SIMILAR PATTERNS OF AMINO ACIDS FOR 5VIM_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		6 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.11A 5vimB-1e08A:
undetectable		 5vimB-1e08A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		6 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
 1.30A 5vimB-1eltA:
undetectable		 5vimB-1eltA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  36
GLY A 101
GLY A 103
GLY A  31
PHE A  77
 None
None
FAD  A 600 (-4.5A)
FAD  A 600 (-3.2A)
FAD  A 600 ( 4.8A)
 0.95A 5vimB-1gpeA:
undetectable		 5vimB-1gpeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 101
GLY A 103
GLY A  32
PHE A  77
ILE A 110
 None
FAD  A 600 (-4.5A)
FAD  A 600 ( 4.6A)
FAD  A 600 ( 4.8A)
None
 0.90A 5vimB-1gpeA:
undetectable		 5vimB-1gpeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 GLY E 142
GLY E 196
GLY E  43
GLY E 140
PHE E  94
 None
 0.93A 5vimB-1h9hE:
undetectable		 5vimB-1h9hE:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 GLY T 142
GLY T 196
GLY T  43
GLY T 140
PHE T  94
 None
 0.92A 5vimB-1j17T:
undetectable		 5vimB-1j17T:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		6 GLY A 111
GLY A 224
GLY A 222
HIS A 352
GLU A 379
PHE A 386
 UD1  A 901 (-3.5A)
None
UD1  A 901 (-3.1A)
None
None
None
 1.31A 5vimB-1jv1A:
undetectable		 5vimB-1jv1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA

(Thermotoga
maritima) 		PF13365
(Trypsin_2) 		5 GLY A 219
GLY A  83
GLY A 207
VAL A 107
ILE A  92
 None
 0.96A 5vimB-1l1jA:
undetectable		 5vimB-1l1jA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.96A 5vimB-1lcyA:
undetectable		 5vimB-1lcyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		5 GLY A 224
GLY A 222
GLY A 170
VAL A 256
ILE A 159
 None
 0.96A 5vimB-1ltmA:
undetectable		 5vimB-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 GLY A 176
GLY A 159
GLY A 154
VAL A  96
PHE A 101
 None
 0.95A 5vimB-1qleA:
undetectable		 5vimB-1qleA:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 181
 SAH  A 887 (-3.0A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SO4  A 901 ( 3.9A)
SAH  A 887 (-3.5A)
SAH  A 887 (-4.1A)
SAH  A 887 ( 4.2A)
None
 0.50A 5vimB-1r6aA:
40.0		 5vimB-1r6aA:
61.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
VAL A 132
ILE A 147
LYS A 181
 SAH  A 887 (-3.0A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SO4  A 902 (-2.7A)
SO4  A 901 ( 3.9A)
SAH  A 887 (-3.5A)
SAH  A 887 ( 4.2A)
None
 0.56A 5vimB-1r6aA:
40.0		 5vimB-1r6aA:
61.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		5 GLY A  22
GLY A 102
GLY A 107
GLY A  44
ILE A 101
 None
 0.96A 5vimB-1v6mA:
undetectable		 5vimB-1v6mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.78A 5vimB-1vcwA:
undetectable		 5vimB-1vcwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.92A 5vimB-1y8tA:
undetectable		 5vimB-1y8tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		6 GLY A   7
GLY A  12
HIS A  23
VAL A 144
PHE A 143
ILE A  64
 None
 1.39A 5vimB-1zejA:
undetectable		 5vimB-1zejA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.94A 5vimB-2asuB:
undetectable		 5vimB-2asuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		6 GLY A 415
GLY A  81
GLY A 439
VAL A 312
ILE A  80
LYS A  41
 ADP  A1001 (-3.6A)
None
ADP  A1001 (-3.4A)
None
None
None
 1.29A 5vimB-2d0oA:
undetectable		 5vimB-2d0oA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.94A 5vimB-2ei8A:
undetectable		 5vimB-2ei8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 GLY A 333
GLY A 404
GLY A 329
GLY A 335
ILE A 405
 None
 0.90A 5vimB-2et6A:
4.8		 5vimB-2et6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 456
