SIMILAR PATTERNS OF AMINO ACIDS FOR 5VIM_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLY A 573
GLY A 643
GLY A 567
GLY A 575
GLU A 403
 None
 0.93A 5vimA-1c30A:
undetectable		 5vimA-1c30A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		6 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.15A 5vimA-1e08A:
undetectable		 5vimA-1e08A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		6 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
 1.32A 5vimA-1eltA:
undetectable		 5vimA-1eltA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 GLY T 142
GLY T 196
GLY T  43
GLY T 140
PHE T  94
 None
 0.90A 5vimA-1j17T:
undetectable		 5vimA-1j17T:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 186
GLY A  51
GLY A 174
VAL A  75
ILE A  60
 None
 0.97A 5vimA-1lcyA:
undetectable		 5vimA-1lcyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		5 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.95A 5vimA-1ltmA:
undetectable		 5vimA-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		5 GLY A 224
GLY A 222
GLY A 170
VAL A 256
ILE A 159
 None
 0.97A 5vimA-1ltmA:
undetectable		 5vimA-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 GLY A 447
GLY A  25
GLY A 452
GLU A 453
VAL A  41
 None
 0.97A 5vimA-1o5wA:
undetectable		 5vimA-1o5wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 GLY A 176
GLY A 159
GLY A 154
VAL A  96
PHE A 101
 None
 0.95A 5vimA-1qleA:
undetectable		 5vimA-1qleA:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 181
 SAH  A 887 (-3.0A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SO4  A 902 (-2.7A)
SO4  A 901 ( 3.9A)
SAH  A 887 (-3.5A)
SAH  A 887 (-4.1A)
SAH  A 887 ( 4.2A)
None
 0.37A 5vimA-1r6aA:
40.1		 5vimA-1r6aA:
61.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  86
TRP A  87
LYS A 105
HIS A 110
PHE A 133
ILE A 147
 SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SO4  A 902 (-2.7A)
SO4  A 901 ( 3.9A)
SAH  A 887 (-4.1A)
SAH  A 887 ( 4.2A)
 1.43A 5vimA-1r6aA:
40.1		 5vimA-1r6aA:
61.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.96A 5vimA-1spjA:
undetectable		 5vimA-1spjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.80A 5vimA-1vcwA:
undetectable		 5vimA-1vcwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY B 677
GLY B 509
GLY B 662
VAL B 536
ILE B 517
 None
 0.96A 5vimA-2asuB:
undetectable		 5vimA-2asuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		6 GLY A 415
GLY A  81
GLY A 439
VAL A 312
ILE A  80
LYS A  41
 ADP  A1001 (-3.6A)
None
ADP  A1001 (-3.4A)
None
None
None
 1.27A 5vimA-2d0oA:
undetectable		 5vimA-2d0oA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		5 GLY A  46
GLY A  23
GLY A  51
HIS A  60
PHE A  88
 None
None
None
MG  A 301 (-3.3A)
None
 0.97A 5vimA-2e67A:
undetectable		 5vimA-2e67A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.92A 5vimA-2ei8A:
undetectable		 5vimA-2ei8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 GLY A 333
GLY A 404
GLY A 329
GLY A 335
ILE A 405
 None
 0.88A 5vimA-2et6A:
3.3		 5vimA-2et6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 456
GLY A  29
GLY A  31
GLY A  36
PHE A 175
 None
FAD  A1000 (-3.3A)
FAD  A1000 (-3.2A)
None
FAD  A1000 (-3.5A)
 0.88A 5vimA-2fjaA:
undetectable		 5vimA-2fjaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 351
GLY A 379
GLY A 346
TRP A 376
ILE A 480
 None
 0.92A 5vimA-2okjA:
undetectable		 5vimA-2okjA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		8 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
HIS A 111
GLU A 112
LYS A 184
 SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
None
SAM  A 300 ( 4.3A)
 0.82A 5vimA-2oxtA:
38.8		 5vimA-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
SAH  A 301 ( 4.9A)
 0.61A 5vimA-2oy0A:
40.4		 5vimA-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		8 GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
VAL A 132
PHE A 133
ILE A 147
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
 0.97A 5vimA-2oy0A:
40.4		 5vimA-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
SAH  A 301 ( 4.9A)
 0.90A 5vimA-2oy0A:
40.4		 5vimA-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
 1.39A 5vimA-2oy0A:
40.4		 5vimA-2oy0A:
68.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A 500 (-3.3A)
SAH  A 500 (-3.4A)
SAH  A 500 ( 3.7A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
None
SAH  A 500 (-3.9A)
SAH  A 500 ( 3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.2A)
SAH  A 500 ( 4.3A)
None
 0.45A 5vimA-2px5A:
