectable		 5vkqB-2j8kA:
8.21
5vkqC-2j8kA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4h HIV-2 MYRISTOYLATED
MATRIX PROTEIN

(Human
immunodeficiency
virus 2) 		PF00540
(Gag_p17) 		4 ILE A  19
ILE A  60
LEU A  51
PHE A  44
 None
None
MYR  A   1 (-3.3A)
None
 0.88A 5vkqB-2k4hA:
undetectable
5vkqC-2k4hA:
undetectable		 5vkqB-2k4hA:
6.68
5vkqC-2k4hA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsz PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		4 ILE A 398
ILE A 368
HIS A 360
PHE A 380
 None
 0.99A 5vkqB-2nszA:
1.1
5vkqC-2nszA:
2.4		 5vkqB-2nszA:
5.47
5vkqC-2nszA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 ILE A 150
LEU A 283
PHE A 276
HIS A 280
 None
 1.01A 5vkqB-2oucA:
undetectable
5vkqC-2oucA:
undetectable		 5vkqB-2oucA:
5.80
5vkqC-2oucA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		4 ILE A 302
ILE A  94
LEU A 267
PHE A 239
 None
 1.01A 5vkqB-2pb0A:
undetectable
5vkqC-2pb0A:
undetectable		 5vkqB-2pb0A:
14.50
5vkqC-2pb0A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ILE A  74
ILE A  86
LEU A 107
PHE A  29
 None
 0.97A 5vkqB-2pcuA:
undetectable
5vkqC-2pcuA:
undetectable		 5vkqB-2pcuA:
11.28
5vkqC-2pcuA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pww UNCHARACTERIZED
PROTEIN

(Bacillus
clausii) 		PF08868
(YugN) 		4 ILE A 113
ILE A  77
LEU A  53
PHE A  27
 None
 0.80A 5vkqB-2pwwA:
undetectable
5vkqC-2pwwA:
undetectable		 5vkqB-2pwwA:
5.08
5vkqC-2pwwA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2

(Homo sapiens) 		PF03031
(NIF) 		4 ILE A 249
ILE A 215
LEU A 214
PHE A 157
 None
 1.01A 5vkqB-2q5eA:
undetectable
5vkqC-2q5eA:
undetectable		 5vkqB-2q5eA:
7.57
5vkqC-2q5eA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 ILE A 236
ILE A  49
LEU A 279
PHE A  62
 None
 1.00A 5vkqB-2qcvA:
undetectable
5vkqC-2qcvA:
undetectable		 5vkqB-2qcvA:
12.35
5vkqC-2qcvA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 ILE A 218
ILE A  49
PHE A 206
PHE A  37
 None
 0.93A 5vkqB-2qj8A:
undetectable
5vkqC-2qj8A:
undetectable		 5vkqB-2qj8A:
11.09
5vkqC-2qj8A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 ILE A  88
ILE A  76
LEU A  38
PHE A  42
 None
 0.93A 5vkqB-2qv6A:
undetectable
5vkqC-2qv6A:
undetectable		 5vkqB-2qv6A:
9.83
5vkqC-2qv6A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 ILE A 641
ILE A 609
LEU A 605
HIS A 602
 None
 1.03A 5vkqB-2v26A:
undetectable
5vkqC-2v26A:
undetectable		 5vkqB-2v26A:
18.81
5vkqC-2v26A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 ILE A 107
ILE A 188
LEU A 191
PHE A 161
PHE A 248
 None
 1.49A 5vkqB-2vhlA:
undetectable
5vkqC-2vhlA:
undetectable		 5vkqB-2vhlA:
12.48
5vkqC-2vhlA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR

(Escherichia
coli) 		PF00158
(Sigma54_activat) 		4 ILE A 195
ILE A 186
LEU A 217
PHE A 209
 None
 0.99A 5vkqB-2viiA:
undetectable
5vkqC-2viiA:
undetectable		 5vkqB-2viiA:
9.52
5vkqC-2viiA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 152
ILE A 285
HIS A 226
PHE A 362
 None
 1.02A 5vkqB-2vr5A:
undetectable
5vkqC-2vr5A:
undetectable		 5vkqB-2vr5A:
17.67
5vkqC-2vr5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxx STARVATION INDUCED
DNA BINDING PROTEIN

(Synechococcus
elongatus) 		PF00210
(Ferritin) 		4 ILE A 129
LEU A  80
PHE A  40
HIS A  76
 None
 1.01A 5vkqB-2vxxA:
3.8
5vkqC-2vxxA:
4.0		 5vkqB-2vxxA:
7.33
5vkqC-2vxxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 ILE A 314
ILE A 130
LEU A 131
PHE A 123
 None
 0.94A 5vkqB-2ww9A:
undetectable
5vkqC-2ww9A:
undetectable		 5vkqB-2ww9A:
14.69
5vkqC-2ww9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		4 ILE A  65
ILE A  56
LEU A  49
PHE A  35
 None
 0.97A 5vkqB-2x7qA:
undetectable
5vkqC-2x7qA:
undetectable		 5vkqB-2x7qA:
10.78
5vkqC-2x7qA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpp IWS1
CHROMATIN STRUCTURE
MODULATOR

(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		PF08711
(Med26)
no annotation 		4 ILE B  56
ILE A 115
LEU A 111
HIS A 150
 None
 0.96A 5vkqB-2xppB:
undetectable
5vkqC-2xppB:
undetectable		 5vkqB-2xppB:
2.36
5vkqC-2xppB:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		4 ILE A  58
ILE A 170
LEU A  12
HIS A   9
 None
 1.04A 5vkqB-3a3hA:
undetectable
5vkqC-3a3hA:
undetectable		 5vkqB-3a3hA:
10.04
5vkqC-3a3hA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ILE A 601
ILE A 563
PHE A 577
HIS A 710
 None
 1.03A 5vkqB-3ahiA:
undetectable
5vkqC-3ahiA:
undetectable		 5vkqB-3ahiA:
19.55
5vkqC-3ahiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ILE A 302
ILE A 237
LEU A 267
PHE A 256
 NDP  A 501 (-4.3A)
None
None
None
 1.04A 5vkqB-3au9A:
undetectable
5vkqC-3au9A:
undetectable		 5vkqB-3au9A:
14.63
5vkqC-3au9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 ILE A 124
ILE A 244
LEU A  94
PHE A 203
 None
 0.82A 5vkqB-3b89A:
undetectable
5vkqC-3b89A:
undetectable		 5vkqB-3b89A:
10.12
5vkqC-3b89A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		4 ILE A  97
ILE A   2
LEU A 326
HIS A 329
 None
 0.95A 5vkqB-3c0bA:
undetectable
5vkqC-3c0bA:
undetectable		 5vkqB-3c0bA:
11.93
5vkqC-3c0bA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 ILE A 277
ILE A 372
LEU A 343
HIS A 342
 None
 0.88A 5vkqB-3c2gA:
3.2
5vkqC-3c2gA:
3.2		 5vkqB-3c2gA:
16.34
5vkqC-3c2gA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 LEU A 150
PHE A 154
HIS A 137
PHE A 417
 None
 0.92A 5vkqB-3ce2A:
2.7
5vkqC-3ce2A:
2.7		 5vkqB-3ce2A:
16.42
5vkqC-3ce2A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4c CASPASE-1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 328
ILE A 243
LEU A 258
PHE A 262
 None
 0.92A 5vkqB-3e4cA:
undetectable
5vkqC-3e4cA:
undetectable		 5vkqB-3e4cA:
10.61
5vkqC-3e4cA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eay SENTRIN-SPECIFIC
PROTEASE 7

