SIMILAR PATTERNS OF AMINO ACIDS FOR 5VIM_B_SAMB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap8 TRANSLATION
INITIATION FACTOR
EIF4E

(Saccharomyces
cerevisiae) 		PF01652
(IF4E) 		4 SER A 210
THR A 167
ASP A  99
ASP A 171
 None
 1.16A 5vimB-1ap8A:
undetectable		 5vimB-1ap8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		4 SER A 375
THR A  92
ASP A 135
ASP A  85
 None
 1.49A 5vimB-1cemA:
undetectable		 5vimB-1cemA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)
C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon;
Microchaete
diplosiphon) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 SER B  10
THR A   6
ASP A  13
ASP B 103
 None
 1.44A 5vimB-1cpcB:
undetectable		 5vimB-1cpcB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		4 SER A  17
THR A 104
ASP A 107
ASP A 205
 NAP  A 800 (-2.2A)
NAP  A 800 ( 4.7A)
None
NAP  A 800 (-2.2A)
 1.45A 5vimB-1oaaA:
4.2		 5vimB-1oaaA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A 887 ( 2.8A)
SAH  A 887 (-4.5A)
SAH  A 887 ( 3.3A)
SAH  A 887 (-3.9A)
 0.30A 5vimB-1r6aA:
40.0		 5vimB-1r6aA:
61.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		4 SER A 228
THR A 181
ASP A 266
ASP A 117
 None
None
None
ZN  A 501 ( 2.4A)
 1.40A 5vimB-2anpA:
undetectable		 5vimB-2anpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 SER A 362
THR A 468
ASP A 465
ASP A 367
 None
 1.23A 5vimB-2iukA:
undetectable		 5vimB-2iukA:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		4 SER A  57
THR A 105
ASP A 132
ASP A 147
 SAM  A 300 (-2.6A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
 0.39A 5vimB-2oxtA:
38.7		 5vimB-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
 0.48A 5vimB-2oy0A:
40.1		 5vimB-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A 500 (-2.5A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.6A)
 0.28A 5vimB-2px5A:
42.1		 5vimB-2px5A:
69.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 SER A 628
THR A 632
ASP A 635
ASP A 639
 None
 1.39A 5vimB-2zaiA:
undetectable		 5vimB-2zaiA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A 901 (-2.6A)
SAH  A 901 (-4.5A)
SAH  A 901 (-3.7A)
SAH  A 901 (-3.8A)
 0.22A 5vimB-3evcA:
41.7		 5vimB-3evcA:
53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-4.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.32A 5vimB-3gczA:
40.8		 5vimB-3gczA:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.32A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 SER A 284
THR A 406
ASP A 433
ASP A 316
 None
 1.26A 5vimB-3omlA:
2.1		 5vimB-3omlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE
NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		4 SER A  65
THR A 123
ASP A 131
ASP B 137
 None
SF4  A 501 (-4.0A)
None
None
 1.24A 5vimB-3pdiA:
undetectable		 5vimB-3pdiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.44A 5vimB-4autA:
undetectable		 5vimB-4autA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechocystis
sp. PCC 6803;
Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 SER B  10
THR A   6
ASP A  13
ASP B 103
 None
 1.49A 5vimB-4f0tB:
undetectable		 5vimB-4f0tB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 SER A 254
THR A 215
ASP A 218
ASP A 194
 None
 1.43A 5vimB-4fhaA:
undetectable		 5vimB-4fhaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.33A 5vimB-4g3tA:
undetectable		 5vimB-4g3tA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A1001 (-2.8A)
SAH  A1001 (-4.7A)
SAH  A1001 (-3.7A)
SAH  A1001 (-3.6A)
 0.25A 5vimB-4k6mA:
41.4		 5vimB-4k6mA:
69.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		4 SER A 381
THR A 393
ASP A 463
ASP A 424
 None
 1.30A 5vimB-4kgbA:
undetectable		 5vimB-4kgbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		4 SER A1049
THR A1041
ASP A 988
ASP A1036
 None
 1.44A 5vimB-4m8nA:
undetectable		 5vimB-4m8nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis) 		PF00994
(MoCF_biosynth) 		4 SER A 107
THR A  76
ASP A  49
ASP A 135
 None
 1.47A 5vimB-4nwoA:
undetectable		 5vimB-4nwoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 SER A 133
THR A 207
ASP A 196
ASP A 344
 ATP  A1201 (-2.9A)
None
None
ATP  A1201 (-2.7A)
 1.50A 5vimB-4wtvA:
undetectable		 5vimB-4wtvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 SER A  87
THR A 223
ASP A 225
ASP A  80
 None
 1.02A 5vimB-4zhtA:
undetectable		 5vimB-4zhtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 SER A  65
THR A 138
ASP A 115
ASP A  68
 BEF  A 402 ( 2.4A)
TRE  A 403 ( 3.9A)
None
None
 1.46A 5vimB-5dxiA:
undetectable		 5vimB-5dxiA:
23.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAM  A 301 (-2.7A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.8A)
 0.14A 5vimB-5e9qA:
40.6		 5vimB-5e9qA:
65.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		4 SER A  64
THR A 330
ASP A 415
ASP A  78
 None
 1.22A 5vimB-5ebbA:
undetectable		 5vimB-5ebbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 SER A  61
THR A 327
ASP A 412
ASP A  75
 None
 1.20A 5vimB-5fcaA:
undetectable		 5vimB-5fcaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		4 SER A 135
THR A  70
ASP A  99
ASP A  65
 SAH  A 301 (-3.1A)
None
None
None
 1.29A 5vimB-5h02A:
8.0		 5vimB-5h02A:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAM  A 311 ( 2.7A)
SAM  A 311 (-4.5A)
MLT  A 313 ( 2.6A)
SAM  A 311 (-3.8A)
 0.20A 5vimB-5ikmA:
41.1		 5vimB-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A1003 (-2.7A)
SAH  A1003 (-4.6A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.8A)
 0.30A 5vimB-5jjrA:
40.9		 5vimB-5jjrA:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A1001 (-2.6A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.9A)
SAH  A1001 (-3.7A)
 0.26A 5vimB-5njuA:
42.3		 5vimB-5njuA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SAH  A1001 (-2.5A)
SAH  A1001 ( 4.9A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.8A)
 0.21A 5vimB-5tmhA:
42.4		 5vimB-5tmhA:
98.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 SER A1034
THR A 899
ASP A 896
ASP A 902
 None
 1.48A 5vimB-5x59A:
undetectable		 5vimB-5x59A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 SER A 745
THR A 790
ASP A 796
ASP A 705
 None
 1.41A 5vimB-5y7oA:
undetectable		 5vimB-5y7oA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 4 SER A 609
THR A 532
ASP A 530
ASP A 613
 None
None
MG  A 721 (-3.5A)
MG  A 727 (-2.9A)
 1.48A 5vimB-5yjhA:
undetectable		 5vimB-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 SER A 377
THR A 228
ASP A 282
ASP A 320
 None
None
NAG  A 701 ( 4.6A)
None
 1.46A 5vimB-6bdzA:
undetectable		 5vimB-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 SER A2352
THR A2146
ASP A2160
ASP A2348
 None
 1.49A 5vimB-6emkA:
undetectable		 5vimB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 SER A 447
THR A 429
ASP A 338
ASP A 426
 None
 1.49A 5vimB-6evgA:
undetectable		 5vimB-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 SER A1575
THR A1554
ASP A1796
ASP A1818
 None
 1.16A 5vimB-6fayA:
undetectable		 5vimB-6fayA:
undetectable