42.1		 5vimA-2px5A:
69.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 ( 3.2A)
SAH  A 500 (-4.2A)
SAH  A 500 ( 4.3A)
None
 1.00A 5vimA-2px5A:
42.1		 5vimA-2px5A:
69.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.78A 5vimA-2r3uA:
undetectable		 5vimA-2r3uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.84A 5vimA-2r9hA:
undetectable		 5vimA-2r9hA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		8 GLY A  59
GLY A  82
GLY A  84
TRP A  88
HIS A 111
VAL A 133
ILE A 148
LYS A 184
 SAM  A1248 ( 3.7A)
SAM  A1248 (-3.3A)
SAM  A1248 (-3.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-3.8A)
SAM  A1248 (-3.4A)
SAM  A1248 ( 4.0A)
None
 0.56A 5vimA-2wa2A:
32.4		 5vimA-2wa2A:
50.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY S 142
GLY S 196
GLY S  43
GLY S 140
PHE S  94
 None
 0.95A 5vimA-2wpmS:
undetectable		 5vimA-2wpmS:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		6 GLY A 200
HIS A 363
GLU A 391
VAL A 397
PHE A 398
ILE A 394
 None
 1.40A 5vimA-2yqhA:
undetectable		 5vimA-2yqhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 146
GLY A 210
GLY A  45
GLY A 144
PHE A  98
 None
 0.92A 5vimA-2zecA:
undetectable		 5vimA-2zecA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		6 GLY A  78
GLY A 147
GLY A 152
VAL A 131
PHE A 138
ILE A 105
 DEP  A 304 ( 3.8A)
None
None
None
None
None
 1.24A 5vimA-3ailA:
undetectable		 5vimA-3ailA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		6 GLY A  31
GLY A 100
GLY A 128
HIS A  60
VAL A  57
PHE A  77
 None
 1.47A 5vimA-3bgkA:
3.8		 5vimA-3bgkA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAM  A4633 ( 3.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 ( 4.2A)
None
 0.56A 5vimA-3eluA:
39.3		 5vimA-3eluA:
56.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		9 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
ILE A 147
LYS A 182
 SAH  A 901 (-3.2A)
SAH  A 901 (-3.4A)
SAH  A 901 (-3.3A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-3.8A)
SAH  A 901 (-3.1A)
SAH  A 901 ( 4.2A)
None
 0.40A 5vimA-3evcA:
41.5		 5vimA-3evcA:
53.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 GLY A 305
GLY A  22
GLY A  24
GLY A  29
ILE A 121
 None
NAP  A4005 (-3.1A)
NAP  A4005 (-3.3A)
None
NAP  A4005 (-3.8A)
 0.94A 5vimA-3f8rA:
undetectable		 5vimA-3f8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		5 GLY A 149
GLY A  52
GLY A 206
GLY A 202
VAL A  60
 None
 0.84A 5vimA-3g01A:
undetectable		 5vimA-3g01A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 GLY A  52
GLY A 278
GLY A  55
VAL A 298
ILE A 294
 None
 0.92A 5vimA-3g0iA:
undetectable		 5vimA-3g0iA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 183
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
SAM  A4633 ( 4.2A)
SAM  A4633 ( 4.8A)
 0.51A 5vimA-3gczA:
40.8		 5vimA-3gczA:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 GLY A  99
GLY A 101
VAL A 357
PHE A 334
ILE A 554
 None
 0.96A 5vimA-3gf7A:
undetectable		 5vimA-3gf7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 GLY A 126
GLY A  28
GLY A 187
GLY A 184
VAL A  36
 None
 0.96A 5vimA-3h7tA:
undetectable		 5vimA-3h7tA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 GLY A 277
GLY A 226
VAL A 532
PHE A 533
ILE A 272
 ORO  A1003 (-3.4A)
FMN  A1002 (-3.0A)
J5Z  A1001 (-4.2A)
None
FMN  A1002 ( 4.1A)
 0.85A 5vimA-3i6rA:
undetectable		 5vimA-3i6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.93A 5vimA-3iccA:
5.2		 5vimA-3iccA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 214
GLY A  82
GLY A 202
VAL A 106
ILE A  91
 None
 0.74A 5vimA-3lgiA:
undetectable		 5vimA-3lgiA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.57A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  81
GLY A  83
GLY A  86
LYS A 105
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 0.93A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.97A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 1.48A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 GLY A 269
GLY A 278
GLY A 157
VAL A 282
PHE A 287
 None
 0.95A 5vimA-3nbuA:
undetectable		 5vimA-3nbuA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		5 GLY A 615
GLY A 612
VAL A 710
PHE A 562
ILE A 638
 None
 0.91A 5vimA-3pgbA:
undetectable		 5vimA-3pgbA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 129
GLY A 137
GLY A 131
HIS A 152
VAL A 392
 FAD  A 499 (-3.6A)
None
FAD  A 499 (-3.5A)
None
None
 0.94A 5vimA-3popA:
undetectable		 5vimA-3popA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 206