(Homo sapiens) 		PF02902
(Peptidase_C48) 		4 ILE A 949
ILE A 785
PHE A 937
PHE A 780
 None
 0.89A 5vkqB-3eayA:
undetectable
5vkqC-3eayA:
undetectable		 5vkqB-3eayA:
11.19
5vkqC-3eayA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A   6
ILE A  26
LEU A  19
HIS A  15
 None
 0.84A 5vkqB-3ezyA:
undetectable
5vkqC-3ezyA:
undetectable		 5vkqB-3ezyA:
11.51
5vkqC-3ezyA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2i ALR0221 PROTEIN

(Nostoc sp. PCC
7120) 		PF00300
(His_Phos_1) 		4 ILE A  10
ILE A 138
LEU A 114
HIS A 110
 None
None
None
PO4  A 201 (-3.9A)
 0.90A 5vkqB-3f2iA:
undetectable
5vkqC-3f2iA:
undetectable		 5vkqB-3f2iA:
7.08
5vkqC-3f2iA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2v GENERAL STRESS
PROTEIN 14

(Treponema
denticola) 		PF02525
(Flavodoxin_2) 		4 ILE A  68
ILE A   6
LEU A   8
HIS A  10
 FMN  A 201 (-4.5A)
None
None
FMN  A 201 (-3.7A)
 0.79A 5vkqB-3f2vA:
undetectable
5vkqC-3f2vA:
undetectable		 5vkqB-3f2vA:
6.93
5vkqC-3f2vA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 248
ILE A 215
LEU A 166
PHE A 239
 None
 0.93A 5vkqB-3fhtA:
undetectable
5vkqC-3fhtA:
undetectable		 5vkqB-3fhtA:
13.37
5vkqC-3fhtA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.) 		PF05721
(PhyH) 		4 ILE A  74
ILE A  31
PHE A 256
PHE A  10
 None
 0.97A 5vkqB-3gjbA:
undetectable
5vkqC-3gjbA:
undetectable		 5vkqB-3gjbA:
10.54
5vkqC-3gjbA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 ILE A 358
ILE A 293
PHE A 389
PHE A 241
 None
 0.95A 5vkqB-3hf8A:
undetectable
5vkqC-3hf8A:
undetectable		 5vkqB-3hf8A:
9.36
5vkqC-3hf8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik5 PROTEIN NEF

(Simian
immunodeficiency
virus) 		PF00469
(F-protein) 		4 ILE A 153
ILE A 123
LEU A 142
PHE A 215
 ILE  A 153 ( 0.7A)
ILE  A 123 ( 0.7A)
LEU  A 142 ( 0.6A)
PHE  A 215 ( 1.3A)
 0.88A 5vkqB-3ik5A:
undetectable
5vkqC-3ik5A:
undetectable		 5vkqB-3ik5A:
6.00
5vkqC-3ik5A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imm PUTATIVE SECRETED
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 ILE A 155
ILE A  97
LEU A 188
PHE A 192
 None
 0.90A 5vkqB-3immA:
undetectable
5vkqC-3immA:
undetectable		 5vkqB-3immA:
8.40
5vkqC-3immA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		4 ILE A 766
LEU A 806
PHE A 704
PHE A 783
 None
 0.87A 5vkqB-3irzA:
undetectable
5vkqC-3irzA:
undetectable		 5vkqB-3irzA:
13.06
5vkqC-3irzA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuw ACTIVATING SIGNAL
COINTEGRATOR