GLY A  29
GLY A  31
GLY A  36
PHE A 175
 None
FAD  A1000 (-3.3A)
FAD  A1000 (-3.2A)
None
FAD  A1000 (-3.5A)
 0.89A 5vimB-2fjaA:
undetectable		 5vimB-2fjaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 351
GLY A 379
GLY A 346
TRP A 376
ILE A 480
 None
 0.90A 5vimB-2okjA:
undetectable		 5vimB-2okjA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		7 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
HIS A 111
LYS A 184
 SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
SAM  A 300 ( 4.3A)
 0.33A 5vimB-2oxtA:
38.7		 5vimB-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		7 GLY A  59
GLY A  84
GLY A  87
TRP A  88
HIS A 111
GLU A 112
LYS A 184
 SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
None
SAM  A 300 ( 4.3A)
 0.75A 5vimB-2oxtA:
38.7		 5vimB-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
SAH  A 301 ( 4.9A)
 0.49A 5vimB-2oy0A:
40.1		 5vimB-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
 0.73A 5vimB-2oy0A:
40.1		 5vimB-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  81
GLY A  85
HIS A 110
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
SAH  A 301 ( 4.9A)
 0.83A 5vimB-2oy0A:
40.1		 5vimB-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A 500 (-3.3A)
SAH  A 500 (-3.4A)
SAH  A 500 ( 3.7A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
None
SAH  A 500 (-3.9A)
SAH  A 500 ( 3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.2A)
SAH  A 500 ( 4.3A)
None
 0.56A 5vimB-2px5A:
42.1		 5vimB-2px5A:
69.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		7 GLY A  81
GLY A  85
HIS A 110
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.9A)
SAH  A 500 ( 3.2A)
SAH  A 500 (-4.2A)
SAH  A 500 ( 4.3A)
None
 0.99A 5vimB-2px5A:
42.1		 5vimB-2px5A:
69.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.77A 5vimB-2r3uA:
undetectable		 5vimB-2r3uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.83A 5vimB-2r9hA:
undetectable		 5vimB-2r9hA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		8 GLY A  59
GLY A  82
GLY A  84
TRP A  88
HIS A 111
VAL A 133
ILE A 148
LYS A 184
 SAM  A1248 ( 3.7A)
SAM  A1248 (-3.3A)
SAM  A1248 (-3.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-3.8A)
SAM  A1248 (-3.4A)
SAM  A1248 ( 4.0A)
None
 0.43A 5vimB-2wa2A:
32.4		 5vimB-2wa2A:
50.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		6 GLY A 228
GLY A 226
GLY A 200
GLU A 391
PHE A 398
ILE A 394
 None
 1.48A 5vimB-2yqhA:
undetectable		 5vimB-2yqhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 146
GLY A 210
GLY A  45
GLY A 144
PHE A  98
 None
 0.93A 5vimB-2zecA:
undetectable		 5vimB-2zecA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		6 GLY A  78
GLY A 147
GLY A 152
VAL A 131
PHE A 138
ILE A 105
 DEP  A 304 ( 3.8A)
None
None
None
None
None
 1.25A 5vimB-3ailA:
undetectable		 5vimB-3ailA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.96A 5vimB-3beuA:
undetectable		 5vimB-3beuA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAM  A4633 ( 3.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 ( 4.2A)
None
 0.44A 5vimB-3eluA:
39.4		 5vimB-3eluA:
56.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		9 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
ILE A 147
LYS A 182
 SAH  A 901 (-3.2A)
SAH  A 901 (-3.4A)
SAH  A 901 (-3.3A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-3.8A)
SAH  A 901 (-3.1A)
SAH  A 901 ( 4.2A)
None
 0.32A 5vimB-3evcA:
41.7		 5vimB-3evcA:
53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
HIS A 110
GLU A 111
ILE A 147
LYS A 182
 SAH  A 901 (-3.4A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-3.8A)
SAH  A 901 (-3.1A)