GLY A  69
GLY A 194
VAL A  94
ILE A  79
 None
 0.83A 5vimA-3pv2A:
undetectable		 5vimA-3pv2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 206
GLY A  69
GLY A 194
VAL A  94
ILE A  79
 None
 0.85A 5vimA-3pv4A:
undetectable		 5vimA-3pv4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 GLY A 167
GLY A  26
GLY A 155
VAL A  51
ILE A  34
 None
 0.95A 5vimA-3ufaA:
undetectable		 5vimA-3ufaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		5 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.93A 5vimA-3ugkA:
undetectable		 5vimA-3ugkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4o CARBONYL REDUCTASE
CPCR2

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  58
GLY A  64
GLY A 120
VAL A  41
PHE A 334
 None
 0.96A 5vimA-4c4oA:
3.4		 5vimA-4c4oA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 172
GLY A 237
GLY A 217
GLY A 170
VAL A 271
 NAP  A1301 (-3.3A)
NAP  A1301 (-3.3A)
NAP  A1301 (-2.8A)
NAP  A1301 (-3.3A)
None
 0.81A 5vimA-4cjxA:
4.3		 5vimA-4cjxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 GLY A 211
GLY A  43
GLY A  45
PHE A 100
ILE A  95
 None
 0.93A 5vimA-4doiA:
undetectable		 5vimA-4doiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		5 GLY A  85
GLY A  14
GLY A  11
PHE A 162
ILE A 102
 None
ACP  A 301 (-3.2A)
ACP  A 301 (-3.5A)
None
None
 0.90A 5vimA-4e09A:
undetectable		 5vimA-4e09A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 GLY D  21
GLY D  96
GLY D  17
GLY D  23
ILE D  97
 None
 0.95A 5vimA-4g81D:
5.5		 5vimA-4g81D:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		5 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.89A 5vimA-4jcnA:
undetectable		 5vimA-4jcnA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.1A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 3.7A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 ( 3.6A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.1A)
SAH  A1001 ( 4.3A)
None
 0.54A 5vimA-4k6mA:
41.4		 5vimA-4k6mA:
69.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
TRP A  87
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.3A)
SAH  A1001 (-4.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.1A)
SAH  A1001 ( 4.3A)
None
 1.15A 5vimA-4k6mA:
41.4		 5vimA-4k6mA:
69.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 GLY A 183
GLY A 229
GLY A 227
GLY A 181
GLU A 206
 PLP  A 403 (-3.4A)
None
CYS  A 402 ( 4.9A)
PLP  A 403 (-3.6A)
None
 0.96A 5vimA-4lmbA:
undetectable		 5vimA-4lmbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 GLY A 288
GLY A 231
GLY A 235
GLY A 267
ILE A 229
 None
 0.94A 5vimA-4q0mA:
undetectable		 5vimA-4q0mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.92A 5vimA-4r0iA:
undetectable		 5vimA-4r0iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 5 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.90A 5vimA-4ra6B:
undetectable		 5vimA-4ra6B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri0 SERINE PROTEASE
HTRA3

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.96A 5vimA-4ri0A:
undetectable		 5vimA-4ri0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 GLY A 367
GLY A 259
GLY A 376
VAL A 268
ILE A 273
 None
 0.95A 5vimA-4u4eA:
undetectable		 5vimA-4u4eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 5vimA-4ynnA:
undetectable		 5vimA-4ynnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo1 DEGQ

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 5vimA-4yo1A:
undetectable		 5vimA-4yo1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.96A 5vimA-4yryB:
3.3		 5vimA-4yryB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.89A 5vimA-5brrE:
undetectable		 5vimA-5brrE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 GLY A 269
GLY A 271
GLU A 266
VAL A 252
ILE A 247
 None
 0.97A 5vimA-5dneA:
undetectable		 5vimA-5dneA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 308
GLY A 318
GLY A 312
GLY A 310
ILE A 216
 SO4  A 709 ( 3.9A)
None
None
None
None
 0.94A 5vimA-5e7qA:
undetectable		 5vimA-5e7qA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.2A)
SAM  A 301 ( 4.8A)
 0.45A 5vimA-5e9qA:
40.8		 5vimA-5e9qA:
65.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 180
 SAM  A 301 (-3.3A)
SAM  A 301 ( 4.4A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.2A)
SAM  A 301 ( 4.8A)
 1.09A 5vimA-5e9qA:
40.8		 5vimA-5e9qA:
65.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		5 GLY A  67
GLY A 258
GLY A  62
PHE A 472
ILE A 421
 None
FAD  A 500 (-3.5A)
FAD  A 500 (-3.1A)
None