(Enterococcus
faecalis) 		PF12961
(DUF3850) 		4 ILE A  63
ILE A  13
LEU A  11
HIS A   9
 None
CAC  A  83 (-4.3A)
None
None
 1.04A 5vkqB-3iuwA:
undetectable
5vkqC-3iuwA:
undetectable		 5vkqB-3iuwA:
4.32
5vkqC-3iuwA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ILE A 267
ILE A 289
PHE A 248
PHE A 332
 None
 0.98A 5vkqB-3j04A:
undetectable
5vkqC-3j04A:
3.0		 5vkqB-3j04A:
20.13
5vkqC-3j04A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 ILE A 133
ILE A 283
LEU A 281
PHE A 324
 None
 0.98A 5vkqB-3j4sA:
undetectable
5vkqC-3j4sA:
undetectable		 5vkqB-3j4sA:
13.84
5vkqC-3j4sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE X1039
ILE X 735
LEU X 757
PHE X 671
 None
 1.03A 5vkqB-3jb9X:
undetectable
5vkqC-3jb9X:
undetectable		 5vkqB-3jb9X:
21.99
5vkqC-3jb9X:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 ILE A  92
LEU A 347
PHE A 346
HIS A 350
 None
 0.77A 5vkqB-3jxeA:
undetectable
5vkqC-3jxeA:
undetectable		 5vkqB-3jxeA:
12.18
5vkqC-3jxeA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		4 ILE A 135
LEU A 158
PHE A 159
HIS A 155
 None
 1.04A 5vkqB-3krvA:
undetectable
5vkqC-3krvA:
undetectable		 5vkqB-3krvA:
8.35
5vkqC-3krvA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyq SYNAPTOBREVIN
HOMOLOG YKT6

(Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		4 ILE A 152
LEU A  94
PHE A  91
HIS A  67
 None
 0.99A 5vkqB-3kyqA:
undetectable
5vkqC-3kyqA:
undetectable		 5vkqB-3kyqA:
7.64
5vkqC-3kyqA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ILE A 129
ILE A  17
LEU A 153
PHE A   3
 None
 1.03A 5vkqB-3kzwA:
undetectable
5vkqC-3kzwA:
undetectable		 5vkqB-3kzwA:
15.19
5vkqC-3kzwA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00696
(AA_kinase) 		4 ILE A  96
ILE A   3
LEU A  38
PHE A 161
 None
 1.01A 5vkqB-3ll5A:
undetectable
5vkqC-3ll5A:
undetectable		 5vkqB-3ll5A:
9.18
5vkqC-3ll5A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9y TRIOSEPHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00121
(TIM) 		4 ILE A  95
ILE A  63
LEU A  46
PHE A  22
 None
 0.89A 5vkqB-3m9yA:
undetectable
5vkqC-3m9yA:
undetectable		 5vkqB-3m9yA:
9.66
5vkqC-3m9yA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml4 PROTEIN DOK-7

(Mus musculus) 		PF02174
(IRS) 		4 ILE A 104
ILE A 199
HIS A 132
PHE A 194
 None
 0.99A 5vkqB-3ml4A:
undetectable
5vkqC-3ml4A:
undetectable		 5vkqB-3ml4A:
8.10
5vkqC-3ml4A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 ILE A 216
ILE A 194
LEU A 130
PHE A 126
 None
 0.89A 5vkqB-3n4tA:
undetectable
5vkqC-3n4tA:
undetectable		 5vkqB-3n4tA:
10.33
5vkqC-3n4tA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 ILE A 216
ILE A 248
LEU A 127
PHE A 126
 None
 1.04A 5vkqB-3n4tA:
undetectable
5vkqC-3n4tA:
undetectable		 5vkqB-3n4tA:
10.33
5vkqC-3n4tA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 474
ILE A 198
LEU A 339
HIS A 338
 None
 0.99A 5vkqB-3na0A:
undetectable
5vkqC-3na0A:
undetectable		 5vkqB-3na0A:
14.09
5vkqC-3na0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ILE A 366
ILE A 348
LEU A 538
PHE A 318
 None
 0.96A 5vkqB-3o8oA:
undetectable
5vkqC-3o8oA:
undetectable		 5vkqB-3o8oA:
19.52
5vkqC-3o8oA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ILE B 358
ILE B 340
LEU B 531
PHE B 310
 None
 0.95A 5vkqB-3o8oB:
undetectable
5vkqC-3o8oB:
undetectable		 5vkqB-3o8oB:
19.21
5vkqC-3o8oB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 ILE A 206
ILE A 133
LEU A 140
PHE A 309
 None
None
EDO  A 403 ( 4.7A)
None
 0.93A 5vkqB-3op7A:
undetectable
5vkqC-3op7A:
undetectable		 5vkqB-3op7A:
12.79
5vkqC-3op7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 ILE A 209
ILE A 135
LEU A 136
PHE A 140
 None
 1.04A 5vkqB-3pihA:
undetectable
5vkqC-3pihA:
undetectable		 5vkqB-3pihA:
18.76
5vkqC-3pihA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 ILE B 252
ILE B 168
LEU B 172
PHE B 181
 None
 1.01A 5vkqB-3pz2B:
undetectable
5vkqC-3pz2B:
undetectable		 5vkqB-3pz2B:
11.28
5vkqC-3pz2B:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 116
ILE A 346
LEU A 388
PHE A 384
 None
 1.04A 5vkqB-3qtpA:
undetectable
5vkqC-3qtpA:
undetectable		 5vkqB-3qtpA:
13.96
5vkqC-3qtpA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2q UNCHARACTERIZED
GST-LIKE PROTEIN
YIBF