SAH  A 901 ( 4.2A)
None
 0.96A 5vimB-3evcA:
41.7		 5vimB-3evcA:
53.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.96A 5vimB-3f8rA:
undetectable		 5vimB-3f8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  47
GLY A  13
GLY A  16
GLY A  44
ILE A  11
 None
 0.96A 5vimB-3fi9A:
5.2		 5vimB-3fi9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		5 GLY A 149
GLY A  52
GLY A 206
GLY A 202
VAL A  60
 None
 0.85A 5vimB-3g01A:
undetectable		 5vimB-3g01A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 GLY A  52
GLY A 278
GLY A  55
VAL A 298
ILE A 294
 None
 0.89A 5vimB-3g0iA:
undetectable		 5vimB-3g0iA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 183
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 ( 4.2A)
SAM  A4633 ( 4.8A)
 0.43A 5vimB-3gczA:
40.8		 5vimB-3gczA:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 GLY A  99
GLY A 101
VAL A 357
PHE A 334
ILE A 554
 None
 0.96A 5vimB-3gf7A:
undetectable		 5vimB-3gf7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 GLY A 277
GLY A 226
VAL A 532
PHE A 533
ILE A 272
 ORO  A1003 (-3.4A)
FMN  A1002 (-3.0A)
J5Z  A1001 (-4.2A)
None
FMN  A1002 ( 4.1A)
 0.88A 5vimB-3i6rA:
undetectable		 5vimB-3i6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.97A 5vimB-3iccA:
5.4		 5vimB-3iccA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.72A 5vimB-3lgiA:
undetectable		 5vimB-3lgiA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.48A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 0.75A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  81
GLY A  85
HIS A 110
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.93A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgw LYSOZYME G

(Salmo salar) 		PF01464
(SLT) 		5 GLY A  60
GLY A 116
GLY A  56
VAL A  96
ILE A 119
 None
 0.92A 5vimB-3mgwA:
undetectable		 5vimB-3mgwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 GLY A 295
GLY A 291
GLY A  84
PHE A 300
ILE A 296
 None
 0.95A 5vimB-3nd0A:
undetectable		 5vimB-3nd0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		5 GLY A 615
GLY A 612
VAL A 710
PHE A 562
ILE A 638
 None
 0.91A 5vimB-3pgbA:
undetectable		 5vimB-3pgbA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 206
GLY A  69
GLY A 194
VAL A  94
ILE A  79
 None
 0.82A 5vimB-3pv2A:
undetectable		 5vimB-3pv2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 206
GLY A  69
GLY A 194
VAL A  94
ILE A  79
 None
 0.82A 5vimB-3pv4A:
undetectable		 5vimB-3pv4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A  90
GLY A  65
GLY A  68
HIS A  61
VAL A  10
 None
 0.93A 5vimB-3r5xA:
undetectable		 5vimB-3r5xA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 GLY A 167
GLY A  26
GLY A 155
VAL A  51
ILE A  34
 None
 0.95A 5vimB-3ufaA:
undetectable		 5vimB-3ufaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		5 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.94A 5vimB-3ugkA:
undetectable		 5vimB-3ugkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  58
GLY A  64
GLY A 120
VAL A  41
PHE A 334
 None
 0.97A 5vimB-4c4oA:
3.1		 5vimB-4c4oA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 172
GLY A 237
GLY A 217
GLY A 170
VAL A 271
 NAP  A1301 (-3.3A)
NAP  A1301 (-3.3A)
NAP  A1301 (-2.8A)
NAP  A1301 (-3.3A)
None
 0.80A 5vimB-4cjxA:
4.3		 5vimB-4cjxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 GLY A 211
GLY A  43
GLY A  45
PHE A 100
ILE A  95
 None
 0.93A 5vimB-4doiA:
undetectable		 5vimB-4doiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		5 GLY A  85
GLY A  14
GLY A  11
PHE A 162
ILE A 102
 None
ACP  A 301 (-3.2A)
ACP  A 301 (-3.5A)
None
None
 0.88A 5vimB-4e09A:
undetectable		 5vimB-4e09A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  63
GLY A  65
GLY A  68
LYS A  86
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.80A 5vimB-4gc5A:
8.1		 5vimB-4gc5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		5 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.89A 5vimB-4jcnA:
undetectable		 5vimB-4jcnA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.1A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 3.7A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 ( 3.6A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.1A)
SAH  A1001 ( 4.3A)
None
 0.47A 5vimB-4k6mA:
41.4		 5vimB-4k6mA:
69.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
HIS A 110
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.3A)
SAH  A1001 (-4.3A)
SAH  A1001 ( 3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 ( 4.3A)
None
 0.93A 5vimB-4k6mA:
41.4		 5vimB-4k6mA:
69.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B

(Danio rerio;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00071
(Ras) 		5 GLY E  15
GLY E  60
GLY E  13
VAL A1004
ILE E  36
 GDP  E 201 (-3.6A)
AF3  E 202 (-3.3A)
GDP  E 201 ( 3.1A)
None
None
 0.95A 5vimB-4m8nE:
undetectable		 5vimB-4m8nE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.94A 5vimB-4r0iA:
undetectable		 5vimB-4r0iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 5 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 5vimB-4ra6B:
undetectable		 5vimB-4ra6B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri0 SERINE PROTEASE
HTRA3

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.96A 5vimB-4ri0A:
undetectable		 5vimB-4ri0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 5vimB-4ynnA:
undetectable		 5vimB-4ynnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo1 DEGQ

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.80A 5vimB-4yo1A:
undetectable		 5vimB-4yo1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.93A 5vimB-4yryB:
3.3		 5vimB-4yryB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.87A 5vimB-5brrE:
undetectable		 5vimB-5brrE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 308
GLY A 318
GLY A 312
GLY A 310
ILE A 216
 SO4  A 709 ( 3.9A)
None
None
None
None
 0.90A 5vimB-5e7qA:
undetectable		 5vimB-5e7qA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.2A)
SAM  A 301 ( 4.8A)
 0.26A 5vimB-5e9qA:
40.6		 5vimB-5e9qA:
65.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  81
GLY A  83
GLY A  86
LYS A 105
HIS A 110
GLU A 111
VAL A 132
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
None
SAM  A 301 ( 3.7A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
 0.98A 5vimB-5e9qA:
40.6		 5vimB-5e9qA:
65.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 180
 SAM  A 301 (-3.3A)
SAM  A 301 ( 4.4A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.2A)
SAM  A 301 ( 4.8A)
 1.03A 5vimB-5e9qA:
40.6		 5vimB-5e9qA:
65.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		6 GLY A 115
GLY A 248
GLY A 364
GLU A 252
VAL A 395
ILE A 354
 GLY  A 115 ( 0.0A)
GLY  A 248 ( 0.0A)
GLY  A 364 ( 0.0A)
GLU  A 252 ( 0.6A)
VAL  A 395 ( 0.5A)
ILE  A 354 ( 0.7A)
 1.31A 5vimB-5ep8A:
undetectable		 5vimB-5ep8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 GLY A  67
GLY A 258
GLY A  62
PHE A 472
ILE A 421
 None
FAD  A 500 (-3.5A)
FAD  A 500 (-3.1A)
None
None
 0.88A 5vimB-5fjnA:
undetectable		 5vimB-5fjnA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 250
GLY A 114
GLY A 238
VAL A 138
ILE A 123
 None
 0.85A 5vimB-5gndA:
undetectable		 5vimB-5gndA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 5 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.85A 5vimB-5gp4C:
undetectable		 5vimB-5gp4C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
 None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.1A)
None
None
 0.87A 5vimB-5hxwA:
2.0		 5vimB-5hxwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
 None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
 0.91A 5vimB-5i39A:
2.6		 5vimB-5i39A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
GLU A 111
LYS A 180
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
None
None
 0.71A 5vimB-5ikmA:
41.1		 5vimB-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
MLT  A 313 ( 3.0A)
SAM  A 311 (-4.1A)
SAM  A 311 (-3.7A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
None
 0.40A 5vimB-5ikmA:
41.1		 5vimB-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
HIS A 110
PHE A 133
ILE A 147
LYS A 180
 SAM  A 311 (-3.2A)
SAM  A 311 ( 4.5A)
SAM  A 311 (-4.1A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
None
 0.97A 5vimB-5ikmA:
41.1		 5vimB-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  86
TRP A  87
LYS A 105
HIS A 110
PHE A 133
ILE A 147
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
MLT  A 313 ( 3.0A)
SAM  A 311 (-4.1A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
 1.44A 5vimB-5ikmA:
41.1		 5vimB-5ikmA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		5 GLY A 278
GLY A 179
GLY A 275
VAL A 171
ILE A 387
 None
 0.96A 5vimB-5j72A:
undetectable		 5vimB-5j72A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd8 PERIPLASMIC SERINE
PEPTIDASE DEGS

(Yersinia pestis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 213
GLY A  82
GLY A 201
VAL A 106
ILE A  91
 None
 0.70A 5vimB-5jd8A:
undetectable		 5vimB-5jd8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA
NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind) 		5 GLY L 250
GLY S 229
VAL L 260
PHE L 356
ILE L 401
 None
FES  S 501 (-3.9A)
None
None
None
 0.93A 5vimB-5jfcL:
3.8		 5vimB-5jfcL:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAH  A1003 (-3.2A)
SAH  A1003 (-3.4A)
SAH  A1003 (-3.5A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
SAH  A1003 (-4.8A)
SAH  A1003 (-3.7A)
SAH  A1003 (-3.3A)
SAH  A1003 (-3.7A)
SAH  A1003 (-4.2A)
SAH  A1003 ( 4.3A)
None
 0.50A 5vimB-5jjrA:
40.9		 5vimB-5jjrA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
HIS A 110
GLU A 111
ILE A 147
LYS A 180
 SAH  A1003 (-3.4A)
SAH  A1003 ( 4.6A)
SAH  A1003 (-3.7A)
SAH  A1003 (-3.3A)
SAH  A1003 ( 4.3A)
None
 1.05A 5vimB-5jjrA:
40.9		 5vimB-5jjrA:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.2A)
SAH  A1001 (-4.2A)
None
 0.35A 5vimB-5njuA:
42.3		 5vimB-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 5 GLY A  81
GLY A  85
HIS A 110
ILE A 147
LYS A 182
 SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.0A)
SAH  A1001 (-4.2A)
None
 0.95A 5vimB-5njuA:
42.3		 5vimB-5njuA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.2A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 3.8A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.0A)
SAH  A1001 (-4.2A)
SAH  A1001 ( 4.8A)
None
 0.27A 5vimB-5tmhA:
42.4		 5vimB-5tmhA:
98.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4q DTDP-GLUCOSE
4,6-DEHYDRATASE

(Klebsiella
pneumoniae) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A 183
GLY A  13
GLY A 186
VAL A   5
ILE A  16
 CL  A 402 (-4.3A)
None
CL  A 402 ( 4.4A)
None
None
 0.77A 5vimB-5u4qA:
5.8		 5vimB-5u4qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2d -

(-) 		no annotation 5 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.88A 5vimB-5y2dA:
undetectable		 5vimB-5y2dA:
undetectable