None
 0.87A 5vimA-5fjnA:
undetectable		 5vimA-5fjnA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 250
GLY A 114
GLY A 238
VAL A 138
ILE A 123
 None
 0.87A 5vimA-5gndA:
undetectable		 5vimA-5gndA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 5 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.87A 5vimA-5gp4C:
undetectable		 5vimA-5gp4C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
 None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.1A)
None
None
 0.84A 5vimA-5hxwA:
2.0		 5vimA-5hxwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
 None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
 0.87A 5vimA-5i39A:
2.4		 5vimA-5i39A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
GLU A 111
LYS A 180
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
None
None
 0.80A 5vimA-5ikmA:
41.0		 5vimA-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
MLT  A 313 ( 3.0A)
SAM  A 311 (-4.1A)
SAM  A 311 (-3.7A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
None
 0.48A 5vimA-5ikmA:
41.0		 5vimA-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  85
PHE A 133
ILE A 147
LYS A 180
 SAM  A 311 (-3.2A)
SAM  A 311 ( 4.5A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
None
 0.97A 5vimA-5ikmA:
41.0		 5vimA-5ikmA:
62.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  86
TRP A  87
LYS A 105
HIS A 110
PHE A 133
ILE A 147
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
MLT  A 313 ( 3.0A)
SAM  A 311 (-4.1A)
SAM  A 311 ( 4.4A)
SAM  A 311 ( 4.3A)
 1.45A 5vimA-5ikmA:
41.0		 5vimA-5ikmA:
62.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		5 GLY A 278
GLY A 179
GLY A 275
VAL A 171
ILE A 387
 None
 0.94A 5vimA-5j72A:
undetectable		 5vimA-5j72A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd8 PERIPLASMIC SERINE
PEPTIDASE DEGS

(Yersinia pestis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 213
GLY A  82
GLY A 201
VAL A 106
ILE A  91
 None
 0.73A 5vimA-5jd8A:
undetectable		 5vimA-5jd8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		6 GLY L 163
GLY L 457
GLY L 459
GLY L 166
VAL L  58
ILE L 453
 FAD  L 503 (-3.2A)
None
None
None
None
SF4  L 501 ( 4.4A)
 1.46A 5vimA-5jfcL:
3.8		 5vimA-5jfcL:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA
NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF10418
(DHODB_Fe-S_bind) 		5 GLY L 250
GLY S 229
VAL L 260
PHE L 356
ILE L 401
 None
FES  S 501 (-3.9A)
None
None
None
 0.94A 5vimA-5jfcL:
3.8		 5vimA-5jfcL:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		11 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAH  A1003 (-3.2A)
SAH  A1003 (-3.4A)
SAH  A1003 (-3.5A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
SAH  A1003 (-3.7A)
SAH  A1003 (-3.3A)
SAH  A1003 (-3.7A)
SAH  A1003 (-4.2A)
SAH  A1003 ( 4.3A)
None
 0.53A 5vimA-5jjrA:
40.9		 5vimA-5jjrA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		9 GLY A  81
GLY A  83
GLY A  86
LYS A 105
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 180
 SAH  A1003 (-3.4A)
SAH  A1003 (-3.5A)
SAH  A1003 (-3.0A)
SAH  A1003 (-4.8A)
SAH  A1003 (-3.7A)
SAH  A1003 (-3.7A)
SAH  A1003 (-4.2A)
SAH  A1003 ( 4.3A)
None
 0.75A 5vimA-5jjrA:
40.9		 5vimA-5jjrA:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.2A)
SAH  A1001 (-4.2A)
None
 0.32A 5vimA-5njuA:
42.7		 5vimA-5njuA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SAH  A1001 (-3.2A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 3.8A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.0A)
SAH  A1001 (-4.2A)
SAH  A1001 ( 4.8A)
None
 0.47A 5vimA-5tmhA:
42.7		 5vimA-5tmhA:
98.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4q DTDP-GLUCOSE
4,6-DEHYDRATASE

(Klebsiella
pneumoniae) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A 183
GLY A  13
GLY A 186
VAL A   5
ILE A  16
 CL  A 402 (-4.3A)
None
CL  A 402 ( 4.4A)
None
None
 0.79A 5vimA-5u4qA:
5.7		 5vimA-5u4qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		6 GLY A 163
GLY A 458
GLY A 460
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
None
SF4  A 501 ( 4.3A)
 1.45A 5vimA-5vj7A:
2.9		 5vimA-5vj7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 GLY A 179
GLY A 226
GLY A 224
GLY A 177
GLU A 203
 LLP  A  44 ( 3.1A)
None
None
LLP  A  44 ( 3.5A)
None
 0.97A 5vimA-5xa2A:
undetectable		 5vimA-5xa2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2d -

(-) 		no annotation 5 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.89A 5vimA-5y2dA:
undetectable		 5vimA-5y2dA:
undetectable