(Escherichia
coli) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A  17
LEU A  20
PHE A  26
PHE A 189
 None
None
None
EDO  A 309 (-3.5A)
 0.98A 5vkqB-3r2qA:
3.1
5vkqC-3r2qA:
3.1		 5vkqB-3r2qA:
7.48
5vkqC-3r2qA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 ILE B 119
LEU B  86
PHE B  80
PHE B 161
 None
 1.03A 5vkqB-3r7wB:
undetectable
5vkqC-3r7wB:
undetectable		 5vkqB-3r7wB:
12.83
5vkqC-3r7wB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 ILE A 214
ILE A 104
LEU A 105
PHE A  10
 None
 0.82A 5vkqB-3sd7A:
undetectable
5vkqC-3sd7A:
undetectable		 5vkqB-3sd7A:
8.33
5vkqC-3sd7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 ILE X1620
ILE X2103
LEU X2121
PHE X1615
 None
 1.04A 5vkqB-3su8X:
1.8
5vkqC-3su8X:
1.9		 5vkqB-3su8X:
16.91
5vkqC-3su8X:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6d PHOTOSYNTHETIC
REACTION CENTER
M-SUBUNIT

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 ILE M  66
LEU M  67
PHE M  71
PHE M  59
 BPB  M 402 ( 4.4A)
LDA  M 713 ( 4.2A)
NS5  M 600 ( 4.3A)
BPB  M 402 ( 3.7A)
 0.98A 5vkqB-3t6dM:
2.3
5vkqC-3t6dM:
2.3		 5vkqB-3t6dM:
10.82
5vkqC-3t6dM:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 ILE A 541
ILE A  68
LEU A  69
HIS A  81
 None
 1.02A 5vkqB-3ujzA:
undetectable
5vkqC-3ujzA:
undetectable		 5vkqB-3ujzA:
18.80
5vkqC-3ujzA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		4 ILE A 169
ILE A 125
LEU A 122
HIS A 148
 None
 0.94A 5vkqB-3uswA:
undetectable
5vkqC-3uswA:
undetectable		 5vkqB-3uswA:
10.58
5vkqC-3uswA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usy FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		4 ILE A 169
ILE A 125
LEU A 122
HIS A 148
 None
 1.04A 5vkqB-3usyA:
undetectable
5vkqC-3usyA:
undetectable		 5vkqB-3usyA:
9.48
5vkqC-3usyA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A 124
ILE A 140
LEU A 155
PHE A 154
 None
 1.01A 5vkqB-3v6aA:
0.4
5vkqC-3v6aA:
0.4		 5vkqB-3v6aA:
15.47
5vkqC-3v6aA:
15.47